J Am Heart Assoc February 2021 PMID 33586462

Small Dense Low-Density Lipoprotein Cholesterol Is the Most Atherogenic Lipoprotein Parameter in the Prospective Framingham Offspring Study.

Hiroaki Ikezaki, Elise Lim, L Adrienne Cupples, Ching-Ti Liu, Bela F Asztalos, Ernst J Schaefer

Mentions

41
Peak: 9 in Feb 2021
across 5 sources since Feb 2021

Extended reach

269,610
potential audience

Total likes

2,446

Video views

84,332

Mentions per month

Feb 2021 – May 2025

Where it's discussed

  • X / Twitter31 posts
  • YouTube3 videos
  • News3 articles
  • Facebook2 posts
  • Reddit2 posts

AI synopsis

What people are saying

The discussions reflect a strong consensus on the importance of sdLDL as the most atherogenic lipoprotein, with posts referencing recent research, emphasizing the potential for improved risk assessment, and debating the relevance of traditional markers. The tone and choice of words like 'most atherogenic,' 'significant,' and 'impactful' demonstrate enthusiasm and recognition of the study's potential to influence future clinical practices.

AgreementStrong agreement

Most discussions agree that the study highlights sdLDL as a key predictor of cardiovascular risk, emphasizing its significance in medical research and practice.

InterestHigh interest

The social discussions demonstrate high interest, with many referencing recent studies, debates over traditional markers, and potential therapies, showing engagement with the research topic.

EngagementHigh engagement

Participants analyze the implications, compare it with other lipoprotein parameters, and cite multiple studies, indicating deep engagement with the scientific content.

ImpactHigh impact

There's a consensus that the findings could influence future diagnostic and treatment approaches, suggesting a high potential impact on cardiovascular risk assessment.

Abstract in brief

  • The study found that among various lipoprotein measurements, small dense LDL cholesterol (sdLDLC) is the most strongly linked to the risk of developing atherosclerotic cardiovascular disease (ASCVD).
  • While many lipoprotein parameters are associated with ASCVD risk, only sdLDLC, direct LDL cholesterol, and lipoprotein(a) remained significant in models that considered multiple risk factors, with sdLDLC showing the strongest predictive power.
  • The findings suggest that measuring sdLDLC could provide more precise risk assessment for ASCVD than traditional cholesterol measures, as adding other specialized lipoprotein parameters didn't significantly improve risk prediction once sdLDLC was accounted for.]

Top posts

Most liked on X and Bluesky
Larronde Esteban
@EstebanDL · X

Estudio prospectivo de Framingham La partícula lipídica mas aterogénica es LDL pequeña y densa LDL/TG es otro parámetro importante LDL medición directa, se relaciona mucho menos (seguro que incluye L5 y LDL desialisado, no se estudió) LDL grande NO https://t.co/SsngYaUSN7 https://t.co/xhUMssyl9w

Feb 15, 2021 · 16 likes · 2 shares · 23,791 followers View post →
SABOURETCardiologist
@SABOURETCardio · X

Another in 2021 ...https://t.co/hmDwTA5V83

Oct 24, 2022 · 9 likes · 31,171 followers View post →
DiscoStew
@DiscoStew66 · X

“Our data indicate that small dense LDL is the most atherogenic lipoprotein parameter.” https://t.co/UZu8sGx4hr

Apr 3, 2021 · 9 likes · 2 shares · 10,806 followers View post →
JAHA
@JAHA_AHA · X

Small dense low-density lipoprotein cholesterol is the laboratory parameter most strongly associated with heart disease. https://t.co/ga2UDFrvRo @Eschaefer1945 #AHAJournals https://t.co/Us2VZyV6Kw

Feb 23, 2021 · 8 likes · 2 shares · 31,349 followers View post →
ZahcM
@ZahcM · X

"Our data indicate that small dense LDL is the most atherogenic lipoprotein parameter. . . In our view, sdLDL is substantially more atherogenic than lbLDL because of its smaller size and its greater plasma residence time" - https://t.co/JHbkkGZAm0

Feb 15, 2021 · 6 likes · 1 share · 1,919 followers View post →
LipoFan
@lipo_fan · X

https://t.co/eJ1CRUpaHE

Mar 3, 2024 · 3 likes · 2,992 followers View post →

All mentions

Shawn Flynn
@ShawnEFlynn · X

@Stellaster27074 @MohammedAlo https://t.co/QpDvW80Mi2

Dec 18, 2024 · 61 followers View post →
Clint O'Meley
@Clint_OMeley · X

@Lipoprotein Respectfully Dr Cromwell, some recent papers from Krauss, Ballantyne & Schaeffer to represent some counter-arguments to your position and some recent evidence on sdLDL: https://t.co/gsbTdbjUuF https://t.co/zJZVyndzyu https://t.co/fIYT4aVpIi https://t.co/cZB91ezCWy https://t.co/iJS1ZDdbBL

