May 2021 PMID 33588378

Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rates in Healthy Older Men.

Andrew M Holwerda, Jorn Trommelen, Imre W K Kouw, Joan M Senden, Joy P B Goessens, Janneau van Kranenburg, Annemie P Gijsen, Lex B Verdijk, Luc J C van Loon

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Mentions

75
Peak: 46 in Feb 2021
across 4 sources since Feb 2021

Extended reach

2,331,463
potential audience

Total likes

61,102

Video views

1,772,451

Mentions per month

Feb 2021 – Oct 2025

Where it's discussed

  • X / Twitter65 posts
  • YouTube4 videos
  • Facebook3 posts
  • News3 articles

AI synopsis

What people are saying

The discussions highlight the relevance of the publication, with users pointing out that combining resistance exercise with pre-sleep protein intake can enhance muscle recovery, particularly in older men. Phrases like 'very cool study' and 'game changer' convey enthusiasm and acknowledgement of the research's potential significance, while some users also seek to validate the findings by referencing other studies on protein synthesis.

AgreementModerate agreement

Overall, there is a moderate level of support for the publication's findings, with many discussions echoing its key points.

InterestHigh interest

Participants express a strong curiosity about the findings and their relevance to fitness and muscle recovery.

EngagementModerate engagement

While some posts merely restate the study, others delve into deeper analysis or raise critical questions, indicating a moderate level of engagement.

ImpactHigh impact

Many believe the findings could significantly influence practices related to exercise and nutrition, especially for older adults.

Abstract in brief

  • Exercise and protein ingestion both boost muscle protein synthesis, especially when combined.
  • A study found that ingesting 40g of protein before sleep alone didn't increase muscle connective tissue synthesis in older men, while those who exercised and then ingested protein had significantly higher synthesis rates.
  • The results suggest that resistance exercise enhances the body's ability to utilize dietary protein for muscle recovery during sleep.

Top posts

Most liked on X and Bluesky
Jeffrey R. Stout
@ExphysPhD · X

Very cool study: Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rates in Healthy Older Men - PubMed https://t.co/K51zHBvtnG

Feb 17, 2021 · 97 likes · 16 shares · 3,507 followers View post →
Jorn Trommelen, PhD
@JornTrommelen · X

Resistance-type exercise plus presleep protein ingestion increases overnight muscle connective tissue protein synthesis rates in older men. Our new study: https://t.co/WRoLHqyxH9 #myotwitter 1/2 https://t.co/XHU0spKdOL

Feb 16, 2021 · 70 likes · 18 shares · 7,620 followers View post →
Dr. Myohead
@DrMyohead · X

"In conclusion, resistance-type exercise plus presleep protein ingestion increases overnight muscle connective tissue protein synthesis rates in older men." Nice work @a_holwerda & @JornTrommelen

Feb 22, 2021 · 45 likes · 8 shares · 2,646 followers View post →
Jorn Trommelen, PhD
@JornTrommelen · X

Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rates in Healthy Older Men Our 2021 paper: https://t.co/nM3RHl990Y A thread

Sep 7, 2022 · 38 likes · 5 shares · 7,620 followers View post →
humanOS.me
@humanOS_me · X

Resistance exercise combined with pre-sleep protein ingestion (40 g casein) increases overnight muscle connective tissue protein synthesis rate in older men, compared to exercise + nonprotein placebo and protein without exercise. https://t.co/m6nOjbKIfj

Feb 25, 2021 · 23 likes · 4 shares · 9,662 followers View post →
IberianCitizen
@IberianCitizen · X

El ejercicio más la ingestión de proteínas antes del sueño aumenta las tasas de síntesis de proteínas del tejido conectivo muscular durante la noche en hombres mayores sanos https://t.co/pGXHAV6g3X https://t.co/HOxKZypVZF

Feb 17, 2021 · 15 likes · 3 shares · 12,934 followers View post →

All mentions

maximum_Q™
@maximum_Q · X

RT @jackmurphylive: evening workouts and pre sleep protein increase overnight muscle building Exercise Plus Presleep Protein Ingestion Inc…

