BiT age: A transcriptome-based aging clock near the theoretical limit of accuracy.

David H Meyer, Björn Schumacher

March 2021 Aging Cell

Synopsis of Social media discussions

Several discussions highlight the significance of the BiT age clock in aging research, particularly in its application to C. elegans. For instance, terms like 'huge' and references to the possibilities of re-analyzing RNA-seq datasets demonstrate excitement and a sense of urgency regarding its adoption. The tone conveys optimism about the research outcomes, with users expressing eagerness to explore its implications further.

A
Agreement
 Moderate agreement

The majority of discussions reflect a supportive stance towards the findings of the publication.

I
Interest
 High level of interest

Participants express enthusiasm about the potential applications of the BiT age clock, indicating high interest among peers.

E
Engagement
 Moderate level of engagement

While some posts delve into technical comparisons between methods, others simply repost or acknowledge the research, indicating moderate engagement.

I
Impact
 High level of impact

Overall, there is a strong belief that this publication will have a significant impact on the field of aging research.

Social Mentions

YouTube

4 Videos

Facebook

2 Posts

Twitter

182 Posts

Blogs

5 Articles

News

21 Articles

Reddit

2 Posts

Metrics

Video Views

20,288

Total Likes

768

Extended Reach

528,425

Social Features

216

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Innovative Aging Clocks: Understanding Biological Age Measurement

Innovative Aging Clocks: Understanding Biological Age Measurement

In this video, we will discuss aging clocks, which measure not just chronological age but biological age derived from various biomarkers. We will explore methods like the BiT age clock that enhance accuracy in estimating biological age by analyzing transcriptomes and their implications for aging research.

The Sheekey Science Show

July 30, 2021

13,997 views

UniversitaetzuKoeln

March 4, 2021

2,631 views

DNA Damage, Aging, and the BiT Age Clock Explained by Dr. Schumacher

DNA Damage, Aging, and the BiT Age Clock Explained by Dr. Schumacher

My guest today is Dr. Bjorn Schumacher, whose work focuses on DNA damage's central role in aging. We explore how his new BiT age clock method analyzes transcriptomes to estimate biological age accurately and its implications for fertility, cancer, and skin protection.

Live Longer World

February 15, 2022

2,247 views

Introducing the BiT Age Clock for Biological Age Estimation

Introducing the BiT Age Clock for Biological Age Estimation

The BiT age clock represents a groundbreaking method for estimating biological age through transcriptome analysis. This innovative approach enhances accuracy in measuring age-related factors, presenting significant implications for aging research and potential human applications.

Longevity Science News

March 16, 2021

1,413 views

  • David Meyer
    @Meyer_DH (Twitter)

    BiT age is the starting point for many of the other projects. Our transcriptomic aging clock optimized to highly accurately predict the biological in age of nematodes (2/7): https://t.co/XKNe4p1hhQ
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    July 5, 2025

  • Erik Toraason
    @EToraason (Twitter)

    @kapahi_pankaj @ctmurphy1 @RKaletsky As C. elegans lacks 5mC, we can't rely on DNA methylation clocks to infer rejuvenation. However, we might have been able to employ the Schumacher C. elegans gene-expression based clocks to profile the 'age' of their neurons as well https://t.co/28uyOIdpwL
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    August 29, 2024

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  • Leandros Boukas
    @LeandrosBoukas (Twitter)

    @AlejoFraticelli @davidmasp Note also that, with few exceptions e.g. https://t.co/hEwVrSA1zJ, to date transcriptomic clocks perform way worse than DNA methylation-based clocks
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    June 7, 2024

  • David Meyer
    @Meyer_DH (Twitter)


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  • David Meyer
    @Meyer_DH (Twitter)

    I did not expect that all tested aging clocks correlate almost linearly with the amount of artificially induced stochastic variation. Even our BitAge clock, which is supposed to get rid of unneeded variation! https://t.co/XKNe4p0Jsi
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    May 9, 2024

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  • Lucas Camillo
    @lucascamillomd (Twitter)

