The discussions reflect a balanced recognition of the article's importance, with examples like mentions of resistance magnitudes and structural changes in the spike protein to underscore its implications. Words such as 'refractory', 'resistant', and phrases like 'greater for monoclonal Abs than vaccines' convey a serious tone, emphasizing the perceived threat posed by the P.1 variant and its potential impact on public health measures.
AgreementModerate agreement
Most discussions acknowledge the findings about the P.1 variant's increased resistance, showing general support for the publication's conclusions.
InterestModerate interest
Participants demonstrate moderate curiosity, referencing details about resistance levels and implications for vaccines and treatments.
EngagementModerate engagement
Many exchanges include references to scientific studies, terminology, and technical details, indicating a deeper engagement.
ImpactHigh impact
The consensus suggests that the findings are viewed as highly significant, especially regarding the potential challenges to current treatments and vaccines.
Abstract in brief
The SARS-CoV-2 P1 variant from Brazil is significantly more resistant to neutralization by both convalescent plasma and vaccinee sera, with resistance increases of 34-fold and 38-48 fold respectively, and also evades multiple monoclonal antibodies.
Structural analysis shows that the P1 spike protein mainly adopts a specific conformation with one receptor-binding domain in the "up" position, caused by local mutations rather than overall shape changes.
While the P1 variant poses a threat to current antibody treatments, it appears less likely to reduce the effectiveness of existing vaccines.]
"Increased resistance of SARS-CoV-2 variant P.1 to antibody neutralization" - Read the Report now in @cellhostmicrobe https://t.co/hJUMQqAKMs
@ColumbiaPS @ColumbiaMed https://t.co/lJBqN7WHm3
May 1, 2021 · 38 likes · 15 shares · 161,889 followersView post →
CP
Cell Press
@CellPressNews · X
"Increased resistance of SARS-CoV-2 variant P.1 to antibody neutralization" - Read the Report now in @cellhostmicrobe https://t.co/iH8R86dyc4
@ColumbiaPS @ColumbiaMed https://t.co/cKfcuJ9v5B
May 3, 2021 · 27 likes · 6 shares · 161,889 followersView post →
CM
Cell Host & Microbe
@cellhostmicrobe · X
Increased Resistance of SARS-CoV-2 Variant P.1 to Ab Neutralization: #SARSCoV2 variant P.1 is relatively resistant to neutralization by multiple therapeutic monoclonal #antibodies, convalescent plasma & vaccinee sera https://t.co/LWLNT3FCeB https://t.co/ediICz7fUJ
Increased Resistance of SARS-CoV-2 Variant P.1 to Ab Neutralization: #SARSCoV2 variant P.1 is relatively resistant to neutralization by multiple therapeutic monoclonal #antibodies, convalescent plasma & vaccinee sera https://t.co/LWLNT3FCeB https://t.co/yLZye5051R
May 13, 2021 · 5 likes · 1 share · 27,593 followersView post →
BM
bioRxiv Microbiology
@biorxiv_micrbio · X
Increased Resistance of SARS-CoV-2 Variant P.1 to Antibody Neutralization https://t.co/hSTUno41Fv #biorxiv_micrbio
Mar 2, 2021 · 5 likes · 5 shares · 20,976 followersView post →
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TF 2
@TonyFauci2 · X
“Emergent variant from Brazil-P.1, (Gamma) not only refractory to multiple neutralizing monoclonal Abs but also more resistant to neutralization by Convalescent plasma & vaccines. Magnitude of resistance is greater for Convalescent Abs than vaccines” https://t.co/ZTaqB5c3Bt $HGEN
Gamma variant P1 is a strain of SARS-CoV 2 that emerged in 2020. It is classified as a Variant of Concern and shows increased resistance to antibody neutralization, evading some vaccine and antibody treatments, which…
The Delta variant B16172 of SARS-CoV 2, classified as a Variant of Concern, emerged in 2020. It transmits rapidly among individuals due to specific mutations. We explore its characteristics, spread, and impact on public…
“Emergent variant from Brazil-P.1, (Gamma) not only refractory to multiple neutralizing monoclonal Abs but also more resistant to neutralization by Convalescent plasma & vaccines. Magnitude of resistance is greater for Convalescent Abs than vaccines” https://t.co/ZTaqB5c3Bt $HGEN
“Emergent variant from Brazil, P.1, (Gamma) not only refractory to multiple neutralizing monoclonal Abs but also more resistant to neutralization by convalescent plasma & vaccines. Magnitude of resistance is greater for monoclonal Abs than vaccines.” https://t.co/ZTaqB5c3Bt $HGEN https://t.co/hS8HjVgXs7
Increased Resistance of SARS-CoV-2 Variant P.1 to Ab Neutralization: #SARSCoV2 variant P.1 is relatively resistant to neutralization by multiple therapeutic monoclonal #antibodies, convalescent plasma & vaccinee sera https://t.co/LWLNT3FCeB https://t.co/yLZye5051R
May 13, 2021 · 5 likes · 1 share · 27,593 followersView post →
SB
Sally Fereday CFIRM MSc BSc (Hons) BSc
@SallyFereday · X
RT @CellPressNews: "Increased resistance of SARS-CoV-2 variant P.1 to antibody neutralization" - Read the Report now in @cellhostmicrobe ht…
May 5, 2021 · 6 shares · 6,420 followersView post →
SK
Susan Kimpton
@KIMPY123 · X
RT @CellPressNews: "Increased resistance of SARS-CoV-2 variant P.1 to antibody neutralization" - Read the Report now in @cellhostmicrobe ht…
May 4, 2021 · 6 shares · 1,221 followersView post →
EM
estornuda.me
@EstornudaM · X
Increased resistance of SARS-CoV-2 variant P.1 to antibody neutralization https://t.co/0hv77NceaF
Increased resistance of SARS-CoV-2 variant P.1 to antibody neutralization.
