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Several posts emphasize the importance of various effector kinase pathways in T cells, indicating excitement about their implications for immunology. Phrases such as 'dedicated effector pathways' and questions about different signaling mechanisms suggest that users are intrigued and invested in understanding the nuanced roles of these pathways. The tone is generally analytical, showing that users are both supportive of the research findings and eager for deeper exploration.
Most discussions are supportive of the article's insights on T cell pathways.
The topic of T cell signaling generates notable curiosity and relevance among participants.
Discussions show moderate depth, with references to signaling pathways but lacking in extensive detail.
Participants perceive the findings as significant for the field, noting potential implications in immunology and inflammation.
Pleased to see our paper with @resiapretorius on ischaemia-reperfusion injury in #LongCOVID passing 40,000 views https://t.co/UyudHsIBce #pwLC #pwME #TeamClots
Our review on the peculiar properties of mitochondrial carriers of the SLC25 family out: portlandpress.com/biochemj/art...
Delighted with our new paper on a novel itaconate transporter in the human pathogen Pseudomonas aeruginosa, led by Javeria and Reyme. @ybri-uoy.bsky.social @javeriamehboob.bsky.social @bethkw.bsky.social A duplicated transporter on its way to itaconate selectivity portlandpress.com/biochemj/art...
My first post on BlueSky. Our latest review delves into the critical roles of ubiquitin E3 ligases in safeguarding genome integrity and their implications in human diseases. @drjhujh.bsky.social @profstewartlab.bsky.social portlandpress.com/biochemj/art...
More wonderful science from my amazing friends and colleagues ‼️
Interesting review about interleukin-6 family of cytokines (there are 9 of them), their receptors, and how glycosylation influences synthesis, receptor binding, signaling, stability, transport, ligand binding, internalization and recycling https://t.co/2kUSc2IUKj #glycotime https://t.co/8QX9Pi5VAR
This video delves into the importance of Vitamin C for physical and mental health. Drawing on significant biochemical studies, it also touches on T cell activation mechanisms and the role of ERK in immune responses…
RT @PPPublishing: Histones play a critical role in eukaryotic cell survival. This #OA review from Gonske et al showcases each step of the h…
Histones play a critical role in eukaryotic cell survival. This #OA review from Gonske et al showcases each step of the histone supply chain and the impact on chromatin structure and cellular identity.https://t.co/XmB9B4W613 https://t.co/pcUib55uxS
FYI and discussion. Further comment invited... https://t.co/mPF1psu3MW
RT @ParadiseLostCA: A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications | Biochemical Jou…
RT @AnneliseBocquet: @TurdFur58439807 https://t.co/muBMDxo1JS https://t.co/0iBDuZUc5R https://t.co/IJQ8lJxT88 https://t.co/fxUY7sxYjH http…
RT @AnneliseBocquet: @TurdFur58439807 https://t.co/muBMDxo1JS https://t.co/0iBDuZUc5R https://t.co/IJQ8lJxT88 https://t.co/fxUY7sxYjH http…
RT @AnneliseBocquet: @TurdFur58439807 https://t.co/muBMDxo1JS https://t.co/0iBDuZUc5R https://t.co/IJQ8lJxT88 https://t.co/fxUY7sxYjH http…
Interested in how the type-I #CRISPR system could be simplified for easier genome editing? Rath et al. evaluate the dispensability of the type-I Cascade components in their new paper in the Biochemical Journal. https://t.co/46u0Zm6JST https://t.co/EXy1wlTNM8
@fitat45plus I know a bit about that as having contributed to its many forms, but it goes back to an old study on potatoes from the 1920’s https://t.co/bDl04WXmsM
Review "And… cut! – how conformational regulation of CRISPR-Cas effectors directs nuclease activity” Calvert RW, Knott GJ. Biochem J. 2025-09-25. https://t.co/vMBiDecW91 Conformational checkpoints in Cas9, Cas12a & Cas13a
Our review "Proteostasis of immune checkpoint receptors" is out in @Biochem_Journal! We highlight how ubiquitylation acts as a key sorting signal, governing the fate of immune checkpoints - from the highly stable PD-L1 to the short-lived CTLA-4. https://t.co/aSw14dTstj
Our review "Proteostasis of immune checkpoint receptors" is out in Biochem J! @biochemsoc.bsky.social We highlight how ubiquitylation acts as a key sorting signal, governing the fate of immune checkpoints - from the highly stable PD-L1 to the short-lived CTLA-4. portlandpress.com/biochemj/art...