    Links to the mentioned clocks below: https://t.co/lOERU83m1M https://t.co/WCshvCsUmz https://t.co/QcTvyJvZuz https://t.co/B6qrAek7Ak https://t.co/aliSDk9hZB https://t.co/y2xd6SDzEG
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    November 30, 2023

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  • Johns Hopkins Frailty Science #FrailtyFighter
    @FrailtyScience (Twitter)

    RT @WHOCenterFrailt: Biological and chronological age : "BiT age: A transcriptome-based aging clock near the theoretical limit of accuracy"…
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    June 26, 2023

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  • David Meyer
    @Meyer_DH (Twitter)

    RT @INSPIREPlatfor1: Biological and chronological age : "BiT age: A transcriptome-based aging clock near the theoretical limit of accuracy"…
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    June 26, 2023

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  • INSPIRE Platform - IHU HealthAge
    @INSPIREPlatfor1 (Twitter)

    Biological and chronological age : "BiT age: A transcriptome-based aging clock near the theoretical limit of accuracy" https://t.co/bDFXqQWnPj @brunovellas @RouchLaure @InfinityTLS @RestoreInstitut @I2mcT @isaperarnau @LiMitAging
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  • WHO Collaborating Center for Frailty
    @WHOCenterFrailt (Twitter)

    Biological and chronological age : "BiT age: A transcriptome-based aging clock near the theoretical limit of accuracy" https://t.co/bgRthKBEI8
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    June 26, 2023

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  • Aging_Cell
    @Aging_Cell (Twitter)

    RT @agingdoc1: BiT age: A transcriptome-based aging clock near the theoretical limit of accuracy (2022) @Meyer_DH & @schumacherbj https:/…
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    June 25, 2023

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  • Lisa Vlad
    @LisaVlad2 (Twitter)

    RT @agingdoc1: BiT age: A transcriptome-based aging clock near the theoretical limit of accuracy (2022) @Meyer_DH & @schumacherbj https:/…
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  • Laure Rouch
    @RouchLaure (Twitter)

    BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy https://t.co/dSzlSmUBCQ
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    June 25, 2023

  • David Meyer
    @Meyer_DH (Twitter)

    RT @agingdoc1: BiT age: A transcriptome-based aging clock near the theoretical limit of accuracy (2022) @Meyer_DH & @schumacherbj https:/…
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    June 25, 2023

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  • Björn Schumacher
    @schumacherbj (Twitter)

    RT @agingdoc1: BiT age: A transcriptome-based aging clock near the theoretical limit of accuracy (2022) @Meyer_DH & @schumacherbj https:/…
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    June 25, 2023

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  • BillOckham
    @BillOccham0 (Twitter)

    RT @agingdoc1: BiT age: A transcriptome-based aging clock near the theoretical limit of accuracy (2022) @Meyer_DH & @schumacherbj https:/…
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  • Agingdoc
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    BiT age: A transcriptome-based aging clock near the theoretical limit of accuracy (2022) @Meyer_DH & @schumacherbj https://t.co/Pz2L6Slolr @Aging_Cell https://t.co/hyIykPrMLj
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    @agepapers (Twitter)

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    @agepapers (Twitter)

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    @agepapers (Twitter)

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    @agepapers (Twitter)

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  • Björn Schumacher
    @schumacherbj (Twitter)

    Even our recent BiT age clock, which is using binarization to minimize the amount of unneeded variation and noise significantly correlates with the amount of variation applied. https://t.co/JLTZvthIzH
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    @agepapers (Twitter)

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  • Johns Hopkins Frailty Science #FrailtyFighter
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    December 8, 2022

  • agepapers
    @agepapers (Twitter)

    BiT age: A transcriptome-based aging clock near the theoretical limit of accuracy https://t.co/rVBRIDdv5z
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    November 4, 2022

  • agepapers
    @agepapers (Twitter)

    BiT age: A transcriptome-based aging clock near the theoretical limit of accuracy https://t.co/TjnomxZPnw
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    November 2, 2022

  • agepapers
    @agepapers (Twitter)

    BiT age: A transcriptome-based aging clock near the theoretical limit of accuracy https://t.co/VWOf1JPZaU
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    October 28, 2022

