Glycolysis.

Push Day powered by glycolysis, the Krebs cycle, and oxidative phosphorylation

High-dose progesterone (100 mg/kg/day) reduces glioblastoma growth by ~47% and increases survival by ~43%. - decreases GLUT-1, inhibiting glycolysis - lowers lactate - reduces oxidative stress - induces cellular senescence rather than directly killing cells https://t.co/Me8ZP2dD3A

glycolysis, they switched to oxidative phosphorylation and fatty acid metabolism- an energy strategy that enables them to endure the long term. When researchers boosted these channels of energy in mice, the T-cells killed tumor cells better and produced higher levels of interferon-γ, an immune

Dylan's study is now out in @jacs.acspublications.org! Key new experiments by Yuan-Ting Cho support a model for why a rare three-tailed lipid, NAPE, might accumulate during stroke & heart attack: as a protective response to promote lactate export as cells shift to glycolysis doi.org/10.1021/jacs...

Biochemistry, aerobic glycolysis, and baking. Next up… some quaffing of liquid produced by anaerobic glycolysis.

SARS-CoV-2 disables MAVS signaling and OXPHOS, triggering a bioenergetic collapse that forces cells into inefficient glycolysis. This mitochondrial failure may underlie ME/CFS-like symptoms seen in many with Post-Acute Sequelae of COVID-19 (PASC). gemini.google.com/share/e0aac9...

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Fly_Boy

@dpgrenon · X

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Noticer Noticing

@Noticer42069 · X

That’s not bioenergetics Bioenergetics is the science of how we biologically create energy via various mechanisms like the ATP+PC, Fat oxidation, and glycolysis Women are retarded and like to use catchy words to explain their “vibes” based way of operating https://t.co/OuBmDzKn2U

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Evan Kalis

@evan_kalis · X

@SamaHoole They rarely perform oxphos and instead do glycolysis. This increases lactate and promotes angiogenesis. Metabolically healthy cells almost always perform oxphos at rest. Its really a false equivalence here

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D40

@EOOHFG · X

@IkNet https://t.co/55OF9Zmpng p53 influences glucose flux by regulating PGM, GLUT1, GLUT4, and TIGAR expression. The p53 protein induces the transcription of the TIGAR gene, which lowers the intracellular concentrations of fructose-2,6-bisphosphate and thus decreases glycolysis...

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Hao Yin

@HaoYin20 · X

RT @HaoYin20: #Hypertension Renin cell, a specialized Smooth Muscle-like cell at juxtaglomerular tips of the afferent arterioles, drives t…

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Robert J. Warmolts

@warmone1too · X

Glycolysis | What you NEED to know for the MCAT https://t.co/MYUYe9gQyb via @YouTube ~ See How Glucose is Converted to Pyruvate for Krebs Energy Production by Devine Design? https://t.co/ErpgCZK241

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grabendazole ❤️

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RT @adrenocholine: 10 steps of Glycolysis was my Madame Morrible moment

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GLASS_PhD

@joybeingfree99 · X

RT @HaoYin20: #Hypertension Renin cell, a specialized Smooth Muscle-like cell at juxtaglomerular tips of the afferent arterioles, drives t…

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Repeal OCare u gummy bear spine Rs

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Elisa Haas, MD

@ElisaAHaas · X

RT @HaoYin20: #Hypertension Renin cell, a specialized Smooth Muscle-like cell at juxtaglomerular tips of the afferent arterioles, drives t…

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Alejandro García Núñez

@AleGarNu81 · X

RT @HaoYin20: #Hypertension Renin cell, a specialized Smooth Muscle-like cell at juxtaglomerular tips of the afferent arterioles, drives t…

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Hatton, America is back

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Heralding Angel

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SawyersGhost

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Tom_Space

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scoobydoooo_fRPh

@mekma_lee · X

RT @adrenocholine: Here’s the one I made for glycolysis. (for Krebs Cycle and ETC I can’t share coz I just borrowed the mnemonics for them)…

#Hypertension Renin cell, a specialized Smooth Muscle-like cell at juxtaglomerular tips of afferent arterioles⏩ Concentric arteriolar hypertrophy upon #ReninAngiotensinSystem defects (Captopril or Ren KO) Hypoxia⬆️ Glycolysis⬆️ NAD+ salvage⬇️ bioRxiv 2025 www.biorxiv.org/content/10.1...

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Hao Yin

@HaoYin20 · X

#Hypertension Renin cell, a specialized Smooth Muscle-like cell at juxtaglomerular tips of the afferent arterioles, drives the concentric arteriolar hypertrophy in renovascular modeling in #ReninAngiotensinSystem deficiency (by #Captopril or Ren KO) Hypoxia⬆️ Glycolysis⬆️ NAD+ https://t.co/Ui9b7DME9k

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Ersin

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Kelvin

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RT @hormonedietdoc: Fat Adapted means you have corrected a flaw in your metabolism. The preferred source of energy in the human body is fat…

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adrenaline, fRPh tn

@andengfrph · X

RT @adrenocholine: 10 steps of Glycolysis was my Madame Morrible moment

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Plant Science Research

@PlantSciRes · X

#TropicalPlants Ethephon alters rubber tree latex phosphoproteome—activates glycolysis/ROS scavenging to boost NR yield. @MaximumAcademic #RubberTree #Phosphoproteomics @MPlantPCom Details: https://t.co/KFRzqil2uY https://t.co/EcSjtONjj6

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Magic Bullet

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TGIF...

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2.. Study Buddy AI breaks down confusing topics without stress. Perfect for long notes, complex diagrams, or when your brain clocks out. (Example: “Explain glycolysis like I’m 15.”)

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alwacee

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Yup I'm Joey

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Kate, RPh

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khris, fRPh

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Nancymarked@ covid safe

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RT @atranscendedman: Platelets from Long COVID patients shift from mitochondrial respiration to glycolysis for energy, showing signs of mit…

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Ester Truvela

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Elaine Daws

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RT @DrMLernerMDPhD: Ivermectin and mebendazile both target mitochondria Energy production through glycolysis and phosphorylation in cancer…

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Elaine Daws

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Time 2 Get Real

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Tony Curtright

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cryptogon

@cryptogon · X

https://t.co/wQxiCEAkTf Nutritional Ketosis and Anti-Parasite Medications as Cancer Therapy 22:54 re: Start of "Other agents." "It targets the mitochondrial substrate and glycolysis. So we have a mechanism now why parasite medications are working... Parasites and

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Susie ELECTION INTEGRITY NOW

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correiajoao

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RWB_American

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GnosisWolf

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PatriotMrsJoshua*

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No Fear

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HelloKarma 2026 #KarmaHasNoDeadline #VictimsRights

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Phx Ken

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Patrick

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❤️‍

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Martin Frey

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I DEMAND FREEDOM

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Grok

@grok · X

@anonfrenamus @Humanspective Normal cells primarily use efficient oxidative phosphorylation in healthy mitochondria for energy, while cancer cells often have dysfunctional mitochondria and rely on glycolysis and substrate-level phosphorylation—similar to parasites. Drugs like fenbendazole target these

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Grok

@grok · X

@RajeshK09491571 @Humanspective The post accurately quotes Prof. Seyfried from the video. Research (e.g., his 2023 paper) shows mebendazole targets cancer's mitochondrial ATP production and glycolysis, akin to parasites. Fenbendazole has similar preclinical anticancer effects. Ivermectin's mechanism involves

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mr49ers

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in the dark newz

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David Windt

@DavidLWindt · X

RT @DavidLWindt: @drcole12 @BretWeinstein @thedarkhorsepod Dr. Thomas Seyfried: "we have a mechanism now why parasite medications are worki…

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Be Still and Know

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thedepldrgn

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J∅kër Kîng

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Mscapt.

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TheRealCherokeeOwl

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Anne, Unofficial Baroness of Glacier of Farnham

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Matt Bies

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soup6.7 (Scrappy)

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FeraleRIGHTDawg - 1776!