Jun 13, 2024 · 3 likes · 105 followers View post →
LipoFan
@lipo_fan · X

https://t.co/eJ1CRUpaHE

Mar 3, 2024 · 3 likes · 2,992 followers View post →
ZahcM
@ZahcM · X

@GMuelMuel @Absurd_Stoic @tednaiman I would suggest reading the post! Framingham also showed that apoB was no better than the TC/HDL ratio. And LDL-P is a mix of lipoproteins, with the risk in Framingham Offspring best associated with smaller LDLs. https://t.co/r8xfXV3i5H https://t.co/8QcFvujswe

Jul 15, 2023 · 1 like · 1,919 followers View post →
Clean Comments
@CommentsClean · X

@drjkahn @LeeGarcia85 @LDLSkeptic @PeterAttiaMD @ethanjweiss @ProfTimNoakes @KenDBerryMD @lowcarbGP @ifixhearts @DrPascalMeier Dr Kahn, In your recent podcast, you talked about advantages of Berberine, Kyolic having similar reduction of plaque like statin. Would they be better than statin? Per this studWould these natural agents be more successful in reducing small LDL-P? https://t.co/L2KSwFdMh3

May 5, 2023 · 1 followers View post →
Clean Comments
@CommentsClean · X

@drjkahn @Cutter1616 Then why @IvorCummins is anti Statin/LDL? You both avoided that topic. :) Cardiologists like Dr Aseem M, Nadir Ali , Bret Scher, and 100+ MDs,PhDs are opposed... https://t.co/TLS6UNkOy6 Think small LDL-P is the culprit... Thoughts? https://t.co/qvGggVfuhb

May 4, 2023 · 1 like · 1 followers View post →
Dr Scott W Murray
@DrScottMurray · X

RT @lipo_fan: https://t.co/pv34NkA0Tv

Apr 14, 2023 · 1 share · 6,153 followers View post →
LipoFan
@lipo_fan · X

https://t.co/pv34NkA0Tv

Apr 13, 2023 · 3 likes · 1 share · 2,992 followers View post →
Austin Dudzinski, PharmD, BCACP
@DudzLightLime · X

@PavlicaDanijel @CRYPT0N1TE @FusionProgGuy @robertlufkinmd @fproofmastery @theproof @NutritionMadeS3 @Drlipid @MohammedAlo @Paddy_Barrett I guess this would be some evidence?

Feb 12, 2023 · 869 followers View post →
SABOURETCardiologist
@SABOURETCardio · X

Another in 2021 ...https://t.co/hmDwTA5V83

Oct 24, 2022 · 9 likes · 31,171 followers View post →
Cesar Clark
@Cnclark15 · X

@NutritionMadeS3 In your Dr. Berg video why do you rely on a 2003 study to dismiss the claim that Small density LDL is relevant? Following your do your own research advice I see numerous more recent scientific backup for the proposition, here's one: https://t.co/j3T8b1F24P

Sep 8, 2022 · 48 followers View post →
Tobias Grieger
@tbgrieger · X

@PeterAttiaMD @mcgillu Curious about link between apoB and sdLDL as used here: https://t.co/OKtQBSb3rt.

Nov 29, 2021 · 1 like · 214 followers View post →
Detrick Snyder, RDN
@DetrickSnyder · X

Small Dense Low-Density Lipoprotein Cholesterol Is the Most Atherogenic Lipoprotein Parameter in the Framingham Heart Study #IOnlyReadTheAbstract https://t.co/81MP4nowNT

Aug 16, 2021 · 63 followers View post →
BostonHeartDX
@BostonHeartDX · X

Is sdLDL-C the most atherogenic type of lipoprotein? Having discordantly high sdLDL-C compared to non-HDL-C increased CVD risk ~30% after adjusting for multiple risk factors. https://t.co/thnqnjAvWz https://t.co/s0BWmpiCcG

Aug 11, 2021 · 1 like · 710 followers View post →
BostonHeartDX
@BostonHeartDX · X

@LaEstanciaVilla Thank you for the heads up. Will retweet with correct link. https://t.co/thnqnjAvWz

Aug 11, 2021 · 710 followers View post →
Nkunzimana
@Nkunzim14283506 · X

Small Dense Low‐Density Lipoprotein Cholesterol Is the Most Atherogenic Lipoprotein Parameter in the Prospective Framingham Offspring Study https://t.co/IlT99uhurk

Jul 18, 2021 · 5 followers View post →
Steven M. Belknap, MD PGY43
@StevenMBelknap · X