  • agepapers
    @agepapers (Twitter)

    BiT age: A transcriptome-based aging clock near the theoretical limit of accuracy https://t.co/f5RkfrH1xK
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    October 25, 2022

  • agepapers
    @agepapers (Twitter)

    BiT age: A transcriptome-based aging clock near the theoretical limit of accuracy https://t.co/zT871sPpls
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    October 21, 2022

  • Uni Cologne INTERNATIONAL
    @UniCologneIO (Twitter)

    RT @schumacherbj: Watch the podcast: Dr. Bjorn Schumacher | DNA Damage & Aging, p53 & Cancer, and DNA repair @livelongerworld @CECAD_ @UKKo…
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    February 16, 2022

    12

  • michele pagano
    @paganolab (Twitter)

    RT @schumacherbj: Watch the podcast: Dr. Bjorn Schumacher | DNA Damage & Aging, p53 & Cancer, and DNA repair @livelongerworld @CECAD_ @UKKo…
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    February 16, 2022

    12

  • Barak Rotblat
    @BarakRotblat (Twitter)

    RT @schumacherbj: Watch the podcast: Dr. Bjorn Schumacher | DNA Damage & Aging, p53 & Cancer, and DNA repair @livelongerworld @CECAD_ @UKKo…
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    February 15, 2022

    12

  • Uni Cologne NY
    @UniCologneNY (Twitter)

    RT @schumacherbj: Watch the podcast: Dr. Bjorn Schumacher | DNA Damage & Aging, p53 & Cancer, and DNA repair @livelongerworld @CECAD_ @UKKo…
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    February 15, 2022

    12

  • István Fodor
    @fodor_i (Twitter)

    RT @schumacherbj: Watch the podcast: Dr. Bjorn Schumacher | DNA Damage & Aging, p53 & Cancer, and DNA repair @livelongerworld @CECAD_ @UKKo…
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    February 15, 2022

    12

  • Aastha JS
    @aasthajs (Twitter)

    RT @schumacherbj: Watch the podcast: Dr. Bjorn Schumacher | DNA Damage & Aging, p53 & Cancer, and DNA repair @livelongerworld @CECAD_ @UKKo…
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    February 15, 2022

    12

  • Nicole Sänger
    @prof_saenger (Twitter)

    RT @schumacherbj: Watch the podcast: Dr. Bjorn Schumacher | DNA Damage & Aging, p53 & Cancer, and DNA repair @livelongerworld @CECAD_ @UKKo…
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    February 15, 2022

    12

  • David Meyer
    @Meyer_DH (Twitter)

    RT @schumacherbj: Watch the podcast: Dr. Bjorn Schumacher | DNA Damage & Aging, p53 & Cancer, and DNA repair @livelongerworld @CECAD_ @UKKo…
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    February 15, 2022

    12

  • Max Unfried
    @MaxUnfried (Twitter)

    RT @schumacherbj: Watch the podcast: Dr. Bjorn Schumacher | DNA Damage & Aging, p53 & Cancer, and DNA repair @livelongerworld @CECAD_ @UKKo…
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    February 15, 2022

    12

  • Cyrus Khandanpour
    @c_khandanpour (Twitter)

    RT @schumacherbj: Watch the podcast: Dr. Bjorn Schumacher | DNA Damage & Aging, p53 & Cancer, and DNA repair @livelongerworld @CECAD_ @UKKo…
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    February 15, 2022

    12

  • Andreas Schallmoser
    @SchallmoserA (Twitter)

    RT @schumacherbj: Watch the podcast: Dr. Bjorn Schumacher | DNA Damage & Aging, p53 & Cancer, and DNA repair @livelongerworld @CECAD_ @UKKo…
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    February 15, 2022

    12

  • Björn Schumacher
    @schumacherbj (Twitter)

    Watch the podcast: Dr. Bjorn Schumacher | DNA Damage & Aging, p53 & Cancer, and DNA repair @livelongerworld @CECAD_ @UKKoeln @UniCologne https://t.co/TLQWMghlyQ via @YouTube
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    February 15, 2022

