Diabetologia July 2021 PMID 33770194

Fasting and fasting-mimicking treatment activate SIRT1/LXRα and alleviate diabetes-induced systemic and microvascular dysfunction.

Sandra S Hammer, Cristiano P Vieira, Delaney McFarland, Maximilian Sandler, Yan Levitsky, Tim F Dorweiler, Todd A Lydic, Bright Asare-Bediako, Yvonne Adu-Agyeiwaah, Micheli S Sielski, Mariana Dupont, Ana Leda Longhini, Sergio Li Calzi, Dibyendu Chakraborty, Gail M Seigel

Mentions

43
Peak: 20 in Mar 2021
across 2 sources since Mar 2021

Extended reach

458,054
potential audience

Total likes

6,731

Video views

168,189

Mentions per month

Mar 2021 – Jan 2025

Where it's discussed

  • X / Twitter41 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions frequently cite the activation of SIRT1 and LXRα pathways by fasting as mechanisms that improve diabetes-related damage, emphasizing potential therapeutic benefits. Words like 'effective,' 'protects,' and 'mechanism' reflect both agreement and recognition of the research's importance, which collectively contribute to a perception of high impact and interest.

AgreementStrong agreement

Most posts support the findings, emphasizing that fasting activates beneficial pathways like SIRT1/LXRα and alleviates diabetic complications, indicating strong agreement with the publication.

InterestHigh interest

Posts show high curiosity, with several mentioning mechanisms, implications for health, and potential therapies, demonstrating keen engagement.

EngagementModerate engagement

While many discussions acknowledge the research, few delve deeply into technical details, leading to moderate engagement depth.

ImpactHigh impact

Users perceive the research as significant, highlighting its potential for influencing diabetes treatment and metabolic health strategies.

Abstract in brief

  • Fasting and fasting-mimicking treatments activate SIRT1, LXR, and improve systemic and retinal health in diabetes, reducing inflammation and vascular damage.
  • Intermittent fasting naturally aligns with human evolution and helps recover from metabolic stress, but modern food habits may cause chronic diseases like diabetes; fasting has shown to benefit metabolic health and prevent diabetic complications.
  • The study demonstrates that fasting boosts SIRT1 levels and activity in liver, retina, and retinal cells, which may contribute to protecting against diabetes-related damage by reducing inflammation and improving cell function.]

Top posts

Most liked on X and Bluesky
Diabetologia
@DiabetologiaJnl · X

Fasting prevents diabetes-induced retinal damage via SIRT1/LXRα signalling. This work suggests a potential mechanism of action responsible for mediating positive health outcomes associated with intermittent fasting. #Diabetes #DiabeticRetinopathy https://t.co/f92GGz7NYD https://t.co/U0SpwVhh5c

Apr 14, 2021 · 40 likes · 25 shares · 19,963 followers View post →
Larronde Esteban
@EstebanDL · X

Ayuno (o simularlo) en ratas diabéticas Mejora SIRT1 Disminuye colesterol en retina, disminuye inflamación En las que no ayunan o lo simulan, se produce retinopatía diabética https://t.co/7icvIYbJuv https://t.co/UtHsOr2Sfr

Mar 29, 2021 · 31 likes · 6 shares · 23,789 followers View post →
J P Fanton
@HealthyFellow · X

#Fasting & fasting-mimicking treatment activate #SIRT1 / #LXRα & alleviate #diabetes-induced systemic and #microvascular #dysfunction https://t.co/TruPACwfDM Attn: @_atanas_ @_INPST @ScienceCommuni2 @drjasonfung @pbroo003 @FastingMethod @agingdoc1 @BenBikmanPhD @FastingLane

Mar 28, 2021 · 22 likes · 5 shares · 26,021 followers View post →
Diabetologia
@DiabetologiaJnl · X

Up front & free to read in our July issue #editorspicks : Fasting and fasting-mimicking treatment activate SIRT1/LXRα and alleviate diabetes-induced systemic and microvascular dysfunction https://t.co/f92GGz7NYD #Diabetes #DiabeticRetinopathy https://t.co/xjghr5jSdk

Jun 11, 2021 · 6 likes · 1 share · 19,963 followers View post →
Maurício Lima
@dj_surfista · X

A ativação da sinalização de SIRT1 por #jejumintermitnte é uma estratégia terapêutica eficaz que fornece uma ligação mecanística entre os efeitos vantajosos associados a regimes de jejum e prevenção de disfunção microvascular e da medula óssea no #diabetes https://t.co/kdfsLrdrlM