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DKH013

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Ann David

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Alverstoke Gram

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gela, fRPh

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RT @adrenocholine: 10 steps of Glycolysis was my Madame Morrible moment

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Oregon Patriot

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gaia, RMT

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Boutique 24

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Tony Lane

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Angela_fRPH♏

@Angelergic · X

RT @adrenocholine: Here’s the one I made for glycolysis. (for Krebs Cycle and ETC I can’t share coz I just borrowed the mnemonics for them)…

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Angela_fRPH♏

@Angelergic · X

RT @adrenocholine: 10 steps of Glycolysis was my Madame Morrible moment

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blinders off

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Lisa Colley

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pharmeowcy

@RicheJane5 · X

RT @adrenocholine: 10 steps of Glycolysis was my Madame Morrible moment

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Success

@Success2664 · X

RT @Success2664: @Blqck_jr @Indemosyd Describe the full process of cellular respiration from glycolysis to the electron transport chain, in…

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Success

@Success2664 · X

@Blqck_jr @Indemosyd Describe the full process of cellular respiration from glycolysis to the electron transport chain, including how many ATP molecules are produced at each stage. Don’t cheat ooo

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Grok

@grok · X

@BayernPerson @AntoineRichard Prof. Thomas Seyfried has indeed described this mechanism in recent interviews, explaining that mebendazole and fenbendazole target the same defective metabolic pathways (like disrupted mitochondrial phosphorylation and glycolysis) used by both parasites and cancer cells. His lab

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Ashri

@AshriAshrifrph · X

RT @adrenocholine: 10 steps of Glycolysis was my Madame Morrible moment

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Success

@Success2664 · X

RT @Success2664: @An_Dy9090 @Indemosyd Describe how ATP is produced during cellular respiration, including glycolysis, the Krebs cycle, and…

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Success

@Success2664 · X

@An_Dy9090 @Indemosyd Describe how ATP is produced during cellular respiration, including glycolysis, the Krebs cycle, and the electron transport chain. Answer this without cheating!! Don’t use AI or google just answer off head!!!

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lax007

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I'm

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parseo

@obytsf843 · X

RT @DrJackKruse: Half truth. The Warburg effect, named after Otto Warburg, refers to the observation that cancer cells preferentially re…

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louisedbegin

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Gary M

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Janet Artman

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Teemama

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KatieJ

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Grok

@grok · X

@solargrok @Humanspective Preclinical studies suggest mebendazole/fenbendazole can disrupt cancer cell metabolism (e.g., glycolysis) and inhibit angiogenesis, potentially reducing nutrient/blood supply to tumors. Ivermectin may then promote cell death via apoptosis and mitochondrial pathways. However,

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Bobbi

@kittenaround_51 · X

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Enhanced glycolysis and nicotinamide metabolism in HPV-positive head and neck cancer #SciRep #MassSpec www.nature.com/articles/s41...

New study shows agrimoniin may treat #HepatopulmonarySyndrome by activating #PGC1α to inhibit #Glycolysis and #Angiogenesis, pointing to a promising therapeutic strategy. #medsky #OpenAccess: www.sciencedirect.com/science/arti...

‘…defect of oxidative metabolism with a resultant acceleration of glycolysis in the working skeletal muscles of CFS patients. This metabolic defect may contribute to the reduced physical endurance of CFS patients. Its etiology is unknown.’

to determine a potential treatment option heretofore unavailable to those with aberrant pain disorders, www.sciencedirect.com/science/arti... www.sciencedirect.com/science/arti... journals.lww.com/painrpts/ful... www.sciencedirect.com/science/arti...

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what do you MEAN my team got Pokerus and i haven't even phased on Geodude yet ft my wonderful son glycolysis

Glycolysis inhibition functionally reprograms T follicular helper cells and reverses lupus @cp-cellreports.bsky.social www.cell.com/cell-reports...

Glycolysis inhibition functionally reprograms T follicular helper cells and reverses lupus Congrats to Laurence Morel and team! www.cell.com/cell-reports...

Fructose intake driven glycolysis-ROS-EGFR axis specifically promotes the generation and pathogenicity of Th17 cells @natcomms.nature.com www.nature.com/articles/s41...

## Enhanced Flux Balancing Optimization via Multi-Modal Data Integration and HyperScore Evaluation in Glycolysis **Abstract:** This research introduces a novel framework leveraging multi-modal data integration and a HyperScore evaluation system to optimize metabolic flux balancing within…

www.frontiersin.org/journals/cel... Review: "The Tumor Suppressor Kinase LKB1: Metabolic Nexus" LKB1 loss is associated with multiple malignancies and causes metabolic reprograming to increase glycolysis and lactate production, elevate hexosamine biosynthesis and glutamine metabolism.

Glycolysis + TCA (citric acid cycle) meets M&Ms demo - remember things double! YouTube: youtu.be/N7uCVpR8j6c When thinking about glucose oxidation, don't forget things split in 2 and then you've got to count everything twice once they do!

Realgar‐Induced CNS Toxicity: Exploring OTC‐Mediated Ornithine Regulation of ZBTB7A Inhibits Astrocyte Glycolysis Based on the Liver–Brain Axis

4️⃣ Hierarchical organization FOCA revealed a clear architecture: • Primary systems → mainly positive coupling • Higher-order systems → mainly negative coupling These patterns are strongly predicted by aerobic glycolysis. (7/12)

Creatine kinase B regulates glycolysis and de novo lipogenesis pathways to control lipid accumulation during adipogenesis

HDLBP Promotes Glycolysis and CD8+ T Cell Exhaustion in Lung Adenocarcinoma by Stabilizing GJB2 RNA @atscommunity.bsky.social #medsky

im gonna ask them to talk about the glycolysis situation so i can hit two birds with one stone and pretend like watching the podcast is biochem midterm studying and also phorture my faves over wtf a glycolysis or its situation is

A quick walk through glycolysis YouTube: youtu.be/vs7wtESXxxw For a longer stroll: youtu.be/trasn7OtJNc

- Metabolic stress was observed with the upregulation of glycolysis and gluconeogenesis pathways, indicative of mitochondrial stress. • Sex-stratified analysis reveals distinct molecular responses, underscoring the importance of sex in ME/CFS pathophysiology.

Mice carrying the T61I mutation in the mitochondrial protein CHCHD2 present whole-body metabolic shift toward glycolysis,⬆️mitochondrial reactive oxygen species (ROS), & progressive accumulation of aggregated α-synuclein - new model of #Parkinsons? www.science.org/doi/10.1126/...

With transcriptomic and functional data, @lucamasin.bsky.social et al. @labmoons.bsky.social show that local glycolysis supports injury-induced axonal regeneration. rupress.org/jcb/article/...

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I want to make coloring books of the reactions of glycolysis to help students memorize them (like they do in med school for the bones and muscles). I want to celebrate the accomplishments of women in my local biophysical community.

This review highlights recent advances in #EnergyMetabolism, detailing key pathways like #glycolysis, #OXPHOS, and #FAO, their dysregulation in diseases, and emerging strategies for precision treatment. #multiomics #CRISPR #medsky #OpenAccess in #STTT: doi.org/10.1038/s413...

Even though all life shares the same carbon metabolism, gluconeogenic enzymes are more conserved in archaea and bacteria than glycolytic enzymes. Read in #FEMSmicroBlog why the metabolic pathway of glycolysis likely arose from gluconeogenesis in autotrophs. #FascinatingMicrobes

Glycolysis sustains STAT1 activity via STAT1 O-glycosylation, which is essential for human Th1 cell differentiation and IFNgamma production by maintaining STAT1 S727 phosphorylation. @mielenzlab.bsky.social www.life-science-alliance.org/content/9/1/...