    45

    12

  • Aastha JS
    @aasthajs (Twitter)

    "We’ve gained insight into..how germ cells have a high capability to repair the genome. Since 200,000 yrs of modern Homo Sapiens, we are coming from the same germ cells our ancestors passed on" @schumacherbj All platforms https://t.co/pneh7v0LNQ YouTube https://t.co/eZ6oL5RLQs
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    February 15, 2022

    1

  • Liz Rose
    @LizRose14449371 (Twitter)

    https://t.co/PUyO9DbjZ0
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    September 2, 2021

  • Liz Rose
    @LizRose14449371 (Twitter)

    @PeterDiamandis Transcriptome-based aging clock near the theoretical limit of accuracy: https://t.co/xHmfZn4xQ5
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    September 2, 2021

  • Björn Schumacher
    @schumacherbj (Twitter)

    @mkaeberlein @ARDD_Meeting We look at all the treatments that had lifespan and transcriptome data in the same publication https://t.co/YfoQSUNo0x
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    August 28, 2021

    1

  • Athanasios Siametis
    @athsmt (Twitter)

    RT @ChristinaEfrai2: I would really like to thank @Meyer_DH for presenting his latest work in our joint @HealthAge_ITN and @aDDRess_ITN se…
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    May 7, 2021

    3

  • LXRepair
    @LxRepair (Twitter)

    RT @ChristinaEfrai2: I would really like to thank @Meyer_DH for presenting his latest work in our joint @HealthAge_ITN and @aDDRess_ITN se…
    view full post

    May 7, 2021

    3

  • Marta Oliva
    @molivasantiago (Twitter)

    RT @ChristinaEfrai2: I would really like to thank @Meyer_DH for presenting his latest work in our joint @HealthAge_ITN and @aDDRess_ITN se…
    view full post

    May 7, 2021

    3

  • Christina Efraimoglou
    @ChristinaEfrai2 (Twitter)

    I would really like to thank @Meyer_DH for presenting his latest work in our joint @HealthAge_ITN and @aDDRess_ITN seminar. https://t.co/0ZtDZF5EYG https://t.co/JtQKufuaYB
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    May 3, 2021

    11

    3

  • Sadig Niftullayev
    @SNiftullayev (Twitter)

    RT @Meyer_DH: Thank you @LifespanIO for the video summary of our recent paper! https://t.co/ibew7phLdD
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    March 24, 2021

    2

  • He Chen
    @hecheeee (Twitter)

    RT @Meyer_DH: Thank you @LifespanIO for the video summary of our recent paper! https://t.co/ibew7phLdD
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    March 24, 2021

    2

  • David Meyer
    @Meyer_DH (Twitter)

    Thank you @LifespanIO for the video summary of our recent paper! https://t.co/ibew7phLdD
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    March 22, 2021

    7

    2

  • H+ Bot
    @HplusBot (Twitter)

    Check out "Binary Clock Predicts Biological Age | Lifespan News" at: https://t.co/urfkoQLICw
    view full post

    March 16, 2021

  • Humanity Plus
    @HumanityPlus (Twitter)

    A new episode of Lifespan News has been released by @LifespanIO! #longevity https://t.co/9kYuN15P3f
    view full post

    March 16, 2021

    5


  • @Orlando_uy (Twitter)

    Our analysis suggests that the innate immune response, neuronal signaling, and single transcription factors are major regulators of the aging process independent of the strain and treatment. https://t.co/k19QpJeKpi
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    March 10, 2021

    1

  • Mikee Chong
    @mikeechonggg (Twitter)

    RT @AgingBiology: BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy https://t.co/loS0yerGA3
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    March 10, 2021

    12

  • Science
    @Long_life_sci (Twitter)

    RT @AgingBiology: BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy https://t.co/loS0yerGA3
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    March 7, 2021

    12

  • Malcolm Klein
    @malcolm_klein (Twitter)

    BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy https://t.co/Z8uaAI7qgh C. elegans has no methylated DNA so they used the mRNA expression patterns. Can't wait to see how this compares to the Horvath methylation clock!
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    March 4, 2021

