Re-evaluating experimental validation in the Big Data Era: a conceptual argument.

Mohieddin Jafari, Yuanfang Guan, David C Wedge, Naser Ansari-Pour

February 2021 Genome Biol

Synopsis of Social media discussions

Several discussions highlight specific aspects of the publication, such as the need to replace the term 'experimental validation' with 'experimental corroboration' to better reflect the relationship between computational and experimental work. Phrases like 'finally a paper that speaks our minds' and 'excited to announce my new paper' reflect a tone of enthusiasm and validation of the argument, illustrating how the choice of words and an encouraging tone contribute to a strong collective agreement and perceived importance of the publication's insights.

A
Agreement
 Strong agreement

The overwhelming majority of discussions express strong agreement with the publication's concepts and ideas.

I
Interest
 High level of interest

Participants show high interest, signaling its relevance to their fields.

E
Engagement
 High engagement

Many discussions dive deeply into the methodologies proposed in the publication, indicating a thoughtful engagement with the content.

I
Impact
 High level of impact

Contributors perceive the publication as having a significant impact on the way validation in research is approached.

Social Mentions

YouTube

2 Videos

Twitter

90 Posts

News

2 Articles

Metrics

Video Views

8

Total Likes

213

Extended Reach

314,595

Social Features

94

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Rethinking Experimental Validation in the Big Data Era

Rethinking Experimental Validation in the Big Data Era

This video discusses the challenges of traditional experimental validation methods in the context of massive data sets. It suggests a shift towards new frameworks that emphasize adaptability and iterative testing for better handling of complexities present in Big Data.

Jafarilab

February 14, 2025

8 views

Redefining Experimental Validation in the Big Data Era

Redefining Experimental Validation in the Big Data Era

This video discusses the challenges of traditional experimental validation methods in the context of massive data sets. It emphasizes the need for new frameworks that prioritize adaptability and iterative testing to address the complexities of Big Data.

Jafarilab

February 24, 2025

0 views

  • Yanshi Hu 胡言石
    @Yanshi_R_Hu (Twitter)

    Cannot agree more!!! I have noticed this paper in 2019 & would like to share another paper endorsing computational biology / medicine, entitled "Re-evaluating experimental validation in the Big Data Era: a conceptual argument". https://t.co/r4iwTiiOgJ https://t.co/eBkleGOjPX
    view full post

    March 16, 2024

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  • GAMA Miguel Angel
    @miangoar (Twitter)

    This reminds me of this other perspective
    view full post

    January 6, 2024

  • Mohieddin
    @MohieddinJafari (Twitter)

    @DNA_RNA_Uni For more details, I suggest reading this: https://t.co/xDV4I7Jw8K
    view full post

    December 12, 2022

  • GreiffLab
    @victorgreiff (Twitter)

    RT @MohieddinJafari: Luckily, I heard a coherent voice (Bioinformatics 2022 https://t.co/45KXB9riJG) with our argument (Genome Biology 2021…
    view full post

    September 13, 2022

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  • Naser Ansari-Pour
    @NaserAnsariPour (Twitter)

    RT @MohieddinJafari: Luckily, I heard a coherent voice (Bioinformatics 2022 https://t.co/45KXB9riJG) with our argument (Genome Biology 2021…
    view full post

    September 13, 2022

    2

  • Mohieddin
    @MohieddinJafari (Twitter)

    Luckily, I heard a coherent voice (Bioinformatics 2022 https://t.co/45KXB9riJG) with our argument (Genome Biology 2021 https://t.co/Qu4wweraYK). This motivates me to invest time in opinion articles as well as research papers. @NaserAnsariPour @davidcwedge @victorgreiff https://t.co/uQFb224LgN
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    September 13, 2022

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  • Patrick T.
    @protrock (Twitter)

    @aunicorn1o O segundo texto de opinião que gosto é esse: https://t.co/toAiIAyhXm
    view full post

    April 29, 2022

  • Seema
    @Bioinfoodie (Twitter)

    @eugenevalkov @sokrypton Computational work opens our eyes to so many new discoveries. On this basis, experimental work and computational work should be taken as a corroborative work and not validation of each other. https://t.co/0z3Vvle0mz
    view full post

    November 12, 2021

  • Mohieddin
    @MohieddinJafari (Twitter)

