The comments reflect strong support for the significance of transcript variant 2 as an aging marker, with mentions of its differential expression during aging and stress, and references to expert opinions and key institutions. The tone and choice of words like 'valuable biomarker' and 'preferentially induced during aging' demonstrate recognition of its potential impact in aging research and therapy development.
AgreementStrong agreement
Most comments strongly support the significance of the research, emphasizing its importance as a biomarker for aging and cellular senescence.
InterestModerate interest
The posts express moderate interest, highlighting the relevance of the research within the broader aging and biomedical communities, but not showing intense curiosity beyond that.
EngagementModerate engagement
Posts reference multiple facets of the research, including the biological implications, methods, and potential applications, indicating some level of active engagement.
ImpactModerate impact
The discussion frames this research as a relevant advancement in the field of aging, suggesting it could influence future studies and therapeutic strategies.
Abstract in brief
Transcript variant 2 of the p21 gene increases with aging and senescence in mice, making it a useful marker for identifying senescent cells.
In cell studies, both p21 transcripts go up during induced senescence, but variant 2 responds more slowly and shows a bigger increase during natural aging and after senescence-inducing treatments like doxorubicin.
Because of its higher sensitivity to senescence and senolytic drugs, transcript variant 2 is a better marker than variant 1 or total p21 protein for tracking aging and cell aging in mice.]
Cdkn1a transcript variant 2 is a marker of aging and cellular senescence @AgingJrnl
https://t.co/vgL3e3vX72
Validation of a valuable senescence biomarker
Credit to Campisi & López-Domínguez @BuckInstitute, Villalba, Cárdenas & colleagues.
@UnityBiotech @gerochile @BerkeleyLab https://t.co/h3FoesqVpg
May 26, 2021 · 9 likes · 1 share · 43,745 followersView post →
ND
Nathaniel David
@NathanielEDavid · X
If you say a cell is senescent, what does that mean? There are "flavors" of senescent cells, shown elegantly here. The CDKi p21 has two transcripts, differentially expressed in #aging/stress. So not all SnCs are alike and have different drug sensitivities https://t.co/6Coxbwl23Z
Jun 4, 2021 · 7 likes · 2,304 followersView post →
AU
Aging-US
@AgingJrnl · X
Watch an #author #interview with co-author Dr. Judith Campisi from @BuckInstitute & @UC_Newsroom about a recent paper published by #Aging: "Cdkn1a transcript variant 2 is a marker of aging and cellular senescence" https://t.co/FcqrezoQRq
#TrendingWithImpact: Researchers from @BuckInstitute, @BerkeleyLab, @Univcordoba, @DiarioMayor, @gerochile, @UnityBiotech, & @ucsantabarbara wrote the #trending #paper: "Cdkn1a transcript variant 2 is a marker of #aging and cellular senescence" https://t.co/wDjUyFRt61 #medEd https://t.co/X78ZmEGl4J
The cover of Aging's latest issue features Figure 1, "The Cdkn1a variant 2 transcript is preferentially induced during aging,“ from López-Domínguez et al. https://t.co/D2GCasAOkV #aging #cellularsenescence #senescence #longevity #medEd #OA https://t.co/avLvFRMjho
May 31, 2021 · 2 likes · 4,400 followersView post →
AU
Aging-US
@AgingJrnl · X
In memoriam, Judy Campisi @BuckInstitute
Jan 23, 2024 · 1 like · 4,400 followersView post →
Transcript variant 2 of the p21 gene increases with aging and senescence in mice, making it a useful marker for identifying senescent cells. It shows a bigger increase during natural aging and after senescence-inducing…
Transcript variant 2 of the p21 gene increases with aging and senescence in mice, making it a useful marker for identifying senescent cells. It responds more slowly but shows a larger increase during natural aging and…
Jan 23, 2024 · 1 like · 4,400 followersView post →
AU
Aging-US
@AgingJrnl · X
#TrendingWithImpact: Researchers from @BuckInstitute, @BerkeleyLab, @Univcordoba, @DiarioMayor, @gerochile, @UnityBiotech, & @ucsantabarbara wrote the #trending #paper: "Cdkn1a transcript variant 2 is a marker of #aging and cellular senescence" https://t.co/wDjUyFRt61 #medEd https://t.co/X78ZmEGl4J
Watch an #author #interview with co-author Dr. Judith Campisi from @BuckInstitute & @UC_Newsroom about a recent paper published by #Aging: "Cdkn1a transcript variant 2 is a marker of aging and cellular senescence" https://t.co/FcqrezoQRq
If you say a cell is senescent, what does that mean? There are "flavors" of senescent cells, shown elegantly here. The CDKi p21 has two transcripts, differentially expressed in #aging/stress. So not all SnCs are alike and have different drug sensitivities https://t.co/6Coxbwl23Z
Jun 4, 2021 · 7 likes · 2,304 followersView post →
AU
Aging-US
@AgingJrnl · X
The cover of Aging's latest issue features Figure 1, "The Cdkn1a variant 2 transcript is preferentially induced during aging,“ from López-Domínguez et al. https://t.co/D2GCasAOkV #aging #cellularsenescence #senescence #longevity #medEd #OA https://t.co/avLvFRMjho
May 31, 2021 · 2 likes · 4,400 followersView post →
BU
Brain tumor ULisboa
@braintumor_UL · X
Cdkn1a transcript variant 2 is a marker of aging and cellular senescence https://t.co/ChRpFyyjnO
RT @agingdoc1: Cdkn1a transcript variant 2 is a marker of aging and cellular senescence @AgingJrnl
https://t.co/vgL3e3vX72
Validation of…
May 26, 2021 · 1 share · 5,256 followersView post →
PI
Proteins InVivo InVitro
@BVpapers · X
Cdkn1a transcript variant 2 is a marker of aging and cellular senescence: Cellular senescence is a cell fate response characterized by a permanent cell cycle arrest driven primarily the by cell cycle inhibitor and tumor suppressor proteins p16^(Ink4a)… https://t.co/YhGKuqDUEf https://t.co/bFwJ9Pki9L
Cdkn1a transcript variant 2 is a marker of aging and cellular senescence @AgingJrnl
https://t.co/vgL3e3vX72
Validation of a valuable senescence biomarker
Credit to Campisi & López-Domínguez @BuckInstitute, Villalba, Cárdenas & colleagues.
@UnityBiotech @gerochile @BerkeleyLab https://t.co/h3FoesqVpg
May 26, 2021 · 9 likes · 1 share · 43,745 followersView post →
N
Aging V15i13 204896 | PDF | Senescence | Cell (Biology)
News
www.aging-us.com 5975 AGING. their biological age ... 2021; 13:13380–92. https://doi.org/10.1091/mbc.E11-10-0884 https://doi.org/10.18632/aging.203110. PMID: ...