May 2021 PMID 33994772

Fructose and Uric Acid as Drivers of a Hyperactive Foraging Response: A Clue to Behavioral Disorders Associated with Impulsivity or Mania?

Richard J Johnson, William L Wilson, Sondra T Bland, Miguel A Lanaspa

Mentions

32
Peak: 10 in Sep 2023
across 6 sources since Mar 2022

Extended reach

9,856
potential audience

Total likes

34

Video views

858

Mentions per month

Mar 2022 – Nov 2025

Where it's discussed

  • Reddit8 posts
  • Facebook7 posts
  • X / Twitter6 posts
  • Instagram4 posts
  • News4 articles
  • YouTube3 videos

AI synopsis

What people are saying

The discussions showcase strong support for the publication’s conclusions, with posts mentioning specific scientists, such as Richard Johnson, to underline the validity of the findings. The tone is affirming and analytical, with phrases like 'new data suggests' and references to studies, which highlight the perceived importance and credibility of the research in understanding behavioral issues related to diet and metabolism.

AgreementStrong agreement

Most discussions strongly support the article's hypothesis, citing research and experts like Richard Johnson to reinforce the connection between fructose metabolism and behavioral disorders.

InterestModerate interest

While a few posts show curiosity about the mechanisms, overall interest remains moderate, as participants mainly agree or affirm existing research rather than explore new perspectives.

EngagementHigh engagement

Posts engage deeply by referencing scientific evidence, experts, and specific mechanisms, indicating thoughtful consideration and discussion.

ImpactHigh impact

The commentary reflects a belief that the research could significantly influence understanding or treatment of behavioral disorders, emphasizing its potential importance.

Abstract in brief

  • The text suggests that high intake of fructose, found in sugar and high fructose corn syrup (HFCS), activates an evolutionary survival pathway that increases foraging behaviors, energy storage, and can lead to behavioral issues like impulsivity, risk-taking, and aggression.
  • It proposes that uric acid, a byproduct of fructose metabolism, may mediate some of these effects, potentially linking sugar consumption to behavioral disorders such as ADHD, bipolar disorder, and aggressive behavior.
  • The hypothesis indicates that chronic activation of this pathway may eventually cause desensitization of pleasure responses, possibly leading to depression, and highlights that other high-glycemic and salty foods might also contribute to this hyperactive foraging response.]

Top posts

Most liked on X and Bluesky
Bob....
@ATallMountain · X

@ChrisPalmerMD Uric acid is driven by fructose metabolism. Richard Johnson has done the work on this and had speculated on a connection. https://t.co/oNfaqucezI

Sep 27, 2023 · 2 likes · 1 share · 89 followers View post →
Steven M. Belknap, MD PGY43
@StevenMBelknap · X

https://t.co/lGQViKBLa6

Mar 30, 2022 · 1 like · 2,288 followers View post →
museofhistory
@museofhistory · X

RT @ATallMountain: @ChrisPalmerMD Uric acid is driven by fructose metabolism. Richard Johnson has done the work on this and had speculated…

Sep 27, 2023 · 1 share · 3,474 followers View post →
rho
@Harpe51585 · X

and aggression that increases the risk for ADHD, bipolar disease and aggressive behavior.” https://t.co/ZIjCrQEh6U Evidence: BVO “New data suggests that brominated vegetable oil (BVO) can cause organs and tissues, including the thyroid, to accumulate bromide at

Feb 18, 2024 · 1,531 followers View post →
CogniSphere
@jorgensenmc1 · X

Fructose and Uric Acid as Drivers of a Hyperactive Foraging Response: A Clue to Behavioral Disorders Associated with Impulsivity or Mania? - PMC https://t.co/EwfbZ04Kkq

Feb 17, 2024 · 827 followers View post →
Frank Illenberger
@depth42 · X

@ViStamatopoulou Newest research provides evidence that ADHD and bipolar disorders are caused by fructose/carbohydrates/uric acid: https://t.co/C7mGEmZodV

May 12, 2022 · 556 followers View post →

All mentions

rho
@Harpe51585 · X

and aggression that increases the risk for ADHD, bipolar disease and aggressive behavior.” https://t.co/ZIjCrQEh6U Evidence: BVO “New data suggests that brominated vegetable oil (BVO) can cause organs and tissues, including the thyroid, to accumulate bromide at