Mechanistic insights into DNA binding by BD1 of the TAF1 tandem bromodomain module https://t.co/nNGCnVtAbb
Characterisation of an allosteric site in PLCγ enzymes and implications for development of their specific inhibitors https://t.co/rxshs3Luns
This small study has been kind of seminal and probably, a landmark study. Low intracellular calcium generates more lipid droplets in cytoplasm :-(. Lots of high-profile papers came out from different lab based on this discovery. portlandpress.com/biochemj/art...
This small study has been kind of seminal and probably, a landmark study. Low intracellular calcium generates more lipid droplets in cytoplasm :-(. Lots of high-profile papers came out from different lab based on this discovery. https://t.co/Zzt9zlD6r4
RT @PPPublishing: Explore the latest issue of the Biochemical Journal, featuring reviews on gut homeostasis and mitochondrial nucleotides,…
Explore the latest issue of the Biochemical Journal, featuring reviews on gut homeostasis and mitochondrial nucleotides, as well as research on phototrophic bacteria, antibody therapeutics and reactive oxygen and nitrogen species https://t.co/4CNnkQWbab https://t.co/EMRlhzgfwg
RT @PPPublishing: Mitochondria support the production of nucleotides required for cell growth and survival, and they depend on nucleotides…
Mitochondria support the production of nucleotides required for cell growth and survival, and they depend on nucleotides for the replication and expression of the mitochondrial genome. Discover this review of mitochondrial nucleotides from Thomas MacVicar https://t.co/YGybvG8YDD https://t.co/sOhef3chmL
Happy to share our recent Research Article. A fruitful collaboration with researchers at @ccg_unam that unveils the role of a bacterial #thioesterase in the production of #2tridecanone https://t.co/Sk93eD8UxD
RT @dbkell: Pleased to see our paper with @resiapretorius on ischaemia-reperfusion injury in #LongCOVID passing 40,000 views https://t.co/…
Realized that I'm pretty weak in understanding viral transduction (was naively assuming the viruses are still replication competent). Hazard of CS background -> pivot to bio. Time for more reading: "Lentiviral vectors: basic to translational" https://t.co/4mLytDHcqx"
De novo talin-1 variant L353F connects multifaceted clinical symptoms to alterations in talin-1 function portlandpress.com/biochemj/art... #hvhebron #upiip #gen [Text complet]
De novo talin-1 variant L353F connects multifaceted clinical symptoms to alterations in talin-1 function https://t.co/Zp4byd29Uh #hvhebron #upiip #gen [Text complet]
RT @PPPublishing: Find out about the activity of granzyme A in the brain in this Biochemical Journal article, where Quinn et al. investigat…
Find out about the activity of granzyme A in the brain in this Biochemical Journal article, where Quinn et al. investigate the possibility of its contribution to tauopathies following release from infiltrating cytotoxic CD8+ cells https://t.co/uRiT3sXOMF https://t.co/WRqc0gVVm3
portlandpress.com/biochemj/art... PhD student Jacquie Mills has been getting to grips with RNAcapology. She has written this review on everything you wanted to know about m7G cap methylation and more....
