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Sci Transl Med February 2021 PMID 33627489

Mechanism and reversal of drug-induced nephrotoxicity on a chip.

Aaron Cohen, Konstantinos Ioannidis, Avner Ehrlich, Shaun Regenbaum, Merav Cohen, Muneef Ayyash, Sigal Shafran Tikva, Yaakov Nahmias

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Mentions

60
Peak: 26 in Mar 2021
across 6 sources since Feb 2021

Extended reach

206,971
potential audience

Total likes

136

Video views

5,624

Mentions per month

Feb 2021 – Oct 2021

Where it's discussed

  • X / Twitter26 posts
  • News22 articles
  • Facebook5 posts
  • YouTube3 videos
  • Blogs3 articles
  • Bluesky1 posts

AI synopsis

What people are saying

Many comments echo enthusiasm, such as 'Now we are talking!!' and praise for the study’s mechanisms, demonstrating active engagement. The focus on new models and implications for drug safety suggest that participants see this work as a potentially transformative advancement in nephrotoxicity research.

AgreementModerate agreement

Most discussions express support and enthusiasm for the research's potential, indicating general agreement with its significance.

InterestHigh interest

Participants show high interest by commenting positively and highlighting the study's importance.

EngagementModerate engagement

Comments include retweets, brief summaries, and expressions of excitement, reflecting moderate-to-high engagement.

ImpactModerate impact

The emphasis on improving drug safety and the mention of potential clinical benefits suggest perceived meaningful impact.

Abstract in brief

  • The kidney is crucial for fluid balance, glucose management, and drug elimination, with drug-induced damage affecting over 20% of adults.
  • A new model using vascularized human kidney spheroids with microsensors reveals that drugs like cyclosporine and cisplatin can disrupt kidney function at low doses, causing harmful glucose buildup.
  • Combining these drugs with SGLT2 inhibitors significantly improves kidney function in patients, highlighting the potential of this technology to improve drug safety and streamline treatment approaches.
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Top posts

Most liked on X and Bluesky
Kenar Jhaveri
@kdjhaveri · X

Now we are talking!! Mechanism and reversal of drug-induced nephrotoxicity on a chip https://t.co/hQd4M27YZU

Mar 20, 2021 · 23 likes · 6 shares · 11,709 followers View post →
Nature Reviews Nephrology
@NatRevNeph · X

New #ResearchHighlight! Vascularized proximal tubule spheroids with metabolic sensors suggest that nephrotoxic drugs might lead to lipotoxicity by dysregulating glucose uptake. go. https://t.co/mnGTUhNiZf (original @ScienceTM article: 10.1126/scitranslmed.abd6299) @YaakovNahmias https://t.co/ZnJXfj0eQG

Mar 19, 2021 · 11 likes · 5 shares · 34,240 followers View post →
Pinelopi Kapitsinou
@kapitsinou · X

Mechanism and reversal of drug-induced nephrotoxicity on a chip | Science Translational Medicine https://t.co/Fej2AeGE8D

Mar 20, 2021 · 8 likes · 266 followers View post →
Ronita De, PhD
@dronita_de · X

Mechanism and reversal of drug-induced nephrotoxicity on a chip https://t.co/7dkfan43Ps #DHPSP

Mar 10, 2021 · 5 likes · 7 shares · 1,504 followers View post →
Atanas G. Atanasov
@_atanas_ · X

RT @dronita_de: Mechanism and reversal of drug-induced nephrotoxicity on a chip https://t.co/7dkfan43Ps #DHPSP

Mar 10, 2021 · 7 shares · 123,746 followers View post →
Digital Health and Patient Safety Platform
@DHPSP · X

RT @dronita_de: Mechanism and reversal of drug-induced nephrotoxicity on a chip https://t.co/7dkfan43Ps #DHPSP

Mar 10, 2021 · 7 shares · 6,750 followers View post →

All mentions

Aditya Pawar
@renalranger · X

Mechanism and reversal of drug-induced nephrotoxicity on a chip https://t.co/FnWjLzVkV0

Mar 21, 2021 · 711 followers View post →
Pinelopi Kapitsinou
@kapitsinou · X

Mechanism and reversal of drug-induced nephrotoxicity on a chip | Science Translational Medicine https://t.co/Fej2AeGE8D

Mar 20, 2021 · 8 likes · 266 followers View post →
manuel macia heras
@mmacia25 · X

RT @kdjhaveri: Now we are talking!! Mechanism and reversal of drug-induced nephrotoxicity on a chip https://t.co/hQd4M27YZU

Mar 20, 2021 · 6 shares · 810 followers View post →
Mehdi Maanaoui
@MaanaouiMehdi · X

RT @kdjhaveri: Now we are talking!! Mechanism and reversal of drug-induced nephrotoxicity on a chip https://t.co/hQd4M27YZU

Mar 20, 2021 · 6 shares · 1,004 followers View post →
Kim Reidy
@KimReidy2 · X

RT @kdjhaveri: Now we are talking!! Mechanism and reversal of drug-induced nephrotoxicity on a chip https://t.co/hQd4M27YZU

Mar 20, 2021 · 6 shares · 972 followers View post →
Maria Jose Soler
@PepaSolerR · X

RT @kdjhaveri: Now we are talking!! Mechanism and reversal of drug-induced nephrotoxicity on a chip https://t.co/hQd4M27YZU

Mar 20, 2021 · 6 shares · 4,712 followers View post →
meeyounglee
@meeyounglee · X

