Front Nutr June 2021 PMID 34179054

A Muscle-Centric Perspective on Intermittent Fasting: A Suboptimal Dietary Strategy for Supporting Muscle Protein Remodeling and Muscle Mass?

Eric Williamson, Daniel R Moore

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Mentions

113
Peak: 17 in May 2021
across 7 sources since May 2021

Extended reach

777,647
potential audience

Total likes

4,903

Video views

105,722

Mentions per month

May 2021 – Dec 2025

Where it's discussed

  • News52 articles
  • X / Twitter51 posts
  • YouTube4 videos
  • Instagram3 posts
  • Facebook1 posts
  • TikTok1 posts
  • Reddit1 posts

AI synopsis

What people are saying

The discussions reveal a skeptical tone towards intermittent fasting's benefits for muscle, citing scientific points about protein synthesis and hormonal effects, while also showing curiosity about research findings. Words like 'problematic,' 'difficult to define,' and references to scientific studies demonstrate critical analysis and active engagement with the publication's claims.

AgreementLow agreement

Most discussions question or critique the benefits of intermittent fasting for muscle health, indicating disagreement or skepticism about its efficacy.

InterestHigh interest

There is high engagement and curiosity about the topic, with detailed comments about muscle protein synthesis and fasting durations.

EngagementModerate engagement

Users reference specific studies, physiological mechanisms, and personal experiences, showing active and thoughtful participation.

ImpactModerate impact

The conversations could influence opinions about fasting and muscle health, especially with scientific references and critique of fasting protocols.

Abstract in brief

  • Intermittent fasting may be less effective for muscle health because it limits the intake of dietary amino acids that are necessary for muscle protein synthesis, which is crucial for maintaining or building muscle mass.
  • The fasting periods in intermittent fasting reduce insulin levels, which can hinder muscle protein remodeling, since insulin has an anti-catabolic (muscle-preserving) effect.
  • The authors suggest that instead of intermittent fasting, regular protein intake during feeding periods is better for supporting muscle growth, especially when energy availability is limited.]

Top posts

Most liked on X and Bluesky
Brad Schoenfeld, PhD
@BradSchoenfeld · X

Longitudinal data is lacking, but given what we know about the MPS response to feeding, this conclusion would seem to make sense from a logical standpoint https://t.co/CL7Z4YJeHu https://t.co/V99qlvpiw5

May 21, 2021 · 90 likes · 17 shares · 95,791 followers View post →
Ale Garcia
@GYM_EXTREMO · X

La palabra ayuno intermitente es muy amplia, difícil de definir y de interpretar. No es lo mismo 12hs de ayuno que 16 o 24 o incluso más. Sin embargo, aparentemente el ayuno intermitente puede ser contraproducente cuando buscamos mejorar la masa muscular. https://t.co/YSzaJHybh4

Jul 12, 2023 · 51 likes · 12 shares · 98,568 followers View post →
PildoraBreve
@pildorabreve · X

“…destacar que la evidencia aguda actual sugiere que el ayuno intermitente

Jun 9, 2021 · 8 likes · 2 shares · 3,791 followers View post →
Ale Garcia
@GYM_EXTREMO · X

Ayuno: ¿que pasa con el músculo?

Apr 29, 2025 · 4 likes · 1 share · 98,568 followers View post →
Nick Krontiris
@nick_krontiris · X

A Muscle-Centric Perspective on Intermittent Fasting: A Suboptimal Dietary Strategy for Supporting Muscle Protein Remodeling and Muscle Mass? (open access) https://t.co/1brrqeGuyi #nutrition #diet #IntermittentFasting #exercise #TrainHard #GymTime #muscle #strength #lift

Jun 9, 2021 · 4 likes · 4 shares · 19,490 followers View post →
Sudās
@sudas1891 · X

https://t.co/nOTHGnil2B @stathitriadis @exfatloss @richcollins interesting discussion on how much dietary protein per meal can stimulate muscle synthesis before being saturated. Basically .25g/kg after which despite amino acidemia no further synthesis occurs

Aug 5, 2023 · 4 likes · 1 share · 638 followers View post →

All mentions

Ale Garcia
@GYM_EXTREMO · X

RT @GYM_EXTREMO: Ayuno: ¿que pasa con el músculo?

Apr 30, 2025 · 1 share · 98,568 followers View post →
Ale Garcia
@GYM_EXTREMO · X

Ayuno: ¿que pasa con el músculo?

