September 2021 PMID 34247957

Differential Gene Expression in Post-Finasteride Syndrome Patients.

Skyler Howell, Weitao Song, Alexander Pastuszak, Mohit Khera

Mentions

50
Peak: 23 in Jul 2021
across 2 sources since Jul 2021

Extended reach

110,864
potential audience

Total likes

1,331

Video views

63,377

Mentions per month

Jul 2021 – Sep 2025

Where it's discussed

  • X / Twitter48 posts
  • YouTube2 videos

AI synopsis

What people are saying

The overall discussions highlight the significance of the study with comments like 'groundbreaking' and 'finally out,' while specific references to over- and under-expressed genes, androgen receptor levels, and the study’s methodology reveal high curiosity and engagement, emphasizing the potential clinical importance of these findings for understanding PFS.

AgreementModerate agreement

Most discussions recognize and support the study’s findings on gene expression changes related to PFS, indicating a general agreement about its significance.

InterestHigh interest

The posts show high interest, with many referencing the importance of the study, its implications, and its details, demonstrating active curiosity.

EngagementHigh engagement

Numerous discussions delve into specific aspects like gene expression, androgen receptors, methodological rigor, and clinical relevance, reflecting deep engagement.

ImpactHigh impact

The collective tone and detail suggest that these discussions could influence understanding, patient advocacy, and future research directions, representing high impact.

Abstract in brief

  • The study investigated gene expression differences in penile skin cells between men with postfinasteride syndrome (PFS) and healthy controls, focusing on genes related to neurosteroid levels and androgen receptor activity.
  • Results showed that men with PFS had significant overexpression and underexpression of numerous genes, with androgen receptor expression notably higher in the PFS group, but no significant differences were found in serum androgen activity markers or trinucleotide repeat counts.
  • The findings suggest a potential link between altered gene expression, particularly of androgen receptors, and the persistent symptoms experienced by PFS patients, though serum markers appeared similar between groups.]

Top posts

Most liked on X and Bluesky
Simon Breidert
@SimonBreidert · X

New PFS study that we were waiting for many years is finally out: https://t.co/A3l90QUDX8 Thanks @SkylerHowell17 and team @CosimoMelcangi @DamilolaGeorhe @PFSFoundation @AmyPearlman1 @DrDavidHealy

Jul 13, 2021 · 13 likes · 5 shares · 740 followers View post →
PFS Network
@pfsnetwork · X

A key investigation into PFS at Baylor College of Medicine has identified significantly elevated androgen receptor expression and symptom-relevant differential gene expression in PFS patient derived tissue https://t.co/DEx9EIgiiH

Jul 13, 2021 · 13 likes · 3 shares · 319 followers View post →
Finasteride Watch
@FinasterideInfo · X

A groundbreaking study in @jsexmed provides evidence for post-finasteride syndrome as a disorder of gene expression. https://t.co/tfv9pwQ8vA @APHAMensHealth @MensHlthNetwork @MensHealthAMHF @AndrologyASA @ISSM_INFO @SMSNA_ORG @EAAndrology @GeneticsSociety @MensHealthMag #sexmed

Jul 13, 2021 · 9 likes · 1 share · 817 followers View post →
PSSD Network | Post-SSRI Sexual Dysfunction
@PSSDNetwork · X

@SupraMiqote Differential gene expression was found in PFS patients: https://t.co/0S37XEfJTj PFS has never been debunked in any study, it's an understudied condition that has led many young people to take their life. Just because something is not understood yet, doesn't mean it's not real.

Jan 27, 2023 · 4 likes · 10,017 followers View post →
たつろう@髪が生える
@Oppp7iQ · X

詳しく知りたい人用 【ポストフィナステリド症候群患者における遺伝子発現の差異】2021 アメリカ https://t.co/AB9Z1ose1r

Jul 9, 2023 · 4 likes · 1 share · 1,847 followers View post →
Finasteride Watch
@FinasterideInfo · X

New study from a lab at Baylor found changes in expression of *thousands* of genes in people with post-finasteride symptoms. "1,446 genes significantly over-expressed and 2,318 genes significantly under-expressed in study patients." https://t.co/tfv9pwQ8vA #dermtwitter

Jul 13, 2021 · 4 likes · 1 share · 817 followers View post →

All mentions

Recall Propecia
@RecallPropecia · X

@7fignigg @PSSDNetwork @wunna1124836 @PFSFoundation @FinasterideInfo Numerous rigorous scientific studies have shown finasteride causes gene expression changes, the likely culprit for the etiology of post finasteride syndrome. https://t.co/uTxZ0IBUA5

Sep 28, 2025 · 2 likes · 616 followers View post →
₿itcoinOasis86
@BitcoinOasis86 · X

