April 2021 PMID 33675103

The ketogenic diet preserves skeletal muscle with aging in mice.

Marita A Wallace, Nicholas W Aguirre, George R Marcotte, Andrea G Marshall, Leslie M Baehr, David C Hughes, Karyn L Hamilton, Megan N Roberts, Jose Alberto Lopez-Dominguez, Benjamin F Miller, Jon J Ramsey, Keith Baar

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Mentions

124

Peak: 78 in Mar 2021

across 4 sources since Mar 2021

Extended reach

1,224,866

potential audience

Total likes

394

Video views

1,163

Mentions per month

Mar 2021 – Sep 2025

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AI synopsis

What people are saying

Numerous discussions cite the study’s findings, highlighting how the ketogenic diet preserves muscle mass and improves mitochondrial function. For example, phrases like 'important because muscle loss is a key correlate of aging' and 'this study shows the effectiveness of a long-term ketogenic diet' underlie a sense of urgency and relevance, indicating the potential for the diet to alter health outcomes in aging populations.

AgreementStrong agreement

The majority of discussions express strong support for the findings of the publication, emphasizing the benefits of the ketogenic diet in preserving muscle mass.

InterestHigh interest

Participants demonstrate high interest in the results, with many engaging in discussions about the implications for aging and health.

EngagementModerate engagement

While many posts reference key findings, there is a mix of engagement depth, with some merely stating facts without deep elaboration.

ImpactHigh impact

Most contributors acknowledge a significant potential impact of the study, believing it could influence dietary choices and research in aging.

Abstract in brief

The ketogenic diet (KD) helps preserve skeletal muscle mass in aging mice by promoting healthier muscle fiber types and improving cellular conditions.
Researchers observed that KD mice had greater muscle mass and shifted from type IIb to more oxidative type IIa fibers, suggesting enhanced endurance.
The diet also improved mitochondrial function and antioxidant capacity while reducing cellular stress, indicating a potential strategy for fighting age-related muscle loss (sarcopenia).

Read the full abstract

All mentions

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Brandon Roberts, PhD, MBA, CSCS, TSAC-F, FISSN

@BM_Roberts_SkM · X

and later Dr. Wallace https://t.co/OsG2ptv0Us

Nov 15, 2022 · 2 likes · 1,593 followers View post →

Daniel González C

@thkat · X

RT @JacobEdwardInc: 1/ Sarcopenia (age related loss of muscle mass) leads to frailty, morbidity, & mortality. In this mouse study, skelet…

Nov 12, 2022 · 2 shares · 418 followers View post →

Jacob Edward

@JacobEdwardInc · X

Nov 11, 2022 · 10 likes · 2 shares · 20,613 followers View post →

Citizen of EU

@wavetossed · X

RT @bendormiki: In mice - The Ketogenic diet preferentially preserved oxidative muscle fibers and improved mitochondrial and antioxidant ca…

Nov 8, 2022 · 2 shares · 9,625 followers View post →

SassMaggs

@Jjulian6412 · X

@The_Nutrivore @KenDBerryMD Wrong. Keto preserves skeletal muscle. https://t.co/EfkbG04BRc

Apr 24, 2022 · 1 like · 5,819 followers View post →

Eagle Community Care

@EagleCommCare · X

The ketogenic diet preserves skeletal muscle with aging in mice - Wallace - 2021 - Aging Cell - Wiley Online Library https://t.co/ryohhzZDBZ

Jun 2, 2021 · 88 followers View post →

dude buddy

@MAGAparasiempre · X

RT @Mangan150: The ketogenic diet preserves skeletal muscle with aging in mice Improved mitochondrial and antioxidant function leads to be…

May 31, 2021 · 18 shares · 277 followers View post →

jbird

@crossthemeadow · X

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May 31, 2021 · 18 shares · 86 followers View post →

Andrew Brooks

@andrewjbrooks1 · X

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May 31, 2021 · 18 shares · 722 followers View post →