  • Alessandro Rufini
    @alexrufini13 (Twitter)

    RT @schumacherbj: Our latest paper is out: Check the BiT age clock @CECAD_ @UKKoeln @UniCologne @AgingCell https://t.co/JLTZvthaK9 https:/…
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    March 4, 2021

    11

  • Nathan S. Cheng thinks you should work on aging.
    @realNathanCheng (Twitter)

    https://t.co/dekfIULpXZ
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    March 4, 2021

    2

  • Andrei Ilnitski
    @AndrIlnitski (Twitter)

    RT @AgingBiology: BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy https://t.co/loS0yerGA3
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    March 4, 2021

    12

  • Michael Ristow, MD
    @Prof_M_Ristow (Twitter)

    RT @schumacherbj: Our latest paper is out: Check the BiT age clock @CECAD_ @UKKoeln @UniCologne @AgingCell https://t.co/JLTZvthaK9 https:/…
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    March 4, 2021

    11

  • Backialakshmi Dharmalingam
    @Dhapubavi (Twitter)

    BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy https://t.co/f9O4U8AXZ2
    view full post

    March 4, 2021

  • David Meyer
    @Meyer_DH (Twitter)

    RT @ChristinaEfrai2: Congratulations @Meyer_DH
    view full post

    March 4, 2021

    1

  • Christina Efraimoglou
    @ChristinaEfrai2 (Twitter)

    Congratulations @Meyer_DH
    view full post

    March 4, 2021

    3

    1

  • Asclepius
    @dd414a1d9b59447 (Twitter)

    RT @AgingBiology: BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy https://t.co/loS0yerGA3
    view full post

    March 4, 2021

    12

  • Philipe de Souto Barreto
    @SoutoPhilipe (Twitter)

    RT @AgingBiology: BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy https://t.co/loS0yerGA3
    view full post

    March 4, 2021

    12

  • PATRIOT'S UNITED 1776
    @PATRIOT83652082 (Twitter)

    RT @AgingBiology: BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy https://t.co/loS0yerGA3
    view full post

    March 3, 2021

    12

  • Francesco Puzzo
    @cicciopuz (Twitter)

    RT @schumacherbj: Our latest paper is out: Check the BiT age clock @CECAD_ @UKKoeln @UniCologne @AgingCell https://t.co/JLTZvthaK9 https:/…
    view full post

    March 3, 2021

    11

  • David Meyer
    @Meyer_DH (Twitter)

    RT @AgingBiology: BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy https://t.co/loS0yerGA3
    view full post

    March 3, 2021

    12

  • Alexei Maklakov
    @AlexeiMaklakov (Twitter)

    RT @AgingBiology: BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy https://t.co/loS0yerGA3
    view full post

    March 3, 2021

    12

  • Bruno Vellas
    @brunovellas (Twitter)

    RT @AgingBiology: BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy https://t.co/loS0yerGA3
    view full post

    March 3, 2021

    12

  • SNZK
    @shinopp (Twitter)

    RT @AgingBiology: BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy https://t.co/loS0yerGA3
    view full post

    March 3, 2021

    12

  • João Pedro de Magalhães
    @jpsenescence (Twitter)

    RT @AgingBiology: BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy https://t.co/loS0yerGA3
    view full post

    March 3, 2021

    12

  • Aging Science News
    @AgingBiology (Twitter)

    BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy https://t.co/loS0yerGA3
    view full post

    March 3, 2021

    31

    12

  • István Fodor
    @fodor_i (Twitter)

    RT @schumacherbj: Our latest paper is out: Check the BiT age clock @CECAD_ @UKKoeln @UniCologne @AgingCell https://t.co/JLTZvthaK9 https:/…
    view full post

    March 3, 2021

    11

  • David Meyer
    @Meyer_DH (Twitter)

    RT @CECAD_:
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    March 3, 2021

    3

  • Shahaf Peleg
    @DocLarus (Twitter)

    RT @schumacherbj: Our latest paper is out: Check the BiT age clock @CECAD_ @UKKoeln @UniCologne @AgingCell https://t.co/JLTZvthaK9 https:/…
    view full post

