November 2021 PMID 33843667

Nattokinase atherothrombotic prevention study: A randomized controlled trial.

Howard N Hodis, Wendy J Mack, Herbert J Meiselman, Vijay Kalra, Howard Liebman, Juliana Hwang-Levine, Laurie Dustin, Naoko Kono, Melissa Mert, Rosalinda B Wenby, Emiliano Huesca, Leanne Rochanda, Yanjie Li, Mingzhu Yan, Jan A St John

Mentions

52
Peak: 11 in Jun 2022
across 3 sources since Apr 2021

Extended reach

1,078,166
potential audience

Total likes

8,076

Video views

280,941

Mentions per month

Apr 2021 – Sep 2025

Where it's discussed

  • X / Twitter47 posts
  • News3 articles
  • YouTube2 videos

AI synopsis

What people are saying

The group’s conversations reveal skepticism and disappointment, exemplified by phrases like 'null results' and 'no effect,' as well as dismissals of the supplement's efficacy. Words like 'meh' and 'disappointing' highlight a tone of skepticism and low enthusiasm, showing that the study's findings are seen as undermining previous positive beliefs about nattokinase’s benefits.

AgreementStrong disagreement

The majority of discussions express disappointment or skepticism about the study's findings, indicating strong disagreement with the idea that nattokinase is effective for heart health.

InterestNeutral interest

Posts show moderate interest, mainly reacting to the study's results without deeper exploration or curiosity, often dismissing or criticizing the findings.

EngagementLow engagement

Many comments reflect superficial reactions or dismissive attitudes, with few engaging in detailed analysis of the methodology or implications.

ImpactLow impact

Overall, the social discussions suggest minimal impact on beliefs or practices, as the consensus appears to be that the research challenges prior claims and leaves little room for influence.

Abstract in brief

  • The study tested whether nattokinase, a supplement thought to benefit heart health, actually slows down the development of early atherosclerosis and improves related blood markers.
  • Over about 3 years, participants taking nattokinase showed no significant difference in the progression of artery wall thickness or stiffness compared to those taking a placebo.
  • The results suggest that nattokinase does not have a meaningful effect on preventing or reducing early signs of heart disease in healthy people at low risk.]

Top posts

Most liked on X and Bluesky
Paul Mason MD
@DrPaulMason · X

1. Lower Doses Ineffective for Atherosclerosis A study found that lower doses of nattokinase (2,000 FU) did not significantly impact the progression of subclinical atherosclerosis (https://t.co/QnRPr0nolE.)

Jan 2, 2025 · 92 likes · 7 shares · 74,668 followers View post →
LongCovidPharmD
@organichemusic · X

However, this larger RCT from 2021 concluded that after a median 3 yrs, daily 2000 FU NK showed no significant effect on blood coagulation and fibrinolysis factors, blood pressure or any other tested labs, & didn't decrease https://t.co/mmDq0h4l58 https://t.co/nPNzB6Clpn

Jun 10, 2022 · 82 likes · 12 shares · 35,447 followers View post →
Mike Lustgarten, PhD
@mike_lustgarten · X

Nattokinase atherothrombotic prevention study: A randomized controlled trial https://t.co/onigGsKWAW

Feb 14, 2025 · 15 likes · 1 share · 9,745 followers View post →
Matt Brignall
@drbrignall · X

Because a prominent anti-vaxxer is now hawking nattokinase to something something vaccine blood etc, now is a good time to share the first clinical trial on this supplement. Spoiler: no effect. https://t.co/WdLmyy56Vv

Feb 21, 2023 · 10 likes · 3 shares · 2,027 followers View post →
Karoyan Philippe
@KaroyanPhilippe · X

@barriere_dr Je ne comprends pas comment on peut croire qu’un enzyme, qui est une proteine, puisse sans dégradation, passer la barrière du tube digestif (estomac, intestin, foie) pour ensuite aller dégrader une autre protéine (spike) dans le sang. Pour les sceptiques:https://t.co/VVtU8dSgsN