https://t.co/QqN0BY3vvs
May 3, 2021 · 2 likes · 1 share · 530 followersView post →
く
くまきち
@kuma_kichi_1Q63 · X
RT @CellPressNews: "Increased resistance of SARS-CoV-2 variant P.1 to antibody neutralization" - Read the Report now in @cellhostmicrobe ht…
May 3, 2021 · 6 shares · 1,029 followersView post →
CP
Cell Press
@CellPressNews · X
"Increased resistance of SARS-CoV-2 variant P.1 to antibody neutralization" - Read the Report now in @cellhostmicrobe https://t.co/iH8R86dyc4
@ColumbiaPS @ColumbiaMed https://t.co/cKfcuJ9v5B
May 3, 2021 · 27 likes · 6 shares · 161,889 followersView post →
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nickname
@JNickname · X
RT @love_nihonsyu: ブラジル型変異株(P1)は回復期血漿とワクチン接種者血清のどちらの抗体に対しても耐性が増加するが、南ア型変異株(B.1.351)と比べると、中和力価の低下幅は少なそう。
Increased Resistance of SARS-CoV-2…
"Increased resistance of SARS-CoV-2 variant P.1 to antibody neutralization" - Read the Report now in @cellhostmicrobe https://t.co/hJUMQqAKMs
@ColumbiaPS @ColumbiaMed https://t.co/lJBqN7WHm3
May 1, 2021 · 38 likes · 15 shares · 161,889 followersView post →
TL
the paper link
@the_paper_link · X
Trend up+6: Wang P, ..., Ho DD (Cell Host Microbe) __Increased resistance of SARS-CoV-2 variant P.1 to antibody neutralization__
https://t.co/bBJ1PfwmY9
Increased Resistance of SARS-CoV-2 Variant P.1 to Ab Neutralization: #SARSCoV2 variant P.1 is relatively resistant to neutralization by multiple therapeutic monoclonal #antibodies, convalescent plasma & vaccinee sera https://t.co/LWLNT3FCeB https://t.co/ediICz7fUJ
The preprint “Increased Resistance of SARS-CoV-2 Variant P.1 to …” (https://t.co/KpFv5l2ub4) has been reviewed by automated tools, find results here: https://t.co/F8aBVJVXwk. We detected 0 of 5 rigor criteria, 0 resources, and no limitations statement.
Spoznali so, da plazma prebovelnic_kov slabše nevtralizira novi različici virusa (B.1.351 in P.1). A tukaj gre za eksperimente v laboratoriju; ne vemo še, kakšen biološki in epidemiološki pomen imajo ti rezultati. (12/22) https://t.co/IJHGtHPwEp https://t.co/t3rxLd03nH
Mar 11, 2021 · 1 like · 2,545 followersView post →
EC
Eduard Centeno
@segol60 · X
RT @dronita_de: Increased Resistance of SARS-CoV-2 Variant P.1 to Antibody Neutralization https://t.co/fEaor3jwwH
#DHPSP
Fungal Infections: September 2021 | PDF | Infection | Pneumonia
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... 10.1101/2021.03.01.433466v1)—reflects there were no known secondary infections in the the lineages that are arriving at the border. A total of community ...
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