J Am Chem Soc February 2021 PMID 33577317

Total Synthesis of the Norditerpenoids (±)-Cephanolides A-D.

Maximilian Haider, Goh Sennari, Alina Eggert, Richmond Sarpong

Mentions

38
Peak: 21 in Feb 2021
across 2 sources since Feb 2021

Extended reach

495,295
potential audience

Total likes

434

Video views

8,079

Mentions per month

Feb 2021 – Nov 2025

Where it's discussed

  • X / Twitter36 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions reflect a highly positive and engaged response to the publication, with examples like 'Congratulations to the team' and references to detailed synthesis strategies such as 'Siegel arene hydroxylation.' The tone is enthusiastic, emphasizing both the technical achievement and its significance, indicating strong appreciation and recognition of the publication's contribution to the field.

AgreementStrong agreement

Most discussions celebrate and support the publication, highlighting its significance in the field, such as reference to the 'total synthesis' and congratulatory messages.

InterestHigh interest

Posts show strong curiosity and enthusiasm, with mentions of video features, synthesis details, and lab group achievements, indicating high engagement with the work.

EngagementHigh engagement

Many comments reference the methodology, congratulate specific team members, and share links to videos, demonstrating participants' deep involvement.

ImpactModerate impact

While most discussions are positive and acknowledge the importance of the research, some are more casual, so the perceived impact is high but slightly less than total for impact.

Abstract in brief

  • This document discusses a method to synthesize the norditerpenoids cephanolides AD in just 14 steps using a common final intermediate, making the process more efficient.
  • The approach was successful because it used chemical network analysis early on to plan which bonds to form, combined with iterative CspCsp cross-coupling to build the carbon skeleton, and a Diels-Alder reaction for cyclization.
  • Strategic late-stage oxidation steps enabled the production of all known versions of cephanolides with a benzenoid structure, completing the synthesis process.

Top posts

Most liked on X and Bluesky
Sarpong Group
@SarpongGroup · X

Congratulations to team cephanolide (Max, Goh, and Alina) on the publication of their syntheses of cephanolides A–D in @J_A_C_S! https://t.co/beriRT5Ztd https://t.co/yO0LP0COba

Feb 12, 2021 · 190 likes · 13 shares · 9,429 followers View post →
Drug Discovery and Synthesis Highlights
@TotalSyntheses · X

Total Synthesis of the Cephalotaxus Norditerpenoids (±)-Cephanolides A–D https://t.co/EIc7lju53A

Feb 14, 2021 · 37 likes · 6 shares · 7,389 followers View post →
Sarpong Group
@SarpongGroup · X

Our group's work on the synthesis of cephanolides is featured in a @J_A_C_S Video Byte. Check it out! https://t.co/gG8eWOjHqQ

Jun 8, 2021 · 35 likes · 3 shares · 9,413 followers View post →
CarreiraGroup
@CarreiraGroup · X

Total Synthesis of the Cephalotaxus Norditerpenoids (±)-Cephanolides A–D https://t.co/KmeDcuauyk Siegel arene hydroxylation and Mukaiyama Hydration are key!

Mar 1, 2021 · 29 likes · 1 share · 6,601 followers View post →
J. Am. Chem. Soc.
@J_A_C_S · X

Introducing @J_A_C_S Video Bytes - short video summaries of articles published in the Journal of the American Chemical Society. The first Video Bytes summarize work by @SarpongGroup @YuanningFeng @sirfrasersays @DeanAstumian Watch now! https://t.co/3jFfzMCz9t https://t.co/R4H9nonqFD

Jun 4, 2021 · 28 likes · 8 shares · 185,341 followers View post →
أ.د/عبدالله محمد عسيري|Prof. A .M. Asiri
@aasiri · X

الاصطناع الكلي للمنتجات الطبيعية فيديو من الجمعية مجلة JACS JACS Video Bytes: Total Synthesis of the Cephalotaxus Norditerpenoids (±... https://t.co/5055No3tNJ #الكيمياء #الكيمياء_العضوية #المنتجات_الطبيعية #Chemistry @J_A_C_S

Jun 8, 2021 · 4 likes · 27,912 followers View post →

All mentions

J. Am. Chem. Soc.
@J_A_C_S · X

RT @SarpongGroup: Our group's work on the synthesis of cephanolides is featured in a @J_A_C_S Video Byte. Check it out! https://t.co/gG8eW…

Jun 10, 2021 · 3 shares · 185,341 followers View post →
BogerLab
@BogerLab · X

RT @SarpongGroup: Our group's work on the synthesis of cephanolides is featured in a @J_A_C_S Video Byte. Check it out! https://t.co/gG8eW…

Jun 8, 2021 · 3 shares · 2,664 followers View post →
Sarpong Group
@SarpongGroup · X

Our group's work on the synthesis of cephanolides is featured in a @J_A_C_S Video Byte. Check it out! https://t.co/gG8eWOjHqQ