Sep 20, 2023 · 10 likes · 401 followers View post →
Szabolcs Sandoly
@sandoly · X

@wideawake_media Hodis2021: at no time point, incl. early time points of 1 wk+1,3&6m post-randomization, did nattokinase suppl. have a detectable treatment effect on any coagulation factor, fibrinolytic factor or platelet aggregation rel. to placebo https://t.co/7wz5kH3Avl https://t.co/hIgVz4oBC0

Nov 14, 2023 · 6 likes · 3 shares · 2,395 followers View post →

All mentions

Eugene Nasuti
@suti363 · X

@dtraderaus @The_Healthy_Man @NutritionTipzzz https://t.co/SNf1miUVjQ

Sep 4, 2025 · 1,971 followers View post →
MarcoPolo
@Marco777Polo · X

@jwmares It sounded too lovely for a final solution

Jun 23, 2025 · 2 likes · 219 followers View post →
The Longevist
@Dr_coachbear · X

RT @mike_lustgarten: Nattokinase atherothrombotic prevention study: A randomized controlled trial https://t.co/onigGsKWAW

Feb 15, 2025 · 1 share · 481,394 followers View post →
Mike Lustgarten, PhD
@mike_lustgarten · X

Nattokinase atherothrombotic prevention study: A randomized controlled trial https://t.co/onigGsKWAW

Feb 14, 2025 · 15 likes · 1 share · 9,745 followers View post →
Awakened Princess
@GastricpH · X

RT @DrPaulMason: 1. Lower Doses Ineffective for Atherosclerosis A study found that lower doses of nattokinase (2,000 FU) did not significan…

Feb 4, 2025 · 7 shares · 1,012 followers View post →
robertaloug
@robertaloug · X

RT @DrPaulMason: 1. Lower Doses Ineffective for Atherosclerosis A study found that lower doses of nattokinase (2,000 FU) did not significan…

Jan 3, 2025 · 7 shares · 1,815 followers View post →
DeTank1979
@DTank1979 · X

RT @DrPaulMason: 1. Lower Doses Ineffective for Atherosclerosis A study found that lower doses of nattokinase (2,000 FU) did not significan…

Jan 3, 2025 · 7 shares · 346 followers View post →
Dr NK Tenai
@eNPire · X

RT @DrPaulMason: 1. Lower Doses Ineffective for Atherosclerosis A study found that lower doses of nattokinase (2,000 FU) did not significan…

Jan 2, 2025 · 7 shares · 156 followers View post →
Paul Mason MD
@DrPaulMason · X

1. Lower Doses Ineffective for Atherosclerosis A study found that lower doses of nattokinase (2,000 FU) did not significantly impact the progression of subclinical atherosclerosis (https://t.co/QnRPr0nolE.)

Jan 2, 2025 · 92 likes · 7 shares · 74,668 followers View post →
Joe Blow
@josephblosef · X

@EchoplexSE @Cernovich https://t.co/rBZWNJStSb lol “some studies” means studies by the people who sell it. Real studies say it’s meh

Dec 14, 2024 · 1 like · 8,817 followers View post →
William Lagakos
@caloriesproper2 · X

Mixed evidence of Nattokinase on blood pressure. Positive (8-week study): https://t.co/g95QEBKe00 Neutral (3 years): https://t.co/uYyxprGDH7 Both used the same dose: 2000 fibrinolytic units/d

Dec 14, 2024 · 2 likes · 3,244 followers View post →
みつき
@901228Mitsuki · X

ナットウキナーゼの大規模かつ長期的な心血管系研究を実施 265名の経口ナットウキナーゼ 2千線溶単位投与のRCTを実施,主要評価は,頸動脈内膜中膜肥厚及び頸動脈硬化とし,6 か月毎に動脈硬化の変化率を測定3年間の観察でナットウキナーゼ補給群とプラセボ群で有意差は無ったhttps://t.co/gbEceWoLXi

Nov 8, 2024 · 449 followers View post →
RHD
@RHd1983 · X

@LDLSkeptic Hodis HN, Mack WJ. Nattokinase atherothrombotic prevention study: A randomized controlled trial. Clin Hemorheol Microcirc. 2021;78(4):339-353. doi: 10.3233/CH-211147. PMID: 33843667.

