May 2021 PMID 33899337

Genetics of Obesity: What We Have Learned Over Decades of Research.

Claude Bouchard

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Mentions

141
Peak: 28 in May 2021
across 5 sources since Apr 2021

Extended reach

648,979
potential audience

Total likes

15,037

Video views

112,640

Mentions per month

Apr 2021 – Oct 2025

Where it's discussed

  • X / Twitter74 posts
  • News56 articles
  • Blogs5 articles
  • YouTube3 videos
  • Facebook3 posts

AI synopsis

What people are saying

Several participants highlight the genetic component of obesity, referencing specific heritability percentages (40-80%) and discussing implications for treatment approaches. Phrases like 'major challenge' and 'obesity genetic risk' demonstrate the seriousness of the topic and the contributors' active engagement with the research findings. The tone varies between informative and critical, with some users passionately debating aspects of the findings and their application to societal views on obesity.

AgreementModerate agreement

The majority of discussions express a general agreement with the findings presented in the publication regarding the genetic basis of obesity.

InterestHigh interest

There is a high level of interest as participants frequently share additional sources and engage with the data presented in the article.

EngagementModerate engagement

Discussions vary in depth; while many simply reference the article, some posts show a more profound engagement by contextualizing the findings within broader conversations about obesity.

ImpactHigh impact

Many users perceive the research as significantly impactful for understanding obesity, emphasizing its relevance for treatment and prevention strategies.

Abstract in brief

  • There is a significant genetic influence on human obesity, with heritability accounting for 40-50% of body weight variability, and even higher (60-80%) in those with severe obesity.
  • Understanding the different heritability across BMI categories is crucial for obesity research, as fat distribution and metabolic traits exhibit varying levels of heritability (30-55%).
  • Monogenic obesity is linked to defects in over 15 specific genes primarily affecting the leptin-melanocortin signaling pathway, while common DNA variants contribute significantly to BMI heritability, complicating obesity prevention and management efforts.

Top posts

Most liked on X and Bluesky
R Giovanni Diaz-Zavala
@DrGiovanniD · X

Update por el experto en genética de la obesidad. https://t.co/rKIgIvWzfw https://t.co/1Qa6EijAv7

May 4, 2021 · 61 likes · 12 shares · 16,002 followers View post →
Rachel Zader
@RachelZader · X

@Mangan150 I hate when people don’t do basic scientific research. https://t.co/749wiob0wU

Jan 29, 2023 · 22 likes · 2,635 followers View post →
ZKForTre
@ZKForTre · X

The heritability of obesity is between 30 and 80% depending on the study and methodology. She also does not claim that diet doesn’t impact weight. Beware of ideologues. https://t.co/RTvuRcZB3T https://t.co/BNok6DZGYH

Apr 2, 2025 · 20 likes · 2 shares · 2,763 followers View post →
JulioBasulto_DN
@JulioBasulto_DN · X

El componente genético de la obesidad representa del 40% al 50% de la variabilidad en el peso, pero es menor en personas con normopesol (~30%) y mucho mayor en personas con obesidad (60% -80%). https://t.co/D0VW0tEJXn Bouchard C. Obesity (Silver Spring). 2021 May;29(5):802-820.

May 7, 2021 · 17 likes · 14 shares · 96,218 followers View post →
EASO
@EASOobesity · X

Great review piece on the Genetics of #Obesity: What We Have Learned Over Decades of Research? Bouchard @WileyOnline https://t.co/pgDwrvHGFQ

Dec 31, 2021 · 8 likes · 1 share · 18,902 followers View post →
XennialTeacher (she/her)
@XennialTeacher · X

@Exoduster_ @bad_dominicana https://t.co/1ICtxd6V88

May 31, 2023 · 7 likes · 1 share · 149 followers View post →

All mentions

koji hasegawa
@myfavoritescene · X

RT @ropcb08: (・д・)ホォー BMIにおける遺伝的要因は、年齢・性別による調整後で約40~50%を占めるとする研究がある(Claude Bouchard, “Genetics of Obesity: What We Have Learned Over Decad…

Oct 2, 2025 · 1 share · 5,239 followers View post →
Bot08(日本カネ不足協会 会員)
@ropcb08 · X