Feb 18, 2024 · 1,531 followers View post →
CogniSphere
@jorgensenmc1 · X

Fructose and Uric Acid as Drivers of a Hyperactive Foraging Response: A Clue to Behavioral Disorders Associated with Impulsivity or Mania? - PMC https://t.co/EwfbZ04Kkq

Feb 17, 2024 · 827 followers View post →
museofhistory
@museofhistory · X

RT @ATallMountain: @ChrisPalmerMD Uric acid is driven by fructose metabolism. Richard Johnson has done the work on this and had speculated…

Sep 27, 2023 · 1 share · 3,474 followers View post →
Bob....
@ATallMountain · X

@ChrisPalmerMD Uric acid is driven by fructose metabolism. Richard Johnson has done the work on this and had speculated on a connection. https://t.co/oNfaqucezI

Sep 27, 2023 · 2 likes · 1 share · 89 followers View post →
Frank Illenberger
@depth42 · X

@ViStamatopoulou Newest research provides evidence that ADHD and bipolar disorders are caused by fructose/carbohydrates/uric acid: https://t.co/C7mGEmZodV

May 12, 2022 · 556 followers View post →
Steven M. Belknap, MD PGY43
@StevenMBelknap · X

https://t.co/lGQViKBLa6

Mar 30, 2022 · 1 like · 2,288 followers View post →
Gift For You Fatima Ramos - Facebook
Facebook

doi:10.1016/j. evolhumbehav.2020.09.006. e [2] Knüppel, A., Shipley, M. J., Llewellyn, C. H., & Brunner, E. J. (2017). Sugar intake from sweet food and ...

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Suplementy od Majorki - Facebook
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Źródło: EvolHumanBehav,2020;doi:10.1016/j.evolhumbehav. 2020.09.006 Ps. Zamiast cukru, włącz u dziecka: odżywienie mózgu - omega 3, lecytyna, jajka na ...

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Quantum Nano Saúde - Facebook
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” Evol Hum Behav. https://doi.org/10.1016/j. evolhumbehav.2020.09.006. Epub 2020 1º de outubro. [ii] Campus Médico Anschutz da Universidade do Colorado ...

Dec 11, 2025 View →
Neuropsicopedagoga | ?guas de São Pedro SP - Facebook
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doi:10.1016/j.evolhumbehav. 2020.09.006. e [2] Knüppel, A., Shipley, M. J., Llewellyn, C. H., & Brunner, E. J. (2017). Sugar intake from sweet food and ...

Dec 11, 2025 View →
Savedrecs 4 | PDF
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10.1016/j.evolhumbehav.2020.04.001. Halder Arpita, 2021, Machine Learning ... 10.1016/j.inffus.2020.09.006. Ronneberger O, 2015, LECT NOTES COMPUT SC ...

Dec 11, 2025 View →
La dipendenza dallo zucchero fa schifo. : r/sugarfree - Reddit
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Evol Hum Behav. 2021 May;42(3):194-203. doi: 10.1016/j.evolhumbehav.2020.09.006. Epub 2020 Oct 1. PMID: 33994772; PMCID: PMC8117086. Sto ...

Sep 25, 2023 View →
Zuckersucht ist scheiße : r/sugarfree - Reddit
Reddit

Evol Hum Behav. 2021 Mai;42(3):194-203. doi: 10.1016/j.evolhumbehav.2020.09.006. Epub 2020 Okt 1. PMID: 33994772; PMCID: PMC8117086. Ich ...

Sep 25, 2023 View →
ติดน้ำตาลนี่มันแย่จริงๆ : r/sugarfree - Reddit
Reddit

Evol Hum Behav. 2021 May;42(3):194-203. doi: 10.1016/j.evolhumbehav.2020.09.006. Epub 2020 Oct 1. PMID: 33994772; PMCID: PMC8117086. ผม ...

Sep 25, 2023 View →
चीनी की लत बेकार है : r/sugarfree - Reddit
Reddit

doi: 10.1016/j.evolhumbehav.2020.09.006. Epub 2020 अक्टूबर 1. PMID: 33994772; PMCID: PMC8117086. मैं इस बारे में ...