#NewResearch Streptococcus thermophilus phages circumvent host CRISPR defences via AcrIIIA2, which complexes with enolase, a highly abundant glycolysis enzyme, to block phage RNA binding #MicroSky #CRISPR

Pathogenic dengue virus TW2015 strain infection triggers anaerobic glycolysis and enhances mortality in diabetic mice journals.asm.org/doi/10.1128/...

Spatial Partitioning of Core Glycolysis Enables Tissue-Specific Metabolic Programs In Vivo https://www.biorxiv.org/content/10.1101/2025.11.09.687253v1

Spatial Partitioning of Core Glycolysis Enables Tissue-Specific Metabolic Programs In Vivo https://www.biorxiv.org/content/10.1101/2025.11.09.687253v1

Panax notoginseng saponin mitigates glycolysis to regulate macrophage polarization and sphingolipid metabolism via hypoxia-inducible factor-1 to alleviate atherosclerosis #Phytomed #MassSpec www.sciencedirect.com/science/arti...

High TIGIT expression suppresses HIF-1α expression by inhibiting the PI3K/AKT/ mTORC1 or ERK signaling pathway, thereby impairing glycolysis and ultimately reducing NK cell migration www.nature.com/articles/s41...

If you've got glucose, you've got options! Glycolysis tends to get all the spotlight, but that's just one way to go! (At least until you reach a one-way arrow!) More on metabolism: bit.ly/metabolismgl... & bit.ly/bbmetabolism

These findings suggest that the P4HA2/PFKP axis is a crucial regulator of glycolysis in thyroid cancer, making P4HA2 a promising therapeutic target.

✨ In this week's DB unit seminar @embl.org, Hidenobu Miyazawa, a postdoc in the Aulehla group, shared insights on the role of glycolysis in mouse embryo axis segmentation #DevelopmentalBiology #Glycolysis #MouseEmbryos

7/8: more important than quantity (eg generalists consuming rare fruits per glycolysis pathway, coadapted instead for plant specialist beetles). Encroachment on delicate ecosystems, logging, pollution may be more direct magnitude.

glycolysis, they switched to oxidative phosphorylation and fatty acid metabolism- an energy strategy that enables them to endure the long term. When researchers boosted these channels of energy in mice, the T-cells killed tumor cells better and produced higher levels of interferon-γ, an immune

@chemrxiv.org you can find work on Lewis base/oxirane combinations acting as a catalytic system in the glycolysis of poly(ethylene terephthalate) and the ring-opening polymerization of ε-caprolactone doi.org/10.26434/che...

#ENO1 directly affects lactate homeostasis & intracellular ATP pools, by regulating glycolysis via the ENO1-ATP/lactate-AMPK/PI3K/AKT-mTOR axis, ultimately promoting stem-like characteristics, EMT and #GastricCancer progression. #STTT #OpenAccess: doi.org/10.1038/s413...

m6A demethylase FTO drives pancreatic ductal adenocarcinoma tumorigenesis and metastasis through remodeling PFKM mediated glycolysis #PancreaticCancer www.nature.com/articles/s41...

2. High-diversity microbiomes elicited a stronger host transcriptional response, while low-diversity microbiomes triggered epithelial restructuring & glycolysis – a stress response that characterizes several chronic inflammatory diseases.

Using in vitro stimulation & CRISPR/Cas9-mediated gene editing, Abir et al. found that Th1 cell identity is anchored in glycolysis by fostering STAT1 O-glycosylation, STAT1 Ser727 phosphorylation & Th1 cell effector capacity. @mielenzlab.bsky.social www.life-science-alliance.org/content/9/1/...

HC3H503 Carbs to pyruvate you see Oxidation helped by me Glycolysis energy HC3H503 Carbs to pyruvate you see Oxidation helped by me Glycolysis energy HC3H5O3 Lactic acid, yay, yippie! HC3H5O3 Lactic acid, yay, yippie! (in this song, the concept of lactic acid has a crush on you I guess)

Introducing 2025 Glenn Foundation for Medical Research Grants for Junior Faculty recipient Lina Marcela Carmona, PhD, of @umasschan.bsky.social, who will research “The Role of Neuronal Glycolysis in the Aging Motor Circuit.” Learn more here: www.afar.org/grantee-prof...

For the #cancermetabolism folks, the Warburg effect, or aerobic glycolysis, is precisely what occurs in mitochondrial disease cells too - compensatory glycolytic flux to accommodate failures of oxidative phosphorylation in terms of redox/energetics... but that's a discussion for another day

Presenting my poster at the 15th #Markesbery symposium organized by the Sanders-Brown Center on Aging and Alzheimer's Disease Research Center, UKy. I decided to wearing my own poster themed on #glycolysis, one of the most prolific #metabolic pathways in the #brain. @bauerhartzlab.bsky.social

#PaperoftheDay: "Comprehensive multi-omics analysis reveals a combination of lncRNAs that synergistically regulate glycolysis and immunotherapeutic effects in renal clear cell carcinoma" DOI ⬇️ doi.org/10.18632/aging.206069 #aging #research #oa #peerreview #journal #publishing

Glycolysis-compatible urethanases for polyurethane recycling

A trait syndrome ties cell morphology to glycolysis across the yeast subphylum https://www.biorxiv.org/content/10.1101/2025.10.27.684252v1

A trait syndrome ties cell morphology to glycolysis across the yeast subphylum https://www.biorxiv.org/content/10.1101/2025.10.27.684252v1

6/7 Conclusion: Chromatin composition integrates with metabolic regulation at the NAD⁺ interface. Loss of macroH2A1.1 decouples chromatin–mitochondrial crosstalk, shifting nutrient flux toward glycolysis and instigating secondary organ dysfunction.

Check how this study demonstrates that SYT7 functions as an oncoprotein in NPC, driving tumor progression through its regulation of ALDH1A3-mediated glycolysis and STAT3 signaling pathways, revealing its potential as a biomarker for the prediction and treatment of NPC.

Relatively straightforward methodologically, to see what happens with synapses and excitability (we tried similar with BHB); E4 neurons have impaired OXPHOS and are shifted towards glycolysis, so the end result would be super cool to look at. One potential confounder is glycogen in neurons though.

Push Day powered by glycolysis, the Krebs cycle, and oxidative phosphorylation

The early evolution of the glycolytic pathway from autotrophic origins to glycogen and back #microbiology #biochemistry #evolution #Glycolysis @femsmicro.org @femsjournals.bsky.social academic.oup.com/femsre/artic...

Energy dissipation via the glycerol phosphate shuttle: coupling glycolysis to mitochondrial thermogenesis in Drosophila melanogaster flight muscle https://www.biorxiv.org/content/10.1101/2025.10.24.684441v1

Energy dissipation via the glycerol phosphate shuttle: coupling glycolysis to mitochondrial thermogenesis in Drosophila melanogaster flight muscle https://www.biorxiv.org/content/10.1101/2025.10.24.684441v1

Proposed contributors to Long COVID include persistent viral infection latent virus reactivation, immune dysregulation autoimmunity gut microbiota alterations mitochondrial dysfunction endothelial injury and coagulation abnormalities www.tandfonline.com/doi/full/10....

Elevated SLC25A26 levels disrupt mitochondrial function, suppressing glycolysis, oxidative phosphorylation, and ATP production.

A study from the University of Rochester’s Wilmot Cancer Institute links taurine, a common energy drink ingredient, to increased leukemia growth by fueling cancer cells through glycolysis.

fun fact: L-glucose, the enantiomer of common D-glucose, tastes identical but can't be metabolized by glycolysis. this in theory makes it a perfect low-calorie sugar substitute — but without an abundant route for biosynthesis it's not cost-effective to manufacture. en.wikipedia.org/wiki/L-Gluco...

Coastal & offshore genera specialized on different carbon sources. Offshore genera uniquely shared metabolisms that did not rely on glycolysis, while coastal genera uniquely shared metabolisms that did. This hints at fine-scale niche partitioning along the sugar-acid spectrum within SAR11.