RT @RecallPropecia: Differential Gene Expression in Post-Finasteride Syndrome Patients https://t.co/uTxZ0IBUA5

Aug 12, 2025 · 1 share · 1,121 followers View post →
Recall Propecia
@RecallPropecia · X

Differential Gene Expression in Post-Finasteride Syndrome Patients https://t.co/uTxZ0IBUA5

Aug 12, 2025 · 1 like · 1 share · 616 followers View post →
Recall Propecia
@RecallPropecia · X

@MentalAcr0bat @Unstoppable218 @churrascooooo Altered gene expression from a pharmaceutical drug. Differential Gene Expression in Post-Finasteride Syndrome Patients https://t.co/uTxZ0IBUA5

Aug 12, 2025 · 1 like · 616 followers View post →
Recall Propecia
@RecallPropecia · X

@MentalAcr0bat @yapofreeland Science https://t.co/uTxZ0IBUA5

Jul 20, 2025 · 616 followers View post →
Recall Propecia
@RecallPropecia · X

@MentalAcr0bat @yapofreeland "Twenty-six men consented to inclusion in the control group." YOU DUMB ILLITERATE FUCK!!!!!!!!!!!! https://t.co/uTxZ0IBUA5

Jul 19, 2025 · 616 followers View post →
Recall Propecia
@RecallPropecia · X

@MentalAcr0bat @yapofreeland Read it an weep, sex minimizer. https://t.co/uTxZ0IBUA5

Jul 19, 2025 · 616 followers View post →
Recall Propecia
@RecallPropecia · X

@MentalAcr0bat @yapofreeland Differential Gene Expression in Post Finasteride Syndrome Patients https://t.co/uTxZ0IBUA5

Jul 19, 2025 · 616 followers View post →
Recall Propecia
@RecallPropecia · X

@MentalAcr0bat @TM_Brown @nytimes @maxwellstrachan Medical Proof: https://t.co/uTxZ0IBUA5

Jul 13, 2025 · 616 followers View post →
Recall Propecia
@RecallPropecia · X

@vimer_republic @NoahRyanCo Study showing an actual pathway that side effects don't subside after the short half life of fin in the body. https://t.co/uTxZ0IBUA5

Jun 24, 2025 · 616 followers View post →
Finasteride Watch
@FinasterideInfo · X

@j60774957 Howell et al, 2021 found higher expression of AR compared to controls, in a penile biopsy. https://t.co/cp5biQSOnk

Jul 3, 2024 · 817 followers View post →
8Eevert ✨
@8Eevert · X

Differential Gene Expression in Post-#Finasteride Syndrome —first study to demonstrate gene expression differences in etiology of sexual dysfunction after 5-alpha-reductase inhibitor exposure —providers should be aware & advise accordingly J Sex Med 2021 https://t.co/4PVajIemkL https://t.co/baiBR6BWxM

Sep 12, 2023 · 1 like · 1,157 followers View post →
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@PieAreSqwared · X

@Fiddaman @rcpsych As an example, PFS sufferers were found with 1,446 genes significantly over-expressed and 2,318 genes significantly under-expressed in study patients. Surely these changes weren’t accounted for, I’d wager the same issue would be prevalent in PSSD. 2/2 https://t.co/YyS77QM8Zl

Jul 12, 2023 · 3 likes · 780 followers View post →
julia Alex
@juliaalex3533 · X

RT @Oppp7iQ: 詳しく知りたい人用 【ポストフィナステリド症候群患者における遺伝子発現の差異】2021 アメリカ https://t.co/AB9Z1ose1r

Jul 10, 2023 · 1 share · 8 followers View post →
たつろう@髪が生える
@Oppp7iQ · X

詳しく知りたい人用 【ポストフィナステリド症候群患者における遺伝子発現の差異】2021 アメリカ https://t.co/AB9Z1ose1r

Jul 9, 2023 · 4 likes · 1 share · 1,847 followers View post →
PfSpain
@pfspain1 · X

RT @RecallPropecia: I agree. Now start by reading this: Differential Gene Expression in Post-Finasteride Syndrome Patients https://t.co/u…

Mar 15, 2023 · 1 share · 62 followers View post →
Recall Propecia
@RecallPropecia · X

I agree. Now start by reading this: Differential Gene Expression in Post-Finasteride Syndrome Patients https://t.co/uTxZ0IBUA5 https://t.co/qMP8YBcLt1

Mar 14, 2023 · 4 likes · 1 share · 616 followers View post →
PSSD Network | Post-SSRI Sexual Dysfunction
@PSSDNetwork · X

@SupraMiqote Differential gene expression was found in PFS patients: https://t.co/0S37XEfJTj PFS has never been debunked in any study, it's an understudied condition that has led many young people to take their life. Just because something is not understood yet, doesn't mean it's not real.

