September 2021 PMID 33837568

Silencing of SARS-CoV-2 with modified siRNA-peptide dendrimer formulation.

Musa Khaitov, Alexandra Nikonova, Igor Shilovskiy, Ksenia Kozhikhova, Ilya Kofiadi, Lyudmila Vishnyakova, Alexander Nikolskii, Pia Gattinger, Valeria Kovchina, Ekaterina Barvinskaia, Kirill Yumashev, Valeriy Smirnov, Artem Maerle, Ivan Kozlov, Artem Shatilov

Mentions

124
Peak: 12 in Apr 2021
across 8 sources since Apr 2021

Extended reach

126,088
potential audience

Total likes

4,101

Video views

84,488

Mentions per month

Apr 2021 – Dec 2025

Where it's discussed

  • Facebook50 posts
  • TikTok45 posts
  • X / Twitter19 posts
  • Instagram3 posts
  • YouTube2 videos
  • Reddit2 posts
  • News2 articles
  • Blogs1 articles

AI synopsis

What people are saying

The discussions reflect high interest and cautious optimism, emphasizing the innovative nature of the siRNA-peptide dendrimer approach and its potential as a targeted COVID-19 therapy. Words like 'very interesting,' 'optimistic,' and mentions of ongoing developments exemplify a generally supportive but cautious attitude, highlighting both the excitement about new research and awareness of limitations or questions surrounding toxicity and regulatory approval.

AgreementModerate agreement

Most discussions are optimistic about the potential of the research, with some recognizing its promise as a treatment option.

InterestHigh interest

The topic of new COVID-19 treatments, especially innovative methods like siRNA formulations, captures high interest among social discussion participants.

EngagementModerate engagement

Participants engage by sharing insights, referencing related research, and expressing curiosity about specific applications such as nasal sprays.

ImpactModerate impact

While some see these developments as promising, the overall consensus suggests moderate impact due to concerns about efficacy and safety, with references to regulatory issues.

Abstract in brief

  • This study explored using a specially designed siRNA (siR7) that targets the SARS-CoV-2 virus to inhibit its replication, with modifications made to increase stability and cellular entry, culminating in an inhalable formulation.
  • In laboratory tests and animal models, the modified siRNA (siR7EM) complexed with a peptide dendrimer effectively reduced viral load and lung inflammation, showing promise as a potential COVID-19 treatment.
  • The research suggests that inhalation of this siRNA-peptide dendrimer formulation could serve as a targeted therapy for COVID-19, addressing unmet medical needs beyond current vaccines.

Top posts

Most liked on X and Bluesky
Sterghios A. Moschos
@DocMoschos · X

Russia has approved this RNAi drug against Sars-CoV-2. Apart from Fig2 panel D missing, there are a host of inflammation controls absent, no dose dependent effect, a dendrimer of questionable providence (they tend to be toxic) & poor antiviral efficacy. https://t.co/cLmvn5NNy6

Dec 25, 2021 · 8 likes · 1 share · 2,766 followers View post →
Allergy EAACI
@AllergyEaaci · X

Free access: Silencing of #SARSCoV2 with modified siRNA‐peptide dendrimer formulation. First and corresponding authors: Musa Khaitov #lunginflammation Read the article here

Apr 30, 2021 · 7 likes · 2 shares · 6,009 followers View post →
Allergy EAACI
@AllergyEaaci · X

Khaitov, M., Nikonova, A., Shilovskiy, I., et al., Silencing of #SARSCoV2 with modified siRNA‐peptide dendrimer formulation. Read more

Apr 21, 2021 · 3 likes · 5 shares · 6,009 followers View post →
MedInCuba
@medincuba · X

En abril la revista científica europea Allergy, de la Academia Europea de Alergia e Inmunología Clínica (EAACI) publicó un artículo de los desarrolladores de MIR-19 sobre el mecanismo de acción del fármaco. https://t.co/PREli3Enxh https://t.co/k4Cvg9u9xt

Dec 22, 2021 · 2 likes · 1,875 followers View post →
субстанциальный деятель
@fazerovich · X

@andrwoodx @Nick_Bulba @rusorrow @Koletje1 @EvgenyFeldman Чтобы не по одной ссылке только рассуждать, в описании к видео побольше ссылок про миокардит:) https://t.co/W66ham1YD3

Jan 17, 2022 · 2 likes · 169 followers View post →
A J
@arlana90 · X

Silencing of SARS‐CoV‐2 with modified siRNA‐peptide dendrimer formulation https://t.co/lgTe908P59

Feb 10, 2022 · 1 like · 2,363 followers View post →

All mentions

A J
@arlana90 · X

Silencing of SARS‐CoV‐2 with modified siRNA‐peptide dendrimer formulation https://t.co/lgTe908P59

