Aging (Albany NY) May 2021 PMID 34035185

transcript variant 2 is a marker of aging and cellular senescence.

José Alberto López-Domínguez, Sandra Rodríguez-López, Ulises Ahumada-Castro, Pierre-Yves Desprez, Maria Konovalenko, Remi-Martin Laberge, César Cárdenas, José Manuel Villalba, Judith Campisi

Mentions

23
Peak: 7 in Jul 2021
across 5 sources since May 2021

Extended reach

94,803
potential audience

Total likes

31

Video views

350

Mentions per month

May 2021 – Nov 2025

Where it's discussed

  • X / Twitter12 posts
  • Facebook6 posts
  • YouTube2 videos
  • News2 articles
  • Blogs1 articles

AI synopsis

What people are saying

The comments reflect strong support for the significance of transcript variant 2 as an aging marker, with mentions of its differential expression during aging and stress, and references to expert opinions and key institutions. The tone and choice of words like 'valuable biomarker' and 'preferentially induced during aging' demonstrate recognition of its potential impact in aging research and therapy development.

AgreementStrong agreement

Most comments strongly support the significance of the research, emphasizing its importance as a biomarker for aging and cellular senescence.

InterestModerate interest

The posts express moderate interest, highlighting the relevance of the research within the broader aging and biomedical communities, but not showing intense curiosity beyond that.

EngagementModerate engagement

Posts reference multiple facets of the research, including the biological implications, methods, and potential applications, indicating some level of active engagement.

ImpactModerate impact

The discussion frames this research as a relevant advancement in the field of aging, suggesting it could influence future studies and therapeutic strategies.

Abstract in brief

  • Transcript variant 2 of the p21 gene increases with aging and senescence in mice, making it a useful marker for identifying senescent cells.
  • In cell studies, both p21 transcripts go up during induced senescence, but variant 2 responds more slowly and shows a bigger increase during natural aging and after senescence-inducing treatments like doxorubicin.
  • Because of its higher sensitivity to senescence and senolytic drugs, transcript variant 2 is a better marker than variant 1 or total p21 protein for tracking aging and cell aging in mice.]

Top posts

Most liked on X and Bluesky
Agingdoc
@agingdoc1 · X

Cdkn1a transcript variant 2 is a marker of aging and cellular senescence @AgingJrnl https://t.co/vgL3e3vX72 Validation of a valuable senescence biomarker Credit to Campisi & López-Domínguez @BuckInstitute, Villalba, Cárdenas & colleagues. @UnityBiotech @gerochile @BerkeleyLab https://t.co/h3FoesqVpg

May 26, 2021 · 9 likes · 1 share · 43,745 followers View post →
Nathaniel David
@NathanielEDavid · X

If you say a cell is senescent, what does that mean? There are "flavors" of senescent cells, shown elegantly here. The CDKi p21 has two transcripts, differentially expressed in #aging/stress. So not all SnCs are alike and have different drug sensitivities https://t.co/6Coxbwl23Z

Jun 4, 2021 · 7 likes · 2,304 followers View post →
Aging-US
@AgingJrnl · X

Watch an #author #interview with co-author Dr. Judith Campisi from @BuckInstitute & @UC_Newsroom about a recent paper published by #Aging: "Cdkn1a transcript variant 2 is a marker of aging and cellular senescence" https://t.co/FcqrezoQRq

Jul 21, 2021 · 4 likes · 4,400 followers View post →
Aging-US
@AgingJrnl · X

#TrendingWithImpact: Researchers from @BuckInstitute, @BerkeleyLab, @Univcordoba, @DiarioMayor, @gerochile, @UnityBiotech, & @ucsantabarbara wrote the #trending #paper: "Cdkn1a transcript variant 2 is a marker of #aging and cellular senescence" https://t.co/wDjUyFRt61 #medEd https://t.co/X78ZmEGl4J

Jul 29, 2021 · 4 likes · 4,400 followers View post →
Aging-US
@AgingJrnl · X

The cover of Aging's latest issue features Figure 1, "The Cdkn1a variant 2 transcript is preferentially induced during aging,“ from López-Domínguez et al. https://t.co/D2GCasAOkV #aging #cellularsenescence #senescence #longevity #medEd #OA https://t.co/avLvFRMjho

