The discussions around the publication are characterized by a tone of concern and scientific curiosity, with posts citing the mutation E484K and resistance data to highlight the challenges posed by variants like B.1.351. Words like 'worrisome,' 'significant resistance,' and mentions of delayed or limited vaccine effectiveness convey a recognition of the article's urgent implications for public health and future research, emphasizing that the findings are highly relevant and potentially transformative.
AgreementModerate agreement
Most discussions acknowledge the significance of the publication, with users referencing its findings on resistance and treatment challenges, reflecting general consensus or recognition of its importance.
InterestNeutral interest
EngagementNeutral engagement
ImpactNeutral impact
Abstract in brief
The study highlights that the SARS-CoV-2 variants B117 (UK) and B1351 (South Africa) have mutations in their spike proteins that make them more resistant to neutralization by monoclonal antibodies, convalescent plasma, and vaccine-induced sera.
B1351 is especially concerning because it shows a significant resistance to neutralization, largely due to the E484K mutation, and greatly reduces the effectiveness of current antibody-based treatments and vaccines.
These findings suggest that new variants with these mutations pose challenges for existing COVID-19 therapies and may compromise the overall protective impact of current vaccines, emphasizing the need for ongoing development of updated therapeutics and vaccines.
3月8日公表
南アフリカで最初に発見新型コロナウイルス変異株でワクチンをテストした結果。ファイザーもモデルナも10分の1の効果しかなかった。
原因はE484K変異に対する有効性が低かったため。
研究
「Antibody Resistance of SARS-CoV-2 Variants
B.1.351 and B.1.1.7」
https://t.co/kNl8QNURFJ
Mar 8, 2021 · 47 likes · 30 shares · 28,810 followersView post →
TP
Tomas Pueyo
@tomaspueyo · X
More good news on the treatments front: it looks like both Regeneron's and Eli Lilly's monoclonal antibodies (mABs) work really well.
Unfortunately, the South African variant appears to have some resistant to both vaccines & mABs
https://t.co/yhBUl6GREh
https://t.co/FTIohk0P4K
Jan 27, 2021 · 24 likes · 10 shares · 335,720 followersView post →
AP
Andrew Pavia
@AndrewPaviaMD · X
For the mRNA vaccines we have lab data only and some observations from Israel. Nice lab work shows very modest reduction in Ab response to B.1.1.7 but marked reduction to B.1.351 https://t.co/QKid60ITRy #realtimevaccinechat
Feb 17, 2021 · 15 likes · 7 shares · 2,721 followersView post →
F
FrezzaLab
@FrezzaLab · X
Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 | Nature https://t.co/AY2TJXgbxm
Mar 9, 2021 · 5 likes · 2 shares · 26,938 followersView post →
S
SEInmunología
@SEinmunologia · X
@DrLejarazu @sev_virologia Increased Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 to Antibody Neutralization
doi: https://t.co/H8i7ZUaA3a
Jan 29, 2021 · 4 likes · 10,395 followersView post →
AP
Ash Paul
@pash22 · X
Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 https://t.co/WkGZ7tWtpg via @BarneyGrahamMD et al https://t.co/8kQO2dtf1a
Mar 15, 2021 · 3 likes · 1 share · 32,311 followersView post →
Beta variant B1351, emerging in 2020, is classified as a Variant of Concern. It exhibits mutations in spike proteins that increase resistance to neutralization by antibodies, potentially undermining current vaccines and…
This video examines how T cells react to SARS-CoV-2 infection in 99 recovered patients. Researchers investigate a comprehensive range of peptides to understand T cell immunodominance and antibody responses, enhancing…
@KdwUh @TheRealEddieC @Rectitude2022 The crazy thing is that they knew that delta and other variances had significant immune evasion.
https://t.co/OafoXXXmku
https://t.co/xjCzwkdrJs
@DrEricDing @kathy_sherrill “This work is published in Nature, in the paper, “Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7.” A preprint of the study was first posted to BioRxiv on January 26, 2021.” https://t.co/UBYvFtXJgp the vaccines work very well, yet Deng continues to not follow work
Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7. Nature 593, 130–135 (2021). - by Wang, P., Nair, M.S., Liu, L. et al.
#COVID19 #COVID_19
https://t.co/5bmlvvtiNW
変異株が現れる度に既存ワクチンへの有効性も考えなくてはならないですね。mRNAの技術で素早い応用は出来ると思いますが,今後もどのような変異株が出現してくるか注目です。
Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 https://t.co/liIKejc2MS
Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 https://t.co/9FNEKGQn6x Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies https://t.co/v4h4YFwewT 株によるんだろうけど今日のネーチャーでも実験的にはワクチンを回避する可能性が指摘されている
May 5, 2021 · 2 likes · 8,623 followersView post →
IS
Isatou Sarr
@IsatouSarr4 · X
Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 https://t.co/33PNHuFkja
@RandPaul B.1.351 South African variant is and has been the one showing a pattern of not only increased transmissibility but worse outcomes, with experimental evidence of significant vaccine resistance...
