Blood Cancer J April 2021 PMID 33824268

CAR-T cell therapy: current limitations and potential strategies.

Robert C Sterner, Rosalie M Sterner

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Mentions

Peak: 3 in Apr 2021

across 4 sources since Apr 2021

Extended reach

4,116,870

potential audience

Total likes

77,475

Video views

4,085,963

Mentions per month

Apr 2021 – Dec 2023

Where it's discussed

News22 articles
X / Twitter11 posts
YouTube3 videos
Blogs3 articles

AI synopsis

What people are saying

Several social discussions mention core aspects of the publication, such as the 'limitations' like side effects and tumor microenvironment interactions, and potential improvements through engineering. The tone emphasizes both the promise and challenges, with phrases like 'current limitations' and 'potential strategies,' indicating a thoughtful yet cautious attitude toward the evolving field.

AgreementModerate agreement

Most discussions acknowledge the challenges and potential of CAR-T therapy, reflecting moderate agreement with the article's focus on current limitations and strategies.

InterestHigh interest

The colorfulness of terms like 'current limitations' and 'potential strategies' shows that participants are highly interested in advancements and ongoing issues.

EngagementModerate engagement

Posts include brief summaries and references, indicating moderate engagement, though most do not deeply analyze the mechanisms involved.

ImpactModerate impact

While some discussions highlight the significance of CAR-T therapy improvements, the overall impact appears balanced, recognizing its promise but cautious of hurdles.

Abstract in brief

CAR-T cell therapy is a groundbreaking cancer treatment that has shown promise, particularly for specific types of B cell leukemia and lymphoma, but faces numerous challenges in treating solid tumors.
Key barriers include severe side effects, limited effectiveness against tumors, antigen escape, insufficient trafficking to tumors, and interactions with the tumor microenvironment that can hinder CAR-T cell function.
To enhance the efficacy and reduce the risks of CAR-T therapy, ongoing innovations in engineering more effective CAR-T cells and addressing existing limitations are essential.

Read the full abstract

All mentions

Why Is There Still No Cure for Cancer?

Cancer treatments have advanced significantly, with breakthroughs like CAR-T cell therapy. However, challenges remain, such as severe side effects and limited effectiveness against solid tumors. This video explores…

Kok Bisa? · Feb 5, 2022 4,083,885 views

Understanding CAR T-Cell Therapy and Its Challenges in Cancer Treatment

Did you know that you hold the key to unlocking a cure to cancer? CAR T-cell therapy is a groundbreaking immunotherapy showing promise for blood cancers but faces challenges with solid tumors. This video explains how it…

Demystifying Medicine McMaster · Jan 6, 2022 1,539 views

Understanding CAR T-Cell Therapy in Cancer Treatment Advances

This video introduces CAR T-cell therapy, a promising cancer treatment, explaining its mechanics and challenges. It highlights the immune system's role, therapy process, and potential strategies to improve efficacy and…

Demystifying Medicine McMaster · Feb 21, 2022 539 views

Javi Ciborro

@papayaykware · X

https://t.co/pWBO9LOkX8 Terapia celular CAR-T: limitaciones actuales y estrategias potenciales

Dec 1, 2023 · 8,040 followers View post →

Suuuuu

@SuLiu2023 · X

CAR-T therapy is to arvest patient's T cells, re-engineer in vitro with surface receptors binding specific proteins, then infuse back into patients. https://t.co/p05XUQANrc (Robert C. Sterner & Rosalie M. Sterner, 2021)

Nov 28, 2023 · 1 followers View post →

Dr.Arwa Z. Al-Riyami,MD,FRCPC Senior Consultant

@DrRiyamia · X

RT @NourAlmozain:

Nov 28, 2022 · 2 shares · 7,813 followers View post →

Saadiya Nazli, MD, BSc, QIA(ASCP)

@docsaadiya · X

RT @NourAlmozain:

Nov 27, 2022 · 2 shares · 593 followers View post →

Nour AlMozain,MD, CABP, QIA نور هشام المزيّن

@NourAlmozain · X

Nov 27, 2022 · 4 likes · 2 shares · 2,797 followers View post →

David Russler-Germain, MD/PhD

@dgermain21 · X

RT @learningbioinfo: CAR-T cell therapy: current limitations and potential strategies | Blood Cancer Journal https://t.co/aTbiT0Eepx

Mar 9, 2022 · 1 share · 3,664 followers View post →

Yingying Cao

@yingyingcaoyyc · X

CAR-T cell therapy: current limitations and potential strategies | Blood Cancer Journal https://t.co/aTbiT0Eepx

Mar 9, 2022 · 1 like · 1 share · 653 followers View post →

Derhsing Lai, Ph.D

@DserhsingLai · X

這篇2021”自然”期刊文章，講了CAR-T治療的限制和潛力 CAR-T cell therapy: current limitations and potential strategies https://t.co/iDpT8TXSq8

Nov 11, 2021 · 147 followers View post →

@SN_Oncology

@SN_Oncology · X

Read 'CAR-T cell therapy: current limitations and potential strategies' from #BloodCancerJournal for free: https://t.co/96yloOzAfV #Immunotherapy https://t.co/9cZcBG7hnF

Apr 8, 2021 · 2,288 followers View post →

Lymphoma Papers

@Lymphoma_Papers · X

CAR-T cell therapy: current limitations and potential strategies #lymphoma #lymsm https://t.co/QucMtgCH7W

Apr 8, 2021 · 2 likes · 2,447 followers View post →