Apr 29, 2025 · 4 likes · 1 share · 98,568 followers View post →
Deanna Harder
@DeannaHarder · X

Skip Intermittent Fasting IF YOU WANT TO BE LEAN AND STRONG IN MIDLIFE! Research indicates that IF can be problematic in women. It increases stress, worsens insulin sensitivity, and may cause hormonal disruption It also can make it hard to maintain muscle! https://t.co/8rMDjduuTo

Nov 14, 2023 · 1 like · 1,365 followers View post →
Cuaderno de psicologia
@Sport__coaching · X

RT @GYM_EXTREMO: La palabra ayuno intermitente es muy amplia, difícil de definir y de interpretar. No es lo mismo 12hs de ayuno que 16 o 24…

Aug 9, 2023 · 12 shares · 186 followers View post →
exfatloss
@exfatloss · X

RT @anti_wokeist: https://t.co/nOTHGnil2B @stathitriadis @exfatloss @richcollins interesting discussion on how much dietary protein per mea…

Aug 5, 2023 · 1 share · 6,829 followers View post →
Sudās
@sudas1891 · X

https://t.co/nOTHGnil2B @stathitriadis @exfatloss @richcollins interesting discussion on how much dietary protein per meal can stimulate muscle synthesis before being saturated. Basically .25g/kg after which despite amino acidemia no further synthesis occurs

Aug 5, 2023 · 4 likes · 1 share · 638 followers View post →
Sudās
@sudas1891 · X

@FilipRanders @ScepticalDoctor Like I said if you’re cool with muscle loss, than prolonged fasting is fine. https://t.co/nOTHGnil2B

Aug 5, 2023 · 638 followers View post →
Skyy
@it_neverend · X

RT @GYM_EXTREMO: La palabra ayuno intermitente es muy amplia, difícil de definir y de interpretar. No es lo mismo 12hs de ayuno que 16 o 24…

Jul 22, 2023 · 12 shares · 1,418 followers View post →
Santiago Manuel Freyre
@Santiag78525068 · X

RT @GYM_EXTREMO: La palabra ayuno intermitente es muy amplia, difícil de definir y de interpretar. No es lo mismo 12hs de ayuno que 16 o 24…

Jul 16, 2023 · 12 shares · 6 followers View post →
Mile Ortega
@MiluuOrtega · X

RT @GYM_EXTREMO: La palabra ayuno intermitente es muy amplia, difícil de definir y de interpretar. No es lo mismo 12hs de ayuno que 16 o 24…

Jul 12, 2023 · 12 shares · 609 followers View post →
Ragnar Reagan !!
@GatoSordido · X

RT @GYM_EXTREMO: La palabra ayuno intermitente es muy amplia, difícil de definir y de interpretar. No es lo mismo 12hs de ayuno que 16 o 24…

Jul 12, 2023 · 12 shares · 1,456 followers View post →
Pedro
@Zirculovizioso · X

RT @GYM_EXTREMO: La palabra ayuno intermitente es muy amplia, difícil de definir y de interpretar. No es lo mismo 12hs de ayuno que 16 o 24…

Jul 12, 2023 · 12 shares · 250 followers View post →
Manuelpk.
@RIP23_03_2018 · X

RT @GYM_EXTREMO: La palabra ayuno intermitente es muy amplia, difícil de definir y de interpretar. No es lo mismo 12hs de ayuno que 16 o 24…

Jul 12, 2023 · 12 shares · 561 followers View post →
xiao_liebao
@xiao_liebao · X

RT @GYM_EXTREMO: La palabra ayuno intermitente es muy amplia, difícil de definir y de interpretar. No es lo mismo 12hs de ayuno que 16 o 24…

Jul 12, 2023 · 12 shares · 60 followers View post →
Yo Nutricionista
@nutricionjavier · X

RT @GYM_EXTREMO: La palabra ayuno intermitente es muy amplia, difícil de definir y de interpretar. No es lo mismo 12hs de ayuno que 16 o 24…

Jul 12, 2023 · 12 shares · 66,929 followers View post →
EDWIN CASTILLO
@damiancasttillo · X

RT @GYM_EXTREMO: La palabra ayuno intermitente es muy amplia, difícil de definir y de interpretar. No es lo mismo 12hs de ayuno que 16 o 24…

Jul 12, 2023 · 12 shares · 63 followers View post →
Ale Garcia
@GYM_EXTREMO · X

La palabra ayuno intermitente es muy amplia, difícil de definir y de interpretar. No es lo mismo 12hs de ayuno que 16 o 24 o incluso más. Sin embargo, aparentemente el ayuno intermitente puede ser contraproducente cuando buscamos mejorar la masa muscular. https://t.co/YSzaJHybh4

Jul 12, 2023 · 51 likes · 12 shares · 98,568 followers View post →
Ale Garcia
@GYM_EXTREMO · X

@pzjarana Lo más coherente que leí hasta ahora https://t.co/YSzaJHybh4

Jul 12, 2023 · 98,568 followers View post →
Lion’s Sin
@TeeRaySays · X

@mightjustchilll https://t.co/eh7SP5YNsB. Can you point me to a study that shows these benefits? Also in the context of the tweet it still doesn’t make sense. Cause she said she lost fat and gained weight.

