The discussions demonstrate broad consensus that lowering oxygen targets does not significantly affect mortality rates, with examples like references to the HOT-ICU trial and multiple mentions of similar mortality outcomes regardless of oxygenation strategy. The tone is analytical and pragmatic, emphasizing the neutrality of the findings while considering implications for hospital protocols and resource management.
AgreementModerate agreement
Most discussions agree that the study shows no significant benefit in choosing higher or lower oxygenation targets for ICU patients, highlighting consensus on the neutrality of these strategies.
InterestHigh interest
There is high interest reflected by frequent references to the study and its implications, including hashtags, podcasts, and discussions on clinical practice changes.
EngagementModerate engagement
Many posts analyze methodology, mention ongoing debates, and consider clinical applications, showing a surface to moderate depth of engagement.
ImpactModerate impact
The discussions suggest the findings influence clinical guidelines and policy debates, especially amid oxygen shortages, indicating a moderate impact.
Abstract in brief
The study compared the effects of lower (PaO2 of 60 mm Hg) versus higher (PaO2 of 90 mm Hg) oxygenation targets on 2,928 ICU patients with acute hypoxemic respiratory failure, finding no significant difference in 90-day mortality rates between the two groups.
There was no notable difference in the days patients were alive without life support, after hospital discharge, or in the occurrence of complications like shock or myocardial ischemia between the lower and higher oxygenation target groups.
Overall, aiming for a lower oxygenation target did not reduce mortality or adverse events compared to a higher target in adult ICU patients with this condition.
Higher or lower oxygenation targets in acute hypoxemic respiratory failure?
#BreatheEasy @ATSCritCare interviewed @DogICUma & @BodilRasmussen4 about their @NEJM articles
Podcast link: https://t.co/4VMog3X0sb
They discuss #oxygen monitoring, targets and #outcomes in the #ICU https://t.co/HvqGS4Uu5b
Congratulations to the investigators of HOT-ICU
Where do we stand now @AndersPerner?
Back to higher targets?
Are you planning a long term follow up looking at cognitive impairment?
Lower or Higher Oxygenation Targets for Acute Hypoxemic RF https://t.co/2RwKjWva8b
Sin cambios en el pronóstico en dos estrategias de objetivo de oxigenoterapia en UCI. 60 vs 90 mm de Hg de PaO2 (¿Por qué iba a ser diferente?).
Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure | NEJM https://t.co/YuESf3QL80
En tiempos de escasez de O2 IMPORTANTE DIFUNDIR:
➡️En múltiples ECRs NO se observó beneficio con uso liberal del O2 en pacientes críticos
➡️El uso restrictivo del O2 es seguro. (target sat >90%)
Acá, solo uno de los ECRs:
https://t.co/eaYF1WBGqE #OxygenShortage https://t.co/dg0k7L3xSt
Among adult patients with acute hypoxemic respiratory failure in the ICU, a lower oxygenation target did not result in lower mortality than a higher target at 90 days. https://t.co/rudslkHoH8 @NEJM
The clinical practice of oxygen therapy must be grounded in the best scientific evidence. This episode discusses proper target saturation levels, monitoring, and individualized approaches to optimize therapy for acutely…
This study investigated blood-pressure targets for comatose adults after cardiac arrest to assess their impact on survival and cognitive outcomes. The trial included 789 patients and found no significant difference…
HOT-ICU - lower mortality with liberal
https://t.co/4IbiyzFEqv
Jun 17, 2025 · 1 like · 10,705 followersView post →
AG
Anders Granholm
@andersgranholm · X
Using data from the COVID STEROID 2 (https://t.co/AiequfNBN6) and HOT-ICU (https://t.co/E9GlOzHjMs) trials, we assessed this following a previously published protocol/SAP (https://t.co/xEVjmrHEDi) 2/..