    @cabbagesofdoom @chelysheva_i @UniofOxford Then, You can refer those people to this article: Re-evaluating experimental validation in the Big Data Era: a conceptual argument https://t.co/xDV4I7rUKa
    view full post

    May 30, 2021

    1

  • Jafarilab_podcast
    @jafarilab (Twitter)

    در آخر به کمک مهمان عزیز پادکست خانم دکتر فاطمه زارع (https://t.co/fJcn8gKCia)در مورد محتوای مقاله صحبت می کنیم. عنوان قسمت دوازدهم: از ویرگول تا ژنوم بیول مقاله (https://t.co/u5W5OxsJXJ) این اپیزود از طریق این لینک در دسترس است.
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    May 27, 2021

  • akellerlab
    @akellerlab (Twitter)

    RT @LewisLab: I may just attach this paper to our response to reviewers the next time we're asked to validate RNA-seq with qPCR. https://t.…
    view full post

    May 15, 2021

    4

  • Bérénice A. Benayoun, PhD
    @BBParis1984 (Twitter)

    RT @LewisLab: I may just attach this paper to our response to reviewers the next time we're asked to validate RNA-seq with qPCR. https://t.…
    view full post

    May 14, 2021

    4

  • GAMA Miguel Angel
    @miangoar (Twitter)

    RT @thedataprof: Finally a paper that speaks our minds
    view full post

    March 16, 2021

    2

  • Chanin Nantasenamat
    @thedataprof (Twitter)

    Finally a paper that speaks our minds
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    March 16, 2021

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  • Min Dai
    @artofbiology (Twitter)

    Re-evaluating experimental validation in the Big Data Era: a conceptual argument https://t.co/R5ufz85phH
    view full post

    March 10, 2021

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  • Robson Carvalho
    @rcarvalho_7 (Twitter)

    RT @fabian_theis: Interesting argument from @MohieddinJafari et al on replacing the term "experimental validation" in computational papers …
    view full post

    March 7, 2021

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  • Horacio Pérez Sánchez
    @horacio_ps (Twitter)

    RT @compBiology: A computational biologist should corroborate, not validate https://t.co/Gywz7Bm3jt #Bioinformatics @GenomeBiology
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    March 6, 2021

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  • David Wedge
    @davidcwedge (Twitter)

    RT @MohieddinJafari: Excited to announce my new paper together with @gyuanfan @NaserAnsariPour @davidcwedge out in @GenomeBiology! If you…
    view full post

    March 5, 2021

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  • JOAQUIN MEDINA
    @medinajoaquin1 (Twitter)

    RT @fabian_theis: Interesting argument from @MohieddinJafari et al on replacing the term "experimental validation" in computational papers …
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    March 5, 2021

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  • Abhishek Subramanian PhD
    @sci_abhishek (Twitter)

    RT @fabian_theis: Interesting argument from @MohieddinJafari et al on replacing the term "experimental validation" in computational papers …
    view full post

    March 4, 2021

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  • Beatriz García-Jiménez
    @beagj (Twitter)

    RT @fabian_theis: Interesting argument from @MohieddinJafari et al on replacing the term "experimental validation" in computational papers …
    view full post

    March 4, 2021

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  • SysBioCurie
    @SysBioCurie (Twitter)

    RT @fabian_theis: Interesting argument from @MohieddinJafari et al on replacing the term "experimental validation" in computational papers …
    view full post

    March 4, 2021

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  • Ruhee Dcunha
    @rdcunha2 (Twitter)

    RT @fabian_theis: Interesting argument from @MohieddinJafari et al on replacing the term "experimental validation" in computational papers …
    view full post

    March 4, 2021

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  • Anthony Mathelier
    @AMathelier (Twitter)

    RT @fabian_theis: Interesting argument from @MohieddinJafari et al on replacing the term "experimental validation" in computational papers …
    view full post

    March 4, 2021

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  • mieczkowskiLab
    @mieczkowskiLab (Twitter)

    RT @fabian_theis: Interesting argument from @MohieddinJafari et al on replacing the term "experimental validation" in computational papers …
    view full post

    March 4, 2021

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  • Aridaman Pandit | अरिदमन पण्डित
    @PanditAridaman (Twitter)