Federico Bernuzzi, PhD

@FedericoBernuzz · X

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May 31, 2021 · 18 shares · 624 followers View post →

kike

@FUENTESMANZULLI · X

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May 31, 2021 · 18 shares · 249 followers View post →

Tim Noakes

@ProfTimNoakes · X

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May 31, 2021 · 18 shares · 158,503 followers View post →

@Kreutzjr1 · X

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Larry Diamond

@natureboyrr · X

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MoKrave

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@consultorvzla · X

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May 31, 2021 · 89 likes · 18 shares · 291,950 followers View post →

Orlando_uy

@Orlando_uy · X

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Apr 20, 2021 · 3 likes · 694 followers View post →

Prof Renato Alvarenga

@Profrenatoalva1 · X

https://t.co/wanLGrR7TK

Apr 18, 2021 · 151 followers View post →

AKA_Sadrien

@AKA_Sadrien · X

@doctorinigo @n0madd https://t.co/o4uhL0BPmt This also discusses the same topic.

Apr 17, 2021 · 2 likes · 792 followers View post →

るぃ | 筋トレ男子 x 生成AI

@luilui2017 · X

RT @MuscleScience: Final version of @Muscle_Wallace's recent paper is open access. A ketogenic diet preserves skeletal muscle mass function…

Apr 14, 2021 · 9 shares · 1,789 followers View post →

Andrew Koutnik, Ph.D.

@AKoutnik · X

RT @MuscleScience: Final version of @Muscle_Wallace's recent paper is open access. A ketogenic diet preserves skeletal muscle mass function…

Apr 14, 2021 · 9 shares · 7,308 followers View post →

Cameron Hill

@CameronHill13 · X

RT @MuscleScience: Final version of @Muscle_Wallace's recent paper is open access. A ketogenic diet preserves skeletal muscle mass function…

Apr 14, 2021 · 9 shares · 830 followers View post →

Thomson Muscle Lab

@thomsonlabbyu · X

RT @MuscleScience: Final version of @Muscle_Wallace's recent paper is open access. A ketogenic diet preserves skeletal muscle mass function…

Apr 14, 2021 · 9 shares · 21 followers View post →

Matías Monsalves-Álvarez

@profemonsalves · X

RT @MuscleScience: Final version of @Muscle_Wallace's recent paper is open access. A ketogenic diet preserves skeletal muscle mass function…

Apr 14, 2021 · 9 shares · 1,510 followers View post →

Gustavo Humeres

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RT @MuscleScience: Final version of @Muscle_Wallace's recent paper is open access. A ketogenic diet preserves skeletal muscle mass function…

Apr 14, 2021 · 9 shares · 371 followers View post →

Henning Langer

@HenningLanger · X

RT @MuscleScience: Final version of @Muscle_Wallace's recent paper is open access. A ketogenic diet preserves skeletal muscle mass function…

Apr 14, 2021 · 9 shares · 1,711 followers View post →

Ketogeen Instituut Nederland

@Ketogenics_Inst · X

RT @MuscleScience: Final version of @Muscle_Wallace's recent paper is open access. A ketogenic diet preserves skeletal muscle mass function…

Apr 14, 2021 · 9 shares · 631 followers View post →

Dave Hughes

@HughesDC_Muscle · X

RT @MuscleScience: Final version of @Muscle_Wallace's recent paper is open access. A ketogenic diet preserves skeletal muscle mass function…

Apr 14, 2021 · 9 shares · 11,026 followers View post →

Keith Baar

@MuscleScience · X

Final version of @Muscle_Wallace's recent paper is open access. A ketogenic diet preserves skeletal muscle mass function with aging in mice https://t.co/iRcuYHhw7H

Apr 14, 2021 · 40 likes · 9 shares · 32,661 followers View post →

Armando Villalta

@VillaltaLab · X

RT @MuscleScience: A ketogenic diet preserves skeletal muscle mass and function with aging in mice. Nice work @Muscle_Wallace and team. htt…