Mar 28, 2021 · 4 likes · 1 share · 743 followers View post →
Agingdoc
@agingdoc1 · X

Fasting and fasting-mimicking treatment activate SIRT1/LXRα and alleviate diabetes-induced systemic and microvascular dysfunction https://t.co/PsMDHLwwhT

Mar 27, 2021 · 3 likes · 41,466 followers View post →

All mentions

Dr. Shashank Joshi
@AskDrShashank · X

RT @DiabetologiaJnl: Up front & free to read in our July issue #editorspicks : Fasting and fasting-mimicking treatment activate SIRT1/LXRα…

Jun 11, 2021 · 1 share · 32,513 followers View post →
Diabetologia
@DiabetologiaJnl · X

Up front & free to read in our July issue #editorspicks : Fasting and fasting-mimicking treatment activate SIRT1/LXRα and alleviate diabetes-induced systemic and microvascular dysfunction https://t.co/f92GGz7NYD #Diabetes #DiabeticRetinopathy https://t.co/xjghr5jSdk

Jun 11, 2021 · 6 likes · 1 share · 19,963 followers View post →
Prof Dr Helen Batty
@hbelfry · X

RT @DiabetologiaJnl: Fasting prevents diabetes-induced retinal damage via SIRT1/LXRα signalling. This work suggests a potential mechanism o…

Apr 14, 2021 · 25 shares · 1,315 followers View post →
Cafasipa
@cafasipa · X

RT @DiabetologiaJnl: Fasting prevents diabetes-induced retinal damage via SIRT1/LXRα signalling. This work suggests a potential mechanism o…

Apr 14, 2021 · 25 shares · 241 followers View post →
Pixapins
@Pixapins_Docker · X

No menjeu a totes hores golafres! Que contràriament al que la indústria difon, el dejuni i la restricció d'ingesta en el temps, son part de la condició humana, afavoreixen la salut metabòlica, l'anti-envelliment, l'autofàgia o vies com les Sirtuines...

Apr 14, 2021 · 1 like · 1,241 followers View post →
Jim Johnson, PhD
@JimJohnsonSci · X

RT @DiabetologiaJnl: Fasting prevents diabetes-induced retinal damage via SIRT1/LXRα signalling. This work suggests a potential mechanism o…

Apr 14, 2021 · 25 shares · 12,807 followers View post →
Nivedita seshadri
@Niveditaseshad2 · X

RT @DiabetologiaJnl: Fasting prevents diabetes-induced retinal damage via SIRT1/LXRα signalling. This work suggests a potential mechanism o…

Apr 14, 2021 · 25 shares · 232 followers View post →
MyDiabetes: Diabetes Tracker & Controler
@MyDiabetes__ · X

RT @DiabetologiaJnl: Fasting prevents diabetes-induced retinal damage via SIRT1/LXRα signalling. This work suggests a potential mechanism o…

Apr 14, 2021 · 25 shares · 776 followers View post →
Sol
@ArualSogar · X

RT @DiabetologiaJnl: Fasting prevents diabetes-induced retinal damage via SIRT1/LXRα signalling. This work suggests a potential mechanism o…

Apr 14, 2021 · 25 shares · 794 followers View post →
MyDiabetes - Control Your Blood Sugar
@MyDiabetes4 · X

RT @DiabetologiaJnl: Fasting prevents diabetes-induced retinal damage via SIRT1/LXRα signalling. This work suggests a potential mechanism o…

Apr 14, 2021 · 25 shares · 585 followers View post →
Katie Guzzetta
@ktguzz · X

RT @DiabetologiaJnl: Fasting prevents diabetes-induced retinal damage via SIRT1/LXRα signalling. This work suggests a potential mechanism o…

Apr 14, 2021 · 25 shares · 4,774 followers View post →
Valérie Dionne
@ValrieDionne2 · X

RT @DiabetologiaJnl: Fasting prevents diabetes-induced retinal damage via SIRT1/LXRα signalling. This work suggests a potential mechanism o…

Apr 14, 2021 · 25 shares · 63 followers View post →
Joan Miro-Blanch
@jmirobla · X

RT @DiabetologiaJnl: Fasting prevents diabetes-induced retinal damage via SIRT1/LXRα signalling. This work suggests a potential mechanism o…

Apr 14, 2021 · 25 shares · 626 followers View post →
EASDelearning
@EASDelearning · X