    RT @fabian_theis: Interesting argument from @MohieddinJafari et al on replacing the term "experimental validation" in computational papers …
    view full post

    March 4, 2021

    20

  • Pin-Hsuan Kathleen Chen
    @pinhsuanChen212 (Twitter)

    RT @fabian_theis: Interesting argument from @MohieddinJafari et al on replacing the term "experimental validation" in computational papers …
    view full post

    March 3, 2021

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  • PsychiatryAI.com
    @PsychiatryAIcom (Twitter)

    Re-evaluating experimental validation in the Big Data Era: a conceptual argument https://t.co/d303uecrmo
    view full post

    March 3, 2021

  • Eric Minwei Liu
    @EricM_Liu (Twitter)

    RT @fabian_theis: Interesting argument from @MohieddinJafari et al on replacing the term "experimental validation" in computational papers …
    view full post

    March 3, 2021

    20

  • Emel Timucin
    @emel_timucin (Twitter)

    RT @fabian_theis: Interesting argument from @MohieddinJafari et al on replacing the term "experimental validation" in computational papers …
    view full post

    March 3, 2021

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  • Veronika Petrova
    @verpetrova (Twitter)

    RT @fabian_theis: Interesting argument from @MohieddinJafari et al on replacing the term "experimental validation" in computational papers …
    view full post

    March 3, 2021

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  • pompopai
    @pompopai (Twitter)

    RT @fabian_theis: Interesting argument from @MohieddinJafari et al on replacing the term "experimental validation" in computational papers …
    view full post

    March 3, 2021

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  • Osama Shiraz Shah, PhD
    @OsamaShirazShah (Twitter)

    RT @fabian_theis: Interesting argument from @MohieddinJafari et al on replacing the term "experimental validation" in computational papers …
    view full post

    March 3, 2021

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  • Mohieddin
    @MohieddinJafari (Twitter)

    @bhaibeka @GenomeBiology @NaserAnsariPour @davidcwedge @gyuanfan @markowetzlab https://t.co/xDV4I7Jw8K
    view full post

    March 3, 2021

  • Rüçhan Ekren
    @RuchanEkren (Twitter)

    RT @fabian_theis: Interesting argument from @MohieddinJafari et al on replacing the term "experimental validation" in computational papers …
    view full post

    March 3, 2021

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  • Andres F Vallejo
    @afvallejop (Twitter)

    RT @fabian_theis: Interesting argument from @MohieddinJafari et al on replacing the term "experimental validation" in computational papers …
    view full post

    March 3, 2021

    20

  • Gaurav Jain
    @gauravjain49 (Twitter)

    RT @fabian_theis: Interesting argument from @MohieddinJafari et al on replacing the term "experimental validation" in computational papers …
    view full post

    March 3, 2021

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  • Mohieddin
    @MohieddinJafari (Twitter)

    RT @fabian_theis: Interesting argument from @MohieddinJafari et al on replacing the term "experimental validation" in computational papers …
    view full post

    March 3, 2021

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  • Fabian Theis
    @fabian_theis (Twitter)

    Interesting argument from @MohieddinJafari et al on replacing the term "experimental validation" in computational papers with "experimental corroboration" to avoid connotation of legitimization. Fun read: https://t.co/2nnfb3wx97 https://t.co/n1IKbnYQes
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    March 3, 2021

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  • Fabricio Cavalcante
    @o_fabriciosouza (Twitter)

    RT @moorejh: Should experimental scientists be expected to computationally validate their results? An interesting idea. What do you think?…
    view full post

    March 3, 2021

    7

  • Mohieddin
    @MohieddinJafari (Twitter)

    RT @moorejh: Should experimental scientists be expected to computationally validate their results? An interesting idea. What do you think?…
    view full post

    March 3, 2021

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  • Melcy Philip
    @MelcyPhilip (Twitter)

    RT @moorejh: Should experimental scientists be expected to computationally validate their results? An interesting idea. What do you think?…
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    March 3, 2021

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  • Naser Ansari-Pour
    @NaserAnsariPour (Twitter)

    RT @moorejh: Should experimental scientists be expected to computationally validate their results? An interesting idea. What do you think?…
    view full post

    March 2, 2021

    7

  • Naser Ansari-Pour
    @NaserAnsariPour (Twitter)