RT @kdjhaveri: Now we are talking!! Mechanism and reversal of drug-induced nephrotoxicity on a chip https://t.co/hQd4M27YZU

Mar 20, 2021 · 6 shares · 123 followers View post →
Kenar Jhaveri
@kdjhaveri · X

Now we are talking!! Mechanism and reversal of drug-induced nephrotoxicity on a chip https://t.co/hQd4M27YZU

Mar 20, 2021 · 23 likes · 6 shares · 11,709 followers View post →
Kenar Jhaveri, MD
@kdjhaveri.bsky.social · Bluesky

Now we are talking!! Mechanism and reversal of drug-induced nephrotoxicity on a chip https://stm.sciencemag.org/content/13/582/eabd6299

Mar 20, 2021 View post →
Alfa
@AlfasaurioAlfa · X

RT @NatRevNeph: New #ResearchHighlight! Vascularized proximal tubule spheroids with metabolic sensors suggest that nephrotoxic drugs might…

Mar 20, 2021 · 5 shares · 326 followers View post →
BT Workeneh
@bdubNephro · X

RT @NatRevNeph: New #ResearchHighlight! Vascularized proximal tubule spheroids with metabolic sensors suggest that nephrotoxic drugs might…

Mar 19, 2021 · 5 shares · 647 followers View post →
Sreedhar Mandayam
@Srmanday · X

RT @NatRevNeph: New #ResearchHighlight! Vascularized proximal tubule spheroids with metabolic sensors suggest that nephrotoxic drugs might…

Mar 19, 2021 · 5 shares · 386 followers View post →
Iván
@Dockat16 · X

RT @NatRevNeph: New #ResearchHighlight! Vascularized proximal tubule spheroids with metabolic sensors suggest that nephrotoxic drugs might…

Mar 19, 2021 · 5 shares · 86 followers View post →
Durangocide
@durangocide · X

RT @NatRevNeph: New #ResearchHighlight! Vascularized proximal tubule spheroids with metabolic sensors suggest that nephrotoxic drugs might…

Mar 19, 2021 · 5 shares · 580 followers View post →
Nature Reviews Nephrology
@NatRevNeph · X

New #ResearchHighlight! Vascularized proximal tubule spheroids with metabolic sensors suggest that nephrotoxic drugs might lead to lipotoxicity by dysregulating glucose uptake. go. https://t.co/mnGTUhNiZf (original @ScienceTM article: 10.1126/scitranslmed.abd6299) @YaakovNahmias https://t.co/ZnJXfj0eQG

Mar 19, 2021 · 11 likes · 5 shares · 34,240 followers View post →
dirley varotti
@hp6940 · X

Mechanism and reversal of drug-induced nephrotoxicity on a chip https://t.co/Gij7w19qEe

Mar 15, 2021 · 26 followers View post →
Joyita Bhattacharya
@JoyitaB · X

RT @dronita_de: Mechanism and reversal of drug-induced nephrotoxicity on a chip https://t.co/7dkfan43Ps #DHPSP

Mar 11, 2021 · 7 shares · 44 followers View post →
Ronita De, PhD
@dronita_de · X

RT @dronita_de: Mechanism and reversal of drug-induced nephrotoxicity on a chip https://t.co/7dkfan43Ps #DHPSP

Mar 11, 2021 · 7 shares · 1,504 followers View post →
Kifri
@l1ght3n · X

RT @dronita_de: Mechanism and reversal of drug-induced nephrotoxicity on a chip https://t.co/7dkfan43Ps #DHPSP

Mar 11, 2021 · 7 shares · 1,847 followers View post →
Steve
@stevie_bro · X

RT @dronita_de: Mechanism and reversal of drug-induced nephrotoxicity on a chip https://t.co/7dkfan43Ps #DHPSP

Mar 11, 2021 · 7 shares · 4,006 followers View post →
Eduard Centeno
@segol60 · X

RT @dronita_de: Mechanism and reversal of drug-induced nephrotoxicity on a chip https://t.co/7dkfan43Ps #DHPSP

Mar 10, 2021 · 7 shares · 409 followers View post →
Atanas G. Atanasov
@_atanas_ · X

RT @dronita_de: Mechanism and reversal of drug-induced nephrotoxicity on a chip https://t.co/7dkfan43Ps #DHPSP

Mar 10, 2021 · 7 shares · 123,746 followers View post →
Science Communication
@ScienceCommuni2 · X

RT @dronita_de: Mechanism and reversal of drug-induced nephrotoxicity on a chip https://t.co/7dkfan43Ps #DHPSP

Mar 10, 2021 · 7 shares · 2,880 followers View post →
Digital Health and Patient Safety Platform
@DHPSP · X

RT @dronita_de: Mechanism and reversal of drug-induced nephrotoxicity on a chip https://t.co/7dkfan43Ps #DHPSP

Mar 10, 2021 · 7 shares · 6,750 followers View post →
Ronita De, PhD
@dronita_de · X

Mechanism and reversal of drug-induced nephrotoxicity on a chip https://t.co/7dkfan43Ps #DHPSP

Mar 10, 2021 · 5 likes · 7 shares · 1,504 followers View post →
Sutheerak
@sutheerak · X

Mechanism and reversal of drug-induced nephrotoxicity on a chip https://t.co/b4NHugEEhC

Feb 27, 2021 · 372 followers View post →
Curt Krafft
@kurtdjrob · X

Mechanism and reversal of drug-induced nephrotoxicity on a chip https://t.co/mwGqsEq4o9

Feb 24, 2021 · 1,430 followers View post →