Jun 8, 2021 · 35 likes · 3 shares · 9,413 followers View post →
قسم الكيمياء
@chemistry_kau · X

JACS Video Bytes: Total Synthesis of the Cephalotaxus Norditerpenoids (±... https://t.co/syDzky6awU عبر @YouTube

Jun 8, 2021 · 3,946 followers View post →
أ.د/عبدالله محمد عسيري|Prof. A .M. Asiri
@aasiri · X

الاصطناع الكلي للمنتجات الطبيعية فيديو من الجمعية مجلة JACS JACS Video Bytes: Total Synthesis of the Cephalotaxus Norditerpenoids (±... https://t.co/5055No3tNJ #الكيمياء #الكيمياء_العضوية #المنتجات_الطبيعية #Chemistry @J_A_C_S

Jun 8, 2021 · 4 likes · 27,912 followers View post →
AppSavvyTalk
@appsavvytalk · X

RT @J_A_C_S: Introducing @J_A_C_S Video Bytes - short video summaries of articles published in the Journal of the American Chemical Society…

Jun 4, 2021 · 8 shares · 154 followers View post →
Wenqi Vince Liu
@vincentchem · X

RT @J_A_C_S: Introducing @J_A_C_S Video Bytes - short video summaries of articles published in the Journal of the American Chemical Society…

Jun 4, 2021 · 8 shares · 1,094 followers View post →
Yuanning Feng
@YuanningFeng · X

RT @J_A_C_S: Introducing @J_A_C_S Video Bytes - short video summaries of articles published in the Journal of the American Chemical Society…

Jun 4, 2021 · 8 shares · 1,005 followers View post →
Northwestern Chemistry
@NUChemistry · X

RT @J_A_C_S: Introducing @J_A_C_S Video Bytes - short video summaries of articles published in the Journal of the American Chemical Society…

Jun 4, 2021 · 8 shares · 7,289 followers View post →
FMS Research Center
@ResearchFMS · X

RT @J_A_C_S: Introducing @J_A_C_S Video Bytes - short video summaries of articles published in the Journal of the American Chemical Society…

Jun 4, 2021 · 8 shares · 306 followers View post →
Nok Piyatida
@Nok_Piyatida · X

RT @J_A_C_S: Introducing @J_A_C_S Video Bytes - short video summaries of articles published in the Journal of the American Chemical Society…

Jun 4, 2021 · 8 shares · 42 followers View post →
Dean Astumian, OFS☮️
@DeanAstumian · X

RT @J_A_C_S: Introducing @J_A_C_S Video Bytes - short video summaries of articles published in the Journal of the American Chemical Society…

Jun 4, 2021 · 8 shares · 1,917 followers View post →
J. Am. Chem. Soc.
@J_A_C_S · X

Introducing @J_A_C_S Video Bytes - short video summaries of articles published in the Journal of the American Chemical Society. The first Video Bytes summarize work by @SarpongGroup @YuanningFeng @sirfrasersays @DeanAstumian Watch now! https://t.co/3jFfzMCz9t https://t.co/R4H9nonqFD

Jun 4, 2021 · 28 likes · 8 shares · 185,341 followers View post →
Jennifer Roizen
@roizengroup · X

RT @CarreiraGroup: Total Synthesis of the Cephalotaxus Norditerpenoids (±)-Cephanolides A–D https://t.co/KmeDcuauyk Siegel arene hydroxylat…

Mar 1, 2021 · 1 share · 2,717 followers View post →
CarreiraGroup
@CarreiraGroup · X

Total Synthesis of the Cephalotaxus Norditerpenoids (±)-Cephanolides A–D https://t.co/KmeDcuauyk Siegel arene hydroxylation and Mukaiyama Hydration are key!

Mar 1, 2021 · 29 likes · 1 share · 6,601 followers View post →
もろどーむ
@piyopiyo_120 · X

RT @SarpongGroup: Congratulations to team cephanolide (Max, Goh, and Alina) on the publication of their syntheses of cephanolides A–D in @J…

Feb 15, 2021 · 13 shares · 232 followers View post →
HLE
@X_ian_Kjemiker · X

RT @TotalSyntheses: Total Synthesis of the Cephalotaxus Norditerpenoids (±)-Cephanolides A–D https://t.co/EIc7lju53A

Feb 15, 2021 · 6 shares · 79 followers View post →
甘ちゃん
@Yuuki_0109 · X

芳香環への水酸基の導入にSiegelらのperoxideの反応が使われている!(D3のとき文献紹介で扱った) Total Synthesis of the Cephalotaxus Norditerpenoids (±)-Cephanolides A–D https://t.co/wADWRh0z5N

Feb 14, 2021 · 192 followers View post →
O-Cortezano (±)
@OCortezano · X

RT @SarpongGroup: Congratulations to team cephanolide (Max, Goh, and Alina) on the publication of their syntheses of cephanolides A–D in @J…