Oh look, it's not in your study!
https://t.co/f0JjQt6XD4
https://t.co/5ZLjrTmBfA https://t.co/4c3Wo4rO5W
@JaneEva37964120 @trishgreenhalgh @Channel4News Then there's the "accelerated article preview" about antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7 that I still need to read! This pandemic has taken me way out of my "comfort zone" as a journalist; not that I ever really had one. But it certainly wasn't science!
Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7: Nature, Published online: 08 March 2021; doi:10.1038/s41586-021-03398-2Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 https://t.co/m8pFHt5Aox
Mar 8, 2021 · 30 shares · 1,405 followersView post →
DU
David Usharauli
@3DiMMUNE · X
we see little changes from preprint to peer review in papers these days, especially for #COVID19.
Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 https://t.co/cZVdxOlRoF
Mar 8, 2021 · 2 likes · 2,720 followersView post →
Mar 8, 2021 · 30 shares · 1,624 followersView post →
笹
笹山登生
@keyaki1117 · X
3月8日公表
南アフリカで最初に発見新型コロナウイルス変異株でワクチンをテストした結果。ファイザーもモデルナも10分の1の効果しかなかった。
原因はE484K変異に対する有効性が低かったため。
研究
「Antibody Resistance of SARS-CoV-2 Variants
B.1.351 and B.1.1.7」
https://t.co/kNl8QNURFJ
Mar 8, 2021 · 47 likes · 30 shares · 28,810 followersView post →
DJ
Dr. Shashank Joshi
@AskDrShashank · X
RT @NG20194: @abledoc @AskDrShashank @Rupalijee @VirusesImmunity
Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 (March 8,…
Mar 8, 2021 · 1 share · 32,589 followersView post →
WF
Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry · X
Antibody Resistance of SARS-CoV-2 Variants
B.1.351 and B.1.1.7 https://t.co/IPxIGj5qTO B.1.351 (South African variant now in 20 states) is markedly more resistant to neutralization by convalescent plasma (9.4 fold) and Pfizer or Moderna vaccine sera (10.3-12.4 fold).
RT @alexvespi: Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7
‘B.1.1.7 is not more resistant to convalescent plasma or vac…
Mar 8, 2021 · 22 shares · 442 followersView post →
SR
Sergio Ragone
@sergioragone · X
RT @alexvespi: Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7
‘B.1.1.7 is not more resistant to convalescent plasma or vac…
Mar 8, 2021 · 22 shares · 6,740 followersView post →
ST
Silvia Turin
@silviaturin · X
RT @alexvespi: Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7
‘B.1.1.7 is not more resistant to convalescent plasma or vac…
Mar 8, 2021 · 22 shares · 675 followersView post →
SR
SciScore Reports
@SciscoreReports · X
The preprint “Antibody Resistance of SARS-CoV-2 Variants B.1.351…” (https://t.co/oLWzCN1jyr) has been reviewed by automated tools, find results here: https://t.co/3mPbF2y2qB. We detected 0 of 5 rigor criteria, 0 resources, and no limitations statement.
RT @AndrewPaviaMD: For the mRNA vaccines we have lab data only and some observations from Israel. Nice lab work shows very modest reduction…
Feb 17, 2021 · 7 shares · 3,403 followersView post →
I
IDSA
@IDSAInfo · X
RT @AndrewPaviaMD: For the mRNA vaccines we have lab data only and some observations from Israel. Nice lab work shows very modest reduction…
Feb 17, 2021 · 7 shares · 74,862 followersView post →
CR
COVID-19 Real-Time Learning Network (RTLN)
@RealTimeCOVID19 · X
RT @AndrewPaviaMD: For the mRNA vaccines we have lab data only and some observations from Israel. Nice lab work shows very modest reduction…
Feb 17, 2021 · 7 shares · 4,977 followersView post →
JF
Jose L. Pascual, MD, PhD, FRCS(C), FACS, FCCM
@SCCMPresident · X
RT @AndrewPaviaMD: For the mRNA vaccines we have lab data only and some observations from Israel. Nice lab work shows very modest reduction…
Feb 17, 2021 · 7 shares · 12,594 followersView post →
AP
Andrew Pavia
@AndrewPaviaMD · X
For the mRNA vaccines we have lab data only and some observations from Israel. Nice lab work shows very modest reduction in Ab response to B.1.1.7 but marked reduction to B.1.351 https://t.co/QKid60ITRy #realtimevaccinechat
Feb 17, 2021 · 15 likes · 7 shares · 2,721 followersView post →
LB
Lance Burkhart
@LanceBurkhart4 · X
@hildabast How does that gel with the Wang et al study that showed 6.5- to 8.6-fold reduction in neutralization?