Sep 8, 2024 · 49 followers View post →
myGene
@mygene · X

@biohacker An RCT showed null results at 2000 u/day https://t.co/xom8PrHSfv

Aug 26, 2024 · 6 likes · 726 followers View post →
じすけ❂✨✨✨ tiamat
@jisukewizon · X

@minamiyoro @UfOrUBZo4T3HcWq @Jimo0404 @q6Aci2K8Jc32740 @KEIZOmini3298 @MCTM524457 @KDMCYcpefGyBUq7 @Kuroi_Yahu @rnHZo8uwzbvtqH5 @gaugaugauta @a7WDZFK5er77036 @PLC_Kei @JESUS2daime @takaku2021 @mcallister11111 @minamiyoroyoro @hide3ttu @tomo_hiko @hime1booo なかったみたい https://t.co/jQn8dJusFr

Jul 31, 2024 · 5 likes · 3,663 followers View post →
後の無い65歳大学院生4回生
@yoho_yam · X

@eagihado @alxd1224 @yC8DsJFnhv78913 ちなみに長期投与のRCTを見つけました。 Nattokinase atherothrombotic prevention study: A randomized controlled trial. Clinical Hemorheology and Microcirculati...(IOS Press) - Vol. 78, Iss: 4, pp 339-353 ここでは、長期投与で凝固線溶系で有意差がなく、意味がないって結論です。

Jul 7, 2024 · 1 like · 452 followers View post →
Siim Land
@siimland · X

A 2017 clinical trial in China found that a dose of 6,000 FU/day was effective https://t.co/znqxFpIoPs But a 2021 clinical trial found that a dose of 2,000 FU/day wasn't effective https://t.co/6ZsFAnZx4X

Apr 30, 2024 · 28,205 followers View post →
R Marcucio
@mcfunny · X

@TheFrankmanMN @VirusSmThanHole @davideyoungmd @Pouldeau61 @TakethatCt @ShaneAKAProp @thecountof1 @sduncanhealth @bjurrows @AnnLove4All @doritmi @runhack @djt10 @Arkout3 @taurusg333 @cappsie @TonyBaduy @Danny459673 @WendyOrent @raoulduke49 @DaveBla81093404 @crabb_vicki @krebiozen @MsTrixter @Hurriquake @MONTMAN9500 @StuWizzle @Golfergirl2018 @dann58638436 @Scary7Dr @BB0941167867205 @Kathmarval @encyclopath @1_TMF_ @Fornowago @FUDyou2 @Catheri49917567 @RadioColor @tonymac5 @groin_hammer @CyclopsSeesAll @ScienceMonkey0 @Just4TheCause @zendogbreath @FormerAntivax @BruceFo43322941 @DK25769559 @BigBopp75348974 @provaxtexan @MarioMoney23 and...no effect compared to placebo... https://t.co/4Im0tIeTAq

Mar 20, 2024 · 2 likes · 2,741 followers View post →
Independent Mind Backup
@IndyGroupMedia · X

@lucindasan15671 @Truth_in_Number @sharkzfanz Why block me when I hadn’t responded?