Apr 11, 2021 · 30 shares · 256 followers View post →

alephh

@alephh · X

Ketogenic diet preserves skeletal muscle with aging — Long-term #LCHF effective in mitigating sarcopenia: preserved oxidative muscle fibers & mitochondrial & antioxidant capacity up — Less protein turnover due to healthier cells, less oxidative & ER stress https://t.co/RXyPf2u6Ht https://t.co/h3nowUnouL

Mar 28, 2021 · 388 followers View post →

(((JReuben1)))

@jreuben1 · X

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Mar 28, 2021 · 1 like · 1,956 followers View post →

Linda Galliher

@LindaGalliher · X

RT @bendormiki: In mice - The Ketogenic diet preferentially preserved oxidative muscle fibers and improved mitochondrial and antioxidant ca…

Mar 18, 2021 · 2 shares · 851 followers View post →

Steve Hajioff

@DrSteveHajioff · X

The ketogenic diet preserves skeletal muscle with aging in mice https://t.co/jwCldfiJSP

Mar 18, 2021 · 667 followers View post →

Stein Olsen

@SteinOOlsen · X

RT @MuscleScience: A ketogenic diet preserves skeletal muscle mass and function with aging in mice. Nice work @Muscle_Wallace and team. htt…

Mar 11, 2021 · 30 shares · 62 followers View post →

Vet Goed

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RT @MuscleScience: A ketogenic diet preserves skeletal muscle mass and function with aging in mice. Nice work @Muscle_Wallace and team. htt…

Mar 11, 2021 · 30 shares · 388 followers View post →

Miki Ben-Dor

@bendormiki · X

In mice - The Ketogenic diet preferentially preserved oxidative muscle fibers and improved mitochondrial and antioxidant capacity. - Aging Cell - Wiley Online Library https://t.co/d5zlkUVngr

Mar 11, 2021 · 6 likes · 2 shares · 4,969 followers View post →

Dr L Boominathan PhD

@DrLBoominathan · X

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@BlaaaaahhX3 · X

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Mar 9, 2021 · 15 shares · 3,524 followers View post →

Nick Krontiris

@nick_krontiris · X

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Mar 9, 2021 · 3 likes · 19,084 followers View post →

mythic health

@MythicHealth · X

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Mar 8, 2021 · 30 shares · 52 followers View post →

LastSamurai

@maciejonob · X

RT @Mangan150: The ketogenic diet preserves skeletal muscle with aging in mice https://t.co/yu4pmFjfhd

Mar 8, 2021 · 15 shares · 27 followers View post →

DesignedByNature

@DesignedNature · X

I just posted "The ketogenic diet preserves skeletal muscle with aging in mice. (Pub Date: 2021-03-06)" on Reddit https://t.co/QrGD3Flh4g

Mar 8, 2021 · 439 followers View post →

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RT @claymoreberserk: https://t.co/QAZEHM9VTR

Mar 8, 2021 · 1 share · 218 followers View post →

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@UpdateonScience · X

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Mar 8, 2021 · 1,883 followers View post →

Eve Beavers

@espacetimeCO · X

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Mar 8, 2021 · 30 shares · 900 followers View post →

Brianna Stubbs

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Mar 8, 2021 · 30 shares · 4,029 followers View post →

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Mar 7, 2021 · 30 shares · 88 followers View post →

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Mar 7, 2021 · 30 shares · 57 followers View post →

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Mar 7, 2021 · 5 shares · 141 followers View post →

Best Health 4 You

@besthealthyou · X

RT @HealthyFellow: The #ketogenic #diet preserves #skeletal #muscle w/ #aging in mice https://t.co/RraLTYzMBE Attn: @_atanas_ @_INPST @Scie…

Mar 7, 2021 · 9 shares · 523 followers View post →

Yoshinori Yamamoto

@claymoreberserk · X

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Mar 7, 2021 · 27 likes · 1 share · 76,740 followers View post →

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@DrJamesDACBN · X

RT @MuscleScience: A ketogenic diet preserves skeletal muscle mass and function with aging in mice. Nice work @Muscle_Wallace and team. htt…

Mar 7, 2021 · 30 shares · 188 followers View post →

sonia salim

@soniasalim · X

RT @dj_surfista: No geral, este estudo mostra a eficácia de uma #dietacetogenica de longo prazo na atenuação da #sarcopenia. #keto https:/…

Mar 7, 2021 · 1 share · 3,152 followers View post →

Pedro Rojas M.

