Discussions highlight support for the publication's controversial claim that DNA damage and telomere attrition do not limit lifespan, as seen when users reference figures like 'fig. 1 A' or question the implications for aging theories. The tone varies from supportive to cautious, reflecting both curiosity and critical engagement with the findings.
AgreementModerate agreement
Most discussions support the idea that DNA damage and telomere shortening are not primary limits on lifespan, reflecting general agreement with the publication’s conclusions.
InterestHigh interest
Many posters are highly engaged, referencing detailed figures, theories, and expressing curiosity, indicating strong interest in the subject.
EngagementModerate engagement
Posts include citations of specific research figures, concepts like hyperfunction theory, and personal endorsements, showing moderate depth in discussion.
ImpactModerate impact
The topics appear to influence opinions and spark ongoing debates among researchers and enthusiasts, suggesting a moderate to high perceived impact.
Abstract in brief
The study shows that rapamycin, a drug known to extend lifespan, does not increase lifespan in mice with compromised DNA repair or missing telomerase, suggesting these factors may not be the main causes of aging.
In contrast, rapamycin does extend lifespan in normal mice, indicating its anti-aging effects are likely independent of DNA damage or telomere length issues.
These findings imply that DNA damage and telomere shortening might not be the primary factors limiting lifespan or driving normal aging processes.]
hello @Blagosklonny how does the current version of hyperfunction theory of aging conceptualise somatic mutations, somatic evolution and clonal hematopoiesis? have a guess based on this paper of yours but better to ask you https://t.co/BxeM9JfTL7
Dec 26, 2022 · 46 likes · 8 shares · 4,290 followersView post →
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Mikhail V. Blagosklonny, MD PhD Professor Oncology
@Blagosklonny · X
https://t.co/bct9SyHPlj
Feb 12, 2021 · 19 likes · 3 shares · 22,256 followersView post →
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Walter M Chesnut
@Parsifaler · X
5) animal lifetime. This damage can only become life-limiting, when artificially accelerated.
https://t.co/6zkqelte2B
https://t.co/xp9VKx8GaM
https://t.co/X6XgzB4hzf
https://t.co/MRieVoZwLn
Aug 13, 2021 · 18 likes · 6 shares · 87,960 followersView post →
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Orlando_uy
@Orlando_uy · X
Hyperfunction is an excessive normal function later in life. It’s NOT necessarily an increase of function; it may even be INSUFFICIENT DECREASE of function
Damage accumulates and must cause death eventually, but quasi-programmed aging terminates life first
https://t.co/DX3yReTdof
Feb 23, 2021 · 16 likes · 2 shares · 698 followersView post →
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Mikhail V. Blagosklonny, MD PhD Professor Oncology
@Blagosklonny · X
@jhillmd Yes, take a look at fig. 1 A. Life-limiting vs non-limiting changes with aging
https://t.co/bct9SyHPlj
This research suggests that normal aging is not caused by molecular damage or telomere shortening, as rapamycin extends lifespan in normal mice but not in those with DNA repair deficiencies. The findings highlight…
Psychological factors such as loneliness and unhappiness contribute up to 1.65 years to biological age, highlighting their role alongside physical health in the aging process. The study uses deep learning to measure…
hello @Blagosklonny how does the current version of hyperfunction theory of aging conceptualise somatic mutations, somatic evolution and clonal hematopoiesis? have a guess based on this paper of yours but better to ask you https://t.co/BxeM9JfTL7
Dec 26, 2022 · 46 likes · 8 shares · 4,290 followersView post →
@Blagosklonny I was reading your paper from 2021 titled "DNA- and telomere-damage does not limit lifespan: evidence from rapamycin" which is a great read. Full disclosure, I'm closely following the science and taking rapamycin myself.
https://t.co/aSigB4IpHn
Oct 25, 2022 · 7 likes · 1,304 followersView post →
RT @Parsifaler: 5) animal lifetime. This damage can only become life-limiting, when artificially accelerated.
https://t.co/6zkqelte2B
ht…
Aug 14, 2021 · 6 shares · 11,580 followersView post →
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Patrick Kenney
@VocationFreedom · X
RT @Parsifaler: 5) animal lifetime. This damage can only become life-limiting, when artificially accelerated.
https://t.co/6zkqelte2B
ht…
Aug 13, 2021 · 6 shares · 3,147 followersView post →
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BreakthroughMedicine&AdvancedResearchTools
@JayChance12 · X
RT @Parsifaler: 5) animal lifetime. This damage can only become life-limiting, when artificially accelerated.