RT @cgraydoc: The initial trial HOT-ICU randomised adult ICU patients with respiratory failure to lower or higher oxygen targets and found…
Aug 1, 2022 · 1 share · 6,933 followersView post →
CG
Chris Gray
@cgraydoc · X
The initial trial HOT-ICU randomised adult ICU patients with respiratory failure to lower or higher oxygen targets and found no difference between those groups in the primary outcome of 90d all cause mortality
#LONGHOTtrial
#CCR22
https://t.co/yJ2dwG28s5
Jun 17, 2022 · 2 likes · 1 share · 1,473 followersView post →
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faizalrasid213
@faizalrasid213 · X
RT @AndyNeill: LOCO2 said low oxy targets were killing people.
https://t.co/1Ygav35beL
Oxygen-ICU said high oxygen as killing people.
ht…
#SCCM2022 @SCCM_Anesth No1: #HOT_ICU https://t.co/DUpRUZHdQD @NEJM which showed that higher or lower PaO2 targets are equally safe in acute hypoxaemic respiratory failure https://t.co/CLR4beYcIx @WICSBottomLine https://t.co/Xf6kgDWMoR
@NIH @NEJM Clear separation in oxygen exposure was achieved
There was no major difference in the primary outcome of 90 day mortality
(10.1056/NEJMoa2032510)
14/16 https://t.co/O9P05wZo2s
RT @neurocritical: NCS Podcast Episode 64: "Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure," is now available…
Jan 29, 2022 · 3 shares · 9,094 followersView post →
KH
Kawthar Hadhiah
@HadhiahKawthar · X
RT @neurocritical: NCS Podcast Episode 64: "Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure," is now available…
Jan 28, 2022 · 3 shares · 727 followersView post →
SA
S.A.
@SalmanAssad1 · X
RT @neurocritical: NCS Podcast Episode 64: "Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure," is now available…
Jan 28, 2022 · 3 shares · 773 followersView post →
NS
Neurocritical Care Society
@neurocritical · X
NCS Podcast Episode 64: "Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure," is now available for streaming. https://t.co/7HkaiRwgrr
Jan 28, 2022 · 5 likes · 3 shares · 13,409 followersView post →
Dec 11, 2021 · 3 shares · 1,462 followersView post →
KC
KristopherMaday PA-C
@PA_Maday · X
HOT-ICU Trial
Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure
https://t.co/akqk5Ye5dQ https://t.co/JxOUuSRhnW
Nov 8, 2021 · 3 likes · 2,438 followersView post →
SS
Shahbaz Syed
@DDxDino · X
RT @emergmedottawa: EMOttawa JC: Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure via @NEJM https://t.co/5WxZKqN…
Oct 12, 2021 · 5 shares · 969 followersView post →
NL
Natalie Lavergne
@LavergneNatalie · X
RT @emergmedottawa: EMOttawa JC: Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure via @NEJM https://t.co/5WxZKqN…
Oct 12, 2021 · 5 shares · 1,230 followersView post →
RR
Robert_Ryman
@RymanAnCritCare · X
RT @emergmedottawa: EMOttawa JC: Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure via @NEJM https://t.co/5WxZKqN…
Oct 12, 2021 · 5 shares · 456 followersView post →
PG
Puneet Gupta
@EMdocinabox · X
RT @emergmedottawa: EMOttawa JC: Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure via @NEJM https://t.co/5WxZKqN…
Oct 12, 2021 · 5 shares · 2,466 followersView post →
HR
Hans Rosenberg
@hrosenberg33 · X
RT @emergmedottawa: EMOttawa JC: Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure via @NEJM https://t.co/5WxZKqN…
Oct 12, 2021 · 5 shares · 1,331 followersView post →
EO
EM Ottawa
@emergmedottawa · X
EMOttawa JC: Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure via @NEJM https://t.co/5WxZKqNn32
Bottom line: It is reasonable to target lower SpO2 (90-96%) for patients with acute hypoxemic respiratory failure requiring oxygenation. https://t.co/ooIVutsDP4
Oct 12, 2021 · 6 likes · 5 shares · 6,602 followersView post →
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Greywolf
@Graywol99982773 · X
RT @ATSCritCare: Higher or lower oxygenation targets in acute hypoxemic respiratory failure?