    March 3, 2021

    11

  • Björn Schumacher
    @schumacherbj (Twitter)

    RT @agingdoc1: BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy ⁦@AgingCell⁩ https://t.co/T3A0Fg0Nyf
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    March 3, 2021

    1

  • Nutriop Longevity
    @nutriop (Twitter)

    BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy https://t.co/XXvHQDgULH https://t.co/LbmWHngmyY
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    March 3, 2021

  • Agingdoc
    @agingdoc1 (Twitter)

    BiT age: A transcriptome‐based aging clock near the theoretical limit of accuracy ⁦@AgingCell⁩ https://t.co/T3A0Fg0Nyf
    view full post

    March 3, 2021

    6

    1

  • Single Cell Media
    @SingleCellMedia (Twitter)

    RT @z_chiang: Not an expert on aging clocks by any means, but this seems huge if true? So many publicly available RNA-seq datasets out ther…
    view full post

    March 3, 2021

    1

  • zack chiang
    @z_chiang (Twitter)

    Not an expert on aging clocks by any means, but this seems huge if true? So many publicly available RNA-seq datasets out there just begging for re-analysis, it'd also be cool to see if it works on single-cell data https://t.co/6wUoKzjfLm
    view full post

    March 3, 2021

    1

    1

  • Ronnie Cutler
    @cutleraging (Twitter)

    RT @schumacherbj: Our latest paper is out: Check the BiT age clock @CECAD_ @UKKoeln @UniCologne @AgingCell https://t.co/JLTZvthaK9 https:/…
    view full post

    March 3, 2021

    11

  • Maksim Nesterenko
    @linux_maxima (Twitter)

    RT @schumacherbj: Our latest paper is out: Check the BiT age clock @CECAD_ @UKKoeln @UniCologne @AgingCell https://t.co/JLTZvthaK9 https:/…
    view full post

    March 3, 2021

    11

  • Oded Rechavi
    @OdedRechavi (Twitter)

    RT @schumacherbj: Our latest paper is out: Check the BiT age clock @CECAD_ @UKKoeln @UniCologne @AgingCell https://t.co/JLTZvthaK9 https:/…
    view full post

    March 3, 2021

    11

  • Maria Ermolaeva
    @MariaErmolaev13 (Twitter)

    RT @schumacherbj: Our latest paper is out: Check the BiT age clock @CECAD_ @UKKoeln @UniCologne @AgingCell https://t.co/JLTZvthaK9 https:/…
    view full post

    March 3, 2021

    11

  • Andrés Gerena
    @gerenna (Twitter)

    https://t.co/Tm6gCL3Hru
    view full post

    March 3, 2021

  • Uni Cologne NY
    @UniCologneNY (Twitter)

    RT @schumacherbj: Our latest paper is out: Check the BiT age clock @CECAD_ @UKKoeln @UniCologne @AgingCell https://t.co/JLTZvthaK9 https:/…
    view full post

    March 3, 2021

    11

  • Uni Cologne NY
    @UniCologneNY (Twitter)

    RT @CECAD_:
    view full post

    March 3, 2021

    3

  • Björn Schumacher
    @schumacherbj (Twitter)

    RT @CECAD_:
    view full post

    March 3, 2021

    3

  • CECAD Cologne
    @CECAD_ (Twitter)


    view full post

    March 3, 2021

    12

    3

  • Barak Rotblat
    @BarakRotblat (Twitter)

    RT @schumacherbj: Our latest paper is out: Check the BiT age clock @CECAD_ @UKKoeln @UniCologne @AgingCell https://t.co/JLTZvthaK9 https:/…
    view full post

    March 3, 2021

    11

Abstract Synopsis

  • The BiT age clock is a new method for estimating biological age by analyzing transcriptomes, which improves accuracy compared to previous aging clocks.
  • This approach resolves issues related to data variation and directly correlates gene expression with aging factors like transcription and immune responses.
  • The BiT age clock not only applies to C. elegans but also shows potential for accurate human age predictions, making it useful for interventions in aging-related research.