Jan 13, 2024 · 24 followers View post →
avo
@thebusiness7 · X

RT @sandoly: @wideawake_media Hodis2021: at no time point, incl. early time points of 1 wk+1,3&6m post-randomization, did nattokinase suppl…

Nov 20, 2023 · 3 shares · 180 followers View post →
Water From Air
@MoistureVapor8r · X

RT @sandoly: @wideawake_media Hodis2021: at no time point, incl. early time points of 1 wk+1,3&6m post-randomization, did nattokinase suppl…

Nov 19, 2023 · 3 shares · 4,475 followers View post →
Szabolcs Sandoly
@sandoly · X

@wideawake_media Hodis2021: at no time point, incl. early time points of 1 wk+1,3&6m post-randomization, did nattokinase suppl. have a detectable treatment effect on any coagulation factor, fibrinolytic factor or platelet aggregation rel. to placebo https://t.co/7wz5kH3Avl https://t.co/hIgVz4oBC0

Nov 14, 2023 · 6 likes · 3 shares · 2,395 followers View post →
Volkhart Vester
@VesterVolkhart · X

@Sabsi0431 @DrSynthetiks @reitschuster 2000IU haben keinen Effekt auf Arteriosklerose https://t.co/oLVvyG3xoR

Nov 3, 2023 · 20 followers View post →
John, PA-C
@javysoler6 · X

@error_dome @BowTiedOx I sure can https://t.co/jCQHdOp21v

Sep 30, 2023 · 2 likes · 262 followers View post →
Karoyan Philippe
@KaroyanPhilippe · X

@barriere_dr Je ne comprends pas comment on peut croire qu’un enzyme, qui est une proteine, puisse sans dégradation, passer la barrière du tube digestif (estomac, intestin, foie) pour ensuite aller dégrader une autre protéine (spike) dans le sang. Pour les sceptiques:https://t.co/VVtU8dSgsN

Sep 20, 2023 · 10 likes · 401 followers View post →
Idiopathic Confusion
@WFPB_Longevity · X

Well .. darn .. they RCT’d my latest N=1 (nattokinase) and found no benefit. But, only used 2000FU. Most papers seem to indicate 10000FU. https://t.co/oTr0LTfVwI

May 9, 2023 · 1 like · 310 followers View post →
Dr Kevin Lee
@dr_kevinlee · X

Nattokinase RCT- 3 yrs of treatment: “Results of this trial show that nattokinase supplementation has a null effect on subclinical atherosclerosis progression in healthy individuals at low risk for CVD” https://t.co/7qvADqUvoG

Mar 9, 2023 · 3 likes · 5,425 followers View post →
Tj
@cali_tami · X

RT @drbrignall: Because a prominent anti-vaxxer is now hawking nattokinase to something something vaccine blood etc, now is a good time to…

Feb 23, 2023 · 3 shares · 2,547 followers View post →
(((Liz Ditz))). Mask up, y'all. Viruses are real.
@lizditz · X

RT @drbrignall: Because a prominent anti-vaxxer is now hawking nattokinase to something something vaccine blood etc, now is a good time to…

Feb 21, 2023 · 3 shares · 10,456 followers View post →
Matt Brignall
@drbrignall · X

Because a prominent anti-vaxxer is now hawking nattokinase to something something vaccine blood etc, now is a good time to share the first clinical trial on this supplement. Spoiler: no effect. https://t.co/WdLmyy56Vv

Feb 21, 2023 · 10 likes · 3 shares · 2,027 followers View post →
Anomic Aphasia
@AphasiaAnomic · X

@florpodesta5 @useless_priest Large, randomized, controlled clinical trial, no effect for nattokinase. https://t.co/f1YpZyJrRj Proteins are simply not effectively delivered across the gut barrier in healthy persons. If your blood was ‘gellish’ before, see a doctor. But enjoy your placebo effect.