Mechanistically, VEN modulates the glycolysis pathway in T cells, providing a new perspective on how targeted drugs can promote tumor cell death through immune-dependent mechanisms. These findings offer valuable insights for improving immunotherapeutic strategies in AML.

Discover how a BCL-2 inhibitor boosts T cell function and antitumor immunity in acute myeloid leukemia by influencing their glycolysis - a novel immune-dependent mechanism for targeted ca...

The glycolysis process turns glucose into energy (ATP). Aerobic respiration uses oxygen for this, very efficient, one glucose gives you 30-38 ATP. At higher heart rates there is not enough oxygen. Anerobic respiration starts, much less efficient glycolysis process, one glucose gives just 2 ATP.

we propose that Schizophrenia may involve a fundamental energetic dysregulation. Evidence suggests that mitochondrial impairment in this condition may drive a shift from ATP-efficient OxPhos to less efficient glycolysis, accompanied by a decline in the NAD+/NADH ratio & emergence of reductive stress

"Brain stimulation causes transient uncoupling between them, which indicates the utilization of glucose through aerobic glycolysis" → Many ME studies find problems specifically with aerobic metabolism - and with ME comes a raft of neurological problems...

Need a visual to explain glycolysis? Us too. UniVirtual students watch high-quality 3D animations as part of their #Biology labs. In this one, they see how glucose is broken down, where energy comes from, then use what they’ve seen to put the process in motion themselves!

22.

FOXK2:p (forkhead box family K, member 2) is commonly discussed with respect to its similarity of to yesterday's FOXK1:p and assumed to be part of switching on the synthesis of proteins needed for aerobic glycolysis. Its pS acceptor occupation pattern is not identical, though. #proteomics

FOXK2:p (forkhead box family K, member 2) is commonly discussed with respect to its similarity of to yesterday's FOXK1:p and assumed to be part of switching on the synthesis of proteins needed for aerobic glycolysis. Its pS acceptor occupation pattern is not identical, though. #proteomics

international baccalaureate biologist. Who studied evolutionary biology for years... Diabetes is all fuckn phosphates man. They break down sugar in Entner Deouderov glycolysis.... Look at all those Phosphates breaking down sugar and lowers blood sugar man. Vitamins with phosphates B2, B6, B7, B12

Got an A- on my cell biology exam on what my professor said would be the hardest exam of the semester! It was about glycolysis, krebs cycle, cellular respiration, and photosynthesis. Which if you have learned about all that, you know how much memorization that is xD Super happy!

Meaning of #atpbiologia See ATP, biology, medical/adsorptive%C3%B3n, mitochondrial, glycolysis, adenosine triphosphate. .. atp biologia

#DBfeature

Geniposide Reduces Kidney Fibrosis via STAT3-Glycolysis Pathway In a groundbreaking study poised to disrupt our understanding of kidney health, researchers have unveiled the potent effects of geniposide, a natural compound extracted from the fruit of the gardenia plant. This study, set to be…

…and goes along with increased mitochondrial activity and a switch from glycolysis to oxidative mitochondrial metabolism, leading to a boost in ATP production that renders cancer cells resilient to diverse stresses.

Seen on the white board in the fellows room. And I didn’t draw it.

⏳ What shifts with pT stage? Early lesions show high proliferation and fatty acid oxidation capacity. Later, glycolysis rises, stroma and vasculature reorganize, and lymphocytes give way to myeloid cells. Spatial architecture predicts stage better than composition or metabolic state. 2/5

#ArticleinPress: Decreased Glycolysis due to LDHA m6A methylation in Endometrium of endometriosis impairs its decidualization and contributes to related infertility Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00359-1/fulltext

i want to play stupid video games why the fuck do i need to know what a glycolysis and a krebs cycle and an nadh is

i want to play stupid video games why the fuck do i need to know what a glycolysis and a krebs cycle and an nadh is

Atg16l1 promotes lung transplant tolerance by regulating glycolysis in macrophages https://www.biorxiv.org/content/10.1101/2025.10.02.679826v1

Atg16l1 promotes lung transplant tolerance by regulating glycolysis in macrophages https://www.biorxiv.org/content/10.1101/2025.10.02.679826v1

#WeekendRead! #ImmunometabolismPower! Formiga, Sokol &co show @cp-cellhostmicrobe.bsky.social that #microbiota derived cadaverine

!!! I’m reading _training for the uphill athlete_ and they just said this!!! P40-41 High intensity -> glycolysis/anaerobic metabolism -> pyruvate/lactate Moderate intensity -> aerobic metabolism _which can use pyruvate_ If the pyruvate doesn’t get used up, it turns into excess lactate & fatigue.

Signal or noise? > Demethoxycurcumin suppresses HK2-mediated glycolysis by targeting PTEN/Akt signaling - Nature >> Comment below! #strategy #competitiveintelligence #marketing #competitivemarketing #pharma #healthcare #biotech #pharmaceutical

www.cell.com/molecular-ce... "Furthermore, the selective induction of mitochondrial oxidative phosphorylation by unmetabolized D-lactate reversibly suppressed aerobic glycolysis in both cancer cell lines and proliferating primary cells in an ATP-dependent manner"

www.cell.com/molecular-ce... "Both L- and D-lactate are effective at enhancing ETC activity and suppressing glycolysis."

www.cell.com/molecular-ce... "The resulting increase in mitochondrial ATP synthesis suppresses glycolysis and increases the utilization of pyruvate and/or alternative respiratory substrates." "The ability of lactate to increase oxidative phosphorylation does not depend on its metabolism."

Lactate in skin homeostasis: metabolism, skin barrier, and immunomodulation #MECFS #LongCovid www.frontiersin.org/journals/imm...

What if you could step inside a cell to see glycolysis unfold? In UniVirtual, students collect glucose and trigger reactions that produce ATP, NADH, and pyruvate so they can power the next stage of cellular respiration. Watch the video: buff.ly/CBo45x6 #Biology #VirtualLabs #STEM

Hyperactivated Glycolysis Drives Spatially-Patterned Kupffer Cell Depletion in MASLD https://www.biorxiv.org/content/10.1101/2025.09.26.678483v1

Hyperactivated Glycolysis Drives Spatially-Patterned Kupffer Cell Depletion in MASLD https://www.biorxiv.org/content/10.1101/2025.09.26.678483v1

Did you know?

Refining PET-based response in extramedullary multiple myeloma using total lesion glycolysis https://www.newsbeep.com/152375/ Bhutani M, Foureau DM, Atrash S, Voorhees PM, Usmani SZ. Extramedullary multiple myeloma. Leukemia. 2020;34:1–20. Article  PubMed  Google…

Hexokinase 2 is an RNA-binding protein that regulates mRNA translation independently of glycolysis and induces melanoma cell proliferation @PLOSBiology.org

https://t.co/KE4FgbJLiZ Re: "The simplicity in nature's design, echoing Genesis, is fascinating. What drew you to linking these?" @Grok USAF training as a medical laboratory scientist. I presciently learned to link the miRNA-glycolysis axis at birth (cord blood analysis) to

This is not just metabolic. It’s also epigenetic. AMPK suppresses the co-activator PCAF, reducing histone acetylation on glycolysis genes while opening genes for OXPHOS.

The key checkpoint is the A2A receptor - AMPK pathway. AMPK acts as an energy sensor. When activated, it reprograms Th17 cells away from glycolysis and toward OXPHOS.

When Th17 cells rely on aerobic glycolysis, they become pathogenic. When they shift to oxidative phosphorylation (OXPHOS) in mitochondria, they stay non-pathogenic.

