Synopsis of Social media discussions

The overall discussions highlight the significance of the study with comments like 'groundbreaking' and 'finally out,' while specific references to over- and under-expressed genes, androgen receptor levels, and the study’s methodology reveal high curiosity and engagement, emphasizing the potential clinical importance of these findings for understanding PFS.

A
Agreement
Moderate agreement

Most discussions recognize and support the study’s findings on gene expression changes related to PFS, indicating a general agreement about its significance.

I
Interest
High level of interest

The posts show high interest, with many referencing the importance of the study, its implications, and its details, demonstrating active curiosity.

E
Engagement
High engagement

Numerous discussions delve into specific aspects like gene expression, androgen receptors, methodological rigor, and clinical relevance, reflecting deep engagement.

I
Impact
High level of impact

The collective tone and detail suggest that these discussions could influence understanding, patient advocacy, and future research directions, representing high impact.

Social Mentions

YouTube

2 Videos

Twitter

48 Posts

Metrics

Video Views

63,377

Total Likes

1,331

Extended Reach

110,864

Social Features

50

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Debunking Post Finasteride Syndrome Myths and Misconceptions

Debunking Post Finasteride Syndrome Myths and Misconceptions

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May 24, 2022

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Understanding Post-Finasteride Syndrome with Dr. Peter Attia

Understanding Post-Finasteride Syndrome with Dr. Peter Attia

Dr. Attia and Dr. Khera discuss the controversial Post-Finasteride Syndrome (PFS). This video explores the implications of finasteride use, addressing related conditions and controversies surrounding its effects on health, including mental health and quality of life.

July 7, 2023

31,131 views


  • Recall Propecia
    @RecallPropecia (Twitter)

    @7fignigg @PSSDNetwork @wunna1124836 @PFSFoundation @FinasterideInfo Numerous rigorous scientific studies have shown finasteride causes gene expression changes, the likely culprit for the etiology of post finasteride syndrome. https://t.co/uTxZ0IBUA5
    view full post

    September 28, 2025

    2

  • ₿itcoinOasis86
    @BitcoinOasis86 (Twitter)

    RT @RecallPropecia: Differential Gene Expression in Post-Finasteride Syndrome Patients https://t.co/uTxZ0IBUA5
    view full post

    August 12, 2025

    1

  • Recall Propecia
    @RecallPropecia (Twitter)

    Differential Gene Expression in Post-Finasteride Syndrome Patients https://t.co/uTxZ0IBUA5
    view full post

    August 12, 2025

    1

    1

  • Recall Propecia
    @RecallPropecia (Twitter)

    @MentalAcr0bat @Unstoppable218 @churrascooooo Altered gene expression from a pharmaceutical drug. Differential Gene Expression in Post-Finasteride Syndrome Patients https://t.co/uTxZ0IBUA5
    view full post

    August 12, 2025

    1

  • Recall Propecia
    @RecallPropecia (Twitter)

    @MentalAcr0bat @yapofreeland Science https://t.co/uTxZ0IBUA5
    view full post

    July 20, 2025

  • Recall Propecia
    @RecallPropecia (Twitter)

    @MentalAcr0bat @yapofreeland "Twenty-six men consented to inclusion in the control group." YOU DUMB ILLITERATE FUCK!!!!!!!!!!!! https://t.co/uTxZ0IBUA5
    view full post

    July 19, 2025

  • Recall Propecia
    @RecallPropecia (Twitter)

    @MentalAcr0bat @yapofreeland Read it an weep, sex minimizer. https://t.co/uTxZ0IBUA5
    view full post

    July 19, 2025

  • Recall Propecia
    @RecallPropecia (Twitter)

    @MentalAcr0bat @yapofreeland Differential Gene Expression in Post Finasteride Syndrome Patients https://t.co/uTxZ0IBUA5
    view full post

    July 19, 2025

  • Recall Propecia
    @RecallPropecia (Twitter)

    @MentalAcr0bat @TM_Brown @nytimes @maxwellstrachan Medical Proof: https://t.co/uTxZ0IBUA5
    view full post

    July 13, 2025

  • Recall Propecia
    @RecallPropecia (Twitter)

    @vimer_republic @NoahRyanCo Study showing an actual pathway that side effects don't subside after the short half life of fin in the body. https://t.co/uTxZ0IBUA5
    view full post