Feb 10, 2022 · 1 like · 2,363 followers View post →
субстанциальный деятель
@fazerovich · X

@andrwoodx @Nick_Bulba @rusorrow @Koletje1 @EvgenyFeldman Чтобы не по одной ссылке только рассуждать, в описании к видео побольше ссылок про миокардит:) https://t.co/W66ham1YD3

Jan 17, 2022 · 2 likes · 169 followers View post →
Руслан Гостев
@Ruslan_Gostev · X

Приемно-сортировочная, выпуск 24 https://t.co/rkICDpTgBy через @YouTube

Dec 27, 2021 View post →
NK Leb #UpdateTheVaccines
@NickytaLeb · X

RT @DocMoschos: Russia has approved this RNAi drug against Sars-CoV-2. Apart from Fig2 panel D missing, there are a host of inflammation co…

Dec 25, 2021 · 1 share · 2,936 followers View post →
Sterghios A. Moschos
@DocMoschos · X

Russia has approved this RNAi drug against Sars-CoV-2. Apart from Fig2 panel D missing, there are a host of inflammation controls absent, no dose dependent effect, a dendrimer of questionable providence (they tend to be toxic) & poor antiviral efficacy. https://t.co/cLmvn5NNy6

Dec 25, 2021 · 8 likes · 1 share · 2,766 followers View post →
Mad Dog
@runmarypls · X

@S__X7 Пока они живут в делирии в 2020, мы уже болеем за наших героев, следим и крестим пальцы в 2025 : https://t.co/9VZgrHAypR

Dec 25, 2021 · 46 followers View post →
ALEX
@ALL0909 · X

Приемно-сортировочная, выпуск 24 https://t.co/R1JERKQjRE через @YouTube

Dec 25, 2021 · 4 followers View post →
MedInCuba
@medincuba · X

En abril la revista científica europea Allergy, de la Academia Europea de Alergia e Inmunología Clínica (EAACI) publicó un artículo de los desarrolladores de MIR-19 sobre el mecanismo de acción del fármaco. https://t.co/PREli3Enxh https://t.co/k4Cvg9u9xt

Dec 22, 2021 · 2 likes · 1,875 followers View post →
Paola Castro
@pao_0pc · X

RT @AllergyEaaci: Free access: Silencing of #SARSCoV2 with modified siRNA‐peptide dendrimer formulation. First and corresponding authors: M…

Apr 30, 2021 · 2 shares · 278 followers View post →
Allergy EAACI
@AllergyEaaci · X

Free access: Silencing of #SARSCoV2 with modified siRNA‐peptide dendrimer formulation. First and corresponding authors: Musa Khaitov #lunginflammation Read the article here

Apr 30, 2021 · 7 likes · 2 shares · 6,009 followers View post →
SLaai
@SocLatAlergia · X

RT @AllergyEaaci: Khaitov, M., Nikonova, A., Shilovskiy, I., et al., Silencing of #SARSCoV2 with modified siRNA‐peptide dendrimer formulat…

Apr 21, 2021 · 5 shares · 1,774 followers View post →
ARIAguideline
@ARIAGuideline · X

RT @AllergyEaaci: Khaitov, M., Nikonova, A., Shilovskiy, I., et al., Silencing of #SARSCoV2 with modified siRNA‐peptide dendrimer formulat…

Apr 21, 2021 · 5 shares · 2,357 followers View post →
Fundación Libra
@FUNDACIONLIBRA · X

RT @AllergyEaaci: Khaitov, M., Nikonova, A., Shilovskiy, I., et al., Silencing of #SARSCoV2 with modified siRNA‐peptide dendrimer formulat…

Apr 21, 2021 · 5 shares · 415 followers View post →
Interasma
@Interasma · X

RT @AllergyEaaci: Khaitov, M., Nikonova, A., Shilovskiy, I., et al., Silencing of #SARSCoV2 with modified siRNA‐peptide dendrimer formulat…

Apr 21, 2021 · 5 shares · 2,446 followers View post →
Juan C Ivancevich MD
@Aller_MD · X

RT @AllergyEaaci: Khaitov, M., Nikonova, A., Shilovskiy, I., et al., Silencing of #SARSCoV2 with modified siRNA‐peptide dendrimer formulat…

Apr 21, 2021 · 5 shares · 7,472 followers View post →
Allergy EAACI
@AllergyEaaci · X

Khaitov, M., Nikonova, A., Shilovskiy, I., et al., Silencing of #SARSCoV2 with modified siRNA‐peptide dendrimer formulation. Read more

Apr 21, 2021 · 3 likes · 5 shares · 6,009 followers View post →
BoichenkoSergey
@Sergulion · X

Сотни моих пациентов вылечились от тяжелого COVID-19 ингаляциями гипохлорита натрия, полученного на советской установке ЭДО-4 1989 г. выпуска, практически даром. Сколько будет стоить чудо генной инженерии с репортерным геном люциферазы светлячка "Мир-19"? https://t.co/EaSUTwXiHM