#BreatheEasy @ATSCritCare interviewed @DogICU…
Aug 13, 2021 · 33 shares · 192 followersView post →
AA
American Thoracic Society (ATS)
@atscommunity · X
In this “Breathe Easy Critical Perspective” podcast, Drs. Dominique Pepper interviews Drs. Rasmussen and Young about lower or higher oxygenation targets in adults with acute hypoxemic respiratory failure. Listen here: https://t.co/krDFvptGVj https://t.co/gLhnLqGr31
Jul 26, 2021 · 1 like · 42,016 followersView post →
LO
La chuleta de Osler
@chuletadeosler · X
RT @ATSCritCare: Higher or lower oxygenation targets in acute hypoxemic respiratory failure?
#BreatheEasy @ATSCritCare interviewed @DogICU…
Enjoyed pairing these two podcasts on physiology & application at the bedside-
https://t.co/wTHDmHP6Kj by @CuriousClinPod
https://t.co/jXTMNsvVcg by @ATSCritCare
Jul 21, 2021 · 1 like · 27,313 followersView post →
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Ornorn
@Ornorn71251818 · X
RT @ATSCritCare: Higher or lower oxygenation targets in acute hypoxemic respiratory failure?
#BreatheEasy @ATSCritCare interviewed @DogICU…
Tap into to the current @ATSCritCare "Breathe Easy" podcast, "Critical Perspective: Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure," with Drs. Rasmussen and Young:
https://t.co/a84sZ2wIcj
Ensayo clínico aleatorizado multinacional en 2928 pacientes con insuficiencia respiratoria aguda en el que se evalúan metas de oxigenación bajas (PaO2 60 mmHg) contra altas (PaO2 de 90 mmHg).
Higher or lower oxygenation targets in acute hypoxemic respiratory failure?
#BreatheEasy @ATSCritCare interviewed @DogICUma & @BodilRasmussen4 about their @NEJM articles
Podcast link: https://t.co/4VMog3X0sb
They discuss #oxygen monitoring, targets and #outcomes in the #ICU https://t.co/HvqGS4Uu5b
Patients with acute hypoxemic respiratory failure in ICU are treated with supplemental oxygen. We hypothesized that using a lower target for partial pressure of arterial oxygen (Pao2) would result in lower mortality than using a higher target.
Ref: https://t.co/fNL2tM8FvV https://t.co/JLWwzlFUPq
@NEJM this article would be really helpful for clinicians and policymakers to reduce oxygen demand right now in countries affected by #OxygenShortage, but the full text is behind a #paywall: https://t.co/z9Q2t6Ja3x. Please provide open access at least during the #CovidPandemic.
En tiempos de escasez de O2 IMPORTANTE DIFUNDIR:
➡️En múltiples ECRs NO se observó beneficio con uso liberal del O2 en pacientes críticos
➡️El uso restrictivo del O2 es seguro. (target sat >90%)
Acá, solo uno de los ECRs:
https://t.co/eaYF1WBGqE #OxygenShortage https://t.co/dg0k7L3xSt
Intersting @NEJM article,
the #HOTICU trial found no diff between high vs low oxygen.
N=2928 ICU pts on high O2, randomized to PaO2 60 vs PaO2 90
No diff in 90 day mortality (~43%), recovery or life support, or adverse events
@OlavSchj
@BodilSRasmussen
https://t.co/5pU928VNKr
@sunjaydevarajan @kumaranupammd @PrathitKulkarni @lilitdoc @Hananianick @GoodishIntent @PatHerlihyMD @CHESTPrez @RozyKhanDO @sargsyanz @UmaAyyala @virenkaul @KantaVelamuri @devarajan_veena @redraiderpulmcc @gretchemaben @AvrahamCooperMD There was no sig mortality difference b/w conservative and liberal O2 in ICU-ROX and HOT-ICU, but the floor in these studies was different (SpO2 90%, pO2 60).