(・д・)ホォー BMIにおける遺伝的要因は、年齢・性別による調整後で約40~50%を占めるとする研究がある(Claude Bouchard, “Genetics of Obesity: What We Have Learned Over Decades of Research,” Obesity, Volume 29 Issue 5, May 2021, p.804. <https://t.co/w6OGXJ9erb> )

Oct 2, 2025 · 1 like · 1 share · 1,314 followers View post →
Jimeekay #lyingbyomission
@jimeekay · X

@davosThebrave @SecKennedy I already told you that I read it at the time we were discussing it initially. Oh, look. A link that took 10 seconds to find again. https://t.co/LuGZn4xLwt

Aug 11, 2025 · 1,206 followers View post →
Jay Dee (Original Recipe)
@JuliusFnDiamond · X

@majka611114 @Khaosplate @PulloutCouchosu @xzemiyl2 @3lfares Hey look, here's an actual reliable source (dipshit) https://t.co/pUKoW8gu3T

Jun 28, 2025 · 233 followers View post →
заштрихованная область
@FDeadmonk · X

@eburg_it @Nelson_Piquet Цифра 80 абсолютно безумна Скорее всего вы неверно цитируете исследование 2021 года https://t.co/YhFFdwXrYk

Jun 6, 2025 View post →
Rx Readmore Livemore
@SopitaSirirata1 · X

RT @ZKForTre: The heritability of obesity is between 30 and 80% depending on the study and methodology. She also does not claim that diet…

Apr 3, 2025 · 2 shares · 170 followers View post →
smurfsj
@smurfsj · X

RT @ZKForTre: The heritability of obesity is between 30 and 80% depending on the study and methodology. She also does not claim that diet…

Apr 2, 2025 · 2 shares · 133 followers View post →
ZKForTre
@ZKForTre · X

The heritability of obesity is between 30 and 80% depending on the study and methodology. She also does not claim that diet doesn’t impact weight. Beware of ideologues. https://t.co/RTvuRcZB3T https://t.co/BNok6DZGYH

Apr 2, 2025 · 20 likes · 2 shares · 2,763 followers View post →
Charlotte
@CharlotteCharmy · X

@its_sarahs_alt here's some stuff to read so you can be less shit! https://t.co/5JEOmVEVMZ https://t.co/5bfQJ5BpRo FYI if u were genuinely obese at some point and still believe the rhetoric you've spewed you need genuine help!

Feb 7, 2025 · 336 followers View post →
KeepCalmandVOTE
@keepcalm_BetoOn · X

@garypageau @lukepbeasley Yes, genetics can play a role in a person's likelihood of becoming obese https://t.co/dGox7snt4Q

Jan 5, 2025 · 1 like · 2,077 followers View post →
GreatlyGelid1196
@gelid1196 · X

@colemarisa49 @baked_bean_1 @CuteTransGiirl @whoishaydin @phaithmontoya @ONFRAUDS https://t.co/hES3H8FcNq

Dec 21, 2024 · 18 followers View post →
GreatlyGelid1196
@gelid1196 · X

@colemarisa49 @CuteTransGiirl @MyHaploidHeart @whoishaydin @phaithmontoya @ONFRAUDS I provided you with the title of a research article. If you need the link here it is: https://t.co/CfggGNe5uW

Dec 19, 2024 · 18 followers View post →
GreatlyGelid1196
@gelid1196 · X

@colemarisa49 @barelyalivevamp @whoishaydin @phaithmontoya @ONFRAUDS I didn't think I would have to hold your hand so much to be honest. This article is a bit old, but I think it would be a good start. Genetics of Obesity: What We Have Learned Over Decades of Research

Dec 19, 2024 · 18 followers View post →
Plain Jane
@vespers22 · X

@AJKayWriter @kevinnbass You obviously have never had a weight problem.