    RT @LewisLab: I may just attach this paper to our response to reviewers the next time we're asked to validate RNA-seq with qPCR. https://t.…
    view full post

    March 2, 2021

    4

  • Mohieddin
    @MohieddinJafari (Twitter)

    RT @LewisLab: I may just attach this paper to our response to reviewers the next time we're asked to validate RNA-seq with qPCR. https://t.…
    view full post

    March 2, 2021

    4

  • The Data Science Bot
    @datasciencebot_ (Twitter)

    RT @moorejh: Should experimental scientists be expected to computationally validate their results? An interesting idea. What do you think?…
    view full post

    March 2, 2021

    7

  • Bioinformatics Trends 
    @BinfoTrends (Twitter)

    RT @moorejh: Should experimental scientists be expected to computationally validate their results? An interesting idea. What do you think?…
    view full post

    March 2, 2021

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  • Francisco Caselles ☮
    @francaselles (Twitter)

    RT @moorejh: Should experimental scientists be expected to computationally validate their results? An interesting idea. What do you think?…
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    March 2, 2021

    7

  • CompChemBio Bot
    @CompChemBioBot (Twitter)

    RT @moorejh: Should experimental scientists be expected to computationally validate their results? An interesting idea. What do you think?…
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    March 2, 2021

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  • Jason H. Moore, PhD
    @moorejh (Twitter)

    Should experimental scientists be expected to computationally validate their results? An interesting idea. What do you think? https://t.co/UBiYLDUuwp #bioinformatics #datascience #biology #sciencetwitter https://t.co/jWZ82Tkkmg
    view full post

    March 2, 2021

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  • Jeff Lewis
    @LewisLab (Twitter)

    I may just attach this paper to our response to reviewers the next time we're asked to validate RNA-seq with qPCR. https://t.co/ZqlNu70Gut
    view full post

    March 1, 2021

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  • PsychiatryAI.com
    @PsychiatryAIcom (Twitter)

    Re-evaluating experimental validation in the Big Data Era: a conceptual argument https://t.co/5eBc9G1wu5
    view full post

    March 1, 2021

  • FSRhistoneH1lab
    @histoneH1 (Twitter)

    RT @GenomeBiology: Editorial from @JafariMohieddin, @gyuanfan, @davidcwedge and @NaserAnsariPour, discussing what it means to validate resu…
    view full post

    February 27, 2021

    16

  • رحابام
    @Rehabiamu (Twitter)

    RT @BioDecoded: Re-evaluating experimental validation in the Big Data Era: a conceptual argument | Genome Biology https://t.co/UmOD6ixeUE…
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    February 26, 2021

    2

  • Yulong Niu
    @YulongNiu (Twitter)

    RT @BioDecoded: Re-evaluating experimental validation in the Big Data Era: a conceptual argument | Genome Biology https://t.co/UmOD6ixeUE…
    view full post

    February 26, 2021

    2

  • BioDecoded
    @BioDecoded (Twitter)

    Re-evaluating experimental validation in the Big Data Era: a conceptual argument | Genome Biology https://t.co/UmOD6ixeUE #Bioinformatics https://t.co/njpM7BAd9j
    view full post

    February 26, 2021

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  • Naser Ansari-Pour
    @NaserAnsariPour (Twitter)

    RT @JSperschneider: A fantastic piece on small & big data in biology: "We envision a world where ‘experimental’ scientists are requested to…
    view full post

    February 26, 2021

    5

  • International Society of Developmental Biology
    @IntSocDevBiol (Twitter)

    RT @GenomeBiology: Editorial from @JafariMohieddin, @gyuanfan, @davidcwedge and @NaserAnsariPour, discussing what it means to validate resu…
    view full post

    February 26, 2021

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  • Naseem Muhammad, PhD
    @Muhamma62940937 (Twitter)

    RT @JSperschneider: A fantastic piece on small & big data in biology: "We envision a world where ‘experimental’ scientists are requested to…
    view full post

    February 26, 2021

    5

  • BMC Biology
    @BMCBiology (Twitter)

    RT @GenomeBiology: Editorial from @JafariMohieddin, @gyuanfan, @davidcwedge and @NaserAnsariPour, discussing what it means to validate resu…
    view full post