RT @PPPublishing: O’Sullivan et al. investigate the key mechanisms and components of the psoriatic CARD14 signalosome in this Biochemical J…
O’Sullivan et al. investigate the key mechanisms and components of the psoriatic CARD14 signalosome in this Biochemical Journal research article https://t.co/hfOe7qokPf https://t.co/kB94FNbnEL
New Paper from I03 in #BiochemJ https://t.co/tkuDJM3iZp (https://t.co/8ghv9kKn5n)
This new Biochemical Journal study from Michael et al. presents a further example of the prevalence of convergent evolution and horizontal gene transfer in polyamine #biosynthesis in bacteria.https://t.co/oF4aqOyeZF https://t.co/B1hhm9EQKe
Interested in the regulation of Rubisco? Lobo et al. investigate the impact of various chloroplast metabolites on Rubisco activity, as well as their potential mechanisms of interaction in this Biochemical Journal article.https://t.co/NQ8oIl71IF https://t.co/ryEyumHZfN
Annals Of Biochemistry Protein Folding Fundamentals & Mechanisms from Ultrafast Approaches: https://t.co/WXMUYuep7K https://t.co/JA71rhWJJw
Delighted with our new paper on a novel itaconate transporter in the human pathogen Pseudomonas aeruginosa, led by Javeria and Reyme. @ybri-uoy.bsky.social @javeriamehboob.bsky.social @bethkw.bsky.social A duplicated transporter on its way to itaconate selectivity portlandpress.com/biochemj/art...
@thesgconline @LabScribbles LabScribbles/Huntington’s & Parkinson’s Disease, “The r(x) of NO & Ferricytochrome C provides a means of producing perioxynitrite in the absence of superoxide, via r(x) of NO & O2.” “Reactions of NO & Mitochondrial cytochrome C: a novel mechanism...” https://t.co/C8hoWUhAOQ
In this Biochemical Journal paper, @biochemprof et al. integrate evolutionary, folding, and mutational data with molecular dynamics simulations to uncover an over 500-million-year-old conserved residue network in apoptotic caspases. https://t.co/IclwwTkhgv https://t.co/zXlI3y1WEm
High tide or low tide: the transport and metabolism of mitochondrial nucleotides portlandpress.com/biochemj/art...
RT @PPPublishing: Trypanosomatid histones: the building blocks of the epigenetic code of highly divergent eukaryotes https://t.co/yaeiXDOd7…
Trypanosomatid histones: the building blocks of the epigenetic code of highly divergent eukaryotes https://t.co/yaeiXDOd7H #BiochemJournal
Expanding the tagging toolbox for visualizing translation live https://t.co/YdnQTXUjkD #BiochemJournal
Explore our latest issue of the Biochemical Journal here, with articles discussing the features of mitochondrial carriers, apoptotic caspases and proteomic analysis in hepatocytes. https://t.co/hRqopZNXYM https://t.co/n6VRDOHoar
Dive into our latest #OA issue, featuring research from the Anthony Wilkinson lab on the development of new anti-leishmanial compounds and work from @GrasLab on the differences between IAV and IBV-specific CD8+ T cell responses.https://t.co/ZLrvHeuY5u https://t.co/KVSXSU6LoC
MUC17 is an essential small intestinal glycocalyx component that is disrupted in Crohn’s disease https://t.co/z1tdzXzIlo https://t.co/hdKjBFvWFJ https://t.co/v3RBVQJs37
#ReviewArticle in #BiochemJournal ‘Leucine-rich repeat kinase 2 biomarkers for Parkinson’s disease’ #OpenAccess https://t.co/0sVWW19Suc
#ResearchArticle from #BiochemJournal ‘Metal sensing properties of the disordered loop from the Arabidopsis metal transceptor IRT’ #OpenAccess https://t.co/zn9mww83Ne
#BiochemJournal #ReviewArticle ‘LRRK2-mediated mitochondrial dysfunction in Parkinson’s disease’ https://t.co/JqzrJWh6vf
#BiochemJournal ‘Role of LRRK2 in axonal transport and Parkinson’s disease’ #ReviewArticle #OpenAccess https://t.co/nps9mNdPQA
RT @mosler302: @DanReach @DiedSuddenly_ @CommunityNotes Here's 1 of a series of videos on spike protein-induced amyloid clots: https://t.co…
RT @dbkell: Pleased to see our paper with @resiapretorius on ischaemia-reperfusion injury in #LongCOVID passing 40,000 views https://t.co/…
21/1 Eine zentrale Rolle von Amyloid-Fibrin-Mikrogerinnseln bei Long COVID/PASC: Ursprünge und therapeutische Implikationen: portlandpress.com/biochemj/art...