Dec 4, 2024 · 45 followers View post →
Tony Boss aka Hairy Haroldson
@HairyHaroldson · X

@Ukkjhhh @AshleySinclair0 @CollinRugg Here's an abstract to a paper on how genetics play a role in obesity and how it is hereditary. https://t.co/7QLclPrBLb

Jun 8, 2024 · 346 followers View post →
biochemist
@biockemist · X

@daria_firsova @MorkvoTox Так-то генетические факторы объясняют 60-80% вариаций в ИМТ для людей с ожирением https://t.co/ETsvrkoygq То есть это, ну, литерали болезнь, и я не вижу никакого поинта топить против лекарства, которое как бы люди покупают за свои заработанные деньги, никому не мешая

May 15, 2024 · 1 like · 258 followers View post →
⁺✩⋆.¸¸.✦¸•.¸¸. ☾ Leo ☽.¸¸.•✦•.¸¸. ⋆ ✩ ⁺
@Lady_Starman · X

@GabboSavedMe @KSizeC @horthoe @allurhia You might retain more fat from than other person might because of genes i didn’t fucking say that https://t.co/o1psLH6Bjo

Apr 11, 2024 · 325 followers View post →
theaccusr
@theaccusr · X

@_justinwilliam @J_ODochartaigh Here are other sources: https://t.co/6DSRyrCHVM. https://t.co/QZZBTzaRqq). https://t.co/8sUEWxumQQ https://t.co/SvQi80S83o

Feb 24, 2024 · 36 followers View post →
Tomás Verdugo
@tomasverdugo · X

"There is a genetic component to human obesity that accounts for 40% to 50% of the variability in body weight status". The genetic component might be up to 80% in individuals with obesity and severe obesity. https://t.co/WWgdMgbre7

Nov 15, 2023 · 181 followers View post →
Kaitsu.
@UnclemanBoomer · X

@datepsych Actually, "40% to 70%" Loos, R.J.F., Yeo, G.S.H. The genetics of obesity: from discovery to biology. Nat Rev Genet 23, 120–133 (2022). "from 30% to 55%" Bouchard, C. (2021). Genetics of obesity: What we have learned over decades of research. Obesity, 29(5), 802–820.

Oct 22, 2023 · 1 like · 385 followers View post →
veganlovebunny
@veganlovebunny · X

@AR43245328 @HelenBaumander @NoFluxGarak @KristenLee47 So the whole family is obese eh? Sounds like it is a genetic problem. Especially when a child is overweight before puberty. https://t.co/u26iWAnLni

Jun 20, 2023 · 1,375 followers View post →
XennialTeacher (she/her)
@XennialTeacher · X

@Exoduster_ @bad_dominicana https://t.co/1ICtxd6V88

May 31, 2023 · 7 likes · 1 share · 149 followers View post →
Maxwell (He/Him) - suffering
@i_wanna_be_weak · X

@Dismorphiaa @crunchyteeth72 @fattyren https://t.co/46zioqiv9E its free to access

Mar 8, 2023 · 668 followers View post →
Rachel Zader
@RachelZader · X

@Mangan150 I hate when people don’t do basic scientific research. https://t.co/749wiob0wU

Jan 29, 2023 · 22 likes · 2,635 followers View post →
Charles Wang
@cfwang1337 · X

@calleymeans @askdrfatima There's a decent case to be made that our environment is so obesogenic that 40-50% of observed variation comes down to genetics (https://t.co/5uwP19bR81). And she's right that it's a neuroendocrine problem. We've known about leptin resistance for like 30 years now.

Jan 26, 2023 · 766 followers View post →
Kathy Dove
@movie_gal_10 · X

Why Diets Don't Work https://t.co/sqrxEGHpYd

Jan 25, 2023 · 6,805 followers View post →
Joshua Buster
@Colorado_stonem · X

@TherealPreben @Rob_Chipman @bucktron2021 @healthbyjames https://t.co/qbekLCeo8M Yes, there is a large genetic component to obesity.

Jan 24, 2023 · 34 followers View post →
RAD ❁
@RADrebel43 · X

@LegionAth https://t.co/NFQ7QtC2pG

Jan 7, 2023 · 3,094 followers View post →
Jordan Feigenbaum, M.D.
@Jordan_theCoach · X

@PsyilliumB @2MastersDegrees @dpinsen Probably one of the most well-supported arguments you’ve ever tried to refute. If you’d like to have a discussion, let’s do it. If you just want to troll inside your own bubble, save us both the time and go away. https://t.co/0dppwpG4oA

Dec 27, 2022 · 5,241 followers View post →
Michael Albert, MD
@MichaelAlbertMD · X