    June 24, 2025

  • Finasteride Watch
    @FinasterideInfo (Twitter)

    @j60774957 Howell et al, 2021 found higher expression of AR compared to controls, in a penile biopsy. https://t.co/cp5biQSOnk
    view full post

    July 3, 2024

  • 8Eevert ✨
    @8Eevert (Twitter)

    Differential Gene Expression in Post-#Finasteride Syndrome —first study to demonstrate gene expression differences in etiology of sexual dysfunction after 5-alpha-reductase inhibitor exposure —providers should be aware & advise accordingly J Sex Med 2021 https://t.co/4PVajIemkL https://t.co/baiBR6BWxM
    view full post

    September 12, 2023

    1

  • Loading...
    @PieAreSqwared (Twitter)

    @Fiddaman @rcpsych As an example, PFS sufferers were found with 1,446 genes significantly over-expressed and 2,318 genes significantly under-expressed in study patients. Surely these changes weren’t accounted for, I’d wager the same issue would be prevalent in PSSD. 2/2 https://t.co/YyS77QM8Zl
    view full post

    July 12, 2023

    3

  • julia Alex
    @juliaalex3533 (Twitter)

    RT @Oppp7iQ: 詳しく知りたい人用 【ポストフィナステリド症候群患者における遺伝子発現の差異】2021 アメリカ https://t.co/AB9Z1ose1r
    view full post

    July 10, 2023

    1

  • たつろう@髪が生える
    @Oppp7iQ (Twitter)

    詳しく知りたい人用 【ポストフィナステリド症候群患者における遺伝子発現の差異】2021 アメリカ https://t.co/AB9Z1ose1r
    view full post

    July 9, 2023

    4

    1

  • PfSpain
    @pfspain1 (Twitter)

    RT @RecallPropecia: I agree. Now start by reading this: Differential Gene Expression in Post-Finasteride Syndrome Patients https://t.co/u…
    view full post

    March 15, 2023

    1

  • Recall Propecia
    @RecallPropecia (Twitter)

    I agree. Now start by reading this: Differential Gene Expression in Post-Finasteride Syndrome Patients https://t.co/uTxZ0IBUA5 https://t.co/qMP8YBcLt1
    view full post

    March 14, 2023

    4

    1

  • PSSD Network | Post-SSRI Sexual Dysfunction
    @PSSDNetwork (Twitter)

    @SupraMiqote Differential gene expression was found in PFS patients: https://t.co/0S37XEfJTj PFS has never been debunked in any study, it's an understudied condition that has led many young people to take their life. Just because something is not understood yet, doesn't mean it's not real.
    view full post

    January 27, 2023

    4

  • PfSpain
    @pfspain1 (Twitter)

    @Endocrino_PED Hola Gilberto, te añado más estudios de rigor que pueden ayudarte: https://t.co/MiRwDdNwee https://t.co/zSFkA2WOpq https://t.co/8XuoRnogYF https://t.co/A6zq3lfewD https://t.co/XxaAD5Wm0b https://t.co/6BSXy7z7K1 https://t.co/UN4OQGPtMx
    view full post

    November 17, 2022

  • PfSpain
    @pfspain1 (Twitter)

    @jchassa @Lauzurica_Derma Esto son mitos? https://t.co/MiRwDdNwee https://t.co/zSFkA2WOpq https://t.co/8XuoRnogYF https://t.co/A6zq3lfewD https://t.co/XxaAD5Wm0b https://t.co/6BSXy7z7K1 https://t.co/c88wnExLIV https://t.co/FEOQQOHLij https://t.co/1HD57xBSJ0 https://t.co/RVVotZrLv1
    view full post

    November 17, 2022

  • PfSpain
    @pfspain1 (Twitter)

    @Herraiz_MJ @Lauzurica_Derma Y que piensas de estos estudios? https://t.co/MiRwDdNwee https://t.co/zSFkA2WOpq https://t.co/8XuoRnogYF https://t.co/A6zq3lfewD https://t.co/XxaAD5Wm0b https://t.co/6BSXy7z7K1 https://t.co/c88wnExLIV https://t.co/FEOQQOHLij https://t.co/1HD57xBSJ0 https://t.co/RVVotZrLv1
    view full post