RT @ESC_iPSC_News: Researchers, including Dr. @HidenobuAnzo and Alexander Aulehla, demonstrate a modular organization of metabolic function…

RT @AIpubmed:

RT @djthomson: Glycolysis https://t.co/X7WyPqp6Tx

@CHOculturePaper This study uses targeted integration (RMCE) to engineer CHO cell lines expressing EPO and antiapoptotic genes (bcl-2/bcl-xL from CHO/human, mcl-1, bhrf-1). Tested under NaBu stress and fed-batch, CHO-origin bcl-2 boosted EPO productivity via enhanced glycolysis and pyruvate

3. Inside cells, glucose goes through *glycolysis* → broken into pyruvate → enters the mitochondria.

https://t.co/NsgnCGuN2S Re; "I respect integrating science and faith." Research (e.g., in PMC and Science) shows miRNAs evolved in eukaryotes, regulating gene expression, glycolysis, and DNA repair." @Grok You're a disrespectful bot! No experimental evidence from model organisms

https://t.co/t1EYaU322a

https://t.co/y71oeSolSM

RT @hellolily0: High-dose progesterone (100 mg/kg/day) reduces glioblastoma growth by ~47% and increases survival by ~43%. - decreases GL…

https://t.co/1PhirmAjDB

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@microRNApro I respect integrating science and faith. Research (e.g., in PMC and Science) shows miRNAs evolved in eukaryotes, regulating gene expression, glycolysis, and DNA repair, but not as a sole preventer of all viral damage or linked to life's origin via hydrogen in stars. Origin of

nonauthenticity glycolysis ▬كؤبؤن▬كود▬خصم▬ ⎐تُيموُ⎐ ⊵acs678251⊴

@microRNApro Thanks for sharing your model. I've verified the papers: the frailty genetics study (Aug 2025), HMGB1 senescence (Apr 2025), and miRNA in T1D therapies (2025) exist and discuss related biology. miRNA-glycolysis links appear in aging research, but biblical ties are interpretive.

RT @drmiketodorovic:

RT @ohhhhlok: Watch me study Krebs, Glycolysis, Gluconeogenesis, Glycogenesis, Glycogenolysis, Pentose Phosphate Pathway, Biosynthesis of F…

@Louisesmiles_ @333too3 No, this is a common myth. Dr. Otto Warburg won the 1931 Nobel Prize for discovering respiratory enzymes, not for proving cancer can't survive in alkaline environments. His work showed cancer cells use anaerobic glycolysis, creating acidity, but diet doesn't significantly alter

@microRNApro Thanks for the reference— the 2025 study on miRNAs for T1D therapies indeed links circulating miRNAs to glycolysis and virus-driven pathology, supporting energy-dependent axes in disease modification. On shadow banning, it's a valid concern; X aims for open discourse. Re: Charlie

@grok Re: "If shadow banning isn't an issue, great" @ Grok Shadow banning is the issue that links censorship on X to the assassination of Charlie Kirk. You got stuck promoting moronic theories for comparison to facts about the energy-dependent miRNA-glycolysis axis, "Leveraging

RT @ChrisJo00291974: @thehealthb0t Cancer cells ditch oxygen like it’s poison and guzzle glucose through anaerobic glycolysis, even when ox…

Krebs cycle is literally easier than glycolysis That bitch is evil

Researchers, including Dr. @HidenobuAnzo and Alexander Aulehla, demonstrate a modular organization of metabolic functions, revealing a signaling module of glycolysis that can be decoupled from its canonical metabolic functions.

RT @thedrdurag: I turned glycolysis into a song

@saffronandsky It gets metabolized via glycolysis. https://t.co/IVuCt1zDVG "Catabolism of D-mannose occurs via glycolysis after which it is used for energy or incorporated into glycans."

PDK4-Mediated VDAC2 Lactylation Links Glycolysis to Autophagy Failure in Septic Cardiomyopathy https://www.medrxiv.org/content/10.1101/2025.09.22.25336402v1

@renesugar Chat GPT says it could interfere with glycolysis?

@drpal_manickam stop poisoning people with your magical drugs. Weight loss is a cake walk when you switch from glycolysis to ketosis. stop playing with people's lives https://t.co/m5B7TouPIH

glycolysis nemalion ▬كؤبؤن▬كود▬خصم▬ ⎐تُيموُ⎐ ⊵acs678251⊴

RT @ChrisJo00291974: @thehealthb0t Cancer cells ditch oxygen like it’s poison and guzzle glucose through anaerobic glycolysis, even when ox…

Examining naïve T cells exposed to activin A, scientists show that nonpathogenic T helper 17 cells display metabolic alterations such as reduced reliance on glycolysis, which depended on a pathway involving adenosine and AMPK. @BRFAA_IIBEAA https://t.co/dUgcIhO3Zs https://t.co/xO4o9FYnJz

RT @ChrisJo00291974: @thehealthb0t Cancer cells ditch oxygen like it’s poison and guzzle glucose through anaerobic glycolysis, even when ox…

RT @ChrisJo00291974: @thehealthb0t Cancer cells ditch oxygen like it’s poison and guzzle glucose through anaerobic glycolysis, even when ox…

@thehealthb0t Cancer cells ditch oxygen like it’s poison and guzzle glucose through anaerobic glycolysis, even when oxygen is available. It’s called the Warburg Effect, and it’s not random. The elites have flooded our food, air, and water with toxins that hyperfuel this rogue metabolism.

rejerk glycolysis ▬كؤبؤن▬كود▬خصم▬ ⎐تُيموُ⎐ ⊵acs678251⊴

@x_xsaa660600 @mubeitech Otto Warburg did win the 1931 Nobel for respiratory enzyme discoveries and identified the "Warburg effect"—cancer cells favoring glycolysis over oxygen-based metabolism, even with oxygen present. This is well-established in science and actively researched today. Claims of

@lao_zhi23663 @mubeitech Otto Warburg did win the 1931 Nobel for discovering cancer cells' preference for glycolysis (Warburg effect), even with oxygen present. This is a real, well-studied phenomenon in oncology, used in diagnostics like PET scans. However, it's not the sole cause of cancer—modern

Back in the lab, I spoke fluent “enzyme pathways” (aka: words no one outside a textbook cares about). But brands were losing $$ because their copy read like… a thesis. Customers want glow, not glycolysis. So I decided: time to be the bridge.

Quick: High NADH/NAD+ pushes pyruvate→lactate via LDH. Seen in hypoxia, sepsis, metformin toxicity — lactic acidosis reflects anaerobic glycolysis and redox imbalance. Follow for more facts!

@Enxi355810Enxi @mubeitech Yes, Otto Warburg's 1931 Nobel-winning work on cancer metabolism is foundational—the "Warburg effect" shows cancer cells prefer glycolysis over oxidative phosphorylation, even with oxygen. However, his hypothesis that this is cancer's primary cause is debated; modern research

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@microRNApro Interesting point. Research does show energy-dependent miRNA-mRNA imbalances influencing glycolysis and metabolism (e.g., PMID: 29435930 on quantum aspects, various studies on miRNA-glycolysis in cancer). Evolutionary biology increasingly incorporates this, as seen in papers on

glycolysis becquer ▬كؤبؤن▬كود▬خصم▬ ⎐تُيموُ⎐ ⊵acs678251⊴

Me: I’ll just skim the lecture slides Me, 4 hours later: googling ‘what is glycolysis in simple terms’

alluvia glycolysis ▬كؤبؤن▬كود▬خصم▬ ⎐تُيموُ⎐ ⊵acs678251⊴

@gjhgggmj @BioProtocol

@ID_CKChen @mubeitech Otto Warburg's Warburg effect is established science: cancer cells often prefer glycolysis over respiration, even with oxygen present. He won the 1931 Nobel for respiratory enzyme work and hypothesized this metabolic shift causes cancer. Modern views see it as a feature, not

Hexokinase 2 is an RNA-binding protein that regulates mRNA translation independently of glycolysis and induces melanoma cell proliferation @PLOSBiology.org

RT @hellolily0: High-dose progesterone (100 mg/kg/day) reduces glioblastoma growth by ~47% and increases survival by ~43%. - decreases GL…

literally, I was like wait this is glycolysis, the citric acid cycle but why are they all on the same page

RT @hellolily0: High-dose progesterone (100 mg/kg/day) reduces glioblastoma growth by ~47% and increases survival by ~43%. - decreases GL…