Apr 12, 2021 · 450 followers View post →
HerniaHerney
@HerniaHerney · X

New potential covid cure Very interesting and optimistic https://t.co/wG8zprpoeP https://t.co/t1yYPBjae6

Apr 12, 2021 · 27 followers View post →
Alexey Z. Spectre
@LoonySpectre · X

@DavidAgus There's apparently a nasal spray in the works, but it's a treatment drug, not a vaccine https://t.co/vd0uhmQmYe

Apr 11, 2021 · 3,103 followers View post →
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Jun 12, 2024 View →
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... all the seasoning and mix together well. Cover, and refrigerate ... doi:10.1111/dom.14850. 3. Jastreboff AM, Aronne LJ, Ahmad NN, et al ...

May 26, 2024 View →
Did you know? Justin helped write songs for Beyonce's self titled ...
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He's all in the backgrounds on rocket too. !! 2024-4-11Reply ... doi:10.1111/dom.14850. 3. Jastreboff AM, Aronne LJ, Ahmad NN, et al ...

Apr 6, 2024 View →
Monarch butterflies unaffected by neonicitinoid pesticides in new study
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Jonathan Jonathan Latham, PhD Executive Director The Bioscience Resource Project Ithaca, NY 14850 ... all the reared monarchs are eating ...

Feb 6, 2024 View →
Today we celebrate the birthday of our founder, the legendary Tom ...
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https://besjournals.onlinelibrary.wiley.com/doi/epdf/10.1111/1365-2664.70149 #raptor #goldeneagle #conservation #openaccess. more. View all 2 ...

Jan 10, 2024 View →
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I hope y'all like my grocery store series becaue I love making them so much! ... doi:10.1111/dom.14850. 3. Jastreboff AM, Aronne LJ, Ahmad NN, et ...

Jul 14, 2023 View →
Micropaleontology specialists, planktonic foraminifera fossils
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I never found forams all that exciting, more of a necessary but critical evil. ... DOI: 10.1111/1462-2920.14433 Kutygin, R.V., Biakov, A.S. ...

May 23, 2023 View →
Neonicotinoids and pyrethroids harm butterflies and bees
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May 15, 2023 View →
Life expectancy in Britain today is at its lowest in 10 years. Evidence ...
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... all-out war on the working class and sent rates of unemployment and ... 14,850 centenarians in England and Wales last year, a drop of 0.5pc.

Mar 30, 2023 View →
# Pyrethroid Exposure Reduces Growth and Development of ...
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... all 20 were infected with OE! They ... Jonathan Jonathan Latham, PhD Executive Director The Bioscience Resource Project Ithaca, NY 14850 ...

Aug 26, 2022 View →
Here is an excerpt from new publication which includes Xylocopia in ...
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... all four Xylocopa species had microbiomes dominated by bacterial ... 14850 PROJECT DESCRIPTION: We seek a PhD student interested in bee ...

Aug 11, 2022 View →
可以改善其記憶功能和緩解抑鬱症狀,但這是一種侵入性治療,並 ...
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... 10.1111/nyas.14850)上發表。 (English version): HKUMed & CityU ... Calling all Hong Kong residents aged 22-50! #HKUSPH is ...

Jul 7, 2022 View →
城大電機工程學系副教授陳儷行博士及香港大學神經科學研究中心主任
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... 10.1111/nyas.14850)上發表。 (English version): HKUMed & CityU ... Calling all Hong Kong residents aged 22-50! #HKUSPH is ...

Jul 7, 2022 View →
Native bee-pollen-microbe dynamics and fungicide misuse
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After all, selling poisons to the world's farmers is profitable. ... 14850 PROJECT DESCRIPTION: We seek a PhD student interested in bee ...

May 27, 2022 View →
انته تحب الببسي لو للاا جاوب بل تعليقات #اجنوبي #stitch #٩ ...
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... all the other dogs in the neighborhood, and nobody knows why. ... doi:10.1111/dom.14850. 3. Jastreboff AM, Aronne LJ, Ahmad NN, et al ...

May 21, 2022 View →
What's a "factory farm"?
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com/doi/epdf/10.1111/j.1541-4337.2010.00108.x https ... We have to make sure all of our calves get fed and watered right on time every day.

Apr 8, 2022 View →
Ph.D. positions in plant-microbe interactions at Clemson University
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... all aspects of the project. For more information visit Working at ... 14850 PROJECT DESCRIPTION: We seek a PhD student interested in ...

Mar 27, 2022 View →
Russia brings Peace-19 – For Better Science
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... all kinds of COVID-19 vaccines, the vaccination rates are ... 10.1111/all.14850. Fig 6: “Effect of repeated low dose modified siR-7 ...