Jun 24, 2023 · 1,499 followers View post →
L
@leidy_joha55 · X

@irwing_25 @Maximo88026240 @AndrsMustaf1 @NutriologaWeb https://t.co/mOvaiivKnq https://t.co/19bLkOImOt En mi caso fue recomendado por una nutricionista y en su momento funcionó, (deje de hacerlo por otras cuestiones) debido a ello encontré este tipo de videos también. https://t.co/r6MZd3XxZz https://t.co/rssgKYfLhK

Oct 31, 2022 · 1 like · 216 followers View post →
Ghaïs Guelaïa
@GeekNfit · X

"While some benefits of Intermittent Fasting are suggested to be mediated by increased autophagy (24), induction of this system with short term fasting (i.e., up to 36h) is not readily apparent in human skeletal muscle, unlike with exercise (25, 26)" DOI=10.3389/fnut.2021.640621 https://t.co/46NqjlHRJN

Nov 17, 2021 · 3 likes · 12,955 followers View post →
Craig A. Goodman
@CraigAGoodman1 · X

RT @AlexViKu: A Muscle-Centric Perspective on Intermittent Fasting: A Suboptimal Dietary Strategy for Supporting Muscle Protein Remodeling…

Jul 16, 2021 · 1 share · 3,945 followers View post →
Alex
@AlexViKu · X

A Muscle-Centric Perspective on Intermittent Fasting: A Suboptimal Dietary Strategy for Supporting Muscle Protein Remodeling and Muscle Mass? https://t.co/krKN5ntzoV

Jul 16, 2021 · 3 likes · 1 share · 96 followers View post →
Sunset HQ
@SunsetHQBC · X

RT @dnewmire: “A limitation in evaluating the impact of IF on SkMM and function is the overreliance on whole body estimates of FFM, which h…

Jun 29, 2021 · 1 share · 15 followers View post →
UpToPhate
@UpToPhate · X

A Muscle-Centric Perspective on Intermittent Fasting: A Suboptimal Dietary Strategy for Supporting Muscle Protein Remodeling and Muscle Mass? https://t.co/wGpz6fRFQG

Jun 29, 2021 · 2 likes · 191 followers View post →
Dan Newmire PhD
@dnewmire · X

“A limitation in evaluating the impact of IF on SkMM and function is the overreliance on whole body estimates of FFM, which have been questioned as to their ability to specifically delineate SkMM given they include substantial organ/non-SkMM lean tissue.” https://t.co/QMrdAYBZSZ

Jun 29, 2021 · 1 like · 1 share · 1,763 followers View post →
Jorge Ruiz-Carrascal
@Elorges · X

A Muscle-Centric Perspective on Intermittent Fasting: A Suboptimal Dietary Strategy for Supporting Muscle Protein Remodeling and Muscle Mass? Vamos, que si te quieres poner cachas, hay que comer https://t.co/BTAVcRIuYE

Jun 15, 2021 · 1,173 followers View post →
Frontiers - Nutrition
@FrontNutrition · X

New Research: A Muscle-Centric Perspective on Intermittent Fasting: A Suboptimal Dietary Strategy for Supporting Muscle Protein Remodeling and Muscle Mass?: Muscle protein is constantly “turning over” through the breakdown of old/damaged… https://t.co/zeyjsGOyaI #Nutrition

Jun 9, 2021 · 1 like · 3,914 followers View post →
Ignacio Vázquez
@mrnachiti · X

RT @pildorabreve: “…destacar que la evidencia aguda actual sugiere que el ayuno intermitente

Jun 9, 2021 · 2 shares · 3,865 followers View post →
Ignacio Hernando Valle
@nachoafysalud · X

RT @pildorabreve: “…destacar que la evidencia aguda actual sugiere que el ayuno intermitente

Jun 9, 2021 · 2 shares · 5,820 followers View post →
PildoraBreve
@pildorabreve · X

“…destacar que la evidencia aguda actual sugiere que el ayuno intermitente

Jun 9, 2021 · 8 likes · 2 shares · 3,791 followers View post →
Rk
@Rk76381544 · X

RT @nick_krontiris: A Muscle-Centric Perspective on Intermittent Fasting: A Suboptimal Dietary Strategy for Supporting Muscle Protein Remod…

Jun 9, 2021 · 4 shares · 3 followers View post →
Riyaz
@Riyaz68287780 · X

RT @nick_krontiris: A Muscle-Centric Perspective on Intermittent Fasting: A Suboptimal Dietary Strategy for Supporting Muscle Protein Remod…