Aug 24, 2023 · 2 shares · 24,704 followers View post →
John “Jack” Murphy Goldman ☀️
@jackmurphylive · X

RT @jackmurphylive: evening workouts and pre sleep protein increase overnight muscle building Exercise Plus Presleep Protein Ingestion Inc…

Aug 24, 2023 · 2 shares · 118,958 followers View post →
John “Jack” Murphy Goldman ☀️
@jackmurphylive · X

evening workouts and pre sleep protein increase overnight muscle building Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rates in Healthy Older Men https://t.co/TXpZKJL8Ra

Aug 24, 2023 · 2 likes · 2 shares · 118,958 followers View post →
Andrew Sheaff
@AndrewKSheaff · X

Connective tissue recovery can limit readiness to train. A potential option for facilitating faster recovery. https://t.co/MCl1x2FNag @ikouw @JornTrommelen @a_holwerda

Dec 17, 2022 · 9 likes · 1 share · 2,625 followers View post →
Keith Baar
@MuscleScience · X

@scubastevesh @mackinprof To date, there is only really one good paper showing any direct affect of any protein on connective tissue synthesis by @a_holwerda out of Luc van Loon's lab. Reasons: Collagen synthesis takes longer? Age of subjects? How synthesis is measured? https://t.co/mYv61Q2xkq

Sep 20, 2022 · 3 likes · 1 share · 32,658 followers View post →
assist prof. aylin buyukkaragoz
@AylinHB · X

RT @JornTrommelen: Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rates in Healthy…

Sep 7, 2022 · 5 shares · 820 followers View post →
stephen LoRusso
@stephenLoRusso2 · X

RT @JornTrommelen: Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rates in Healthy…

Sep 7, 2022 · 5 shares · 209 followers View post →
Tom Hill
@tommmhill · X

RT @JornTrommelen: Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rates in Healthy…

Sep 7, 2022 · 5 shares · 712 followers View post →
James Betts
@DrBSteamjets · X

RT @JornTrommelen: Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rates in Healthy…

Sep 7, 2022 · 5 shares · 3,871 followers View post →
Jorn Trommelen, PhD
@JornTrommelen · X

In conclusion, resistance exercise stimulates muscle collagen synthesis during overnight sleep, with no added effect of pre-sleep casein ingestion. Our study: https://t.co/nM3RHl990Y 8/8 https://t.co/THlpSMHlWJ

Sep 7, 2022 · 2 likes · 7,620 followers View post →
Jorn Trommelen, PhD
@JornTrommelen · X

Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rates in Healthy Older Men Our 2021 paper: https://t.co/nM3RHl990Y A thread

Sep 7, 2022 · 38 likes · 5 shares · 7,620 followers View post →
Eve Beavers
@espacetimeCO · X

RT @nick_krontiris: Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rates in Health…

Jun 1, 2021 · 1 share · 899 followers View post →
Nick Krontiris
@nick_krontiris · X

Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rates in Healthy Older Men https://t.co/teEOTIWNtT #protein #nutrition #diet #exercise #Workout #TrainHard #GymLife #GymTime #muscle #strength #lift #GetStrong #gainz #gains

Jun 1, 2021 · 4 likes · 1 share · 19,019 followers View post →
Stephen Smith, PhD.
@stephensmithPN · X

5 studies examining the effects of exercise plus nutrition on connective tissue protein synthesis

May 15, 2021 · 6 likes · 1 share · 2,068 followers View post →
Darren Delaney, MSc ASCC
@DarDelFitness · X

RT @Human_Kinetics: Check out an #openaccess article from the @IJSNEMjournal! Exercise Plus Presleep Protein Ingestion Increases Overnight…

May 12, 2021 · 1 share · 371 followers View post →
LibKey
@libkey_io · X

@Human_Kinetics @IJSNEMJournal Access the paywalled article from your library: https://t.co/Vc807Q9O2B Promote scholarly access to content by simply adding https://t.co/SXSePSX5De in front of any DOI