21/1 Eine zentrale Rolle von Amyloid-Fibrin-Mikrogerinnseln bei Long COVID/PASC: Ursprünge und therapeutische Implikationen: https://t.co/CDOSP9zOH3
RT @dbkell: Pleased to see our paper with @resiapretorius on ischaemia-reperfusion injury in #LongCOVID passing 40,000 views https://t.co/…
RT @dbkell: Pleased to see our paper with @resiapretorius on ischaemia-reperfusion injury in #LongCOVID passing 40,000 views https://t.co/…
RT @dbkell: Pleased to see our paper with @resiapretorius on ischaemia-reperfusion injury in #LongCOVID passing 40,000 views https://t.co/…
RT @dbkell: Pleased to see our paper with @resiapretorius on ischaemia-reperfusion injury in #LongCOVID passing 40,000 views https://t.co/…
@UCSDHealth @UCSDJacobs LabScribbles/Huntington’s & Parkinson’s Disease/Multiple Sclerosis/ALS, (Bacterial Biofilms) “Bacterial conversion of phenylalanine & aromatic carboxylic acids [DOPA decarboxylase?] into dihydrols (1981)” https://t.co/0Wp1DYiLzX Enjoy
RT @PPPublishing: Tau is subject to a broad range of post-translational modifications to regulate its biological activity. Alhadidy et al e…
RT @dbkell: Pleased to see our paper with @resiapretorius on ischaemia-reperfusion injury in #LongCOVID passing 40,000 views https://t.co/…
RT @dbkell: Pleased to see our paper with @resiapretorius on ischaemia-reperfusion injury in #LongCOVID passing 40,000 views https://t.co/…
RT @dbkell: Pleased to see our paper with @resiapretorius on ischaemia-reperfusion injury in #LongCOVID passing 40,000 views https://t.co/…
RT @dbkell: Pleased to see our paper with @resiapretorius on ischaemia-reperfusion injury in #LongCOVID passing 40,000 views https://t.co/…
More wonderful science from my amazing friends and colleagues ‼️
Tau is subject to a broad range of post-translational modifications to regulate its biological activity. Alhadidy et al examines the effects of spermidine polyamination on tau biology. Dive into the results here. https://t.co/q2sYPR6Ayv https://t.co/tHjbjO97KN
RT @dbkell: Pleased to see our paper with @resiapretorius on ischaemia-reperfusion injury in #LongCOVID passing 40,000 views https://t.co/…
RT @dbkell: Pleased to see our paper with @resiapretorius on ischaemia-reperfusion injury in #LongCOVID passing 40,000 views https://t.co/…
@MichaelAndre81 @HughCam34026215 @Humanspective Are fibrinaloid microclots a cause of autoimmunity in Long Covid and other post-infection diseases? | Biochemical Journal | Portland Press https://t.co/7RkAGId9HL
RT @dbkell: Pleased to see our paper with @resiapretorius on ischaemia-reperfusion injury in #LongCOVID passing 40,000 views https://t.co/…
RT @dbkell: Pleased to see our paper with @resiapretorius on ischaemia-reperfusion injury in #LongCOVID passing 40,000 views https://t.co/…
RT @dbkell: Pleased to see our paper with @resiapretorius on ischaemia-reperfusion injury in #LongCOVID passing 40,000 views https://t.co/…
RT @dbkell: Pleased to see our paper with @resiapretorius on ischaemia-reperfusion injury in #LongCOVID passing 40,000 views https://t.co/…
RT @dbkell: Pleased to see our paper with @resiapretorius on ischaemia-reperfusion injury in #LongCOVID passing 40,000 views https://t.co/…