Feb 14, 2021 · 13 shares · 327 followers View post →
Peijun Li
@impj_li · X

RT @TotalSyntheses: Total Synthesis of the Cephalotaxus Norditerpenoids (±)-Cephanolides A–D https://t.co/EIc7lju53A

Feb 14, 2021 · 6 shares · 147 followers View post →
MedChem & ONCo&
@MedChem314 · X

RT @TotalSyntheses: Total Synthesis of the Cephalotaxus Norditerpenoids (±)-Cephanolides A–D https://t.co/EIc7lju53A

Feb 14, 2021 · 6 shares · 588 followers View post →
Alex Zografos
@zografos_alex · X

RT @TotalSyntheses: Total Synthesis of the Cephalotaxus Norditerpenoids (±)-Cephanolides A–D https://t.co/EIc7lju53A

Feb 14, 2021 · 6 shares · 1,221 followers View post →
Drug Discovery and Synthesis Highlights
@TotalSyntheses · X

Total Synthesis of the Cephalotaxus Norditerpenoids (±)-Cephanolides A–D https://t.co/EIc7lju53A

Feb 14, 2021 · 37 likes · 6 shares · 7,389 followers View post →
Rubén Miguélez
@MorenRmm · X

RT @SarpongGroup: Congratulations to team cephanolide (Max, Goh, and Alina) on the publication of their syntheses of cephanolides A–D in @J…

Feb 13, 2021 · 13 shares · 595 followers View post →
CarreiraGroup
@CarreiraGroup · X

RT @SarpongGroup: Congratulations to team cephanolide (Max, Goh, and Alina) on the publication of their syntheses of cephanolides A–D in @J…

Feb 13, 2021 · 13 shares · 6,601 followers View post →
MedChem & ONCo&
@MedChem314 · X

RT @SarpongGroup: Congratulations to team cephanolide (Max, Goh, and Alina) on the publication of their syntheses of cephanolides A–D in @J…

Feb 13, 2021 · 13 shares · 588 followers View post →
Peijun Li
@impj_li · X

RT @SarpongGroup: Congratulations to team cephanolide (Max, Goh, and Alina) on the publication of their syntheses of cephanolides A–D in @J…

Feb 12, 2021 · 13 shares · 147 followers View post →
Conner Pope
@carbonandcoffee · X

RT @SarpongGroup: Congratulations to team cephanolide (Max, Goh, and Alina) on the publication of their syntheses of cephanolides A–D in @J…

Feb 12, 2021 · 13 shares · 73 followers View post →
Brian Stoltz
@brianstoltz70 · X

RT @SarpongGroup: Congratulations to team cephanolide (Max, Goh, and Alina) on the publication of their syntheses of cephanolides A–D in @J…

Feb 12, 2021 · 13 shares · 3,432 followers View post →
ナメタケ⌬
@nametakeshi · X

RT @SarpongGroup: Congratulations to team cephanolide (Max, Goh, and Alina) on the publication of their syntheses of cephanolides A–D in @J…

Feb 12, 2021 · 13 shares · 262 followers View post →
exp
@exp24659809 · X

RT @SarpongGroup: Congratulations to team cephanolide (Max, Goh, and Alina) on the publication of their syntheses of cephanolides A–D in @J…

Feb 12, 2021 · 13 shares · 19 followers View post →
Rosa
@relia_iv · X

RT @SarpongGroup: Congratulations to team cephanolide (Max, Goh, and Alina) on the publication of their syntheses of cephanolides A–D in @J…

Feb 12, 2021 · 13 shares · 1,023 followers View post →
Karl Haelsig
@KHaelsig · X

Congrats to the Sarpong group, and to my friend and hilarious former post-doc Dr. Haider. https://t.co/2GTIL9WUz5 https://t.co/xzpSxRyq5R

Feb 12, 2021 · 4 likes · 129 followers View post →
Total Synthesis
@TotalSynthesis · X

RT @SarpongGroup: Congratulations to team cephanolide (Max, Goh, and Alina) on the publication of their syntheses of cephanolides A–D in @J…

Feb 12, 2021 · 13 shares · 17,359 followers View post →
Thomas Poulsen
@ThomasBPoulsen · X

RT @SarpongGroup: Congratulations to team cephanolide (Max, Goh, and Alina) on the publication of their syntheses of cephanolides A–D in @J…

Feb 12, 2021 · 13 shares · 1,069 followers View post →
Sarpong Group
@SarpongGroup · X

Congratulations to team cephanolide (Max, Goh, and Alina) on the publication of their syntheses of cephanolides A–D in @J_A_C_S! https://t.co/beriRT5Ztd https://t.co/yO0LP0COba

Feb 12, 2021 · 190 likes · 13 shares · 9,429 followers View post →