Jan 27, 2023 · 4 likes · 10,017 followers View post →
PfSpain
@pfspain1 · X

@Endocrino_PED Hola Gilberto, te añado más estudios de rigor que pueden ayudarte: https://t.co/MiRwDdNwee https://t.co/zSFkA2WOpq https://t.co/8XuoRnogYF https://t.co/A6zq3lfewD https://t.co/XxaAD5Wm0b https://t.co/6BSXy7z7K1 https://t.co/UN4OQGPtMx

Nov 17, 2022 · 62 followers View post →
PfSpain
@pfspain1 · X

@jchassa @Lauzurica_Derma Esto son mitos? https://t.co/MiRwDdNwee https://t.co/zSFkA2WOpq https://t.co/8XuoRnogYF https://t.co/A6zq3lfewD https://t.co/XxaAD5Wm0b https://t.co/6BSXy7z7K1 https://t.co/c88wnExLIV https://t.co/FEOQQOHLij https://t.co/1HD57xBSJ0 https://t.co/RVVotZrLv1

Nov 17, 2022 · 62 followers View post →
PfSpain
@pfspain1 · X

@Herraiz_MJ @Lauzurica_Derma Y que piensas de estos estudios? https://t.co/MiRwDdNwee https://t.co/zSFkA2WOpq https://t.co/8XuoRnogYF https://t.co/A6zq3lfewD https://t.co/XxaAD5Wm0b https://t.co/6BSXy7z7K1 https://t.co/c88wnExLIV https://t.co/FEOQQOHLij https://t.co/1HD57xBSJ0 https://t.co/RVVotZrLv1

Nov 17, 2022 · 62 followers View post →
PfSpain
@pfspain1 · X

@Dr_AhmedAlturki @MoonHeart_0 U tal about these studies: https://t.co/MiRwDdNwee https://t.co/zSFkA2WOpq https://t.co/8XuoRnogYF https://t.co/A6zq3lfewD https://t.co/XxaAD5Wm0b https://t.co/6BSXy7z7K1

Nov 17, 2022 · 62 followers View post →
PfSpain
@pfspain1 · X

RT @medicinareal1: @victordnicolas @JJVEscuderos @SergioVanoG En cuento a vuestra evidencia encontrá de esta condición, porque existen esto…

Nov 15, 2022 · 1 share · 62 followers View post →
medicinareal
@medicinareal1 · X

@victordnicolas @JJVEscuderos @SergioVanoG En cuento a vuestra evidencia encontrá de esta condición, porque existen estos estudios entonces? Tienen errores metodoligos con mala calidad científica supongo https://t.co/zoc7MRt7oq https://t.co/AEqIqca5rh https://t.co/B9sIsSjz7O https://t.co/tW3M6C1NF0 https://t.co/85gNNPIS16

Nov 15, 2022 · 1 like · 1 share View post →
Ryan Clark
@RyanCla64726007 · X

RT @pfsnetwork: A key investigation into PFS at Baylor College of Medicine has identified significantly elevated androgen receptor expressi…

Nov 25, 2021 · 3 shares · 98 followers View post →
PFS Help
@PostFinHelp · X

Differential Gene Expression in Post-Finasteride Syndrome Patients #Finasteride #PostFinasterideSyndrome #PFS https://t.co/DNMAoUExho

Jul 17, 2021 · 2 followers View post →
Recall Propecia
@RecallPropecia · X

@IHEC_Epigenomes Please take a look at the groundbreaking study 'Differential Gene Expression in Post-Finasteride Syndrome Patients.' Pharma drugs like finasteride are causing epigenetic changes in patients and this study demonstrates that. https://t.co/uTxZ0ISXC5

Jul 17, 2021 · 616 followers View post →
PSSD WARRIOR
@PssdWarrior · X

RT @FinasterideInfo: The groundbreaking study is here: https://t.co/tfv9pwQ8vA

Jul 15, 2021 · 1 share · 1,428 followers View post →
Finasteride Watch
@FinasterideInfo · X

The groundbreaking study is here: https://t.co/tfv9pwQ8vA

Jul 15, 2021 · 1 like · 1 share · 817 followers View post →
Ryan Clark
@RyanCla64726007 · X

RT @SimonBreidert: New PFS study that we were waiting for many years is finally out: https://t.co/A3l90QUDX8 Thanks @SkylerHowell17 and te…

Jul 14, 2021 · 5 shares · 98 followers View post →
PSSD WARRIOR
@PssdWarrior · X

RT @SimonBreidert: New PFS study that we were waiting for many years is finally out: https://t.co/A3l90QUDX8 Thanks @SkylerHowell17 and te…

Jul 13, 2021 · 5 shares · 1,428 followers View post →
Mary G
@conalls_mum · X

RT @FinasterideInfo: New study from a lab at Baylor found changes in expression of *thousands* of genes in people with post-finasteride sym…