@PRojasMorales · X

RT @MuscleScience: A ketogenic diet preserves skeletal muscle mass and function with aging in mice. Nice work @Muscle_Wallace and team. htt…

Mar 7, 2021 · 30 shares · 51 followers View post →

Gregoire Millet

@GregoireMillet1 · X

RT @MuscleScience: A ketogenic diet preserves skeletal muscle mass and function with aging in mice. Nice work @Muscle_Wallace and team. htt…

Mar 7, 2021 · 30 shares · 5,785 followers View post →

Carbon Knowledge

@CarbonKnowledge · X

The ketogenic diet preserves skeletal muscle with aging in mice (March 2021) https://t.co/g06cB0M4pf

Mar 7, 2021 · 63 followers View post →

Dominic D'Agostino

@DominicDAgosti2 · X

RT @MuscleScience: A ketogenic diet preserves skeletal muscle mass and function with aging in mice. Nice work @Muscle_Wallace and team. htt…

Mar 7, 2021 · 30 shares · 77,949 followers View post →

Professor Adam Sharples

@DrAdamPSharples · X

RT @MuscleScience: A ketogenic diet preserves skeletal muscle mass and function with aging in mice. Nice work @Muscle_Wallace and team. htt…

Mar 7, 2021 · 30 shares · 7,313 followers View post →

Nutriop Longevity

@nutriop · X

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Mar 7, 2021 · 80 followers View post →

Matías Monsalves-Álvarez

@profemonsalves · X

RT @MuscleScience: A ketogenic diet preserves skeletal muscle mass and function with aging in mice. Nice work @Muscle_Wallace and team. htt…

Mar 7, 2021 · 30 shares · 1,510 followers View post →

WellSense Media

@DaneShearer · X

RT @HealthyFellow: The #ketogenic #diet preserves #skeletal #muscle w/ #aging in mice https://t.co/RraLTYzMBE Attn: @_atanas_ @_INPST @Scie…

Mar 7, 2021 · 9 shares · 28 followers View post →

Dr Anthony Martin

@AMAinsight · X

RT @HealthyFellow: The #ketogenic #diet preserves #skeletal #muscle w/ #aging in mice https://t.co/RraLTYzMBE Attn: @_atanas_ @_INPST @Scie…

Mar 7, 2021 · 9 shares · 915 followers View post →

Orlando_uy

@Orlando_uy · X

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Mar 7, 2021 · 5 shares · 694 followers View post →

Psychfarm

@psychfarm · X

RT @HealthyFellow: The #ketogenic #diet preserves #skeletal #muscle w/ #aging in mice https://t.co/RraLTYzMBE Attn: @_atanas_ @_INPST @Scie…

Mar 7, 2021 · 9 shares · 23 followers View post →

Anjali Anand | Metabolic Health Coach

@anjupete · X

This is why even when one loses 20+ kgs with Ketogenic diet, they don't have saggy skin or muscles. #lowcarbdiet #muscleatrophy "The ketogenic diet preserves skeletal muscle with aging in mice" https://t.co/66zEUKbSxr

Mar 7, 2021 · 4 likes · 4,372 followers View post →

Eve Beavers

@espacetimeCO · X

⁦@DrSarahHallberg⁩ The ketogenic diet preserves skeletal muscle with aging in mice - PubMed https://t.co/VDzvuXOybz

Mar 7, 2021 · 1 like · 900 followers View post →

Agingdoc

@agingdoc1 · X

@CaloriesProper Hi Bill, can you please clarify your comments

Mar 7, 2021 · 2 likes · 41,667 followers View post →

Ketoisnotdangerous

@Ketogranny · X

RT @HealthyFellow: The #ketogenic #diet preserves #skeletal #muscle w/ #aging in mice https://t.co/RraLTYzMBE Attn: @_atanas_ @_INPST @Scie…