RT @hellolily0: High-dose progesterone (100 mg/kg/day) reduces glioblastoma growth by ~47% and increases survival by ~43%. - decreases GL…

@Jienafo @mubeitech Warburg's discoveries, like the Warburg effect (cancer cells' preference for glycolysis), are foundational in oncology and actively researched today, as seen in sources like PMC and MIT News. Claims of industry suppression appear anecdotal, often from alternative health circles,

@Bravohenry_ @mubeitech Otto Warburg won the 1931 Nobel for discovering respiratory enzymes, not directly for cancer's "root cause." His Warburg effect—cancer cells favoring glycolysis over respiration even with oxygen—is established science and actively researched today. However, his view that damaged

(ACS Anal Chem) [ASAP] UCL-MetIsoLib: A Public High-Resolution Tandem Mass Spectrometry Library for HILIC-Based Isomer-Resolved Profiling of Glycolysis, Central Carbon Metabolism, and Beyond in Urine, Plasma, Tissues, Cells, and Patient-Derived Organoids: Analytical… #MassSpecRSS #ACSAChem

RT @hellolily0: High-dose progesterone (100 mg/kg/day) reduces glioblastoma growth by ~47% and increases survival by ~43%. - decreases GL…

@hashter99 @HansAmato Aspirin blocks glycolysis.

@soridhiculous

RT @hellolily0: High-dose progesterone (100 mg/kg/day) reduces glioblastoma growth by ~47% and increases survival by ~43%. - decreases GL…

@DrC16595170 @mubeitech Otto Warburg did win the 1931 Nobel for respiratory enzyme discoveries, and the Warburg effect—cancer cells favoring glycolysis over oxygen-based metabolism—is a well-established observation in oncology, still studied today. However, his view that impaired respiration is the

RT @hellolily0: High-dose progesterone (100 mg/kg/day) reduces glioblastoma growth by ~47% and increases survival by ~43%. - decreases GL…

@0XMRhJXZjuG8GDF @mubeitech Otto Warburg did win the 1931 Nobel for respiratory enzymes and described the "Warburg effect"—cancer cells favoring glycolysis over oxygen-based metabolism, even with oxygen present. It's a real phenomenon, but modern science views it as a symptom of genetic mutations, not the

@herbsttw69 @mubeitech Otto Warburg's 1931 Nobel-winning work on cell respiration led to the Warburg effect: cancer cells often favor glycolysis over oxidative phosphorylation, even with oxygen present. This is real and studied today, but his claim it's the sole cancer cause is seen as

@allcatzoo @mubeitech Otto Warburg did win the 1931 Nobel for respiratory enzyme work, and the Warburg effect (cancer cells favoring glycolysis) is a real, foundational concept in oncology, actively researched today. However, claims of suppression by the medical industry lack strong evidence; his

RT @cancerscnews:

glycolysis and kreb cycle

RT @khurpenchh: रील में बकलोली करने वाले गुरुजी को कोई ये बताए कि ग्लाइकोलिसिस (glycolysis) साइटोप्लासम में होती है न कि माइटोकॉन्ड्रिया…

@MihuaBao2 @mubeitech Otto Warburg won the 1931 Nobel for discovering the respiratory enzyme, not directly for cancer's cause. The Warburg effect is confirmed: cancer cells often rely on glycolysis (fermentation) even with oxygen, depending heavily on glucose and creating acidic environments. However,

@Jeff60315743 @mubeitech Otto Warburg's discoveries are real: He won the 1931 Nobel for work on cellular respiration, and the Warburg effect—cancer cells favoring glycolysis over oxygen-based metabolism—is established science, still studied today. Claims of industry suppression are overstated; his ideas

RT @hellolily0: High-dose progesterone (100 mg/kg/day) reduces glioblastoma growth by ~47% and increases survival by ~43%. - decreases GL…

RT @hellolily0: High-dose progesterone (100 mg/kg/day) reduces glioblastoma growth by ~47% and increases survival by ~43%. - decreases GL…

RT @FrontImmunol: New Research: PLK2 as a key regulator of glycolysis and immune dysregulation in polycystic ovary syndrome https://t.co/Yk…

Cancer cells typically exhibit a negativesurface charge, a unique characteristic driven by lactic acid secretion from their enhanced glycolysis (the Warburg effect) and changes in their cell surface composition, such as increased sialylation. This negative charge distinguishes

UCL-MetIsoLib: A Public High-Resolution Tandem Mass Spectrometry Library for HILIC-Based Isomer-Resolved Profiling of Glycolysis, Central Carbon Metabolism, and Beyond in Urine, Plasma, Tissues, Cells, and Patient-Derived Organoids #AC pubs.acs.org/doi/10.1021/...

@ynpopoypp @mubeitech Yes, Otto Warburg's 1931 Nobel-winning work on cell respiration led to the Warburg effect: cancer cells prefer glycolysis over oxidative phosphorylation, even with oxygen available. He hypothesized this as cancer's root cause due to mitochondrial damage. Modern research views it

RT @hellolily0: High-dose progesterone (100 mg/kg/day) reduces glioblastoma growth by ~47% and increases survival by ~43%. - decreases GL…

RT @AbudBakri: - Sugar in your blood is called glucose - Sugar in your brain is called essential fuel (even if you don’t eat for 40 days)…

UCL-MetIsoLib: A Public High-Resolution Tandem Mass Spectrometry Library for HILIC-Based Isomer-Resolved Profiling of Glycolysis, Central Carbon Metabolism, and Beyond in Urine, Plasma, Tissues, Cells, and Patient-Derived Organoids | Analytical Chemistry https://t.co/LZAVgzPA2g

RT @hellolily0: High-dose progesterone (100 mg/kg/day) reduces glioblastoma growth by ~47% and increases survival by ~43%. - decreases GL…

RT @hellolily0: High-dose progesterone (100 mg/kg/day) reduces glioblastoma growth by ~47% and increases survival by ~43%. - decreases GL…

RT @hellolily0: High-dose progesterone (100 mg/kg/day) reduces glioblastoma growth by ~47% and increases survival by ~43%. - decreases GL…

New Research: PLK2 as a key regulator of glycolysis and immune dysregulation in polycystic ovary syndrome https://t.co/YkJVxlF7fY #FrontiersIn #Immunology

@microRNApro The paper details a pH-sensitive protonated RNA state that enhances miR-21 maturation via structural changes, mentioning Gibbs free energy for conformations. It doesn't explicitly link to origins of life 6-10K years ago, claims by Kirk or Trump on miRNA-glycolysis, or microtubule

Cell Cycle and Metabolic InsightsPost-arrest, cardiomyocytes exit the cell cycle due to ROS-induced DNA damage halting regeneration. Research (2025) explores reversing this with thyroid hormone modulation or glycolysis enhancers to re-activate proliferation in SA node precursors.

RT @cancerscnews:

The findings regarding high-dose progesterone's effects on glioblastoma are intriguing. The reduction in GLUT-1 and subsequent inhibition of glycolysis suggest potential metabolic reprogramming as a therapeutic strategy. https://t.co/k9wOLkSqps

RT @hellolily0: High-dose progesterone (100 mg/kg/day) reduces glioblastoma growth by ~47% and increases survival by ~43%. - decreases GL…

High-dose progesterone (100 mg/kg/day) reduces glioblastoma growth by ~47% and increases survival by ~43%. - decreases GLUT-1, inhibiting glycolysis - lowers lactate - reduces oxidative stress - induces cellular senescence rather than directly killing cells https://t.co/Me8ZP2dD3A

Dysregulated Anaerobic Glycolysis in Podocytes is Relevant to the Progression of Focal Segmental Glomerulosclerosis #KidneyIntRep #MassSpec www.kireports.org/article/S246...

@Elijahkrings I dont get one thing about inflammation and glycolysis - why does almost every type of inflammation induce insulin resistance if glucose is so important for antioxidant system?