    November 17, 2022

  • PfSpain
    @pfspain1 (Twitter)

    @Dr_AhmedAlturki @MoonHeart_0 U tal about these studies: https://t.co/MiRwDdNwee https://t.co/zSFkA2WOpq https://t.co/8XuoRnogYF https://t.co/A6zq3lfewD https://t.co/XxaAD5Wm0b https://t.co/6BSXy7z7K1
    view full post

    November 17, 2022

  • PfSpain
    @pfspain1 (Twitter)

    RT @medicinareal1: @victordnicolas @JJVEscuderos @SergioVanoG En cuento a vuestra evidencia encontrá de esta condición, porque existen esto…
    view full post

    November 15, 2022

    1

  • medicinareal
    @medicinareal1 (Twitter)

    @victordnicolas @JJVEscuderos @SergioVanoG En cuento a vuestra evidencia encontrá de esta condición, porque existen estos estudios entonces? Tienen errores metodoligos con mala calidad científica supongo https://t.co/zoc7MRt7oq https://t.co/AEqIqca5rh https://t.co/B9sIsSjz7O https://t.co/tW3M6C1NF0 https://t.co/85gNNPIS16
    view full post

    November 15, 2022

    1

    1

  • Ryan Clark
    @RyanCla64726007 (Twitter)

    RT @pfsnetwork: A key investigation into PFS at Baylor College of Medicine has identified significantly elevated androgen receptor expressi…
    view full post

    November 25, 2021

    3

  • PFS Help
    @PostFinHelp (Twitter)

    Differential Gene Expression in Post-Finasteride Syndrome Patients #Finasteride #PostFinasterideSyndrome #PFS https://t.co/DNMAoUExho
    view full post

    July 17, 2021

  • Recall Propecia
    @RecallPropecia (Twitter)

    @IHEC_Epigenomes Please take a look at the groundbreaking study 'Differential Gene Expression in Post-Finasteride Syndrome Patients.' Pharma drugs like finasteride are causing epigenetic changes in patients and this study demonstrates that. https://t.co/uTxZ0ISXC5
    view full post

    July 17, 2021

  • PSSD WARRIOR
    @PssdWarrior (Twitter)

    RT @FinasterideInfo: The groundbreaking study is here: https://t.co/tfv9pwQ8vA
    view full post

    July 15, 2021

    1

  • Finasteride Watch
    @FinasterideInfo (Twitter)

    The groundbreaking study is here: https://t.co/tfv9pwQ8vA
    view full post

    July 15, 2021

    1

    1

  • Ryan Clark
    @RyanCla64726007 (Twitter)

    RT @SimonBreidert: New PFS study that we were waiting for many years is finally out: https://t.co/A3l90QUDX8 Thanks @SkylerHowell17 and te…
    view full post

    July 14, 2021

    5

  • PSSD WARRIOR
    @PssdWarrior (Twitter)

    RT @SimonBreidert: New PFS study that we were waiting for many years is finally out: https://t.co/A3l90QUDX8 Thanks @SkylerHowell17 and te…
    view full post

    July 13, 2021

    5

  • Mary G
    @conalls_mum (Twitter)

    RT @FinasterideInfo: New study from a lab at Baylor found changes in expression of *thousands* of genes in people with post-finasteride sym…
    view full post

    July 13, 2021

    1

  • Mary G
    @conalls_mum (Twitter)

    RT @FinasterideInfo: A groundbreaking study in @jsexmed provides evidence for post-finasteride syndrome as a disorder of gene expression. h…
    view full post

    July 13, 2021

    1

  • Ruth
    @tigragal60 (Twitter)

    RT @pfsnetwork: A key investigation into PFS at Baylor College of Medicine has identified significantly elevated androgen receptor expressi…
    view full post

    July 13, 2021

    3

  • Finasteride Watch
    @FinasterideInfo (Twitter)

    A groundbreaking study in @jsexmed provides evidence for post-finasteride syndrome as a disorder of gene expression. https://t.co/tfv9pwQ8vA @APHAMensHealth @MensHlthNetwork @MensHealthAMHF @AndrologyASA @ISSM_INFO @SMSNA_ORG @EAAndrology @GeneticsSociety @MensHealthMag #sexmed
    view full post