RT @dbkell: Pleased to see our paper with @resiapretorius on ischaemia-reperfusion injury in #LongCOVID passing 40,000 views https://t.co/…
RT @dbkell: Pleased to see our paper with @resiapretorius on ischaemia-reperfusion injury in #LongCOVID passing 40,000 views https://t.co/…
Pleased to see our paper with @resiapretorius on ischaemia-reperfusion injury in #LongCOVID passing 40,000 views https://t.co/UyudHsIBce #pwLC #pwME #TeamClots
@NatalieCapeTown @Arukuathome As expected https://t.co/zfiB1BaP9g
RT @PPPublishing: Plant iron-regulated transporter 1 (IRT1) takes up iron in root under iron-limited conditions. IRT1 transports other diva…
Plant iron-regulated transporter 1 (IRT1) takes up iron in root under iron-limited conditions. IRT1 transports other divalent metals that overaccumulate in plants when soil iron is low. Cointry et al investigate non-iron metal sensing and signaling of IRT1 https://t.co/lwoFe7ayyj https://t.co/lLaqb3EWsh
RT @PPPublishing: EZH2, best known for gene silencing, also activates transcription via three transactivation domains that bind to the TAZ2…
EZH2, best known for gene silencing, also activates transcription via three transactivation domains that bind to the TAZ2 domain of p300, in turn, boosting p300’s acetyltransferase activity. Explore the findings from Becht et al to find out more. https://t.co/vraVUsRWsO https://t.co/gHcJVNERgl
Discover this review article from 2024 Centenary Award winner Professor Gideon Davies that highlights activity-based probes for dynamic characterisation of polysaccharide-degrading enzymes. https://t.co/RXAcoDfsLn https://t.co/Ga8eKyuafh
Our review on the peculiar properties of mitochondrial carriers of the SLC25 family out: portlandpress.com/biochemj/art...
In this review article from @MFZlab, the authors explore the role of histone lysine methyltransferases in pancreatic ductal adenocarcinoma development, highlighting potential therapeutic targets. #Cancer #Epigenetics https://t.co/vAbp614TEa https://t.co/XhDWys5K8C
RT @Biochem_Journal: Constipation is a forerunner to Parkinson’s disease diagnosis, worsening thereafter. New research from Umamahesan et a…
Constipation is a forerunner to Parkinson’s disease diagnosis, worsening thereafter. New research from Umamahesan et al examines the relationship of intestinal barrier dysfunction to constipation and whether intestinal fungal load is an aggravating factor. https://t.co/UvLGqtQvHu https://t.co/KmT3nto54q
RT @CzerwinsMarcin: Interesting review about interleukin-6 family of cytokines (there are 9 of them), their receptors, and how glycosylatio…
Explore the latest issue of the Biochemical Journal! Featuring the latest research into the aetiopathogenesis of Parkinson’s disease, tau biology, the CRISPR system, arginine metabolism, heme-regulated inhibitor, and cytochrome P450 4A11. https://t.co/CExuP2xB6Q https://t.co/yfU1FJBisF
Interesting review about interleukin-6 family of cytokines (there are 9 of them), their receptors, and how glycosylation influences synthesis, receptor binding, signaling, stability, transport, ligand binding, internalization and recycling https://t.co/2kUSc2IUKj #glycotime https://t.co/8QX9Pi5VAR
Cyanobacterial redox carriers support photosynthesis in a purple phototrophic bacterium portlandpress.com/biochemj/art...