Dec 5, 2022 · 122 followers View post →
山口幸三 | 腸活研究者
@yguchi53 · X

「ナットウキナーゼ意味ない」という論文 https://t.co/KuKk6vFZLy

Sep 19, 2022 · 227 followers View post →
Dr Melanie
@MelanieWeckert · X

RT @organichemusic: However, this larger RCT from 2021 concluded that after a median 3 yrs, daily 2000 FU NK showed no significant effect o…

Jul 10, 2022 · 12 shares · 11,325 followers View post →
Dr Melanie
@MelanieWeckert · X

RT @organichemusic: However, this larger RCT from 2021 concluded that after a median 3 yrs, daily 2000 FU NK showed no significant effect o…

Jun 20, 2022 · 12 shares · 11,325 followers View post →
Howard Phillips
@SirDagon · X

RT @organichemusic: However, this larger RCT from 2021 concluded that after a median 3 yrs, daily 2000 FU NK showed no significant effect o…

Jun 11, 2022 · 12 shares · 1,093 followers View post →
The Left Independent ✊
@Left_Indy · X

RT @organichemusic: However, this larger RCT from 2021 concluded that after a median 3 yrs, daily 2000 FU NK showed no significant effect o…

Jun 10, 2022 · 12 shares · 2,917 followers View post →
AMARESH KUMAR
@amareshskumar · X

RT @organichemusic: However, this larger RCT from 2021 concluded that after a median 3 yrs, daily 2000 FU NK showed no significant effect o…

Jun 10, 2022 · 12 shares · 1,277 followers View post →
Constellation
@Clear_Purpose · X

RT @organichemusic: However, this larger RCT from 2021 concluded that after a median 3 yrs, daily 2000 FU NK showed no significant effect o…

Jun 10, 2022 · 12 shares · 233 followers View post →
Sue Jackson
@SueJack41372586 · X

RT @organichemusic: However, this larger RCT from 2021 concluded that after a median 3 yrs, daily 2000 FU NK showed no significant effect o…

Jun 10, 2022 · 12 shares · 239 followers View post →
CM they/them ASD EDS MDD OA etc
@CM_7505 · X

RT @organichemusic: However, this larger RCT from 2021 concluded that after a median 3 yrs, daily 2000 FU NK showed no significant effect o…

Jun 10, 2022 · 12 shares · 1,686 followers View post →
Paul B |
@Paul_Briley · X

RT @organichemusic: However, this larger RCT from 2021 concluded that after a median 3 yrs, daily 2000 FU NK showed no significant effect o…

Jun 10, 2022 · 12 shares · 6,212 followers View post →
Cissi
@_Cissi__ · X

RT @organichemusic: However, this larger RCT from 2021 concluded that after a median 3 yrs, daily 2000 FU NK showed no significant effect o…

Jun 10, 2022 · 12 shares · 203 followers View post →
Angela Howard
@AngelaH40381359 · X

RT @organichemusic: However, this larger RCT from 2021 concluded that after a median 3 yrs, daily 2000 FU NK showed no significant effect o…

Jun 10, 2022 · 12 shares · 16 followers View post →
LongCovidPharmD
@organichemusic · X

However, this larger RCT from 2021 concluded that after a median 3 yrs, daily 2000 FU NK showed no significant effect on blood coagulation and fibrinolysis factors, blood pressure or any other tested labs, & didn't decrease https://t.co/mmDq0h4l58 https://t.co/nPNzB6Clpn

Jun 10, 2022 · 82 likes · 12 shares · 35,447 followers View post →
Joel "Heart Prevention" Kahn MD, FACC
@drjkahn · X

BUMMER! Nattokinase atherothrombotic prevention study: A randomized controlled trial https://t.co/raqN6CeRgg #kahnchronicle

Oct 10, 2021 · 32,190 followers View post →
Agingdoc
@agingdoc1 · X

Nattokinase atherothrombotic prevention study: A randomized controlled trial (null) https://t.co/vWQv57LB7x

Sep 8, 2021 · 43,806 followers View post →
SoybeanPapers
@SoybeanPapers · X

Nattokinase atherothrombotic prevention study: A randomized controlled trial https://t.co/Eohc4cIrnW https://t.co/TPIfZqrNc4

Apr 13, 2021 · 286 followers View post →
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