Mar 6, 2021 · 9 shares · 3,700 followers View post →

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Mar 6, 2021 · 5 shares · 704 followers View post →

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Gustavo Domeniconi

@gdomeni · X

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Mar 6, 2021 · 5 shares · 907 followers View post →

Agingdoc

@agingdoc1 · X

The ketogenic diet preserves skeletal muscle with aging in mice ⁦@AgingCell⁩ https://t.co/k3BWabHws0

Mar 6, 2021 · 9 likes · 5 shares · 41,667 followers View post →

PC ⛓

@PC65049955 · X

RT @HealthyFellow: The #ketogenic #diet preserves #skeletal #muscle w/ #aging in mice https://t.co/RraLTYzMBE Attn: @_atanas_ @_INPST @Scie…

Mar 6, 2021 · 9 shares · 1,469 followers View post →

Rodney C. Root, CSCS

@RodCRoot · X

RT @HealthyFellow: The #ketogenic #diet preserves #skeletal #muscle w/ #aging in mice https://t.co/RraLTYzMBE Attn: @_atanas_ @_INPST @Scie…

Mar 6, 2021 · 9 shares · 1,406 followers View post →

Dominic D'Agostino

@DominicDAgosti2 · X

RT @HealthyFellow: The #ketogenic #diet preserves #skeletal #muscle w/ #aging in mice https://t.co/RraLTYzMBE Attn: @_atanas_ @_INPST @Scie…

Mar 6, 2021 · 9 shares · 77,949 followers View post →

Dr Joshua Neale

@Jphneale · X

RT @MuscleScience: A ketogenic diet preserves skeletal muscle mass and function with aging in mice. Nice work @Muscle_Wallace and team. htt…

Mar 6, 2021 · 30 shares · 540 followers View post →

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RT @Mangan150: The ketogenic diet preserves skeletal muscle with aging in mice https://t.co/yu4pmFjfhd

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@ralzahrani2020 · X

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Mar 6, 2021 · 9 shares · 4,361 followers View post →

Erica Rubio

@NerdyRubi · X

RT @MuscleScience: A ketogenic diet preserves skeletal muscle mass and function with aging in mice. Nice work @Muscle_Wallace and team. htt…

Mar 6, 2021 · 30 shares · 18 followers View post →

J P Fanton

@HealthyFellow · X

Mar 6, 2021 · 37 likes · 9 shares · 26,027 followers View post →

JT | Jerry Teixeira

@jerryteixeira · X

RT @MuscleScience: A ketogenic diet preserves skeletal muscle mass and function with aging in mice. Nice work @Muscle_Wallace and team. htt…

Mar 6, 2021 · 30 shares · 79,104 followers View post →

Amurtab

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RT @MuscleScience: A ketogenic diet preserves skeletal muscle mass and function with aging in mice. Nice work @Muscle_Wallace and team. htt…

Mar 6, 2021 · 30 shares · 82 followers View post →

Adam J Rose

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Mar 6, 2021 · 30 shares · 810 followers View post →

eleanorina

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RT @MuscleScience: A ketogenic diet preserves skeletal muscle mass and function with aging in mice. Nice work @Muscle_Wallace and team. htt…

Mar 6, 2021 · 30 shares · 3,172 followers View post →

Anthony Hessel, PhD

@HesselAnthony · X

RT @MuscleScience: A ketogenic diet preserves skeletal muscle mass and function with aging in mice. Nice work @Muscle_Wallace and team. htt…

Mar 6, 2021 · 30 shares · 611 followers View post →

Health N Fitness Products

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RT @Mangan150: The ketogenic diet preserves skeletal muscle with aging in mice https://t.co/yu4pmFjfhd

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Lakey Farm

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Dr L Boominathan PhD

@DrLBoominathan · X

RT @Mangan150: The ketogenic diet preserves skeletal muscle with aging in mice https://t.co/yu4pmFjfhd