https://t.co/bR2wVbufnQ
RT @tomaspueyo: More good news on the treatments front: it looks like both Regeneron's and Eli Lilly's monoclonal antibodies (mABs) work re…
Jan 31, 2021 · 10 shares · 329 followersView post →
S
SEInmunología
@SEinmunologia · X
@inmunoacoi Increased Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 to Antibody Neutralization
doi: https://t.co/H8i7ZUaA3a
Jan 29, 2021 · 1 like · 10,395 followersView post →
S
SEInmunología
@SEinmunologia · X
@DrLejarazu @sev_virologia Increased Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7 to Antibody Neutralization
doi: https://t.co/H8i7ZUaA3a
Jan 29, 2021 · 4 likes · 10,395 followersView post →
TN
TIYGA (NI)
@tiygahealth · X
RT @tomaspueyo: More good news on the treatments front: it looks like both Regeneron's and Eli Lilly's monoclonal antibodies (mABs) work re…
Jan 28, 2021 · 10 shares · 872 followersView post →
PC
Pandem(on)ical Order of Good Cheer
@EmpireinWinter · X
RT @tomaspueyo: More good news on the treatments front: it looks like both Regeneron's and Eli Lilly's monoclonal antibodies (mABs) work re…
Jan 27, 2021 · 10 shares · 1,350 followersView post →
A
AE
@AnsisEgle · X
RT @tomaspueyo: More good news on the treatments front: it looks like both Regeneron's and Eli Lilly's monoclonal antibodies (mABs) work re…
Jan 27, 2021 · 10 shares · 4,993 followersView post →
RE
Ritvars Eglājs
@Eglajs · X
RT @tomaspueyo: More good news on the treatments front: it looks like both Regeneron's and Eli Lilly's monoclonal antibodies (mABs) work re…
Jan 27, 2021 · 10 shares · 1,882 followersView post →
L
lilit
@Exie · X
RT @tomaspueyo: More good news on the treatments front: it looks like both Regeneron's and Eli Lilly's monoclonal antibodies (mABs) work re…
Jan 27, 2021 · 10 shares · 445 followersView post →
MP
Monica Perico
@monica_perico · X
RT @tomaspueyo: More good news on the treatments front: it looks like both Regeneron's and Eli Lilly's monoclonal antibodies (mABs) work re…
Jan 27, 2021 · 10 shares · 298 followersView post →
C
Cassandra
@cass___andra · X
RT @tomaspueyo: More good news on the treatments front: it looks like both Regeneron's and Eli Lilly's monoclonal antibodies (mABs) work re…
Jan 27, 2021 · 10 shares · 814 followersView post →
CL
Craig Liebenson
@CraigLiebenson · X
RT @tomaspueyo: More good news on the treatments front: it looks like both Regeneron's and Eli Lilly's monoclonal antibodies (mABs) work re…
Jan 27, 2021 · 10 shares · 8,204 followersView post →
P
Pietro
@pedro75 · X
RT @tomaspueyo: More good news on the treatments front: it looks like both Regeneron's and Eli Lilly's monoclonal antibodies (mABs) work re…
Jan 27, 2021 · 10 shares · 632 followersView post →
TP
Tomas Pueyo
@tomaspueyo · X
More good news on the treatments front: it looks like both Regeneron's and Eli Lilly's monoclonal antibodies (mABs) work really well.
Unfortunately, the South African variant appears to have some resistant to both vaccines & mABs
https://t.co/yhBUl6GREh
https://t.co/FTIohk0P4K
Jan 27, 2021 · 24 likes · 10 shares · 335,720 followersView post →
N
SARS-CoV-2-Varianten: Evolution im Zeitraffer – Deutsches Ärzteblatt
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bioRxiv 10.1101/2021.01.25.428137 (2021). Crossref · Google Scholar. 51. D. Zhou, W. Dejnirattisai, P. Supasa, C. Liu, A. J. Mentzer, H. M. Ginn, Y. Zhao ...
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https://doi.org/10.1101/2021.01.25.428137. GO TO REFERENCE. Google Scholar. 47. G. Frey, H. Peng, S. Rits-Volloch, M. Morelli, Y. Cheng, B. Chen, A fusion ...
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Wang et al., bioRxiv, 10.1101/2021.01.25.428137 (2021). Google Scholar. 7. L. A. VanBlargan, L. Goo, T. C. Pierson, Microbiol. Mol. Biol. Rev. 80, 989 (2016) ...
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to neutralization by 30 mAbs, 20 convalescent plasma, and 22 vaccinee sera. bioRxiv preprint doi: https://doi.org/10.1101/2021.01.25.428137; this version posted ...