Delve into the mechanisms of mtDNA replication and repair, and well as how this can lead to mtDNA instability and pathological consequences, in this Biochemical Journal review from Nicholls et al.https://t.co/yrNF3Pb6IM https://t.co/vvN6uYaldO
RT @Biochem_Journal: Proteolysis-targeting chimeras (PROTACs) represent a promising modality for probing biological systems and identifying…
Proteolysis-targeting chimeras (PROTACs) represent a promising modality for probing biological systems and identifying potential therapeutic leads. This review from Osman et al describe the methods used to accelerate PROTAC drug discovery. https://t.co/AkVbll3SRs https://t.co/ZAdXxIvTfY
RT @Biochem_Journal: Emerging evidence is linking Parkinson’s disease-causing mutations in the LRRK2 gene to dysfunctional axonal transport…
Emerging evidence is linking Parkinson’s disease-causing mutations in the LRRK2 gene to dysfunctional axonal transport. This review from Twellsieck et al reviews the role of LRRK2 in axonal transport and Parkinson’s disease.https://t.co/EjH2DT64Vh https://t.co/r5ryICfyOU
New Paper from I03 in #BiochemJ https://t.co/2z66SqSBJ4 (https://t.co/NSOIU8SIJJ)
Arginine is a conditionally essential amino acid, with roles in protein production and intracellular signalling. New research from Hamanaka examined the role and regulation of arginine metabolism in lung fibroblasts activated with TGF-β.https://t.co/HKw3yg11wa https://t.co/HIBYSe3MnR
RT @Biochem_Journal: Are you interested in the underlying molecular mechanisms of life? Explore the latest completed issue of the Biochemic…
Are you interested in the underlying molecular mechanisms of life? Explore the latest completed issue of the Biochemical Journal which delves into the newest developments in this exciting area! https://t.co/uG6VJgLKn1 https://t.co/mBgkdGwNPJ
In the absence of RNase HI, #Rho, by its RNA-dependent helicase activity, is capable of unwinding RNA: DNA hybrids #RDHs in a rut-site-dependent manner. Read more: https://t.co/WZVxRT2Ayh #Rho @DrJitendraSingh @rajesh_gokhale @BricDbt @DBT_CDFD @UllasKolthur https://t.co/4BQzZLenGi
RT @dbkell: @LadyLonghaul All at https://t.co/qWBJ2lx36V. Start with https://t.co/zfiB1BbmYO
@rencar130 https://t.co/vSgKXOz5NS
@LadyLonghaul All at https://t.co/qWBJ2lx36V. Start with https://t.co/zfiB1BbmYO
RT @PPPublishing: Nucleic acid joining enzymes: biological functions and synthetic applications beyond DNA: https://t.co/UqcMVKVDDB
Respect +++ to anyone working in the PROTACs space. These molecules aren’t easy to develop. Great review article below: https://t.co/HRFhM6aFcy
Nucleic acid joining enzymes: biological functions and synthetic applications beyond DNA: https://t.co/UqcMVKVDDB
RT @Biochem_Journal: Interested in evolutionary biology? This perspective argues that origins of protein kinase A interface with A-Kinase a…
RT @Biochem_Journal: Interested in evolutionary biology? This perspective argues that origins of protein kinase A interface with A-Kinase a…
Interested in evolutionary biology? This perspective argues that origins of protein kinase A interface with A-Kinase anchoring proteins can be traced to unicellular organisms, which existed long before the emergence of either kinase or anchoring proteins.https://t.co/yVYNgipDpR https://t.co/WQTC4wvobJ
Role of LRRK2 in axonal transport and Parkinson’s disease | Biochemical Journal | Portland Press https://t.co/r9KRAajhx2
A useful short review on the role of LRRK2 in axonal transport & #Parkinsons; "Hyperactive LRRK2 disrupts the normally processive retrograde transport of autophagosomes, leading to impaired fusion with lysosomes" portlandpress.com/biochemj/art...
@Anna86933178 @DorissLoh In this paper evidence that supports a new role for melatonin as a negative endogenous regulator of cytosolic phospholipase A(2) (cPLA(2)) is presented: „Negative regulation of cytosolic phospholipase A2 by melatonin in the rat pineal gland” #AnatomiaRaka https://t.co/SI1g9YOzdk https://t.co/4EmeYEdTDN
Basic features of cellular inositol metabolism as revealed by a newly developed LC-MS method url:https://portlandpress.com/biochemj/article/482/11/675/236037/Basic-features-of-cellular-inositol-metabolism-as
portlandpress.com/biochemj/art...
Structural Insights into allosteric inhibition of HRI kinase by heme binding via HDX-MS #BiochemJ portlandpress.com/biochemj/art...
New review explores "current knowledge implicating LRRK2 in mitochondrial energetics, oxidative stress, genome integrity, fission/fusion, mitophagy, & ion/protein transport in #Parkinsons" portlandpress.com/biochemj/art...
We wrote a review for the Biochemical Journal on the importance of using macroscopic reconstructions at the network level to better understand key issues related to the actin cytoskeleton: portlandpress.com/biochemj/art...
Congrats Danielle!!! Excess Wnt in neurological disease url:https://portlandpress.com/biochemj/article/482/10/BCJ20240265/236054/Excess-Wnt-in-neurological-disease
Basic features of cellular inositol metabolism as revealed by a newly developed LC-MS method. #BiochemJ portlandpress.com/biochemj/art...