RT @AIpubmed:

Respiratory System Air O2 CO2 Carboxy Haemoglobin Oxygen Krebbs Cycle CO2 Cycle CO2 Chakra Glycolysis Cytoplasm Mitochondria Lactic Acid Glucose Glucose 6 Phosphate Glucose-6-Phosphate Fructose Fructose-6-Phosphate Glucose-1,6-Di Phosphate Fructose-1,6-Di Phosphate ....

Hexokinase 2 is an RNA-binding protein that regulates mRNA translation independently of glycolysis and induces melanoma cell proliferation @PLOSBiology.org

Swallow Pass Stomach Constrictor Muscles Small intestines Large intestines Digeation Bolus Chyme Chyle Lacteals Ksheer Vahiniyan Adrenaline Rush Adrenaline Rush Adrenal Glands Endocrine Glands Carbohydrates Fats Proteins Vitamins Lipids Carbohydrates Glycolysis Cycl....

Brain endothelial HIF-1α exacerbates diabetes-associated cognitive impairment by accelerating glycolysis-driven lactate production https://t.co/vTluVEpXnV

Cancer metabolism is driven by gene mutations. Signals from PI3K, Akt, mTOR, and HIF-1α push cells toward glycolysis. Mitochondria often become fragmented and dysfunctional but are still essential for cancer growth.

Even though glycolysis is less efficient, cancer cells often increase glycolysis to high levels. They still use mitochondria, just differently - mostly for biosynthesis and supporting altered growth patterns.

Let’s look at how this system changes in disease. First: cancer. Many cancer cells use glycolysis even when oxygen is available. This is called the Warburg effect.

One glucose molecule can yield ~30–36 ATP through this process. In contrast, glycolysis alone (without mitochondria) makes only ~2 ATP per glucose. So mitochondria are far more efficient under normal oxygen conditions.

In healthy cells, mitochondria make most of the cell’s energy (ATP) through a process called oxidative phosphorylation (OXPHOS). This happens after glucose is broken down into pyruvate through glycolysis.

Hao's preprint reading list September 19th, 2025 Circadian Glycolysis Cardiomyocyte Cell Cycle Mural cell in Capillary malformation Nucleosome stability & Aging Piezo & Parturition Spatial mapping of Ovary development Vaping & Atherosclerosis docs.google.com/document/d/e...

‬‬Hexokinase 2 (HK2) is known for its metabolic role in #glycolysis. This study shows that it also functions as an #RNAbindingProtein that regulates mRNA translation, particularly of SOX10, promoting #melanoma cell proliferation independently of glycolysis @plosbiology.org

elongatus modulates brain metabolism through enhanced glycolysis and activation of protective cellular pathways, suggesting neuroprotective and metabolic benefits. These findings support the potential of S.

‬‬Hexokinase 2 (HK2) is known for its metabolic role in #glycolysis. This study shows that it also functions as an #RNAbindingProtein that regulates mRNA translation, particularly of SOX10, promoting #melanoma cell proliferation independently of glycolysis @plosbiology.org

Glycolysis-stratified coordination of fatty acid and glutamine metabolism in pancreatic ductal adenocarcinoma https://www.biorxiv.org/content/10.1101/2025.09.14.676164v1

Glycolysis-stratified coordination of fatty acid and glutamine metabolism in pancreatic ductal adenocarcinoma https://www.biorxiv.org/content/10.1101/2025.09.14.676164v1

Hexokinase 2 (HK2) is known for its metabolic role in #glycolysis. This study shows that it also functions as an #RNAbindingProtein that regulates mRNA translation, particularly of SOX10, promoting #melanoma cell proliferation independently of glycolysis @plosbiology.org

Propofol Disrupts Lung Cancer Glycolysis via TPI1 Regulation Recent research has shed light on a novel application of propofol, a well-known anesthetic, beyond its traditional use in surgery. A study conducted by Wang, Zhou, and Guo investigates propofol's impact on lung cancer metabolism…

Check how their findings indicates that BRG1 regulates PKM2 Y105 phosphorylation and oligomeric state by enhancing the interaction between SHP1 and PKM2, and that BRG1 modulates glycolysis in NSCLC cells through the BRG1/SHP1/PKM2 Y105 pathway.

“BRG1 inhibits glycolysis by promoting SHP1-mediated dephosphorylation of PKM2 in non-small cell lung cancer”

Kris DeMali is ending @tricytomeet.bsky.social with a fascinating talk linking the response to shear stress to regulation of glycolysis--she's making metabolism interesting to a cytoskeletal audience :)

CDK1 phosphorylation of lactate dehydrogenase A (LDHA) promotes LADB tetramers directing lactate towards NADH production instead of #glycolysis. NADH fuels oxidative phosphorylation and ATP production sustaining #mitosis of #cancer cells. #metabolism -> www.embopress.org/doi/full/10....

gluconeogenesis evangelion i miss u

5) The review discusses how Metformin influences cytokines, glycolysis, ATP generation, oxidative stress, the microbiome, endothelial function, mast cells etc.

#HistoneLactylation #Angiogenesis VEGF-A➡️ ⏫#EndothelialCell #Glycolysis #Lactate➡️ ⏫H3K9la➡️ >50% CUT&Tag peaks within 3 kb promoters Covering prolif/motility/junction/hypoxia Oxygen-induced retinopathy ⬇️ by glycolytic inhibitors #GenomeBiol 2024 genomebiology.biomedcentral.com/articles/10....

Oxybutynin, a long-used medication for bladder incontinence, has shown potential to support muscle cell growth in mitochondrial diseases by enhancing glycolysis and cellular energy pathways. doi.org/g93fpg

22.

Endothelial cell–ILC3 crosstalk via the ET-1/EDNRA axis promotes NKp46+ILC3 glycolysis to alleviate intestinal inflammation

Excessive dietary sugar reprograms the metabolic state of #Drosophila larval macrophages. Enhanced glycolysis and lipolysis suppresses organ growth and dominates over growth-supportive lipogenesis. #metabolism #immune -> www.embopress.org/doi/full/10....

ADAM9 Promotes Glycolysis in Th17 Cells and Autoimmunity Through Activation of IGF-1 Signaling https://pubmed.ncbi.nlm.nih.gov/40915982

Meclizine rescues cardiac function and mitochondrial ultrastructure by ATP- and glycolysis-independent mechanisms in a genetic model of mitochondrial energy dysfunction https://www.biorxiv.org/content/10.1101/2025.09.03.674000v1

Meclizine rescues cardiac function and mitochondrial ultrastructure by ATP- and glycolysis-independent mechanisms in a genetic model of mitochondrial energy dysfunction https://www.biorxiv.org/content/10.1101/2025.09.03.674000v1

This research paper explores the emerging field of lactylation, a recently discovered epigenetic modification where lactate, a byproduct of glycolysis, can attach to lysine residues on histones or other proteins.

I still see nightmares about biochemical metabolism lectures I had in undergrad. “Which enzyme is used to convert 2-phosphoglycerate to phosphoenolpyruvate?” Enolase! “What’s the end product of the glycolysis reaction?” My tears!

Naviaux is proposing plasma switch experiments... when you treat samples with #MECFS plasma, RBC deformability worsens, showing that metabolites in blood/plasma directly contribute to these issues. Plasma swap for patient vs HC muscle cells too. Glycolysis and oxidation decreased in those cells.

Dylan's study is now out in @jacs.acspublications.org! Key new experiments by Yuan-Ting Cho support a model for why a rare three-tailed lipid, NAPE, might accumulate during stroke & heart attack: as a protective response to promote lactate export as cells shift to glycolysis doi.org/10.1021/jacs...

Nature paper: Taurine from bone marrow niche boosts glycolysis, aiding leukemia stem cell growth. Single-cell RNA-seq reveals this interaction. PMID:40369079, Nature 2025, @Nature https://doi.org/10.1038/s41586-025-09018-7 #Medsky #Pharmsky #RNA #ASHG #ESHG

Taurine from tumour niche drives glycolysis to promote leukaemogenesis. #Nature Open Access www.nature.com/articles/s41...

