PubHawk
June 2021 PMID 33837376

Spatial and temporal scales of dopamine transmission.

Changliang Liu, Pragya Goel, Pascal S Kaeser

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Mentions

45
Peak: 28 in Apr 2021
across 4 sources since Apr 2021

Extended reach

324,605
potential audience

Total likes

1,287

Video views

33,029

Mentions per month

Apr 2021 – Mar 2024

Where it's discussed

  • X / Twitter33 posts
  • YouTube8 videos
  • Facebook2 posts
  • News2 articles

AI synopsis

What people are saying

Discussions highlight the novel insights about dopamine signaling, with examples such as references to the domain-overlap model and its role in action selection, revealing a keen interest in the implications of the research. The tone varies from informative to enthusiastic, especially when mentioning how the study challenges traditional views and its potential to influence future neuroscience research.

AgreementModerate agreement

Most discussions recognize the significance of the research, with users commenting on its potential to challenge existing theories and enhance understanding, indicating general agreement.

InterestHigh interest

The topics and references to specific models and methodologies suggest high interest among neuroscience enthusiasts and professionals.

EngagementModerate engagement

Comments include mentions of detailed concepts such as spatial-temporal scales, action selection, and receptor organization, demonstrating thoughtful engagement.

ImpactModerate impact

The emphasis on how this research could influence theories of dopamine transmission and neuronal action suggests moderate impact, though some posts are more sharing than critically analyzing.

Abstract in brief

  • Dopamine functions as a neuromodulator that influences brain circuits through G protein-coupled receptor signaling, and its transmission involves volume transmission via diffusion, allowing widespread receptor activation.
  • Recent research indicates that some dopamine signaling requires precise timing and spatial organization, leading to the proposal of the domain-overlap model, where release sites and receptors are arranged in micrometerscale structures.
  • This model differs from traditional point-to-point synaptic transmission and broad neuromodulation, allowing selective receptor activation within localized domains during baseline activity and broader activation during synchronized firing, which helps explain dopamine's versatile roles.
Read the full abstract

Top posts

Most liked on X and Bluesky
CLaE
@leafs_s · X

Nature Reviews Neuroscience Spatial and temporal scales of dopamine transmission https://t.co/VOWDkctN1q

Apr 14, 2021 · 42 likes · 14 shares · 28,042 followers View post →
Nature Rev Neurosci
@NatRevNeurosci · X

Spatial and temporal scales of #dopamine transmission – a new Review by Changliang Liu, Pragya Goel (@pragya1211) and Pascal Kaeser https://t.co/JHYdyseVN8 @harvardbrainsci @harvardmed @HarvardResearch https://t.co/w5iBmSRDOE

Apr 12, 2021 · 34 likes · 10 shares · 78,626 followers View post →
Nature Rev Neurosci
@NatRevNeurosci · X

Spatial and temporal scales of #dopamine transmission – a new Review by Changliang Liu, Pragya Goel (@pragya1211) and Pascal Kaeser https://t.co/JHYdyseVN8 @harvardbrainsci @harvardmed @HarvardResearch https://t.co/8IyMvWhESz

Apr 14, 2021 · 14 likes · 5 shares · 78,626 followers View post →
Chris Rourk
@ChrisJRourk · X

@PessoaBrain It also mediates action selection, challenging the theory from predictive reward signaling that it is only modulatory. Liu, Changliang, Pragya Goel, and Pascal S. Kaeser. "Spatial and temporal scales of dopamine transmission." Nature Reviews Neuroscience 22.6 (2021): 345-358.

Dec 10, 2022 · 2 likes · 25 followers View post →
Mr. Cookie Risin'
@AlexInChaaains · X

Spatial and temporal scales of dopamine transmission https://t.co/A9bOQUva6K

Mar 22, 2023 · 1 like · 403 followers View post →
Chris Rourk
@ChrisJRourk · X

@ZestyXenina @ManuelScheftner @WiringTheBrain Researchgate is a good resource for preprints: https://t.co/NXoExXQidt

Dec 17, 2022 · 1 like · 25 followers View post →

All mentions

Mr. Cookie Risin'
@AlexInChaaains · X

Spatial and temporal scales of dopamine transmission https://t.co/A9bOQUva6K

Mar 22, 2023 · 1 like · 403 followers View post →
Chris Rourk
@ChrisJRourk · X

@ZestyXenina @ManuelScheftner @WiringTheBrain Researchgate is a good resource for preprints: https://t.co/NXoExXQidt

Dec 17, 2022 · 1 like · 25 followers View post →
Chris Rourk
@ChrisJRourk · X

@PessoaBrain It also mediates action selection, challenging the theory from predictive reward signaling that it is only modulatory. Liu, Changliang, Pragya Goel, and Pascal S. Kaeser. "Spatial and temporal scales of dopamine transmission." Nature Reviews Neuroscience 22.6 (2021): 345-358.