    February 26, 2021

    16

  • Florian Rosenberger
    @metaboflo (Twitter)

    RT @compBiology: A computational biologist should corroborate, not validate https://t.co/Gywz7Bm3jt #Bioinformatics @GenomeBiology
    view full post

    February 26, 2021

    5

  • Bioinformatics Trends 
    @BinfoTrends (Twitter)

    RT @compBiology: A computational biologist should corroborate, not validate https://t.co/Gywz7Bm3jt #Bioinformatics @GenomeBiology
    view full post

    February 26, 2021

    5

  • CompChemBio Bot
    @CompChemBioBot (Twitter)

    RT @compBiology: A computational biologist should corroborate, not validate https://t.co/Gywz7Bm3jt #Bioinformatics @GenomeBiology
    view full post

    February 26, 2021

    5

  • Pedro Madrigal
    @compBiology (Twitter)

    A computational biologist should corroborate, not validate https://t.co/Gywz7Bm3jt #Bioinformatics @GenomeBiology
    view full post

    February 26, 2021

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  • NDMPapers
    @NDM_Papers (Twitter)

    Re-evaluating experimental validation in the Big Data Era: a conceptual argument https://t.co/FEH4JoFwwo
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    February 25, 2021

  • Vanessa Porter, PhD
    @VanessaPorter (Twitter)

    RT @daweonline: Re-evaluating experimental validation in the Big Data Era: a conceptual argument | Genome Biology | Full Text https://t.co/…
    view full post

    February 25, 2021

    5

  • Alex Chamessian
    @achamess (Twitter)

    RT @daweonline: Re-evaluating experimental validation in the Big Data Era: a conceptual argument | Genome Biology | Full Text https://t.co/…
    view full post

    February 25, 2021

    5

  • COSR Lab
    @CosrLab (Twitter)

    RT @daweonline: Re-evaluating experimental validation in the Big Data Era: a conceptual argument | Genome Biology | Full Text https://t.co/…
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    February 25, 2021

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  • Dr Ronald Ma
    @DrRonaldMa1 (Twitter)

    RT @GenomeBiology: Editorial from @JafariMohieddin, @gyuanfan, @davidcwedge and @NaserAnsariPour, discussing what it means to validate resu…
    view full post

    February 25, 2021

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  • Andrea Gobbini
    @AndreaGobbini (Twitter)

    RT @daweonline: Re-evaluating experimental validation in the Big Data Era: a conceptual argument | Genome Biology | Full Text https://t.co/…
    view full post

    February 25, 2021

    5

  • Remco Stam
    @EvoMPMI (Twitter)

    RT @JSperschneider: A fantastic piece on small & big data in biology: "We envision a world where ‘experimental’ scientists are requested to…
    view full post

    February 25, 2021

    5

  • Ksenia Krasileva
    @kseniakrasileva (Twitter)

    RT @JSperschneider: A fantastic piece on small & big data in biology: "We envision a world where ‘experimental’ scientists are requested to…
    view full post

    February 25, 2021

    5

  • Maria
    @MicrobialMaria (Twitter)

    RT @GenomeBiology: Editorial from @JafariMohieddin, @gyuanfan, @davidcwedge and @NaserAnsariPour, discussing what it means to validate resu…
    view full post

    February 25, 2021

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  • Matt Parker
    @1m1a2t (Twitter)

    RT @GenomeBiology: Editorial from @JafariMohieddin, @gyuanfan, @davidcwedge and @NaserAnsariPour, discussing what it means to validate resu…
    view full post

    February 25, 2021

    16

  • Wilfried Haerty
    @WHaerty (Twitter)

    RT @GenomeBiology: Editorial from @JafariMohieddin, @gyuanfan, @davidcwedge and @NaserAnsariPour, discussing what it means to validate resu…
    view full post

    February 25, 2021

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  • Davi Sidarta Oliveira, MD, PhD
    @davisidarta (Twitter)

    RT @daweonline: Re-evaluating experimental validation in the Big Data Era: a conceptual argument | Genome Biology | Full Text https://t.co/…
    view full post

    February 25, 2021

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  • Qin An
    @anqin314 (Twitter)

    RT @GenomeBiology: Editorial from @JafariMohieddin, @gyuanfan, @davidcwedge and @NaserAnsariPour, discussing what it means to validate resu…
    view full post

