transcript variant 2 is a marker of aging and cellular senescence.

José Alberto López-Domínguez, Sandra Rodríguez-López, Ulises Ahumada-Castro, Pierre-Yves Desprez, Maria Konovalenko, Remi-Martin Laberge, César Cárdenas, José Manuel Villalba, Judith Campisi

May 2021 Aging (Albany NY)

Synopsis of Social media discussions

The comments reflect strong support for the significance of transcript variant 2 as an aging marker, with mentions of its differential expression during aging and stress, and references to expert opinions and key institutions. The tone and choice of words like 'valuable biomarker' and 'preferentially induced during aging' demonstrate recognition of its potential impact in aging research and therapy development.

A
Agreement
 Strong agreement

Most comments strongly support the significance of the research, emphasizing its importance as a biomarker for aging and cellular senescence.

I
Interest
 Moderate level of interest

The posts express moderate interest, highlighting the relevance of the research within the broader aging and biomedical communities, but not showing intense curiosity beyond that.

E
Engagement
 Moderate level of engagement

Posts reference multiple facets of the research, including the biological implications, methods, and potential applications, indicating some level of active engagement.

I
Impact
 Moderate level of impact

The discussion frames this research as a relevant advancement in the field of aging, suggesting it could influence future studies and therapeutic strategies.

Social Mentions

YouTube

2 Videos

Facebook

6 Posts

Twitter

12 Posts

Blogs

1 Articles

News

2 Articles

Metrics

Video Views

350

Total Likes

31

Extended Reach

94,803

Social Features

23

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Transcript Variant 2 as a Marker of Aging and Cellular Senescence in Mice

Transcript Variant 2 as a Marker of Aging and Cellular Senescence in Mice

Transcript variant 2 of the p21 gene increases with aging and senescence in mice, making it a useful marker for identifying senescent cells. It shows a bigger increase during natural aging and after senescence-inducing treatments, making it a superior marker for tracking cellular aging.

Aging-US

July 21, 2021

221 views

Cdkn1a Transcript Variant 2 as a Marker of Aging and Cellular Senescence

Cdkn1a Transcript Variant 2 as a Marker of Aging and Cellular Senescence

Transcript variant 2 of the p21 gene increases with aging and senescence in mice, making it a useful marker for identifying senescent cells. It responds more slowly but shows a larger increase during natural aging and senescence-inducing treatments.

Aging-US

July 30, 2021

129 views

  • Aging-US
    @AgingJrnl (Twitter)

    In memoriam, Judy Campisi @BuckInstitute
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    January 23, 2024

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  • Aging-US
    @AgingJrnl (Twitter)

    #TrendingWithImpact: Researchers from @BuckInstitute, @BerkeleyLab, @Univcordoba, @DiarioMayor, @gerochile, @UnityBiotech, & @ucsantabarbara wrote the #trending #paper: "Cdkn1a transcript variant 2 is a marker of #aging and cellular senescence" https://t.co/wDjUyFRt61 #medEd https://t.co/X78ZmEGl4J
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    July 29, 2021

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  • Health Research
    @GuiltFreeTips (Twitter)

    RT @AgingJrnl: The trending Aging #PaperoftheDay: "Cdkn1a transcript variant 2 is a marker of aging and cellular senescence https://t.co/wD…
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    July 29, 2021

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  • MedEdBot
    @MedEdBot (Twitter)

    RT @AgingJrnl: The trending Aging #PaperoftheDay: "Cdkn1a transcript variant 2 is a marker of aging and cellular senescence https://t.co/wD…
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    July 29, 2021

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  • Aging-US
    @AgingJrnl (Twitter)

    Watch an #author #interview with co-author Dr. Judith Campisi from @BuckInstitute & @UC_Newsroom about a recent paper published by #Aging: "Cdkn1a transcript variant 2 is a marker of aging and cellular senescence" https://t.co/FcqrezoQRq
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    July 21, 2021

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  • Ken Gusler
    @kgusler (Twitter)

    Aging Cdkn1a transcript variant 2 is a marker of aging and cellular senescence - https://t.co/X1uB9Cqrxl
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    July 21, 2021

  • Nathaniel David
    @NathanielEDavid (Twitter)

    If you say a cell is senescent, what does that mean? There are "flavors" of senescent cells, shown elegantly here. The CDKi p21 has two transcripts, differentially expressed in #aging/stress. So not all SnCs are alike and have different drug sensitivities https://t.co/6Coxbwl23Z
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    June 4, 2021

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  • Aging-US
    @AgingJrnl (Twitter)

    The cover of Aging's latest issue features Figure 1, "The Cdkn1a variant 2 transcript is preferentially induced during aging,“ from López-Domínguez et al. https://t.co/D2GCasAOkV #aging #cellularsenescence #senescence #longevity #medEd #OA https://t.co/avLvFRMjho
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    May 31, 2021

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  • Brain tumor ULisboa
    @braintumor_UL (Twitter)

    Cdkn1a transcript variant 2 is a marker of aging and cellular senescence https://t.co/ChRpFyyjnO
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    May 27, 2021

    1

  • AgingResearch
    @TheAgingField (Twitter)

    RT @agingdoc1: Cdkn1a transcript variant 2 is a marker of aging and cellular senescence @AgingJrnl https://t.co/vgL3e3vX72 Validation of…
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    May 26, 2021

    1

  • Proteins InVivo InVitro
    @BVpapers (Twitter)

    Cdkn1a transcript variant 2 is a marker of aging and cellular senescence: Cellular senescence is a cell fate response characterized by a permanent cell cycle arrest driven primarily the by cell cycle inhibitor and tumor suppressor proteins p16^(Ink4a)… https://t.co/YhGKuqDUEf https://t.co/bFwJ9Pki9L
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    May 26, 2021

  • Agingdoc
    @agingdoc1 (Twitter)

    Cdkn1a transcript variant 2 is a marker of aging and cellular senescence @AgingJrnl https://t.co/vgL3e3vX72 Validation of a valuable senescence biomarker Credit to Campisi & López-Domínguez @BuckInstitute, Villalba, Cárdenas & colleagues. @UnityBiotech @gerochile @BerkeleyLab https://t.co/h3FoesqVpg
    view full post

    May 26, 2021

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    1

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Abstract Synopsis

  • Transcript variant 2 of the p21 gene increases with aging and senescence in mice, making it a useful marker for identifying senescent cells.
  • In cell studies, both p21 transcripts go up during induced senescence, but variant 2 responds more slowly and shows a bigger increase during natural aging and after senescence-inducing treatments like doxorubicin.
  • Because of its higher sensitivity to senescence and senolytic drugs, transcript variant 2 is a better marker than variant 1 or total p21 protein for tracking aging and cell aging in mice.]