May 12, 2021 · 556 followers View post →
Human Kinetics
@Human_Kinetics · X

Check out an #openaccess article from the @IJSNEMjournal! Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rates in Healthy Older Men https://t.co/8KCvfwpghq #sportnutrition #geriatricresearch #nutritionresearch https://t.co/sUOGB6L5Om

May 12, 2021 · 5 likes · 1 share · 41,818 followers View post →
David Scott
@DavidScottPhD · X

RT @LiamOliverNutri: Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rates in Healt…

Apr 13, 2021 · 1 share · 2,953 followers View post →
ANITA LWANGA MD FACP
@LwangaMD · X

RT @humanOS_me: Resistance exercise combined with pre-sleep protein ingestion (40 g casein) increases overnight muscle connective tissue pr…

Mar 7, 2021 · 4 shares · 976 followers View post →
Sasera
@Sasera_beauty · X

دراسه جديده: عند دمج تمارين المقاومه مع مكملات بروتين قبل النوم (٤٠ غم من بروتين الكيسين) زادت معدل صناعه البروتين بأنسجه العضل بفتره الليل مقارنه بتمارين المقاومه لوحدها او مكملات البروتين لوحدها يعني هنا مكملات البروتين تشتغل افضل مع تمارين المقاومه https://t.co/A1XAiAwKzm https://t.co/oYEjEjWm1H

Feb 26, 2021 · 4 likes · 254 followers View post →
Ma ri us
@Kizamius · X

RT @humanOS_me: Resistance exercise combined with pre-sleep protein ingestion (40 g casein) increases overnight muscle connective tissue pr…

Feb 25, 2021 · 4 shares · 6 followers View post →
Mike Lustgarten, PhD
@mike_lustgarten · X

RT @humanOS_me: Resistance exercise combined with pre-sleep protein ingestion (40 g casein) increases overnight muscle connective tissue pr…

Feb 25, 2021 · 4 shares · 9,729 followers View post →
Fit-Drive
@salama_sohaib · X

Resistance exercise in combination with 40g casein protein elevate myosceletale protien synthesis https://t.co/RvLQApJeTw

Feb 25, 2021 · 27 followers View post →
humanOS.me
@humanOS_me · X

Resistance exercise combined with pre-sleep protein ingestion (40 g casein) increases overnight muscle connective tissue protein synthesis rate in older men, compared to exercise + nonprotein placebo and protein without exercise. https://t.co/m6nOjbKIfj

Feb 25, 2021 · 23 likes · 4 shares · 9,662 followers View post →
Toppform Oslo
@Toppform_gym · X

RT @DrMyohead: "In conclusion, resistance-type exercise plus presleep protein ingestion increases overnight muscle connective tissue protei…

Feb 24, 2021 · 8 shares · 244 followers View post →
Mårten Fredriksson
@MartenExxentric · X

RT @DrMyohead: "In conclusion, resistance-type exercise plus presleep protein ingestion increases overnight muscle connective tissue protei…

Feb 23, 2021 · 8 shares · 389 followers View post →
Koushik
@koushikphysio · X

RT @DrMyohead: "In conclusion, resistance-type exercise plus presleep protein ingestion increases overnight muscle connective tissue protei…

Feb 22, 2021 · 8 shares · 519 followers View post →
rah
@hettinga · X

RT @DrMyohead: "In conclusion, resistance-type exercise plus presleep protein ingestion increases overnight muscle connective tissue protei…

Feb 22, 2021 · 8 shares · 1,423 followers View post →
AJ Lamb, PhD(c)
@AJLamb9 · X

RT @DrMyohead: "In conclusion, resistance-type exercise plus presleep protein ingestion increases overnight muscle connective tissue protei…

Feb 22, 2021 · 8 shares · 295 followers View post →
Stuart Phillips (he/him)
@mackinprof · X

RT @DrMyohead: "In conclusion, resistance-type exercise plus presleep protein ingestion increases overnight muscle connective tissue protei…

Feb 22, 2021 · 8 shares · 55,942 followers View post →
Jorn Trommelen, PhD
@JornTrommelen · X