Jul 13, 2021 · 1 share · 1,887 followers View post →
Mary G
@conalls_mum · X

RT @FinasterideInfo: A groundbreaking study in @jsexmed provides evidence for post-finasteride syndrome as a disorder of gene expression. h…

Jul 13, 2021 · 1 share · 1,887 followers View post →
Ruth
@tigragal60 · X

RT @pfsnetwork: A key investigation into PFS at Baylor College of Medicine has identified significantly elevated androgen receptor expressi…

Jul 13, 2021 · 3 shares · 55 followers View post →
Finasteride Watch
@FinasterideInfo · X

A groundbreaking study in @jsexmed provides evidence for post-finasteride syndrome as a disorder of gene expression. https://t.co/tfv9pwQ8vA @APHAMensHealth @MensHlthNetwork @MensHealthAMHF @AndrologyASA @ISSM_INFO @SMSNA_ORG @EAAndrology @GeneticsSociety @MensHealthMag #sexmed

Jul 13, 2021 · 9 likes · 1 share · 817 followers View post →
PSSD WARRIOR
@PssdWarrior · X

RT @pfsnetwork: A key investigation into PFS at Baylor College of Medicine has identified significantly elevated androgen receptor expressi…

Jul 13, 2021 · 3 shares · 1,428 followers View post →
Finasteride Watch
@FinasterideInfo · X

New study from a lab at Baylor found changes in expression of *thousands* of genes in people with post-finasteride symptoms. "1,446 genes significantly over-expressed and 2,318 genes significantly under-expressed in study patients." https://t.co/tfv9pwQ8vA #dermtwitter

Jul 13, 2021 · 4 likes · 1 share · 817 followers View post →
Mary G
@conalls_mum · X

RT @SimonBreidert: New PFS study that we were waiting for many years is finally out: https://t.co/A3l90QUDX8 Thanks @SkylerHowell17 and te…

Jul 13, 2021 · 5 shares · 1,887 followers View post →
Mary G
@conalls_mum · X

RT @FinasterideInfo: A long-awaited study is out today in @jsexmed Study measured gene expression in penile tissue of people with post-fi…

Jul 13, 2021 · 1 share · 1,887 followers View post →
Finasteride Watch
@FinasterideInfo · X

A long-awaited study is out today in @jsexmed Study measured gene expression in penile tissue of people with post-finasteride symptoms vs. controls & found: “Androgen receptor expression was significantly higher in study patients compared to controls.” https://t.co/tfv9pwQ8vA

Jul 13, 2021 · 1 share · 817 followers View post →
Recall Propecia
@RecallPropecia · X

Differential Gene Expression in Post-Finasteride Syndrome Patients https://t.co/uTxZ0ISXC5

Jul 13, 2021 · 1 like · 616 followers View post →
recovery&renewal
@recover2renew · X

RT @SimonBreidert: New PFS study that we were waiting for many years is finally out: https://t.co/A3l90QUDX8 Thanks @SkylerHowell17 and te…

Jul 13, 2021 · 5 shares · 4,161 followers View post →
Alyne Duthie
@DuthieAlyne · X

RT @SimonBreidert: New PFS study that we were waiting for many years is finally out: https://t.co/A3l90QUDX8 Thanks @SkylerHowell17 and te…

Jul 13, 2021 · 5 shares · 1,912 followers View post →
Simon Breidert
@SimonBreidert · X

New PFS study that we were waiting for many years is finally out: https://t.co/A3l90QUDX8 Thanks @SkylerHowell17 and team @CosimoMelcangi @DamilolaGeorhe @PFSFoundation @AmyPearlman1 @DrDavidHealy

Jul 13, 2021 · 13 likes · 5 shares · 740 followers View post →
Ryan Clark
@RyanCla64726007 · X

Differential Gene Expression in Post-Finasteride Syndrome Patients - PubMed 24

Jul 13, 2021 · 1 like · 98 followers View post →
PFS Network
@pfsnetwork · X

A key investigation into PFS at Baylor College of Medicine has identified significantly elevated androgen receptor expression and symptom-relevant differential gene expression in PFS patient derived tissue https://t.co/DEx9EIgiiH

Jul 13, 2021 · 13 likes · 3 shares · 319 followers View post →
SexGenomics
@sexgenomics · X

Differential Gene Expression in Post-Finasteride Syndrome Patients https://t.co/OBJgt4MlHj

Jul 12, 2021 · 813 followers View post →
University of Utah Microbiology & Immunology
@UofUMandI · X

M&I #research alert! Differential Gene Expression in Post-Finasteride Syndrome Patients https://t.co/4URObQ9Fcr #science #immunology #microbiology #infectiousdiseases

Jul 12, 2021 · 4 likes · 465 followers View post →