PubHawk
Proc Natl Acad Sci U S A April 2021 PMID 33876755

Immune cells fold and damage fungal hyphae.

Judith M Bain, M Fernanda Alonso, Delma S Childers, Catriona A Walls, Kevin Mackenzie, Arnab Pradhan, Leanne E Lewis, Johanna Louw, Gabriela M Avelar, Daniel E Larcombe, Mihai G Netea, Neil A R Gow, Gordon D Brown, Lars P Erwig, Alistair J P Brown

Full text PDF Download social card

Mentions

22
Peak: 14 in Apr 2021
across 4 sources since Apr 2021

Extended reach

20,968
potential audience

Total likes

98

Video views

242

Mentions per month

Apr 2021 – Jun 2024

Where it's discussed

  • X / Twitter15 posts
  • Blogs3 articles
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

The group generally reacts positively, calling the findings 'simply amazing' and emphasizing the immune cells' ability to fold and damage hyphae, with posts acknowledging the contribution of specific research teams. The tone is one of admiration and curiosity, reflecting an appreciation for the scientific breakthrough, yet most comments stay at a surface level without deep technical discussion.

AgreementStrong agreement

All posts strongly agree with the significance of the findings, describing the process as 'simply amazing' and emphasizing the breakthrough nature of how immune cells fight fungi.

InterestHigh interest

The posts express high interest by highlighting the innovative mechanism with enthusiasm and curiosity about immune responses to fungal infections.

EngagementModerate engagement

Most messages are brief but show engagement through repeated acknowledgment of the discovery, with some referencing specific research teams and collaborations.

ImpactModerate impact

The discussions suggest recognition of the research's potential impact on understanding immune defense and possible implications for medical advancements, albeit in an enthusiastic but somewhat simplified tone.

Abstract in brief

  • The text explains that innate immune cells, like macrophages, fight fungal infections, but some fungi can evade this by forming long hyphae that are difficult to engulf.
  • Researchers found that macrophages can combat these hyphae by folding them using the proteins Dectin1, integrins, VASP, and actin-myosin, which helps in full engulfment and inhibits fungal growth.
  • This ability to fold and contain the hyphae increases the chances of the immune system successfully clearing the fungal infection.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Neil Gow
@neil_gow · X

Al Brown’s team show how macrophages can fold up and damage long Candida hyphae to be able to engulf them. https://t.co/3mA21P5z8F doi:10.1073/pnas.2020484118/-/DCSupplemental ⁦@MRCcmm⁩ ⁦@UoEBiosciences⁩ ⁦⁦@eurconfmedmycol⁩ ⁦⁦@ISHAM_Mycology⁩ https://t.co/uwaszay3Xe

Apr 7, 2021 · 68 likes · 12 shares · 5,737 followers View post →
MRC Centre for Medical Mycology
@MRCcmm · X

RT @neil_gow: Al Brown’s team show how macrophages can fold up and damage long Candida hyphae to be able to engulf them. https://t.co/3mA21…

Apr 8, 2021 · 12 shares · 4,108 followers View post →
Émer Hickey
@emerhickk · X

RT @neil_gow: Al Brown’s team show how macrophages can fold up and damage long Candida hyphae to be able to engulf them. https://t.co/3mA21…

Apr 7, 2021 · 12 shares · 1,829 followers View post →
Exeter Biosciences
@UoEBiosciences · X

RT @neil_gow: Al Brown’s team show how macrophages can fold up and damage long Candida hyphae to be able to engulf them. https://t.co/3mA21…

Apr 12, 2021 · 12 shares · 1,673 followers View post →
BrownLabUtah
@BrownLabUtah · X

RT @neil_gow: Al Brown’s team show how macrophages can fold up and damage long Candida hyphae to be able to engulf them. https://t.co/3mA21…

Apr 7, 2021 · 12 shares · 1,495 followers View post →
Marc Swidergall
@Swidergall_lab · X

RT @neil_gow: Al Brown’s team show how macrophages can fold up and damage long Candida hyphae to be able to engulf them. https://t.co/3mA21…