Dec 10, 2022 · 2 likes · 25 followers View post →
Chris Rourk
@ChrisJRourk · X

@BernardJBaars Prof. Kaeser at Harvard has shown that diverse cortical signals are integrated by large dopamine neurons to mediate action selection by temporally and spatially precise release of dopamine. https://t.co/ldR7XADpUY. Action selection = work = workspace?

Nov 19, 2022 · 25 followers View post →
iBraiN Inserm Lab
@iBrain_Inserm · X

RT @NatRevNeurosci: Spatial and temporal scales of #dopamine transmission – a new Review by Changliang Liu, Pragya Goel (@pragya1211) and P…

Aug 11, 2021 · 5 shares · 1,726 followers View post →
@alaterstage
@alaterstage · X

RT @leafs_s: Nature Reviews Neuroscience Spatial and temporal scales of dopamine transmission https://t.co/VOWDkctN1q

Apr 18, 2021 · 14 shares · 128 followers View post →
CLaE
@leafs_s · X

RT @leafs_s: Nature Reviews Neuroscience Spatial and temporal scales of dopamine transmission https://t.co/VOWDkctN1q

Apr 15, 2021 · 14 shares · 28,042 followers View post →
Sveta Molchanova
@Svetadotfi · X

RT @leafs_s: Nature Reviews Neuroscience Spatial and temporal scales of dopamine transmission https://t.co/VOWDkctN1q

Apr 15, 2021 · 14 shares · 206 followers View post →
Raphaël Béné
@neuroraf · X

RT @leafs_s: Nature Reviews Neuroscience Spatial and temporal scales of dopamine transmission https://t.co/VOWDkctN1q

Apr 15, 2021 · 14 shares · 3,281 followers View post →
priya joseph
@ayirpelle · X

RT @leafs_s: Nature Reviews Neuroscience Spatial and temporal scales of dopamine transmission https://t.co/VOWDkctN1q

Apr 15, 2021 · 14 shares · 4,898 followers View post →
Kevin Mitchell
@WiringTheBrain · X

RT @leafs_s: Nature Reviews Neuroscience Spatial and temporal scales of dopamine transmission https://t.co/VOWDkctN1q

Apr 15, 2021 · 14 shares · 40,157 followers View post →
Alex Fornito
@AFornito · X

RT @leafs_s: Nature Reviews Neuroscience Spatial and temporal scales of dopamine transmission https://t.co/VOWDkctN1q

Apr 15, 2021 · 14 shares · 7,784 followers View post →
Sean James Fallon
@dopaminded · X

RT @leafs_s: Nature Reviews Neuroscience Spatial and temporal scales of dopamine transmission https://t.co/VOWDkctN1q

Apr 15, 2021 · 14 shares · 771 followers View post →
Karen Mejia
@karenszia · X

RT @leafs_s: Nature Reviews Neuroscience Spatial and temporal scales of dopamine transmission https://t.co/VOWDkctN1q

Apr 14, 2021 · 14 shares · 390 followers View post →
Sidhant Chopra
@SidChop · X

RT @leafs_s: Nature Reviews Neuroscience Spatial and temporal scales of dopamine transmission https://t.co/VOWDkctN1q

Apr 14, 2021 · 14 shares · 1,513 followers View post →
Max Puelma Touzel
@mptouzel · X

RT @leafs_s: Nature Reviews Neuroscience Spatial and temporal scales of dopamine transmission https://t.co/VOWDkctN1q

Apr 14, 2021 · 14 shares · 504 followers View post →
Rei Akaishi
@rei_akaishi · X

RT @leafs_s: Nature Reviews Neuroscience Spatial and temporal scales of dopamine transmission https://t.co/VOWDkctN1q

Apr 14, 2021 · 14 shares · 2,858 followers View post →
Alberto Antonietti - @aalpha@sigmoid.social
@_AAlpha · X

RT @NatRevNeurosci: Spatial and temporal scales of #dopamine transmission – a new Review by Changliang Liu, Pragya Goel (@pragya1211) and P…