Mar 6, 2021 · 15 shares · 880 followers View post →

Craig A. Goodman

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RT @MuscleScience: A ketogenic diet preserves skeletal muscle mass and function with aging in mice. Nice work @Muscle_Wallace and team. htt…

Mar 6, 2021 · 30 shares · 3,915 followers View post →

⫷ Age of Endarkenment ⫸

@ExistentialEDU · X

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Mar 6, 2021 · 15 shares · 1,278 followers View post →

htw

@heniek_htw · X

Ketogenic Diet & Aging ✅ Overall, this study shows the effectiveness of a long‐term ketogenic diet in mitigating sarcopenia. ⬆️ Mitochondrial proteins ⬆️ Antioxidant proteins ⬆️ Phosphorylation of eIF2α

Mar 6, 2021 · 1 like · 1 share · 11,279 followers View post →

PC ⛓

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L ❤ V E

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kike

@FUENTESMANZULLI · X

RT @Mangan150: The ketogenic diet preserves skeletal muscle with aging in mice https://t.co/yu4pmFjfhd

Mar 6, 2021 · 15 shares · 249 followers View post →

Des G

@post1984world · X

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Mar 6, 2021 · 15 shares · 308 followers View post →

Olivier Antonini

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RT @Mangan150: The ketogenic diet preserves skeletal muscle with aging in mice https://t.co/yu4pmFjfhd

Mar 6, 2021 · 15 shares · 3,329 followers View post →

Henning Langer

@HenningLanger · X

RT @MuscleScience: A ketogenic diet preserves skeletal muscle mass and function with aging in mice. Nice work @Muscle_Wallace and team. htt…

Mar 6, 2021 · 30 shares · 1,711 followers View post →

Pete Edwards

@CoachEdwardsUK · X

RT @MuscleScience: A ketogenic diet preserves skeletal muscle mass and function with aging in mice. Nice work @Muscle_Wallace and team. htt…

Mar 6, 2021 · 30 shares · 340 followers View post →

Maurício Lima

@dj_surfista · X

No geral, este estudo mostra a eficácia de uma #dietacetogenica de longo prazo na atenuação da #sarcopenia. #keto https://t.co/At9EvzXhg6

Mar 6, 2021 · 1 like · 1 share · 742 followers View post →

Vern Gambetta

@coachgambetta · X

RT @MuscleScience: A ketogenic diet preserves skeletal muscle mass and function with aging in mice. Nice work @Muscle_Wallace and team. htt…

Mar 6, 2021 · 30 shares · 27,032 followers View post →

Cell Mol Ex Physiol

@CelMolExPhysiol · X

RT @MuscleScience: A ketogenic diet preserves skeletal muscle mass and function with aging in mice. Nice work @Muscle_Wallace and team. htt…

Mar 6, 2021 · 30 shares · 2,292 followers View post →

Ketogeen Instituut Nederland

@Ketogenics_Inst · X

RT @MuscleScience: A ketogenic diet preserves skeletal muscle mass and function with aging in mice. Nice work @Muscle_Wallace and team. htt…

Mar 6, 2021 · 30 shares · 631 followers View post →

RobertoAguilar

@RobWFAguilar · X

RT @MuscleScience: A ketogenic diet preserves skeletal muscle mass and function with aging in mice. Nice work @Muscle_Wallace and team. htt…

Mar 6, 2021 · 30 shares · 92 followers View post →

Dave Hughes

@HughesDC_Muscle · X

RT @MuscleScience: A ketogenic diet preserves skeletal muscle mass and function with aging in mice. Nice work @Muscle_Wallace and team. htt…

Mar 6, 2021 · 30 shares · 11,026 followers View post →

Keith Baar

@MuscleScience · X

A ketogenic diet preserves skeletal muscle mass and function with aging in mice. Nice work @Muscle_Wallace and team. https://t.co/RvKd0nEfqy

Mar 6, 2021 · 124 likes · 30 shares · 32,661 followers View post →

The ketogenic diet preserves skeletal muscle with aging in mice.

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