Int J Pharm May 2021 PMID 33839230

mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability.

Linde Schoenmaker, Dominik Witzigmann, Jayesh A Kulkarni, Rein Verbeke, Gideon Kersten, Wim Jiskoot, Daan J A Crommelin

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Mentions

136

Peak: 37 in Jun 2022

across 4 sources since Apr 2021

Extended reach

633,223

potential audience

Total likes

6,471

Video views

372,887

Mentions per month

Apr 2021 – Dec 2023

Where it's discussed

X / Twitter69 posts
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Blogs3 articles
YouTube2 videos

AI synopsis

What people are saying

In these discussions, users express a clear interest in the publication's findings on mRNA vaccine stability. Phrases like 'excited to understand stability issues' and references to the necessity of low-temperature storage highlight the importance of the article. The inclusion of terms like 'completely fabricated nonsense' showcases skepticism towards some interpretations of the study, demonstrating a mix of agreement and critique within the conversation.

AgreementModerate agreement

A majority of the discussions reflect a general acknowledgment of the importance of the publication, with some skepticism presented.

InterestHigh interest

There is a high level of curiosity regarding the stability issues of mRNA vaccines, as indicated by various users expressing excitement and engagement with the topic.

EngagementModerate engagement

Discussion depth appears moderate, with users mentioning specific concepts and implications but not diving too deeply into the complexities.

ImpactHigh impact

Many users believe the findings could lead to significant improvements in vaccine technology and public health.

Abstract in brief

Current mRNA-lipid nanoparticle (LNP) COVID-19 vaccines require ultralow temperatures for storage due to stability issues, primarily linked to mRNA hydrolysis.
Understanding the interactions between mRNA, cationic lipids, and water in the LNP core is essential for enhancing the stability of these vaccines.
Strategies for improving stability include optimizing mRNA nucleotide composition and exploring drying techniques like lyophilization.

Read the full abstract

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Stan Sands

@stan_sands · X

@01Nov2022 @c_plushie Here is the link. Title: mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability https://t.co/z8PbeG3qjA

Dec 6, 2023 · 1 like · 817 followers View post →

trainerrueben

@trainerrueben · X

https://t.co/aEZ8FR4azD mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability

Dec 3, 2023 · 1 like · 946 followers View post →

Tat Yana

@Tat_Yana_13 · X

mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability - PMC https://t.co/WU1FdIWiyy

Sep 2, 2023 · 16 followers View post →

BANned Research

@BannedResearch · X

@skohayes https://t.co/z4DDHKoAWf

Jun 18, 2023 · 247 followers View post →

Judyth Vary Baker

@Judyth · X

Report shows mRNA vaccines must be kept frozen at low temps, then refrigerated to avoid degradation & health problems. (graph: RT=room temp) "mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability" Int J Pharm. 2021 May 15; 601: 120586. https://t.co/wQM2KX60xz https://t.co/vV75htoE5j

Jun 8, 2023 · 9,121 followers View post →

Smokeyjune1

@falsestartopto1 · X

RT @Judyth: PROBLEM HERE: Dr. B cites an article that doesn't have much to do with what he is presenting: https://t.co/wQM2KX60xz "…

May 30, 2023 · 1 share · 496 followers View post →

Judyth Vary Baker

@Judyth · X

PROBLEM HERE: Dr. B cites an article that doesn't have much to do with what he is presenting: https://t.co/wQM2KX60xz "Int J Pharm. 2021 May 15; 601: 120586... mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability Who is Dr. B? https://t.co/6eM1eVpUz3

May 30, 2023 · 1 share · 9,121 followers View post →

Siddhartha Das

@Sidd_Tufts · X

RT @BiologicalDrugs: Carriers for Macromolecule Delivery: mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability https://t.co/…

May 29, 2023 · 1 share · 18 followers View post →

Satirical Scientist

@SatireScience · X

mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability https://t.co/EcF4kjjNif

Feb 4, 2023 · 705 followers View post →

けとん

@ken3_ketone · X

ワクチンの接種券届いたらファイザーかモデルナかどちらを打とうか考えている。まあ予約取れる方なんだけど。ついでにワクチン関連で脂質の構造ググって見たらOpen Accessの総説を見つけた https://t.co/5KetIQ73hA

Nov 7, 2022 · 2,194 followers View post →

Miguel A.

@AsimovIsaac1919 · X