Jun 9, 2021 · 4 shares · 2 followers View post →
Nick Krontiris
@nick_krontiris · X

A Muscle-Centric Perspective on Intermittent Fasting: A Suboptimal Dietary Strategy for Supporting Muscle Protein Remodeling and Muscle Mass? (open access) https://t.co/1brrqeGuyi #nutrition #diet #IntermittentFasting #exercise #TrainHard #GymTime #muscle #strength #lift

Jun 9, 2021 · 4 likes · 4 shares · 19,490 followers View post →
Gabriela Llerena P.
@nutgllerena · X

RT @BradSchoenfeld: Longitudinal data is lacking, but given what we know about the MPS response to feeding, this conclusion would seem to m…

May 24, 2021 · 17 shares · 888 followers View post →
Roland
@gabboud66 · X

RT @BradSchoenfeld: Longitudinal data is lacking, but given what we know about the MPS response to feeding, this conclusion would seem to m…

May 23, 2021 · 17 shares · 61 followers View post →
Xenon
@CO2caine · X

RT @BradSchoenfeld: Longitudinal data is lacking, but given what we know about the MPS response to feeding, this conclusion would seem to m…

May 23, 2021 · 17 shares · 557 followers View post →
Jc Rodriguez
@jc_rfitness · X

RT @BradSchoenfeld: Longitudinal data is lacking, but given what we know about the MPS response to feeding, this conclusion would seem to m…

May 22, 2021 · 17 shares · 50 followers View post →
André Katayama Yamada
@KatayamaYamada · X

RT @BradSchoenfeld: Longitudinal data is lacking, but given what we know about the MPS response to feeding, this conclusion would seem to m…

May 21, 2021 · 17 shares · 404 followers View post →
Craig Liebenson
@CraigLiebenson · X

RT @BradSchoenfeld: Longitudinal data is lacking, but given what we know about the MPS response to feeding, this conclusion would seem to m…

May 21, 2021 · 17 shares · 8,199 followers View post →
Argón
@metilargon · X

RT @BradSchoenfeld: Longitudinal data is lacking, but given what we know about the MPS response to feeding, this conclusion would seem to m…

May 21, 2021 · 17 shares · 350 followers View post →
Dr. Robert Evans
@DrEvansGuelph · X

RT @BradSchoenfeld: Longitudinal data is lacking, but given what we know about the MPS response to feeding, this conclusion would seem to m…

May 21, 2021 · 17 shares · 169 followers View post →
Mass Migration
@BChinatti · X

RT @BradSchoenfeld: Longitudinal data is lacking, but given what we know about the MPS response to feeding, this conclusion would seem to m…

May 21, 2021 · 17 shares · 1,205 followers View post →
Martino V. Franchi
@MVFranchi · X

RT @BradSchoenfeld: Longitudinal data is lacking, but given what we know about the MPS response to feeding, this conclusion would seem to m…

May 21, 2021 · 17 shares · 6,003 followers View post →
Alex
@AlexViKu · X

RT @BradSchoenfeld: Longitudinal data is lacking, but given what we know about the MPS response to feeding, this conclusion would seem to m…

May 21, 2021 · 17 shares · 96 followers View post →
Ciarán Foy - PT
@FoyPt · X

RT @BradSchoenfeld: Longitudinal data is lacking, but given what we know about the MPS response to feeding, this conclusion would seem to m…

May 21, 2021 · 17 shares · 2,606 followers View post →
James Rutherford
@TheJBlade · X

RT @BradSchoenfeld: Longitudinal data is lacking, but given what we know about the MPS response to feeding, this conclusion would seem to m…

May 21, 2021 · 17 shares · 251 followers View post →
2Fi
@2fi_nance_tness · X

RT @BradSchoenfeld: Longitudinal data is lacking, but given what we know about the MPS response to feeding, this conclusion would seem to m…

May 21, 2021 · 17 shares · 247 followers View post →
Bhopender Thakur
@TheBhupiThakur · X

RT @BradSchoenfeld: Longitudinal data is lacking, but given what we know about the MPS response to feeding, this conclusion would seem to m…

May 21, 2021 · 17 shares · 1,362 followers View post →
Kevin Tipton
@proftipper · X

RT @BradSchoenfeld: Longitudinal data is lacking, but given what we know about the MPS response to feeding, this conclusion would seem to m…

May 21, 2021 · 17 shares · 18,195 followers View post →
Brad Schoenfeld, PhD
@BradSchoenfeld · X

Longitudinal data is lacking, but given what we know about the MPS response to feeding, this conclusion would seem to make sense from a logical standpoint https://t.co/CL7Z4YJeHu https://t.co/V99qlvpiw5

May 21, 2021 · 90 likes · 17 shares · 95,791 followers View post →
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