Despite...... The authors would like to highlight that the main conclusions reported in this article remain valid. I'm sure we all can easily imagine how this could happen by mistake......
Landmark paper on covid longterm effects, published 2022 I think the team interprets microclots as causing almost ALL effects such as post-exertional fatigue etc. I think that may be going too far as I've seen other good explanations. But microclots are important. portlandpress.com/biochemj/art...
#Hypertension #SmoothMuscleCell #Microtubule Spontaneous Hypertensive rat Mesenteric Artery #Acetylome TUBA1A α-tubulin K40Ac⏫ Tubacin HDAC6i➡️ ⏫endothelium-dependent vasorelaxation ⏬endothelium-independent relaxation (via⏫SMC MT stability?
portlandpress.com/biochemj/art... Microclots found in platelet-poor plasma could hold a significant diagnostic value for clotting-related issues in inflammatory diseases & other similar conditions , postviral syndromes or #NeuroCovid www.thieme-connect.com/products/ejo...
D-dimer tests clot degradation, not microclot presence. portlandpress.com/biochemj/art...
Are you currently researching new developments in glycobiology? Submit your work to our new special collection on Glycobiology, guest edited by Natasha Zachara. We welcome original research papers, review articles and opinion pieces.
Very interesting review that chimes with a lot of our thinking (and some of our current experimental directions) on N-degron pathway components portlandpress.com/biochemj/art...
How many E3 ligases participate in the plant Arg/N-degron pathway? Our review of the key players in the pathway and perspectives on BIG (UBR4) and PRT7 (UBR7) is now out at #Biochemj. portlandpress.com/biochemj/art...
How do massive megaDalton-sized transmembrane mucins reach the plasma membrane in intestinal epithelial cells?
Latest publication with a contribution from Otago Biochemistry. On the function of TRAP substrate-binding proteins: the isethionate-specific binding protein IseP portlandpress.com/biochemj/art...
Thrilled to welcome the Biochemical Journal as a sponsor of #mbiosys25! Highlighting rigorous work exploring the fundamental mechanisms of life, the Biochemical Journal has been at the forefront for over 100 years!
My first post on BlueSky. Our latest review delves into the critical roles of ubiquitin E3 ligases in safeguarding genome integrity and their implications in human diseases. @drjhujh.bsky.social @profstewartlab.bsky.social portlandpress.com/biochemj/art...
Flurry of new followers from ubiquitin biology yesterday. I left academia five years ago, but I miss it too sometimes. Here's my major research paper from grad school years if anyone's interested. portlandpress.com/biochemj/art...
Thackray, A. M., McNulty, E. E., Nalls, A. V., Cardova, A., Tran, L., Telling, G., Benestad, S. L., Gilch, S., Mathiason, C. K., Bujdoso, R. (2023). Genetic modulation of CWD prion propagation in cervid PrP Drosophila. Biochem J, 480(19):1485-1501 portlandpress.com/biochemj/art...
The role of filamentous matrix molecules in shaping the architecture and emergent properties of bacterial biofilms Biochem_Journal by @janboehning.bsky.social @abultarafder.bsky.social and Tamay Bharat portlandpress.com/biochemj/art...
Weingartner, K. A., Tran, T., Tripp, K. W. and Kavran, J. M. (2023). Dimerization and autophosphorylation of the MST family of kinases are controlled by the same set of residues. Biochem J 480(15): portlandpress.com/biochemj/art...
I don't think it's known. Maybe why Max Artymov and others use the methylated version to get it in. But derivatives like that make me nervous. E.g. methyl pyruvate--it's not clear to me it ever gets metabolized. portlandpress.com/biochemj/art...
T cells: a dedicated effector kinase pathways for every trait? Read our new commentary to find out more https://t.co/iqSFEsFtsD #signaling #immunology #inflammation https://t.co/e3VOksyHeF
T cells: a dedicated effector kinase pathways for every trait? https://t.co/LYRLWP3cGP https://t.co/1A3spx42l6
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