RT @DiabetologiaJnl: Fasting prevents diabetes-induced retinal damage via SIRT1/LXRα signalling. This work suggests a potential mechanism o…

Apr 14, 2021 · 25 shares · 5,270 followers View post →
د. فيصل الجهني استشاري غدد صماء و سكري و سمنة
@Fajehani · X

RT @DiabetologiaJnl: Fasting prevents diabetes-induced retinal damage via SIRT1/LXRα signalling. This work suggests a potential mechanism o…

Apr 14, 2021 · 25 shares · 22,937 followers View post →
Cristina Tejera
@cristinatejerap · X

RT @DiabetologiaJnl: Fasting prevents diabetes-induced retinal damage via SIRT1/LXRα signalling. This work suggests a potential mechanism o…

Apr 14, 2021 · 25 shares · 11,473 followers View post →
Mimi_ Cardio
@mimi_cardio · X

RT @DiabetologiaJnl: Fasting prevents diabetes-induced retinal damage via SIRT1/LXRα signalling. This work suggests a potential mechanism o…

Apr 14, 2021 · 25 shares · 188 followers View post →
Dr. د. عبدالواحد الزهراني
@ralzahrani2020 · X

RT @DiabetologiaJnl: Fasting prevents diabetes-induced retinal damage via SIRT1/LXRα signalling. This work suggests a potential mechanism o…

Apr 14, 2021 · 25 shares · 4,348 followers View post →
Inserm U1190
@InsermU1190 · X

RT @DiabetologiaJnl: Fasting prevents diabetes-induced retinal damage via SIRT1/LXRα signalling. This work suggests a potential mechanism o…

Apr 14, 2021 · 25 shares · 96 followers View post →
Cristina de la Mata
@Crisirenedlm · X

RT @DiabetologiaJnl: Fasting prevents diabetes-induced retinal damage via SIRT1/LXRα signalling. This work suggests a potential mechanism o…

Apr 14, 2021 · 25 shares · 283 followers View post →
Diabetologia
@DiabetologiaJnl · X

Fasting prevents diabetes-induced retinal damage via SIRT1/LXRα signalling. This work suggests a potential mechanism of action responsible for mediating positive health outcomes associated with intermittent fasting. #Diabetes #DiabeticRetinopathy https://t.co/f92GGz7NYD https://t.co/U0SpwVhh5c

Apr 14, 2021 · 40 likes · 25 shares · 19,963 followers View post →
RRID Robot
@RobotRrid · X

RRIDs were included in the Diabetologia paper "Fasting and fasting-mimicking treatment activate S…" (https://t.co/go9zTNbGOO). RRIDs like this improve reproducibility in scientific research. #ReproducibleResearch #methodsmatter

Mar 31, 2021 · 161 followers View post →
Public Health Bulletin
@BulletinPublic · X

Fasting and fasting-mimicking treatment activate SIRT1/LXRα and alleviate diabetes-induced systemic and microvascular dysfunction. https://t.co/LqKdAayNwT

Mar 31, 2021 · 19 followers View post →
Dr Daniel Valencia Torres
@Doc_Valencia · X

RT @EstebanDL: Ayuno (o simularlo) en ratas diabéticas Mejora SIRT1 Disminuye colesterol en retina, disminuye inflamación En las que no ay…

Mar 31, 2021 · 6 shares · 569 followers View post →
José Alexander
@JosAlexanderso · X

RT @EstebanDL: Ayuno (o simularlo) en ratas diabéticas Mejora SIRT1 Disminuye colesterol en retina, disminuye inflamación En las que no ay…

Mar 30, 2021 · 6 shares · 57 followers View post →
Tita Rmz☆
@titaramirez03 · X

RT @EstebanDL: Ayuno (o simularlo) en ratas diabéticas Mejora SIRT1 Disminuye colesterol en retina, disminuye inflamación En las que no ay…

Mar 30, 2021 · 6 shares · 727 followers View post →
claimshero.eth
@claimshero__eth · X

RT @EstebanDL: Ayuno (o simularlo) en ratas diabéticas Mejora SIRT1 Disminuye colesterol en retina, disminuye inflamación En las que no ay…

Mar 30, 2021 · 6 shares · 128 followers View post →
¡¡ Ah VAINA !!!
@quevainon · X

RT @EstebanDL: Ayuno (o simularlo) en ratas diabéticas Mejora SIRT1 Disminuye colesterol en retina, disminuye inflamación En las que no ay…