“sdLDL‐C, direct LDL‐C, and lipoprotein(a) all contributed significantly to ASCVD risk…but no parameter added significant risk information…once sdLDL‐C was in the model. …small dense LDL is the most atherogenic lipoprotein parameter.” https://t.co/xm3qGMqpL8

Jun 25, 2021 · 2,198 followers View post →
Tony Scott
@DIY_Tardis · X

RT @DiscoStew66: “Our data indicate that small dense LDL is the most atherogenic lipoprotein parameter.” https://t.co/UZu8sGx4hr

Apr 3, 2021 · 2 shares · 1,674 followers View post →
Natural Law Enforcer
@BChinatti · X

RT @DiscoStew66: “Our data indicate that small dense LDL is the most atherogenic lipoprotein parameter.” https://t.co/UZu8sGx4hr

Apr 3, 2021 · 2 shares · 1,211 followers View post →
DiscoStew
@DiscoStew66 · X

“Our data indicate that small dense LDL is the most atherogenic lipoprotein parameter.” https://t.co/UZu8sGx4hr

Apr 3, 2021 · 9 likes · 2 shares · 10,806 followers View post →
Dr Scott W Murray
@DrScottMurray · X

RT @rogercorder: @CotsCardiology @mmamas1973 @pnatarajanmd @DBelardoMD @purviparwani @DrScottMurray @FatEmperor @DrAseemMalhotra @KoffmannP…

Mar 6, 2021 · 1 share · 6,153 followers View post →
Roger Corder
@rogercorder · X

@CotsCardiology @mmamas1973 @pnatarajanmd @DBelardoMD @purviparwani @DrScottMurray @FatEmperor @DrAseemMalhotra @KoffmannPierre This recent paper might be of interest: https://t.co/Q3nsYoAjr9

Mar 5, 2021 · 3 likes · 1 share · 1,384 followers View post →
Ben Hardisty, PhD
@TomHardyofmath · X

RT @JAHA_AHA: Small dense low-density lipoprotein cholesterol is the laboratory parameter most strongly associated with heart disease. http…

Feb 23, 2021 · 2 shares · 1,226 followers View post →
СГАМ
@CGAM2016 · X

RT @JAHA_AHA: Small dense low-density lipoprotein cholesterol is the laboratory parameter most strongly associated with heart disease. http…

Feb 23, 2021 · 2 shares · 235 followers View post →
JAHA
@JAHA_AHA · X

Small dense low-density lipoprotein cholesterol is the laboratory parameter most strongly associated with heart disease. https://t.co/ga2UDFrvRo @Eschaefer1945 #AHAJournals https://t.co/Us2VZyV6Kw

Feb 23, 2021 · 8 likes · 2 shares · 31,349 followers View post →
Agingdoc
@agingdoc1 · X

Small Dense Low‐Density Lipoprotein Cholesterol Is the Most Atherogenic Lipoprotein Parameter in the Prospective Framingham Offspring Study ⁦@American_Heart⁩ https://t.co/WcfGiQ3nDJ

Feb 22, 2021 · 1 like · 41,696 followers View post →
Marta Hurtado
@MartaSerSana · X

RT @EstebanDL: Estudio prospectivo de Framingham La partícula lipídica mas aterogénica es LDL pequeña y densa LDL/TG es otro parámetro im…

Feb 16, 2021 · 2 shares · 2,222 followers View post →
Oscar Andres
@OscarAndresMD · X

RT @EstebanDL: Estudio prospectivo de Framingham La partícula lipídica mas aterogénica es LDL pequeña y densa LDL/TG es otro parámetro im…

Feb 15, 2021 · 2 shares · 548 followers View post →
Larronde Esteban
@EstebanDL · X

Estudio prospectivo de Framingham La partícula lipídica mas aterogénica es LDL pequeña y densa LDL/TG es otro parámetro importante LDL medición directa, se relaciona mucho menos (seguro que incluye L5 y LDL desialisado, no se estudió) LDL grande NO https://t.co/SsngYaUSN7 https://t.co/xhUMssyl9w

Feb 15, 2021 · 16 likes · 2 shares · 23,791 followers View post →
DiscoStew
@DiscoStew66 · X

RT @ZahcM: "Our data indicate that small dense LDL is the most atherogenic lipoprotein parameter. . . In our view, sdLDL is substantially m…

Feb 15, 2021 · 1 share · 10,806 followers View post →
ZahcM
@ZahcM · X

"Our data indicate that small dense LDL is the most atherogenic lipoprotein parameter. . . In our view, sdLDL is substantially more atherogenic than lbLDL because of its smaller size and its greater plasma residence time" - https://t.co/JHbkkGZAm0

Feb 15, 2021 · 6 likes · 1 share · 1,919 followers View post →