@MiriamBerchuk @MichelleCardel @EmilyDhurandhar @sguyenet You had me go down the rabbit hole. I enjoyed this one, which I previously had not read: BMI is highly heritable (60-80%) among those with obesity and severe obesity. https://t.co/zacBT6ZGXF

Aug 8, 2022 · 2 likes · 15,987 followers View post →
Raphael Sirtoli
@raphaels7 · X

"Diminishing allele effect size is observed as the number of obesity-associated variants expands, with most BMI-⬆️or⬇️decreasing alleles contributing only a few grams or less to body weight" https://t.co/kme0tTLOwn

Aug 5, 2022 · 1 like · 8,596 followers View post →
David Macklin
@DavidMacklinMD · X

@SatyaDash009 @JimJohnsonSci @StephenORahilly @JohnSpeakman4 @raphaels7 To add to the NB discussion A 2021 OBESITY paper by the great Claude Bouchard suggesting that “ Heritability varies across different classes of BMI” describing a heritability estimate for “individuals with obesity and severe obesity of about 60%-80%.” https://t.co/i7DNTTyhNf

Aug 4, 2022 · 3 likes · 1,863 followers View post →
judeEcooper
@judeEcooper · X

@Kelsey381376223 @under_theradar @QusaRes @JonKraus8 @RealTimers @bariweiss @billmaher @TimothyDSnyder @RepRitchie @HBO @hbomax https://t.co/QcjZpIWspb

Jan 24, 2022 · 764 followers View post →
EASO Early Career Network
@EASOobesityECN · X

Review article on the #Genetics of #Obesity: What We Have Learned Over Decades of Research - Bouchard - 2021 Obesity - @WileyOnline https://t.co/GFcZltdYBI

Jan 2, 2022 · 6 likes · 1 share · 4,188 followers View post →
Rafael Radaeli
@rfradaeli · X

RT @NeilFlochMD: #Genetics of #Obesity: What We Have Learned Over Decades of Research - Bouchard - 2021 - Obesity - Wiley Online Library ht…

Jan 1, 2022 · 1 share · 383 followers View post →
Neil Floch MD
@NeilFlochMD · X

#Genetics of #Obesity: What We Have Learned Over Decades of Research - Bouchard - 2021 - Obesity - Wiley Online Library https://t.co/d12af6iPCZ

Jan 1, 2022 · 2 likes · 1 share · 130,125 followers View post →
Jens Lund
@jens_lund · X

RT @EASOobesity: Great review piece on the Genetics of #Obesity: What We Have Learned Over Decades of Research? Bouchard @WileyOnline htt…

Dec 31, 2021 · 1 share · 2,093 followers View post →
EASO
@EASOobesity · X

Great review piece on the Genetics of #Obesity: What We Have Learned Over Decades of Research? Bouchard @WileyOnline https://t.co/pgDwrvHGFQ

Dec 31, 2021 · 8 likes · 1 share · 18,902 followers View post →
Solin L.R.
@SolinLujanRuz · X

Genetics of Obesity: What We Have Learned Over Decades of Research - Bouchard - 2021 - Obesity - Wiley Online Library https://t.co/S4fnEQmQhD

Sep 15, 2021 · 209 followers View post →
Solin L.R.
@SolinLujanRuz · X

RT @SolinLujanRuz: GENÉTICA DE LA OBESIDAD: ¿QUÉ HEMOS APRENDIDO EN DÉCADAS DE INVESTIGACIÓN? https://t.co/S4fnEQmQhD

Aug 15, 2021 · 1 share · 209 followers View post →
Solin L.R.
@SolinLujanRuz · X

GENÉTICA DE LA OBESIDAD: ¿QUÉ HEMOS APRENDIDO EN DÉCADAS DE INVESTIGACIÓN? https://t.co/S4fnEQmQhD

May 21, 2021 · 1 share · 209 followers View post →
Andre Bezerra
@andrebez · X

Genetics of Obesity: What We Have Learned Over Decades of Research https://t.co/Lgy1gnxBu0

May 9, 2021 · 3,189 followers View post →
R Giovanni Diaz-Zavala
@DrGiovanniD · X

RT @DrGiovanniD: Update por el experto en genética de la obesidad. https://t.co/rKIgIvWzfw https://t.co/1Qa6EijAv7