Apr 7, 2021 · 12 shares · 1,202 followers View post →

All mentions

One Tail, One Head
@Perlascar · X

Simply amazing. Immune cells fold and damage fungal hyphae https://t.co/jybAAx4EbP

May 31, 2021 · 28 followers View post →
Renaud Poincloux
@RenaudPoincloux · X

Immune cells fold and damage fungal hyphae https://t.co/rhEFlidC5r

Apr 26, 2021 · 1,136 followers View post →
micropapers
@micro_papers · X

Immune cells fold and damage fungal hyphae https://t.co/oJvz34FlaU

Apr 20, 2021 · 331 followers View post →
Exeter Biosciences
@UoEBiosciences · X

RT @neil_gow: Al Brown’s team show how macrophages can fold up and damage long Candida hyphae to be able to engulf them. https://t.co/3mA21…

Apr 12, 2021 · 12 shares · 1,673 followers View post →
sfmm_myco
@sfmm_myco · X

RT @neil_gow: Al Brown’s team show how macrophages can fold up and damage long Candida hyphae to be able to engulf them. https://t.co/3mA21…

Apr 10, 2021 · 12 shares · 378 followers View post →
Daniel Irimia
@D__Irimia · X

RT @neil_gow: Al Brown’s team show how macrophages can fold up and damage long Candida hyphae to be able to engulf them. https://t.co/3mA21…

Apr 8, 2021 · 12 shares · 1,005 followers View post →
Anja Forche
@AnjaForche · X

RT @neil_gow: Al Brown’s team show how macrophages can fold up and damage long Candida hyphae to be able to engulf them. https://t.co/3mA21…

Apr 8, 2021 · 12 shares · 272 followers View post →
MRC Centre for Medical Mycology
@MRCcmm · X

RT @neil_gow: Al Brown’s team show how macrophages can fold up and damage long Candida hyphae to be able to engulf them. https://t.co/3mA21…

Apr 8, 2021 · 12 shares · 4,108 followers View post →
ExeterMicrobes
@ExeterMicrobes · X

RT @neil_gow: Al Brown’s team show how macrophages can fold up and damage long Candida hyphae to be able to engulf them. https://t.co/3mA21…

Apr 8, 2021 · 12 shares · 461 followers View post →
Marc Swidergall
@Swidergall_lab · X

RT @neil_gow: Al Brown’s team show how macrophages can fold up and damage long Candida hyphae to be able to engulf them. https://t.co/3mA21…

Apr 7, 2021 · 12 shares · 1,202 followers View post →
BrownLabUtah
@BrownLabUtah · X

RT @neil_gow: Al Brown’s team show how macrophages can fold up and damage long Candida hyphae to be able to engulf them. https://t.co/3mA21…

Apr 7, 2021 · 12 shares · 1,495 followers View post →
Fabio Palmieri
@Palmieri_F_ · X

RT @neil_gow: Al Brown’s team show how macrophages can fold up and damage long Candida hyphae to be able to engulf them. https://t.co/3mA21…

Apr 7, 2021 · 12 shares · 667 followers View post →
Qinxi Ma
@QinxiMa · X

RT @neil_gow: Al Brown’s team show how macrophages can fold up and damage long Candida hyphae to be able to engulf them. https://t.co/3mA21…

Apr 7, 2021 · 12 shares · 117 followers View post →
Émer Hickey
@emerhickk · X

RT @neil_gow: Al Brown’s team show how macrophages can fold up and damage long Candida hyphae to be able to engulf them. https://t.co/3mA21…

Apr 7, 2021 · 12 shares · 1,829 followers View post →
Neil Gow
@neil_gow · X

Al Brown’s team show how macrophages can fold up and damage long Candida hyphae to be able to engulf them. https://t.co/3mA21P5z8F doi:10.1073/pnas.2020484118/-/DCSupplemental ⁦@MRCcmm⁩ ⁦@UoEBiosciences⁩ ⁦⁦@eurconfmedmycol⁩ ⁦⁦@ISHAM_Mycology⁩ https://t.co/uwaszay3Xe

Apr 7, 2021 · 68 likes · 12 shares · 5,737 followers View post →