Dec 28, 2021 View →
Colony size crucial for bee 'superorganism' survival
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... all for one, one for all. The bee colony consists of the queen ... 14850 PROJECT DESCRIPTION: We seek a PhD student interested in bee ...

Nov 10, 2021 View →
Decoys, mirrors, bird calls blasted from speakers — here's how ...
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... all along the coast If you could look honestly at the ... Ithaca, NY 14850 You received this email because you are subscribed ...

Jul 28, 2021 View →
Call for papers: Journal of the Society for Asian Humanities
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... all parts of the world. Southeast Asia is a world region that is ... 14850, USA Mariam Lam, Associate Professor of Comparative ...

Jul 26, 2021 View →
Neue Therapie-Option bei schwerer Covid-19-Erkrankung
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doi: 10.1111/all.14850. Epub ahead of print. PMID: 33837568. LINK: [https://onlinelibrary.wiley.com/doi/10.1111/all.14850] (https ...

Apr 12, 2021 View →
Silencing of SARS-CoV-2 with modified siRNA-peptide dendrimer ...
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Apr 11, 2021 View →
#Cultural_Classicists_Challenge ...
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... all focusing on the various ways regional “traditions” of art and ... 14850, USA Mariam Lam, Associate Professor of Comparative ...

Feb 3, 2021 View →
Decolonizing theory in Southeast Asia studies
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... everything together and review all of the abstracts. Here's our ... 14850, USA Mariam Lam, Associate Professor of Comparative ...

Aug 25, 2020 View →
Reducing childhood lead exposure through soil amendments
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Tompkins County HEALTH DEPARTMENT 55 Brown Road Ithaca, NY 14850 ... Wash all produce thoroughly. *Protect garden from airborne ...

Nov 1, 2019 View →
Even the internal world of microbes on which almost every plant and ...
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https: //doi.org/10.1111/ele.70031 Microorganisms underpin numerous ecosystem processes and support biodiversity globally. ... 14850 PROJECT ...

Aug 29, 2019 View →
Even the internal world of microbes on which almost every plant and ...
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... 14850 PROJECT DESCRIPTION: We seek a PhD student interested in bee ... https: //doi.org/10.1111/ele.70031 Microorganisms underpin numerous ...

Aug 29, 2019 View →
Bees are supreme pollinators because of what their babies eat. Most ...
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... all the bees studied was 2.6, putting them squarely in the omnivore ... 14850 PROJECT DESCRIPTION: We seek a PhD student interested in ...

Aug 23, 2019 View →
Tracking data from studies of species like migratory marine animals ...
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... all over the world to better understand and protect the birds we all love. ... Ithaca, NY 14850 You received this email because you are subscribed ...

Mar 19, 2019 View →
Eileen Iorio, Co-author of the new book; HPV Vaccine On Trial ...
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... all of the below proposed legislation: S3899a (Krueger) /A973a ... 10.1111/pde. 12516/full A link between human papilloma virus ...

Mar 5, 2019 View →
Thanks to Allah almighty, published 4th paper in International ...
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... 14850 PROJECT DESCRIPTION: We seek a PhD student interested in bee ... all biogeoscientists, especially those with an interest in microbiology or ...

Jun 28, 2018 View →
Interesting read on breeding patterns influence
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Heath First published: 21 November 2016 DOI: 10.1111/1365-2656.12604 Summary 1. ... All I know is, every thing is based on genetics and enviroment ...

Apr 25, 2018 View →
Southeast Asia in world literature panel cfp
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Hello all, here's a CFP for a panel I'm organising at the upcoming ... 14850, USA Mariam Lam, Associate Professor of Comparative ...

Feb 27, 2018 View →
Declines in insectivorous birds are associated with high ...
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... All the conventional landscaping ... Jonathan Jonathan Latham, PhD Executive Director The Bioscience Resource Project Ithaca, NY 14850 ...

Jan 14, 2018 View →
PhD studentship in insect-microbiome interactions available
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... 14850 PROJECT DESCRIPTION: We seek a PhD student interested in bee ... all fueled by our shared passion for entomology," Doctoral ...

Nov 16, 2017 View →
http://huntingwithnonlead.org/scientific_evidence2015.html Carrol ...
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Ithaca, NY 14850 You received this email because you are subscribed ... wiley.com/doi/abs/10.1111/j.1365-2311.1978. tb00912.x Below is ...

Oct 23, 2017 View →
An interesting study showing relationships between genetics and ...
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... all issues encountered. 9 yrs. Other posts.

Aug 1, 2016 View →
East Asia as method: culture, knowledge, space conference
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All papers relating to “East Asia,” broadly conceived, are welcome. ... 14850, USA Mariam Lam, Associate Professor of Comparative ...

Mar 29, 2016 View →