Sep 25, 2023 View →
Vício em açúcar é péssimo : r/sugarfree - Reddit
Reddit

Evol Hum Behav. 2021 maio;42(3):194-203. doi: 10.1016/j.evolhumbehav.2020.09.006. Epub 2020 1 de outubro. PMID: 33994772; PMCID: PMC8117086 ...

Sep 25, 2023 View →
La dépendance au sucre, c'est nul : r/sugarfree - Reddit
Reddit

J'ai avoué à mes parents que j'étais grave accro au sucre ; ils ont ... doi: 10.1016/j.evolhumbehav.2020.09.006. Epub 2020 Oct 1. PMID ...

Sep 25, 2023 View →
Sugar addiction sucks : r/sugarfree
Reddit

Evol Hum Behav. 2021 May;42(3):194-203. doi: 10.1016/j.evolhumbehav.2020.09.006. Epub 2020 Oct 1. PMID: 33994772; PMCID: PMC8117086. I am ...

Sep 25, 2023 View →
I need do quit sugar! : r/sugarfree
Reddit

Evol Hum Behav. 2021 May;42(3):194-203. doi: 10.1016/j.evolhumbehav.2020.09.006. Epub 2020 Oct 1. PMID: 33994772; PMCID: PMC8117086.

Sep 22, 2023 View →
Gera compulsão? Afeta o comportamento? O que o açúcar faz no ...
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doi:10.1016/j.evolhumbehav.2020.09.006. Hirode G, Wong RJ. Trends in the Prevalence of Metabolic Syndrome in the United States, 2011-2016 ...

Jan 23, 2023 View →
I have talked before about the detrimental effects of fructose on ...
Instagram

... Evol Hum Behav. 2021 May;42(3):194-203. doi: 10.1016/j.evolhumbehav.2020.09.006.Epub 2020 Oct 1. • Link: https://www.sciencedirect.com ...

Oct 27, 2022 View →
I have talked before about the detrimental effects of fructose on ...
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Reference: Evol Hum Behav. 2021 May;42(3):194-203. doi: 10.1016/j.evolhumbehav.2020.09.006.Epub 2020 Oct 1. ... Link: https://www.sciencedirect.

Oct 27, 2022 View →
Every mother knows that sugar affects the behaviour of her children ...
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Dec 11, 2020 View →
Posted @withregram • @meucerebro Um estudo recente apontou ...
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... J. Johnson, William L. Wilson, Sondra T ... 10.1016/j.evolhumbehav.2020.09.006. e [ ... J. Johnson, William L. Wilson, Sondra T ...

Nov 16, 2020 View →
Suplementy od Majorki - Facebook
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Źródło: EvolHumanBehav,2020;doi:10.1016/j.evolhumbehav. 2020.09.006 Ps. Zamiast cukru, włącz u dziecka: odżywienie mózgu - omega 3 ...

Nov 16, 2020 View →
Le SUCRE rend-il agressif ?! | santé log
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Source: Evolution and Human Behavior 1 October 2020 DOI : 10.1016/j.evolhumbehav.2020.09.006 Fructose and uric acid as drivers of a ...

Oct 29, 2020 View →
#repost @clinicavanbers ・・・ Um estudo recente apontou que a ...
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Evolution and Human Behavior, 2020. doi:10.1016/j.evolhumbehav.2020.09.006. e [2] Knüppel, A., Shipley, M. J., Llewellyn, C. H., & Brunner, ...

Oct 18, 2020 View →
Um estudo recente apontou que a ingestão excessiva de frutose ...
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doi: 10.1016/j.evolhumbehav.2020.09.006. e [2] Knüppel, A. , Shipley, M. J., Llewellyn, C. H., & Brunner, E. J. (2017). Sugar intake from ...

Oct 18, 2020 View →
Could excessive sugar intake contribute to aggressive behaviors ...
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Evolution and Human Behavior, 2020; DOI: 10.1016/j.evolhumbehav.2020.09.006. Cite This Page: MLA; APA; Chicago. University of Colorado Anschutz ...

Oct 16, 2020 View →