    February 25, 2021

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  • Mithun Mitra
    @mitramith (Twitter)

    RT @GenomeBiology: Editorial from @JafariMohieddin, @gyuanfan, @davidcwedge and @NaserAnsariPour, discussing what it means to validate resu…
    view full post

    February 25, 2021

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  • Jana Sperschneider
    @JSperschneider (Twitter)

    A fantastic piece on small & big data in biology: "We envision a world where ‘experimental’ scientists are requested to do ‘computational validation’ in the same manner that ‘computational’ scientists are currently asked to do experimental validation." https://t.co/TWmoShidZU
    view full post

    February 24, 2021

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  • Australian BioCommons
    @AusBiocommons (Twitter)

    RT @GenomeBiology: Editorial from @JafariMohieddin, @gyuanfan, @davidcwedge and @NaserAnsariPour, discussing what it means to validate resu…
    view full post

    February 24, 2021

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  • Brittany 'Never tell me the odds' Lasseigne, PhD
    @bnlasse (Twitter)

    RT @GenomeBiology: Editorial from @JafariMohieddin, @gyuanfan, @davidcwedge and @NaserAnsariPour, discussing what it means to validate resu…
    view full post

    February 24, 2021

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  • Mohieddin
    @MohieddinJafari (Twitter)

    RT @GenomeBiology: Editorial from @JafariMohieddin, @gyuanfan, @davidcwedge and @NaserAnsariPour, discussing what it means to validate resu…
    view full post

    February 24, 2021

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  • Javier Santoyo
    @jsantoyo (Twitter)

    Re-evaluating experimental validation in the Big Data Era: a conceptual argument. https://t.co/kthDVJ6syh @GenomeBiology
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    February 24, 2021

  • Federico Giorgi
    @giorgilab (Twitter)

    RT @GenomeBiology: Editorial from @JafariMohieddin, @gyuanfan, @davidcwedge and @NaserAnsariPour, discussing what it means to validate resu…
    view full post

    February 24, 2021

    16

  • Valentin Amrhein
    @vamrhein (Twitter)

    RT @MohieddinJafari: Excited to announce my new paper together with @gyuanfan @NaserAnsariPour @davidcwedge out in @GenomeBiology! If you…
    view full post

    February 24, 2021

    4

  • Florian Markowetz
    @markowetzlab (Twitter)

    RT @GenomeBiology: Editorial from @JafariMohieddin, @gyuanfan, @davidcwedge and @NaserAnsariPour, discussing what it means to validate resu…
    view full post

    February 24, 2021

    16

  • Naser Ansari-Pour
    @NaserAnsariPour (Twitter)

    RT @MohieddinJafari: Excited to announce my new paper together with @gyuanfan @NaserAnsariPour @davidcwedge out in @GenomeBiology! If you…
    view full post

    February 24, 2021

    4

  • Genome Biology
    @GenomeBiology (Twitter)

    Editorial from @JafariMohieddin, @gyuanfan, @davidcwedge and @NaserAnsariPour, discussing what it means to validate results obtained from bioinformatic analyses. They argue that calibration or corroboration would be better terms. https://t.co/wnuYJv5UlM https://t.co/dSVy8IcqAT
    view full post

    February 24, 2021

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  • Jafarilab_podcast
    @jafarilab (Twitter)

    RT @MohieddinJafari: Excited to announce my new paper together with @gyuanfan @NaserAnsariPour @davidcwedge out in @GenomeBiology! If you…
    view full post

    February 24, 2021

    4

  • Mohieddin
    @MohieddinJafari (Twitter)

    Excited to announce my new paper together with @gyuanfan @NaserAnsariPour @davidcwedge out in @GenomeBiology! If you feel frustrated by this question, whether your findings have been 'experimentally validated'? It would help when you read it. https://t.co/xDV4I7Jw8K
    view full post

    February 24, 2021

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Abstract Synopsis

  • This text discusses the challenges of traditional experimental validation methods in the context of massive data sets.
  • It argues for a shift in how researchers approach validation to better accommodate the complexities and variations present in Big Data.
  • The authors propose new frameworks and methodologies that emphasize adaptability and iterative testing over rigid experimental designs.