Apr 14, 2021 · 5 shares · 218 followers View post →
Martin Smith
@Trevor87Smith · X

RT @NatRevNeurosci: Spatial and temporal scales of #dopamine transmission – a new Review by Changliang Liu, Pragya Goel (@pragya1211) and P…

Apr 14, 2021 · 5 shares · 276 followers View post →
Dmitrii Bozhko
@dvbozhko · X

RT @NatRevNeurosci: Spatial and temporal scales of #dopamine transmission – a new Review by Changliang Liu, Pragya Goel (@pragya1211) and P…

Apr 14, 2021 · 5 shares · 53 followers View post →
David V. Smith (@dvsmith.bsky.social)
@DVSneuro · X

RT @leafs_s: Nature Reviews Neuroscience Spatial and temporal scales of dopamine transmission https://t.co/VOWDkctN1q

Apr 14, 2021 · 14 shares · 1,542 followers View post →
CLaE
@leafs_s · X

Nature Reviews Neuroscience Spatial and temporal scales of dopamine transmission https://t.co/VOWDkctN1q

Apr 14, 2021 · 42 likes · 14 shares · 28,042 followers View post →
Alejandro Jimenez
@thealjiro · X

RT @NatRevNeurosci: Spatial and temporal scales of #dopamine transmission – a new Review by Changliang Liu, Pragya Goel (@pragya1211) and P…

Apr 14, 2021 · 5 shares · 256 followers View post →
Nature Rev Neurosci
@NatRevNeurosci · X

Spatial and temporal scales of #dopamine transmission – a new Review by Changliang Liu, Pragya Goel (@pragya1211) and Pascal Kaeser https://t.co/JHYdyseVN8 @harvardbrainsci @harvardmed @HarvardResearch https://t.co/8IyMvWhESz

Apr 14, 2021 · 14 likes · 5 shares · 78,626 followers View post →
Pragya Goel
@pragya1211 · X

RT @NatRevNeurosci: Spatial and temporal scales of #dopamine transmission – a new Review by Changliang Liu, Pragya Goel (@pragya1211) and P…

Apr 13, 2021 · 10 shares · 164 followers View post →
Richard Held
@rgsheld · X

RT @NatRevNeurosci: Spatial and temporal scales of #dopamine transmission – a new Review by Changliang Liu, Pragya Goel (@pragya1211) and P…

Apr 12, 2021 · 10 shares · 386 followers View post →
HarvardBrainScience
@harvardbrainsci · X

RT @NatRevNeurosci: Spatial and temporal scales of #dopamine transmission – a new Review by Changliang Liu, Pragya Goel (@pragya1211) and P…

Apr 12, 2021 · 10 shares · 6,885 followers View post →
Gergo Gomori
@GergoGomori · X

RT @NatRevNeurosci: Spatial and temporal scales of #dopamine transmission – a new Review by Changliang Liu, Pragya Goel (@pragya1211) and P…

Apr 12, 2021 · 10 shares · 61 followers View post →
Savyasachi
@drnagu2008 · X

RT @NatRevNeurosci: Spatial and temporal scales of #dopamine transmission – a new Review by Changliang Liu, Pragya Goel (@pragya1211) and P…

Apr 12, 2021 · 10 shares · 169 followers View post →
Vladimir Martínez-Álvarez
@vladiberto · X

RT @NatRevNeurosci: Spatial and temporal scales of #dopamine transmission – a new Review by Changliang Liu, Pragya Goel (@pragya1211) and P…

Apr 12, 2021 · 10 shares · 239 followers View post →
ARMMD
@jaag89 · X

RT @NatRevNeurosci: Spatial and temporal scales of #dopamine transmission – a new Review by Changliang Liu, Pragya Goel (@pragya1211) and P…

Apr 12, 2021 · 10 shares · 97 followers View post →
Nature Rev Neurosci
@NatRevNeurosci · X

Spatial and temporal scales of #dopamine transmission – a new Review by Changliang Liu, Pragya Goel (@pragya1211) and Pascal Kaeser https://t.co/JHYdyseVN8 @harvardbrainsci @harvardmed @HarvardResearch https://t.co/w5iBmSRDOE

Apr 12, 2021 · 34 likes · 10 shares · 78,626 followers View post →
Paul McCullough
@ThePostsynaptic · X

Spatial and temporal scales of dopamine transmission https://t.co/qIOdMmkIQi

Apr 12, 2021 · 2,591 followers View post →