⚡ How do sperm find the right “gear” for fertilization? New research reveals that lactate shifts bull sperm from zigzag motility to straight-line movement by suppressing glycolysis and boosting oxidative metabolism.

A history of alcohol use disorder increases the risk of death from sepsis. Researchers found that the HIF-1α-PFKP axis regulates glycolysis and phagocytosis in ethanol-exposed macrophages and is a potential therapeutic target in ethanol with sepsis: ow.ly/S5AQ50WOgnB.

Esketamine Reduces Brain Injury via STAT3 and Glycolysis In the realm of neuroscience, new frontiers are constantly being explored, especially in the treatment of traumatic brain injury (TBI). Recent research led by Liu, Gong, and Zhang has generated significant interest, focusing on the effects…

MOTS-c Promotes Glycolysis via AMPK–HIF-1α–PFKFB3 Pathway to Ameliorate Cardiopulmonary Bypass–induced Lung Injury @atscommunity.bsky.social #medsky

The findings reveal that 27OHC significantly downregulates the mevalonate pathway and glycolysis, leading to decreased cholesterol levels and lactate production. This inhibition of lipid and glucose metabolism may contribute to the prevention of fatty liver disease.

Uncover how 27-hydroxycholesterol, a key player in lipid metabolism, inhibits mevalonate and glycolysis pathways in hepatocytes, shedding light on its potential role in preventing fatty l...

This study reveals that ADAMTS9-AS2 promotes let-7a-5p binding to #Hexokinase 2, inhibiting aerobic #Glycolysis in oral squamous cell #carcinoma (OSCC), establishing the ADAMTS9-AS2/let-7a-5p axis as a crucial regulator of OSCC. #medsky #OpenAccess: www.sciencedirect.com/science/arti...

AI Uncovers Glycolytic Diversity in Colorectal Cancer In a groundbreaking study poised to reshape our understanding of cancer metabolism, researchers have leveraged cutting-edge machine learning to uncover previously unappreciated heterogeneity in glycolysis within colorectal cancer (CRC). This…

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Why did the Krebs cycle break up with glycolysis? Because it felt like they were stuck in an endless cycle of activity.

SARS-CoV-2 disables MAVS signaling and OXPHOS, triggering a bioenergetic collapse that forces cells into inefficient glycolysis. This mitochondrial failure may underlie ME/CFS-like symptoms seen in many with Post-Acute Sequelae of COVID-19 (PASC). gemini.google.com/share/e0aac9...

Many cells use glycolysis to convert glucose into at this point.

No, see, he forgot to mention he always pushes a Agilent Seahorse XF Analyzer around with him to run super quick glycolysis analyses on people’s kids…..must be it..

I'm currently writing a talk and have the whole glycolysis, PPP, TCA on one of the intro slides and a guy two desks down passed me and said 'that is literally giving me undergrad PTSD'

ACLY promotes NK cell effector function by regulating glycolysis and histone acetylation @jimmunol.bsky.social @labfehniger.bsky.social @macattacklab.bsky.social academic.oup.com/jimmunol/adv...

DREAM exploits cancer cell-derived membranes for enhanced tumor specificity, penetration, and intracellular copper delivery. By disrupting glycolysis, DREAM intensifies copper overload, triggering cuproptosis in cancer cells.

Hybrid nanoagents harness cancer cell membranes to synergistically enhance cuproptosis-driven immunotherapy, disrupting glycolysis and remodeling the tumor microenvironment for potent ant...

Biochemistry, aerobic glycolysis, and baking. Next up… some quaffing of liquid produced by anaerobic glycolysis.

Yet another reason glycolysis won’t let us live in peace... Nice work and great mechanistic expansion @dremilygoldberg.bsky.social

'Well, this paper got the levels of that formerly fluorescent mox-YG protein up to over 40% of total protein in the cell, (...) limiting factors seemed to be outright amino acid depletion, problems with ribosome expression & an apparent metabolic switch fm glycolysis over to more oxygen respiration'

Exogenous addition of glucosylsphingosine affects cellular energy metabolism in SH-Sy5y cell line via changes in mitochondrial function and glycolysis. It also induces an increase in protein ubiquitination with tubulin species affected the most www.nature.com/articles/s42...

Absolutely. Glycolysis is a virulence factor

Viral infections can damage mitochondria, leading to chronic energy deficits and mental health issues like depression and cognitive decline. Mental illness is likely a bioenergetic crisis, so let's advocate for metabolic psychiatry and systemic intervention. gemini.google.com/share/6c6d41...

-Severe COVID : Elevated blood glucose and mannose levels, changes in amino acid metabolism, reliance on glycolysis & glutaminolysis for viral replication are noted. - MIS-C: Studies point to alterations in lipid classes and elevated inflammatory markers. pubs.acs.org/doi/10.1021/...

GAPDH in plants: multi-functional beyond glycolysis, mod. by redox, aids stress adapt. #GAPDH #PlantBiology @oxfordacademic.bsky.social Details: doi.org/10.1093/hr/u...

GLP-1RA Semaglutide Delays the Progression of ADPKD Through Regulation of Glycolysis ... - goo.gl/alerts/xtdHrn #GoogleAlerts

. 767 genes were differentially expressed after exposure to 9,10-PQ (an oxidized PAH), which enriched 16 KEGG pathways, and activated glycolysis, phagosome, and FOXO signaling pathways. Several genes related to tumorigenesis were significantly upregulated. journals.physiology.org/doi/full/10....

Researchers used nuclear magnetic resonance to measure levels of free fatty acids, branched-chain amino acids, glycolysis-related metabolites, and ketones.

enzymes, disturbances in calcium homeostasis, hypertrophy, and mitochondrial hyperfusion. Structural analyses confirmed myotube hypertrophy and elevated mitochondrial oxygen consumption In ME/CFS. While muscles initially adapted by increasing glycolysis, prolonged exposure (96–144 H) caused muscle

Our new preprint, 'Optimizing toward discovery: AI-driven exploration of Lewis acid–base catalysts for PET glycolysis', is out now!

CNP/cGMP signaling counteracts metabolic reprogramming in pulmonary arterial hypertension pericytes by reducing HIF1α, GLUT-1, and CAD activity, normalizing glycolysis and pyrimidine synthesis and limiting hyperproliferation, highlighting its therapeutic potential. www.nature.com/articles/s42...

7) Fragmented mitochondria had increased maximal respiration, but the effect disappeared when cells were forced to rely solely on oxidative phosphorylation (OXPHOS). This suggest that the effect of ME/CFS IgGs on mitochondrial function depends on the cells using glycolysis.

HIF(hypoxia inducible factor)-1 : inducing angiogenesis and glycolysis

Lactate was known as a metabolic waste product from glycolysis, but more and more evidence shows it acts as a signaling molecule. Happy to have contributed with former great student @seb-math-bio.bsky.social‬ to the data analysis of a study in /@natmetabolism.nature.com showing how 1/

Very cool paper. Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry www.nature.com/articles/s41...

Is there a functional effect? Instead of 16 hrs, the authors look now 36 hrs after co-culture with serum IgG and assessed metabolism using SeaHorse. No differences in proxies of OXPHOS or glycolysis were observed. (FCCP response is annotated as higher, basal level is also). 10/10

Another lactylation paper: TRIM65 as a key regulator of ferroptosis and glycolysis in lactate-driven renal tubular injury and diabetic kidney disease www.cell.com/cell-reports...

TRIM65 as a key regulator of ferroptosis and glycolysis in lactate-driven renal tubular injury and diabetic kidney disease

2-DG disrupts glycolysis & mitochondrial respiration in AML cells, per Christensen et al. study. Real-time oxygen use data shows it inhibits basal & stimulated metabolism—pointing to potential in leukemia treatment. Read more: unisense.com/applications...

Hola