RT @DrMyohead: "In conclusion, resistance-type exercise plus presleep protein ingestion increases overnight muscle connective tissue protei…

Feb 22, 2021 · 8 shares · 7,620 followers View post →
Dr. Myohead
@DrMyohead · X

"In conclusion, resistance-type exercise plus presleep protein ingestion increases overnight muscle connective tissue protein synthesis rates in older men." Nice work @a_holwerda & @JornTrommelen

Feb 22, 2021 · 45 likes · 8 shares · 2,646 followers View post →
Gregory Miller, Ph.D.
@drdairy50 · X

Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rates https://t.co/BtjB6ugQqz

Feb 22, 2021 · 1 like · 10,731 followers View post →
The Powermania
@PowermaniaT · X

RT @JornTrommelen: Resistance-type exercise plus presleep protein ingestion increases overnight muscle connective tissue protein synthesis…

Feb 21, 2021 · 18 shares · 48 followers View post →
Ahmad Dashti
@AhmadDashti92 · X

RT @JornTrommelen: Resistance-type exercise plus presleep protein ingestion increases overnight muscle connective tissue protein synthesis…

Feb 19, 2021 · 18 shares · 113 followers View post →
Virginia Santesteban
@virginiasanmor3 · X

RT @ExphysPhD: Very cool study: Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rat…

Feb 18, 2021 · 16 shares · 449 followers View post →
algeciras
@Andresfitbike · X

RT @ExphysPhD: Very cool study: Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rat…

Feb 18, 2021 · 16 shares · 231 followers View post →
Jake Thompson
@sjake77 · X

RT @ExphysPhD: Very cool study: Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rat…

Feb 18, 2021 · 16 shares · 574 followers View post →
FitGreyStrong
@FitGreyStrong · X

RT @JornTrommelen: Resistance-type exercise plus presleep protein ingestion increases overnight muscle connective tissue protein synthesis…

Feb 18, 2021 · 18 shares · 2,311 followers View post →
Frederic Danel
@Frederic_Danel · X

RT @ExphysPhD: Very cool study: Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rat…

Feb 18, 2021 · 16 shares · 330 followers View post →
Virgile Faber
@VirgileFaber · X

RT @ExphysPhD: Very cool study: Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rat…

Feb 17, 2021 · 16 shares · 32 followers View post →
Clyde Barretto
@clydebarretto · X

RT @ExphysPhD: Very cool study: Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rat…

Feb 17, 2021 · 16 shares · 660 followers View post →
Jose Antonio PhD
@JoseAntonioPhD · X

RT @ExphysPhD: Very cool study: Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rat…

Feb 17, 2021 · 16 shares · 22,176 followers View post →
Joaquín San José
@jsanjosea · X

RT @ExphysPhD: Very cool study: Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rat…

Feb 17, 2021 · 16 shares · 410 followers View post →
claimshero.eth
@claimshero__eth · X

RT @IberianCitizen: El ejercicio más la ingestión de proteínas antes del sueño aumenta las tasas de síntesis de proteínas del tejido conect…

Feb 17, 2021 · 3 shares · 128 followers View post →
Oscar Andres
@OscarAndresMD · X

RT @IberianCitizen: El ejercicio más la ingestión de proteínas antes del sueño aumenta las tasas de síntesis de proteínas del tejido conect…

Feb 17, 2021 · 3 shares · 553 followers View post →
S Craig Bryan CSCS
@bodydr0613 · X

RT @ExphysPhD: Very cool study: Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rat…

Feb 17, 2021 · 16 shares · 517 followers View post →
Argón
@metilargon · X

RT @ExphysPhD: Very cool study: Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rat…

Feb 17, 2021 · 16 shares · 356 followers View post →
Stewart Jeromson
@StewartJeromson · X

RT @ExphysPhD: Very cool study: Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rat…

Feb 17, 2021 · 16 shares · 406 followers View post →
Todd Wilson
@LeanStrength · X

RT @ExphysPhD: Very cool study: Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rat…