https://t.co/mYS1ZNeqUQ
https://t.co/hH1ZrJUzDe
Apr 21, 2021 · 1 like · 10,243 followersView post →
AS
Ajay Sheshadri
@ajaysheshadri · X
@sunjaydevarajan @accpchest @SCCM @atscommunity @rgbMDPhD @ChrisCarrollMD @ivanorosas Great thread! This article suggests PaO2 targets of 60 v 90 had similar outcomes, but PaO2 may not be the right way to measure oxygen delivery as you say - SaO2 only differed 3-4%
https://t.co/X2ZV6yeEOQ
Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure | NEJM https://t.co/YekeglwTrO
Apr 13, 2021 · 1 like · 1,463 followersView post →
AR
Ahmad M Rashid
@Amrashidmd · X
-PaO2 target of 60 mmHg = 90 mm Hg in terms of mortality in ICU patients
- Very important for those parts of the world facing O2 shortages
Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure | NEJM https://t.co/HEvwQYmFFj
https://t.co/X6HUOniPOB
"Among adult patients with acute hypoxemic respiratory failure in the ICU, a lower oxygenation target did not result in lower mortality than a higher target at 90 days."
https://t.co/kgouW8UQbc
Among adult patients with acute hypoxemic respiratory failure in the ICU, a lower oxygenation target did not result in lower mortality than a higher target at 90 days.
Menos es mejor (o igual, al menos). Menos oxígeno en pacientes ingresados en la UCI.
https://t.co/JoM1ZK2dXm
Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure | NEJM https://t.co/5NjFOXqqfP There is no difference between a PaO2 target of 60 or 90 mmHg.
Among adult patients with acute hypoxemic respiratory failure in the ICU, a lower oxygenation target did not result in lower mortality than a higher target at 90 days. https://t.co/rudslkHoH8 @NEJM
Congratulations to the investigators of HOT-ICU
Where do we stand now @AndersPerner?
Back to higher targets?
Are you planning a long term follow up looking at cognitive impairment?
Lower or Higher Oxygenation Targets for Acute Hypoxemic RF https://t.co/2RwKjWva8b
Sin cambios en el pronóstico en dos estrategias de objetivo de oxigenoterapia en UCI. 60 vs 90 mm de Hg de PaO2 (¿Por qué iba a ser diferente?).
Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure | NEJM https://t.co/YuESf3QL80
RT @WICSBottomLine: TBL 368: HOT-ICU - Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure
https://t.co/OVXaPX0zL8…
Feb 27, 2021 · 18 shares · 103 followersView post →
T
Taisa
@TmahAisa · X
RT @WICSBottomLine: TBL 368: HOT-ICU - Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure
https://t.co/OVXaPX0zL8…
Feb 26, 2021 · 18 shares · 25 followersView post →
DL
Dr Rani Lakhe
@lakhe_dr · X
RT @WICSBottomLine: TBL 368: HOT-ICU - Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure
https://t.co/OVXaPX0zL8…
Feb 26, 2021 · 18 shares · 39 followersView post →
CS
Christine sølling
@soellingforever · X
RT @WICSBottomLine: TBL 368: HOT-ICU - Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure
https://t.co/OVXaPX0zL8…
Feb 26, 2021 · 18 shares · 103 followersView post →
CP
Cheryl Peters
@CherylPetersMD · X
RT @WICSBottomLine: TBL 368: HOT-ICU - Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure
https://t.co/OVXaPX0zL8…
Feb 25, 2021 · 18 shares · 156 followersView post →
B
Batsuren
@Batsrn_ · X
RT @WICSBottomLine: TBL 368: HOT-ICU - Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure
https://t.co/OVXaPX0zL8…
Feb 25, 2021 · 18 shares · 27 followersView post →
QH
Quintard hervé
@QuintardH · X
RT @WICSBottomLine: TBL 368: HOT-ICU - Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure
https://t.co/OVXaPX0zL8…
Feb 25, 2021 · 18 shares · 162 followersView post →
SG
SHINE research group
@SHINEGROUP_DK · X
RT @WICSBottomLine: TBL 368: HOT-ICU - Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure
https://t.co/OVXaPX0zL8…
Feb 25, 2021 · 18 shares · 91 followersView post →
TD
Tatjana Dill
@inspiro_expiro · X
RT @WICSBottomLine: TBL 368: HOT-ICU - Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure
https://t.co/OVXaPX0zL8…
Feb 25, 2021 · 18 shares · 674 followersView post →
JU
Jonathan Underwood
@Dr_J_Underwood · X
@jfdwolff @medichulston @EmergencyMedBMJ @acutemedicine @DanLasserson Pure hypoxia is tolerated very well as COVID and those trips up everest have shown as has this recent RCT.