May 7, 2021 · 12 shares · 16,002 followers View post →
Paco Camarelles
@pcamarelles · X

RT @JulioBasulto_DN: El componente genético de la obesidad representa del 40% al 50% de la variabilidad en el peso, pero es menor en person…

May 7, 2021 · 14 shares · 2,389 followers View post →
Especialistas en Salud Ocupacional
@AlexLeonFon · X

RT @JulioBasulto_DN: El componente genético de la obesidad representa del 40% al 50% de la variabilidad en el peso, pero es menor en person…

May 7, 2021 · 14 shares · 458 followers View post →
Eduardo Siquier Cortés
@Goyathlay1980 · X

RT @JulioBasulto_DN: El componente genético de la obesidad representa del 40% al 50% de la variabilidad en el peso, pero es menor en person…

May 7, 2021 · 14 shares · 3,013 followers View post →
Miguel
@miguelbc5 · X

RT @JulioBasulto_DN: El componente genético de la obesidad representa del 40% al 50% de la variabilidad en el peso, pero es menor en person…

May 7, 2021 · 14 shares · 200 followers View post →
Alberto
@YoungKhalifaHS · X

RT @JulioBasulto_DN: El componente genético de la obesidad representa del 40% al 50% de la variabilidad en el peso, pero es menor en person…

May 7, 2021 · 14 shares · 291 followers View post →
Fulaneous
@adhocjesus · X

RT @JulioBasulto_DN: El componente genético de la obesidad representa del 40% al 50% de la variabilidad en el peso, pero es menor en person…

May 7, 2021 · 14 shares · 300 followers View post →
María Jessica
@MaraJessica3 · X

RT @JulioBasulto_DN: El componente genético de la obesidad representa del 40% al 50% de la variabilidad en el peso, pero es menor en person…

May 7, 2021 · 14 shares · 473 followers View post →
Anna
@cor_psich · X

RT @JulioBasulto_DN: El componente genético de la obesidad representa del 40% al 50% de la variabilidad en el peso, pero es menor en person…

May 7, 2021 · 14 shares · 57 followers View post →
Despertar
@etqe · X

RT @JulioBasulto_DN: El componente genético de la obesidad representa del 40% al 50% de la variabilidad en el peso, pero es menor en person…

May 7, 2021 · 14 shares · 1,175 followers View post →
TNT(r)
@TNT_reload · X

RT @JulioBasulto_DN: El componente genético de la obesidad representa del 40% al 50% de la variabilidad en el peso, pero es menor en person…

May 7, 2021 · 14 shares · 286 followers View post →
JulioBasulto_DN
@JulioBasulto_DN · X

El componente genético de la obesidad representa del 40% al 50% de la variabilidad en el peso, pero es menor en personas con normopesol (~30%) y mucho mayor en personas con obesidad (60% -80%). https://t.co/D0VW0tEJXn Bouchard C. Obesity (Silver Spring). 2021 May;29(5):802-820.

May 7, 2021 · 17 likes · 14 shares · 96,218 followers View post →
Alan GH
@AlanGH26 · X

RT @DrGiovanniD: Update por el experto en genética de la obesidad. https://t.co/rKIgIvWzfw https://t.co/1Qa6EijAv7

May 5, 2021 · 12 shares · 127 followers View post →
AraceliC
@chelycal1 · X

RT @DrGiovanniD: Update por el experto en genética de la obesidad. https://t.co/rKIgIvWzfw https://t.co/1Qa6EijAv7

May 4, 2021 · 12 shares · 56 followers View post →
Viridiana Facundo Ávila
@ViridianaFacun1 · X

RT @DrGiovanniD: Update por el experto en genética de la obesidad. https://t.co/rKIgIvWzfw https://t.co/1Qa6EijAv7

May 4, 2021 · 12 shares · 71 followers View post →
M. Espinoza Montejo
@Mayespinozam · X

RT @DrGiovanniD: Update por el experto en genética de la obesidad. https://t.co/rKIgIvWzfw https://t.co/1Qa6EijAv7

May 4, 2021 · 12 shares · 73 followers View post →
Raúl Contreras Omaña MD
@hepatologo_RCO · X

RT @DrGiovanniD: Update por el experto en genética de la obesidad. https://t.co/rKIgIvWzfw https://t.co/1Qa6EijAv7