Feb 17, 2021 · 16 shares · 658 followers View post →
PT_Thunem
@PT_Thunem · X

RT @ExphysPhD: Very cool study: Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rat…

Feb 17, 2021 · 16 shares · 81 followers View post →
IberianCitizen
@IberianCitizen · X

El ejercicio más la ingestión de proteínas antes del sueño aumenta las tasas de síntesis de proteínas del tejido conectivo muscular durante la noche en hombres mayores sanos https://t.co/pGXHAV6g3X https://t.co/HOxKZypVZF

Feb 17, 2021 · 15 likes · 3 shares · 12,934 followers View post →
Fábio L Orsatti, PhD
@fabiorsatti · X

RT @JornTrommelen: Resistance-type exercise plus presleep protein ingestion increases overnight muscle connective tissue protein synthesis…

Feb 17, 2021 · 18 shares · 644 followers View post →
Jeffrey R. Stout
@ExphysPhD · X

Very cool study: Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rates in Healthy Older Men - PubMed https://t.co/K51zHBvtnG

Feb 17, 2021 · 97 likes · 16 shares · 3,507 followers View post →
Bag Handler
@baghandIer · X

RT @JornTrommelen: Resistance-type exercise plus presleep protein ingestion increases overnight muscle connective tissue protein synthesis…

Feb 17, 2021 · 18 shares · 467 followers View post →
فيصل بن فهد العوسي Faisal F. Alousi
@FaisalOusi · X

RT @JornTrommelen: Resistance-type exercise plus presleep protein ingestion increases overnight muscle connective tissue protein synthesis…

Feb 17, 2021 · 18 shares · 657 followers View post →
Jessica Urteaga
@JessUrteaga · X

RT @JornTrommelen: Resistance-type exercise plus presleep protein ingestion increases overnight muscle connective tissue protein synthesis…

Feb 17, 2021 · 18 shares · 487 followers View post →
andres acevedo
@andresace260695 · X

RT @JornTrommelen: Resistance-type exercise plus presleep protein ingestion increases overnight muscle connective tissue protein synthesis…

Feb 16, 2021 · 18 shares · 1,937 followers View post →
Villa
@Villa_M_J · X

RT @JornTrommelen: Resistance-type exercise plus presleep protein ingestion increases overnight muscle connective tissue protein synthesis…

Feb 16, 2021 · 18 shares · 155 followers View post →
Eric Rawson, Ph.D.
@EricRawsonPhD · X

RT @JornTrommelen: Resistance-type exercise plus presleep protein ingestion increases overnight muscle connective tissue protein synthesis…

Feb 16, 2021 · 18 shares · 7,537 followers View post →
IJSNEMJournal
@IJSNEMJournal · X

RT @JornTrommelen: Resistance-type exercise plus presleep protein ingestion increases overnight muscle connective tissue protein synthesis…

Feb 16, 2021 · 18 shares · 2,673 followers View post →
Frederic Danel
@Frederic_Danel · X

RT @JornTrommelen: Resistance-type exercise plus presleep protein ingestion increases overnight muscle connective tissue protein synthesis…

Feb 16, 2021 · 18 shares · 330 followers View post →
Konstantinos Prokopidis
@KostasProko · X

RT @JornTrommelen: Resistance-type exercise plus presleep protein ingestion increases overnight muscle connective tissue protein synthesis…

Feb 16, 2021 · 18 shares · 1,487 followers View post →
Jorn Trommelen, PhD
@JornTrommelen · X

Resistance-type exercise plus presleep protein ingestion increases overnight muscle connective tissue protein synthesis rates in older men. Our new study: https://t.co/WRoLHqyxH9 #myotwitter 1/2 https://t.co/XHU0spKdOL

Feb 16, 2021 · 70 likes · 18 shares · 7,620 followers View post →
PsychiatryAI.com
@PsychiatryAIcom · X

Exercise Plus Presleep Protein Ingestion Increases Overnight Muscle Connective Tissue Protein Synthesis Rates in Healthy Older Men. https://t.co/vp3C1KV2y8

Feb 16, 2021 · 435 followers View post →