Lots of evidence of harm from hyperoxia. Why not change the NEWS2 charts to say stop/reduce oxygen if sats >94%?
https://t.co/lFNp5x5CHY
Feb 25, 2021 · 2 likes · 1,610 followersView post →
DF
Dr Sarang Patil, MD, ATSF, FCCP
@sarangspatil1 · X
RT @atscommunity: Lower or higher oxygenation targets for acute hypoxemic respiratory failure: https://t.co/akGPcKWdn8
Feb 18, 2021 · 2 shares · 1,780 followersView post →
P
PneumoImagem
@pneumoimagem_ · X
RT @atscommunity: Lower or higher oxygenation targets for acute hypoxemic respiratory failure: https://t.co/akGPcKWdn8
Feb 18, 2021 · 2 shares · 674 followersView post →
AA
American Thoracic Society (ATS)
@atscommunity · X
Lower or higher oxygenation targets for acute hypoxemic respiratory failure: https://t.co/akGPcKWdn8
Feb 18, 2021 · 7 likes · 2 shares · 42,016 followersView post →
FU
FcM|Critical Care Update
@FcM33189202 · X
Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure https://t.co/Nn7RXs6GpO
“Among adult patients with acute hypoxemic respiratory failure in the ICU, a lower oxygenation target (8kPa) did not result in lower mortality than a higher target (12kPa) at 90 days” https://t.co/JFxmNYNdhl
Feb 12, 2021 · 7 likes · 1 share · 697 followersView post →
PD
Pol Domingo
@PolDomingo · X
RT @atscommunity: Lower or higher oxygenation targets for acute hypoxemic respiratory failure: https://t.co/akGPcKWdn8
RT @atscommunity: Lower or higher oxygenation targets for acute hypoxemic respiratory failure: https://t.co/akGPcKWdn8
Feb 12, 2021 · 4 shares · 11,569 followersView post →
S
SENP
@SENPneumoped · X
Más no siempre es mejor: Adultos en UCI con IRA (grave) hipoxémica. Aleatorizados a recibir O2 para conseguir PpO2 60 vs 90 mmHg. Ambos grupos tuvieron la misma mortalidad (alrededor de 42%) a los 90 días. Vía @NEJM https://t.co/2fgaSYqH28
RT @giovannilandoni: nice #NEJM mRCT on different oxygenation targets in pts with acute hypoxemic respiratory failure. Mortality 42% in bot…
Jan 22, 2021 · 3 shares · 388 followersView post →
VF
vittorio ferrari
@vittoriofer · X
RT @giovannilandoni: nice #NEJM mRCT on different oxygenation targets in pts with acute hypoxemic respiratory failure. Mortality 42% in bot…
Jan 21, 2021 · 3 shares · 506 followersView post →
TM
Tommaso Scquizzato, MD
@tscquizzato · X
RT @giovannilandoni: nice #NEJM mRCT on different oxygenation targets in pts with acute hypoxemic respiratory failure. Mortality 42% in bot…
Jan 21, 2021 · 3 shares · 5,154 followersView post →
GM
Giovanni Landoni, MD
@giovannilandoni · X
nice #NEJM mRCT on different oxygenation targets in pts with acute hypoxemic respiratory failure. Mortality 42% in both groups. Did you plan an IQ test at middle term follow up? Is it worth considering it or RMN in ongoing trials (at least in subgroups)?
https://t.co/vAWs5MppVk https://t.co/05dWU0kxlV
Jan 21, 2021 · 6 likes · 3 shares · 4,749 followersView post →
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NEJMoa2032510 218 Tisminetzky M, Ferreyro BL, Fan E. Extracorporeal Membrane ... doi:10.1056/ 224 Semler MW, Casey JD, Lloyd BD, et al. PILOT Investigators ...