J Med Chem June 2021 PMID 34101446

Discovery of Arylsulfonamides as Dual Orexin Receptor Agonists.

Dehui Zhang, David A Perrey, Ann M Decker, Tiffany L Langston, Vijayakumar Mavanji, Danni L Harris, Catherine M Kotz, Yanan Zhang

Mentions

9
Peak: 3 in Sep 2025
across 3 sources since Jun 2021

Extended reach

18,201
potential audience

Total likes

9

Video views

258

Mentions per month

Jun 2021 – Nov 2025

Where it's discussed

  • X / Twitter6 posts
  • YouTube2 videos
  • News1 articles

AI synopsis

What people are saying

The posts reflect strong interest, with phrases like "discovery" and "promising potential", emphasizing the significance of the research. The tone is optimistic yet measured, referencing how these compounds could improve narcolepsy symptoms, which indicates a recognition of the research's potential impact while maintaining scientific caution.

AgreementModerate agreement

Most discussions recognize the significance of the discovery, though some show cautious optimism.

InterestHigh interest

The posts demonstrate high curiosity and enthusiasm about the potential applications of dual orexin receptor agonists.

EngagementModerate engagement

Users engage by sharing admiration and asking questions, indicating a moderate depth of discussion.

ImpactModerate impact

There's a shared view that this research could notably influence future treatments for sleep disorders, but some posts are more speculative.

Abstract in brief

  • Researchers discovered arylsulfonamides that act as dual agonists for orexin receptors (OX2R and OX1R), which are involved in regulating wakefulness.
  • Through structure-activity relationship studies and computational modeling, they identified compounds like RTOXA43 that effectively target both receptors, with potential to improve narcolepsy symptoms.
  • In animal experiments, these dual agonists increased wakefulness and sleep quality, indicating their promise as treatments for orexin deficiency disorders such as narcolepsy.]

Top posts

Most liked on X and Bluesky
nor
@noriji0 · X

Discovery of Arylsulfonamides as Dual Orexin Receptor Agonists https://t.co/smvw0AafZG #nor論文

Jun 15, 2021 · 5 likes · 2 shares · 826 followers View post →
Chidambara .ML.
@chidambara09 · X

https://t.co/3TkuV5s7G5 ThX

Sep 9, 2025 · 11,679 followers View post →
divetoinfinity@創薬研究
@divetoinfinity · X

RT @noriji0: Discovery of Arylsulfonamides as Dual Orexin Receptor Agonists https://t.co/smvw0AafZG #nor論文

Jun 15, 2021 · 2 shares · 4,150 followers View post →
Acta Materia Medica
@AMM_journal · X

RT @CHOculturePaper:

Sep 9, 2025 · 1 share · 615 followers View post →
パーマくん(欺瞞に満ちた真空)
@48heaven · X

https://t.co/oXo5HjDbvX

May 30, 2022 · 565 followers View post →
CHO Cell Papers
@CHOculturePaper · X

Sep 9, 2025 · 1 share · 87 followers View post →

All mentions

Acta Materia Medica
@AMM_journal · X

RT @CHOculturePaper:

Sep 9, 2025 · 1 share · 615 followers View post →
Chidambara .ML.
@chidambara09 · X

https://t.co/3TkuV5s7G5 ThX

Sep 9, 2025 · 11,679 followers View post →
CHO Cell Papers
@CHOculturePaper · X

Sep 9, 2025 · 1 share · 87 followers View post →
パーマくん(欺瞞に満ちた真空)
@48heaven · X

https://t.co/oXo5HjDbvX

May 30, 2022 · 565 followers View post →
divetoinfinity@創薬研究
@divetoinfinity · X

RT @noriji0: Discovery of Arylsulfonamides as Dual Orexin Receptor Agonists https://t.co/smvw0AafZG #nor論文

Jun 15, 2021 · 2 shares · 4,150 followers View post →
nor
@noriji0 · X

Discovery of Arylsulfonamides as Dual Orexin Receptor Agonists https://t.co/smvw0AafZG #nor論文

Jun 15, 2021 · 5 likes · 2 shares · 826 followers View post →
Microbial NP | PDF | Metabolomics | Biology
News

actives undermine natural product-based drug discovery? J Med Chem 59(5):1671–1690. https://doi.org/10.1021/acs.jmedchem.5b01009 2 Metabolomics Applied to ...

Dec 14, 2025 View →