Front Mol Biosci April 2021 PMID 33987207

Pathways and Mechanism of Caffeine Binding to Human Adenosine A Receptor.

Hung N Do, Sana Akhter, Yinglong Miao

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Mentions

10
Peak: 4 in May 2021
across 3 sources since May 2021

Extended reach

40,739
potential audience

Total likes

2,734

Video views

34,776

Mentions per month

May 2021 – Sep 2025

Where it's discussed

  • X / Twitter7 posts
  • YouTube2 videos
  • Bluesky1 posts

AI synopsis

What people are saying

The discussions show genuine interest, evidenced by references to the detailed molecular pathways and the use of advanced visualization tools, such as Blender3D. Examples include mentions of the receptor's extracellular mouth, hydrogen bonding with residue N655, and potential for developing selective drugs, with an enthusiastic tone highlighting the significance and exciting potential of the research.

AgreementModerate agreement

Most discussions acknowledge the significance of the research, with some explicitly supporting the findings, such as gratitude expressed for the detailed mechanisms uncovered.

InterestHigh interest

The discussions reflect high interest, especially with mentions of new videos, molecular modeling techniques, and the implications for caffeine's action on adenosine receptors.

EngagementModerate engagement

Participants actively engage with the content by referencing specific molecular pathways, methods, and potential applications, indicating thoughtful involvement.

ImpactModerate impact

While mostly positive, the perceived impact is moderate as the research advances understanding of caffeine's binding but has yet to translate into immediate practical or clinical applications.

Abstract in brief

  • This study uses advanced molecular dynamics simulations to investigate how caffeine (CFF) binds to the human adenosine A receptor (AAR), a key target for drugs treating various diseases.
  • Researchers found that caffeine binds through pathways similar to other GPCRs, with a specific hydrogen bond involving residue N655, and identified an intermediate binding state at the receptor’s extracellular mouth.
  • The findings suggest that the ECL2 region, which varies between receptor types, could be targeted to develop more selective allosteric drugs for the AAR.

Top posts

Most liked on X and Bluesky
Clockwork
@watchclockwork.com · Bluesky

New video about caffeine linked here: youtu.be/fNR-GY-WoAI Rendered in #blender3d using @bradyajohnston.bsky.social 's brilliant Molecular Nodes extension. Make sure you check out the incredible coffee from @thegooddotstore.bsky.social 's Keats & Co by visiting keats.watchclockwork.com

Sep 16, 2025 · 5 likes · 2 shares View post →
Inner Banks Tea
@IBXtea · X

H N Do et al, 2021. Pathways and Mechanism of Caffeine Binding to Human Adenosine A 2A Receptor,... https://t.co/N8O1kTTYEL

May 22, 2021 · 1 like · 2,149 followers View post →
MiaoLab
@lab_miao · X

Pathways and Mechanism of Caffeine Binding to Human Adenosine A2A Receptor https://t.co/B6ibLZbCIO

May 19, 2021 · 1 like · 1 share · 147 followers View post →
Frontiers - Molecular Biology
@FrontMolBioSci · X

New Research: Pathways and Mechanism of Caffeine Binding to Human Adenosine A2A Receptor https://t.co/S0CkPGkPfa #MolBioSci

May 3, 2021 · 2,530 followers View post →
Dataemia
@Dataemia · X

(Pathways and Mechanism of Caffeine Binding to Human Adenosine A<sub>2A</sub> Receptor) https://t.co/Qwf0HYY1xV

May 14, 2021 · 963 followers View post →
Hung Do
@hungd238 · X

RT @lab_miao: Pathways and Mechanism of Caffeine Binding to Human Adenosine A2A Receptor https://t.co/B6ibLZbCIO

Feb 27, 2022 · 1 share · 104 followers View post →

All mentions

萌派(MPI)
@ngunlp · X

The WEIRD Way Caffeine Works https://t.co/cpfqFXAIAQ via @YouTube

Sep 16, 2025 · 46 followers View post →
Clockwork
@watchclockwork.com · Bluesky

New video about caffeine linked here: youtu.be/fNR-GY-WoAI Rendered in #blender3d using @bradyajohnston.bsky.social 's brilliant Molecular Nodes extension. Make sure you check out the incredible coffee from @thegooddotstore.bsky.social 's Keats & Co by visiting keats.watchclockwork.com

Sep 16, 2025 · 5 likes · 2 shares View post →
Hung Do
@hungd238 · X

RT @lab_miao: Pathways and Mechanism of Caffeine Binding to Human Adenosine A2A Receptor https://t.co/B6ibLZbCIO

Feb 27, 2022 · 1 share · 104 followers View post →
QUSAC Decaf Inc.
@GoDecaf · X

H N Do et al, 2021. Pathways and Mechanism of Caffeine Binding to Human Adenosine A 2A Receptor, Frontiers in Molecular Bioscience, Volume 8. - https://t.co/S0nee22HDT

Jun 3, 2021 · 16 followers View post →
Inner Banks Tea
@IBXtea · X

H N Do et al, 2021. Pathways and Mechanism of Caffeine Binding to Human Adenosine A 2A Receptor,... https://t.co/N8O1kTTYEL

May 22, 2021 · 1 like · 2,149 followers View post →
MiaoLab
@lab_miao · X

Pathways and Mechanism of Caffeine Binding to Human Adenosine A2A Receptor https://t.co/B6ibLZbCIO

May 19, 2021 · 1 like · 1 share · 147 followers View post →
Dataemia
@Dataemia · X

(Pathways and Mechanism of Caffeine Binding to Human Adenosine A<sub>2A</sub> Receptor) https://t.co/Qwf0HYY1xV

May 14, 2021 · 963 followers View post →
Frontiers - Molecular Biology
@FrontMolBioSci · X

New Research: Pathways and Mechanism of Caffeine Binding to Human Adenosine A2A Receptor https://t.co/S0CkPGkPfa #MolBioSci

May 3, 2021 · 2,530 followers View post →