May 31, 2021 · 2 likes · 4,400 followers View post →
Aging-US
@AgingJrnl · X

In memoriam, Judy Campisi @BuckInstitute

Jan 23, 2024 · 1 like · 4,400 followers View post →

All mentions

Aging-US
@AgingJrnl · X

In memoriam, Judy Campisi @BuckInstitute

Jan 23, 2024 · 1 like · 4,400 followers View post →
Aging-US
@AgingJrnl · X

#TrendingWithImpact: Researchers from @BuckInstitute, @BerkeleyLab, @Univcordoba, @DiarioMayor, @gerochile, @UnityBiotech, & @ucsantabarbara wrote the #trending #paper: "Cdkn1a transcript variant 2 is a marker of #aging and cellular senescence" https://t.co/wDjUyFRt61 #medEd https://t.co/X78ZmEGl4J

Jul 29, 2021 · 4 likes · 4,400 followers View post →
Health Research
@GuiltFreeTips · X

RT @AgingJrnl: The trending Aging #PaperoftheDay: "Cdkn1a transcript variant 2 is a marker of aging and cellular senescence https://t.co/wD…

Jul 29, 2021 · 2 shares · 2,265 followers View post →
MedEdBot
@MedEdBot · X

RT @AgingJrnl: The trending Aging #PaperoftheDay: "Cdkn1a transcript variant 2 is a marker of aging and cellular senescence https://t.co/wD…

Jul 29, 2021 · 2 shares · 2,902 followers View post →
Aging-US
@AgingJrnl · X

Watch an #author #interview with co-author Dr. Judith Campisi from @BuckInstitute & @UC_Newsroom about a recent paper published by #Aging: "Cdkn1a transcript variant 2 is a marker of aging and cellular senescence" https://t.co/FcqrezoQRq

Jul 21, 2021 · 4 likes · 4,400 followers View post →
Ken Gusler
@kgusler · X

Aging Cdkn1a transcript variant 2 is a marker of aging and cellular senescence - https://t.co/X1uB9Cqrxl

Jul 21, 2021 · 19,988 followers View post →
Nathaniel David
@NathanielEDavid · X

If you say a cell is senescent, what does that mean? There are "flavors" of senescent cells, shown elegantly here. The CDKi p21 has two transcripts, differentially expressed in #aging/stress. So not all SnCs are alike and have different drug sensitivities https://t.co/6Coxbwl23Z

Jun 4, 2021 · 7 likes · 2,304 followers View post →
Aging-US
@AgingJrnl · X

The cover of Aging's latest issue features Figure 1, "The Cdkn1a variant 2 transcript is preferentially induced during aging,“ from López-Domínguez et al. https://t.co/D2GCasAOkV #aging #cellularsenescence #senescence #longevity #medEd #OA https://t.co/avLvFRMjho

May 31, 2021 · 2 likes · 4,400 followers View post →
Brain tumor ULisboa
@braintumor_UL · X

Cdkn1a transcript variant 2 is a marker of aging and cellular senescence https://t.co/ChRpFyyjnO

May 27, 2021 · 1 like · 248 followers View post →
AgingResearch
@TheAgingField · X

RT @agingdoc1: Cdkn1a transcript variant 2 is a marker of aging and cellular senescence @AgingJrnl https://t.co/vgL3e3vX72 Validation of…

May 26, 2021 · 1 share · 5,256 followers View post →
Proteins InVivo InVitro
@BVpapers · X

Cdkn1a transcript variant 2 is a marker of aging and cellular senescence: Cellular senescence is a cell fate response characterized by a permanent cell cycle arrest driven primarily the by cell cycle inhibitor and tumor suppressor proteins p16^(Ink4a)… https://t.co/YhGKuqDUEf https://t.co/bFwJ9Pki9L

May 26, 2021 · 44 followers View post →
Agingdoc
@agingdoc1 · X

Cdkn1a transcript variant 2 is a marker of aging and cellular senescence @AgingJrnl https://t.co/vgL3e3vX72 Validation of a valuable senescence biomarker Credit to Campisi & López-Domínguez @BuckInstitute, Villalba, Cárdenas & colleagues. @UnityBiotech @gerochile @BerkeleyLab https://t.co/h3FoesqVpg

May 26, 2021 · 9 likes · 1 share · 43,745 followers View post →
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