https://t.co/6zkqelte2B
ht…
Aug 13, 2021 · 6 shares · 642 followersView post →
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Adam Carchidi
@Adam_Carchidi · X
RT @Parsifaler: 5) animal lifetime. This damage can only become life-limiting, when artificially accelerated.
https://t.co/6zkqelte2B
ht…
Aug 13, 2021 · 6 shares · 539 followersView post →
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SDpeggysue
@XpfG99 · X
RT @Parsifaler: 5) animal lifetime. This damage can only become life-limiting, when artificially accelerated.
https://t.co/6zkqelte2B
ht…
Aug 13, 2021 · 6 shares · 1,309 followersView post →
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Walter M Chesnut
@Parsifaler · X
5) animal lifetime. This damage can only become life-limiting, when artificially accelerated.
https://t.co/6zkqelte2B
https://t.co/xp9VKx8GaM
https://t.co/X6XgzB4hzf
https://t.co/MRieVoZwLn
Aug 13, 2021 · 18 likes · 6 shares · 87,960 followersView post →
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Ricky
@ricky89449195 · X
RT @agingdoc1: @LammingLab @mkaeberlein @Aging_Scientist @davidasinclair @JohnSpeakman4 Every compound has a finite Therapeutic Index tho R…
@LammingLab @mkaeberlein @Aging_Scientist @davidasinclair @JohnSpeakman4 Every compound has a finite Therapeutic Index tho Rapamycin's is impressively wide.
Regarding your citation Dudley, your thoughts on @Blagosklonny's interpretation of that study?
Aug 10, 2021 · 5 likes · 1 share · 43,745 followersView post →
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Mikhail V. Blagosklonny, MD PhD Professor Oncology
@Blagosklonny · X
@apedragosa I tweeted many times on that and you may read a special article on this
https://t.co/JYAjzPSLfu
Listen to the blog summary on #Soundcloud of the recent research perspective: “DNA- and telomere-damage does not limit lifespan: evidence from rapamycin,” by @Blagosklonny. https://t.co/E4hQXM6rYC #rapamycin #aging #DNAdamage #longevity
Top-Performer: Watch the #AgingShort video about Dr. Mikhail Blagosklonny's recent research perspective: “DNA- and telomere-damage does not limit lifespan: evidence from rapamycin.” #rapamycin #aging #DNAdamage #longevity https://t.co/vdJ313KX6i
Hyperfunction is an excessive normal function later in life. It’s NOT necessarily an increase of function; it may even be INSUFFICIENT DECREASE of function
Damage accumulates and must cause death eventually, but quasi-programmed aging terminates life first
https://t.co/DX3yReTdof
Feb 23, 2021 · 16 likes · 2 shares · 698 followersView post →
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Science
@Long_life_sci · X
RT @agingdoc1: DNA- and telomere-damage does not limit lifespan: evidence from rapamycin https://t.co/QPzahxCvF0
Commentary by @Blagosklo…
RT @agingdoc1: DNA- and telomere-damage does not limit lifespan: evidence from rapamycin https://t.co/QPzahxCvF0
Commentary by @Blagosklo…
Feb 15, 2021 · 4 shares · 3,437 followersView post →
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Michael Padula HPA.Coach
@MJPadula · X
@Nate_D_Stone @_CynthiaThurlow thoughts? https://t.co/KGzipYHzZI Also Dr Attia had a podcast last week saying telomere length is not the answer according to the expert.
The cover of Aging's latest issue features Figure 1 "#Rapamycin extends lifespan in natural but not progeroid mice“ by Dr. Misha Blagosklonny
https://t.co/LUbT7Z9xce
Feb 15, 2021 · 5 likes · 4,400 followersView post →
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Aging-US
@AgingJrnl · X
RT @agingdoc1: DNA- and telomere-damage does not limit lifespan: evidence from rapamycin https://t.co/QPzahxCvF0
Commentary by @Blagosklo…
Feb 15, 2021 · 4 shares · 4,400 followersView post →
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Mikhail V. Blagosklonny, MD PhD Professor Oncology
@Blagosklonny · X
https://t.co/JYAjzPSLfu
Feb 15, 2021 · 11 likes · 22,256 followersView post →
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AdapMolEvol papers
@adapmolevol · X
DNA- and telomere-damage does not limit lifespan: evidence from rapamycin. https://t.co/WpBqi8WDhn
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