Mar 29, 2021 · 6 shares · 1,821 followers View post →
HarmoniaIntegral
@AbrahamPerezGo2 · X

RT @EstebanDL: Ayuno (o simularlo) en ratas diabéticas Mejora SIRT1 Disminuye colesterol en retina, disminuye inflamación En las que no ay…

Mar 29, 2021 · 6 shares · 216 followers View post →
Larronde Esteban
@EstebanDL · X

Ayuno (o simularlo) en ratas diabéticas Mejora SIRT1 Disminuye colesterol en retina, disminuye inflamación En las que no ayunan o lo simulan, se produce retinopatía diabética https://t.co/7icvIYbJuv https://t.co/UtHsOr2Sfr

Mar 29, 2021 · 31 likes · 6 shares · 23,789 followers View post →
Adolfo Duarte
@DrAdolfoDuarte · X

RT @dj_surfista: A ativação da sinalização de SIRT1 por #jejumintermitnte é uma estratégia terapêutica eficaz que fornece uma ligação mecan…

Mar 29, 2021 · 1 share · 190 followers View post →
The Doctors Post
@DoctorsPost_ · X

Fasting and fasting-mimicking treatment activate SIRT1/LXRα and alleviate diabetes-induced systemic and microvascular dysfunction. https://t.co/eBfkPKsIwA

Mar 29, 2021 · 29 followers View post →
Orlando_uy
@Orlando_uy · X

RT @HealthyFellow: #Fasting & fasting-mimicking treatment activate #SIRT1 / #LXRα & alleviate #diabetes-induced systemic and #microvascular…

Mar 28, 2021 · 5 shares · 691 followers View post →
RRID Robot
@RobotRrid · X

The authors of "Fasting and fasting-mimicking treatment activate S…" (https://t.co/go9zTNbGOO) included RRIDs in their paper! Thank you for making your #methodsmatter. #ReproducibleResearch

Mar 28, 2021 · 161 followers View post →
Modjtaba Emadi-Baygi
@EmadiBaygi · X

RT @HealthyFellow: #Fasting & fasting-mimicking treatment activate #SIRT1 / #LXRα & alleviate #diabetes-induced systemic and #microvascular…

Mar 28, 2021 · 5 shares · 99 followers View post →
Larry Diamond
@natureboyrr · X

RT @HealthyFellow: #Fasting & fasting-mimicking treatment activate #SIRT1 / #LXRα & alleviate #diabetes-induced systemic and #microvascular…

Mar 28, 2021 · 5 shares · 5,624 followers View post →
Agingdoc
@agingdoc1 · X

RT @HealthyFellow: #Fasting & fasting-mimicking treatment activate #SIRT1 / #LXRα & alleviate #diabetes-induced systemic and #microvascular…

Mar 28, 2021 · 5 shares · 41,466 followers View post →
Maurício Lima
@dj_surfista · X

A ativação da sinalização de SIRT1 por #jejumintermitnte é uma estratégia terapêutica eficaz que fornece uma ligação mecanística entre os efeitos vantajosos associados a regimes de jejum e prevenção de disfunção microvascular e da medula óssea no #diabetes https://t.co/kdfsLrdrlM

Mar 28, 2021 · 4 likes · 1 share · 743 followers View post →
Dr. د. عبدالواحد الزهراني
@ralzahrani2020 · X

RT @HealthyFellow: #Fasting & fasting-mimicking treatment activate #SIRT1 / #LXRα & alleviate #diabetes-induced systemic and #microvascular…

Mar 28, 2021 · 5 shares · 4,348 followers View post →
J P Fanton
@HealthyFellow · X

#Fasting & fasting-mimicking treatment activate #SIRT1 / #LXRα & alleviate #diabetes-induced systemic and #microvascular #dysfunction https://t.co/TruPACwfDM Attn: @_atanas_ @_INPST @ScienceCommuni2 @drjasonfung @pbroo003 @FastingMethod @agingdoc1 @BenBikmanPhD @FastingLane

Mar 28, 2021 · 22 likes · 5 shares · 26,021 followers View post →
Agingdoc
@agingdoc1 · X

Fasting and fasting-mimicking treatment activate SIRT1/LXRα and alleviate diabetes-induced systemic and microvascular dysfunction https://t.co/PsMDHLwwhT

Mar 27, 2021 · 3 likes · 41,466 followers View post →