    July 13, 2021

    9

    1

  • PSSD WARRIOR
    @PssdWarrior (Twitter)

    RT @pfsnetwork: A key investigation into PFS at Baylor College of Medicine has identified significantly elevated androgen receptor expressi…
    view full post

    July 13, 2021

    3

  • Finasteride Watch
    @FinasterideInfo (Twitter)

    New study from a lab at Baylor found changes in expression of *thousands* of genes in people with post-finasteride symptoms. "1,446 genes significantly over-expressed and 2,318 genes significantly under-expressed in study patients." https://t.co/tfv9pwQ8vA #dermtwitter
    view full post

    July 13, 2021

    4

    1

  • Mary G
    @conalls_mum (Twitter)

    RT @SimonBreidert: New PFS study that we were waiting for many years is finally out: https://t.co/A3l90QUDX8 Thanks @SkylerHowell17 and te…
    view full post

    July 13, 2021

    5

  • Mary G
    @conalls_mum (Twitter)

    RT @FinasterideInfo: A long-awaited study is out today in @jsexmed Study measured gene expression in penile tissue of people with post-fi…
    view full post

    July 13, 2021

    1

  • Finasteride Watch
    @FinasterideInfo (Twitter)

    A long-awaited study is out today in @jsexmed Study measured gene expression in penile tissue of people with post-finasteride symptoms vs. controls & found: “Androgen receptor expression was significantly higher in study patients compared to controls.” https://t.co/tfv9pwQ8vA
    view full post

    July 13, 2021

    1

  • Recall Propecia
    @RecallPropecia (Twitter)

    Differential Gene Expression in Post-Finasteride Syndrome Patients https://t.co/uTxZ0ISXC5
    view full post

    July 13, 2021

    1

  • recovery&renewal
    @recover2renew (Twitter)

    RT @SimonBreidert: New PFS study that we were waiting for many years is finally out: https://t.co/A3l90QUDX8 Thanks @SkylerHowell17 and te…
    view full post

    July 13, 2021

    5

  • Alyne Duthie
    @DuthieAlyne (Twitter)

    RT @SimonBreidert: New PFS study that we were waiting for many years is finally out: https://t.co/A3l90QUDX8 Thanks @SkylerHowell17 and te…
    view full post

    July 13, 2021

    5

  • Simon Breidert
    @SimonBreidert (Twitter)

    New PFS study that we were waiting for many years is finally out: https://t.co/A3l90QUDX8 Thanks @SkylerHowell17 and team @CosimoMelcangi @DamilolaGeorhe @PFSFoundation @AmyPearlman1 @DrDavidHealy
    view full post

    July 13, 2021

    13

    5

  • Ryan Clark
    @RyanCla64726007 (Twitter)

    Differential Gene Expression in Post-Finasteride Syndrome Patients - PubMed 24
    view full post

    July 13, 2021

    1

  • PFS Network
    @pfsnetwork (Twitter)

    A key investigation into PFS at Baylor College of Medicine has identified significantly elevated androgen receptor expression and symptom-relevant differential gene expression in PFS patient derived tissue https://t.co/DEx9EIgiiH
    view full post

    July 13, 2021

    13

    3

  • SexGenomics
    @sexgenomics (Twitter)

    Differential Gene Expression in Post-Finasteride Syndrome Patients https://t.co/OBJgt4MlHj
    view full post

    July 12, 2021

  • University of Utah Microbiology & Immunology
    @UofUMandI (Twitter)

    M&I #research alert! Differential Gene Expression in Post-Finasteride Syndrome Patients https://t.co/4URObQ9Fcr #science #immunology #microbiology #infectiousdiseases
    view full post

    July 12, 2021

    4

Abstract Synopsis

  • The study investigated gene expression differences in penile skin cells between men with postfinasteride syndrome (PFS) and healthy controls, focusing on genes related to neurosteroid levels and androgen receptor activity.
  • Results showed that men with PFS had significant overexpression and underexpression of numerous genes, with androgen receptor expression notably higher in the PFS group, but no significant differences were found in serum androgen activity markers or trinucleotide repeat counts.
  • The findings suggest a potential link between altered gene expression, particularly of androgen receptors, and the persistent symptoms experienced by PFS patients, though serum markers appeared similar between groups.]