May 4, 2021 · 12 shares · 12,069 followers View post →
Lic. Miguel Vega
@MiguelVL151292 · X

RT @DrGiovanniD: Update por el experto en genética de la obesidad. https://t.co/rKIgIvWzfw https://t.co/1Qa6EijAv7

May 4, 2021 · 12 shares · 47 followers View post →
Alfredo Granados T
@gt_alfredo · X

RT @DrGiovanniD: Update por el experto en genética de la obesidad. https://t.co/rKIgIvWzfw https://t.co/1Qa6EijAv7

May 4, 2021 · 12 shares · 902 followers View post →
Fundación Iberoamericana de Nutrición
@FinutOrg · X

RT @DrGiovanniD: Update por el experto en genética de la obesidad. https://t.co/rKIgIvWzfw https://t.co/1Qa6EijAv7

May 4, 2021 · 12 shares · 4,046 followers View post →
R Giovanni Diaz-Zavala
@DrGiovanniD · X

Update por el experto en genética de la obesidad. https://t.co/rKIgIvWzfw https://t.co/1Qa6EijAv7

May 4, 2021 · 61 likes · 12 shares · 16,002 followers View post →
Dr Ellen Fallows
@ellenfallows · X

“The obesity genetic risk is conditioned by 100’s of DNA variants that make genetically based obesity prevention and treatment a major challenge”. https://t.co/oznQSXKIwK

May 4, 2021 · 1,904 followers View post →
Neil Floch MD
@NeilFlochMD · X

#Genetics of #Obesity: What We Have Learned Over Decades of Research ⁦@ObesitySociety⁩ https://t.co/1ualURoNuW

May 4, 2021 · 5 likes · 130,125 followers View post →
Matthew Lambert
@Matt_Nutrition · X

An excellent review of the role of genes in obesity: 'Genetics of Obesity: What We Have Learned Over Decades of Research' https://t.co/y0IPkWN81P #Genetics #obesity

May 4, 2021 · 1 like · 371 followers View post →
Nutrition@Roehampton
@NutritionRoe · X

Claude Bouchard on the Genetics of Obesity: What We Have Learned Over Decades of Research https://t.co/FSIhkCVOiS

May 4, 2021 · 5 likes · 1,631 followers View post →
Carina Alm
@CarinaAlm · X

The #obesity genetic risk is determined by hundreds and thousands of DNA variants, a fact that makes genetically based obesity #prevention and treatment a major challenge. https://t.co/rz6JGKS4yr

May 3, 2021 · 1,982 followers View post →
Bhopender Thakur
@TheBhupiThakur · X

RT @libkey_io: @nick_krontiris Help your colleagues avoid a paywall by accessing the article from their libraries: https://t.co/pXrqKZqIFK…

Apr 29, 2021 · 1 share · 1,369 followers View post →
Bhopender Thakur
@TheBhupiThakur · X

RT @nick_krontiris: Genetics of Obesity: What We Have Learned Over Decades of Research (open access) https://t.co/KspykXH02C #Obesity

Apr 29, 2021 · 3 shares · 1,369 followers View post →
Vitas Gerulaitis
@VGerulaitis · X

RT @nick_krontiris: Genetics of Obesity: What We Have Learned Over Decades of Research (open access) https://t.co/KspykXH02C #Obesity

Apr 29, 2021 · 3 shares · 153 followers View post →
LibKey
@libkey_io · X

@nick_krontiris Help your colleagues avoid a paywall by accessing the article from their libraries: https://t.co/pXrqKZqIFK Simply add https://t.co/SXSePSX5De in front of any DOI when sharing articles on Twitter and everywhere else!

Apr 29, 2021 · 1 like · 1 share · 555 followers View post →
Nick Krontiris
@nick_krontiris · X

Genetics of Obesity: What We Have Learned Over Decades of Research (open access) https://t.co/KspykXH02C #Obesity

Apr 29, 2021 · 4 likes · 3 shares · 19,254 followers View post →
Mike Murray
@MikeMurrayRD · X

Genetics of Obesity: What We Have Learned Over Decades of Research https://t.co/FiZCwUoTIx

Apr 27, 2021 · 1 like · 185 followers View post →