July 2021 PMID 34249513

A synthetic defective interfering SARS-CoV-2.

Shun Yao, Anoop Narayanan, Sydney A Majowicz, Joyce Jose, Marco Archetti

Mentions

78
Peak: 34 in Jul 2021
across 5 sources since Jul 2021

Extended reach

173,059
potential audience

Total likes

126

Video views

213

Mentions per month

Jul 2021 – Jun 2024

Where it's discussed

  • X / Twitter39 posts
  • News33 articles
  • YouTube2 videos
  • Facebook2 posts
  • Blogs2 articles

AI synopsis

What people are saying

Several discussions highlight the novelty and potential of the synthetic defective interfering SARS-CoV-2, with phrases like 'interesting proof of principle' and calls to understand 'RNA viruses' first. The tone suggests a cautious optimism about the research's implications, primarily focused on understanding mechanisms rather than immediate practical use.

AgreementModerate agreement

Most discussions acknowledge the scientific significance of the publication, with comments like 'interesting proof of principle' and references to how the defective interfering virus might influence future treatments.

InterestHigh interest

Posts show curiosity about the research, mentioning terms like 'good read' and prompting readers to understand concepts like 'RNA viruses', indicating moderate to high curiosity.

EngagementModerate engagement

Some posts reference related work and broader implications, such as collaboration efforts and viral interference mechanisms, demonstrating a moderate level of engagement.

ImpactModerate impact

While there is recognition of the potential impact, the conversation mostly centers on understanding rather than immediate application, leading to a modest impact perception.

Abstract in brief

  • The study discusses creating a synthetic defective interfering SARS-CoV-2 virus that cannot produce proteins but can still replicate and interfere with the normal virus, ultimately reducing the viral load in infected cells.
  • This defective genome reproduces three times faster than the original virus and can be efficiently transmitted, hinting at the location of the virus's packaging signal.
  • Such a synthetic virus could potentially be used as a self-promoting antiviral therapy, where the virus’s own replication promotes its destruction.

Top posts

Most liked on X and Bluesky
Aris Katzourakis
@ArisKatzourakis · X

Virus can catch viruses too, and they can really put a damper on replication. Interesting proof of principle of a synthetic defective interfering SARS-CoV-2. https://t.co/JFR2vVshfT

Jul 1, 2021 · 97 likes · 28 shares · 33,316 followers View post →
Claudia Thompson
@clauthompson · X

Título do artigo discutido: A synthetic defective interfering SARS-CoV-2 https://t.co/lda5ykqUQm

Mar 31, 2022 · 11 likes · 2 shares · 14,087 followers View post →
Jose Lab
@joselab_psu · X

Our SARS-CoV-2 work with Archetti Lab. @ciddpsu @anoop74_a @SMajowicz @BMB_PSU https://t.co/I8dEUg3Igf

Jul 1, 2021 · 10 likes · 4 shares · 1,215 followers View post →
zijizhanchu_5
@zijizhanchu_5 · X

8 gab created and rescued anninfectious clone of RaTG13.) https://t.co/Z9EJcD2d9e The background SRA file came from an already isolated strain that was grown in RaK4324-BamHI/ACE2 cells. https://t.co/qSfrsnSiHa https://t.co/XgrzqLrPUX

May 1, 2023 · 1 like · 1,788 followers View post →
Roselyn Martin
@roslmartin · X

RT @ArisKatzourakis: Virus can catch viruses too, and they can really put a damper on replication. Interesting proof of principle of a synt…

Jul 2, 2021 · 28 shares · 46,946 followers View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @ArisKatzourakis: Virus can catch viruses too, and they can really put a damper on replication. Interesting proof of principle of a synt…

Jul 2, 2021 · 28 shares · 32,506 followers View post →

All mentions

Evil Embryo
@EvilEmbryo · X

@WrongWayGo6969 This is also a good read, but first understand "RNA viruses". https://t.co/HDFSlZA2z1

Jun 14, 2024 · 196 followers View post →
zijizhanchu_5
@zijizhanchu_5 · X

8 gab created and rescued anninfectious clone of RaTG13.) https://t.co/Z9EJcD2d9e The background SRA file came from an already isolated strain that was grown in RaK4324-BamHI/ACE2 cells. https://t.co/qSfrsnSiHa https://t.co/XgrzqLrPUX

May 1, 2023 · 1 like · 1,788 followers View post →
Diego Fuschi
@DiegoFuschi · X

RT @clauthompson: Título do artigo discutido: A synthetic defective interfering SARS-CoV-2 https://t.co/lda5ykqUQm

Apr 8, 2022 · 2 shares · 742 followers View post →
LUCIANO
@LUCIANONCOMODO · X

RT @clauthompson: Título do artigo discutido: A synthetic defective interfering SARS-CoV-2 https://t.co/lda5ykqUQm

Mar 31, 2022 · 2 shares · 1,948 followers View post →
Claudia Thompson
@clauthompson · X

Título do artigo discutido: A synthetic defective interfering SARS-CoV-2 https://t.co/lda5ykqUQm

Mar 31, 2022 · 11 likes · 2 shares · 14,087 followers View post →
碧水
@bub7wells · X

RT @bub7wells: 目には目を、歯には歯を、そしてコロナウイルスにはコロナウイルスを。 https://t.co/ss85ren7IS

Sep 7, 2021 · 1 share · 147 followers View post →
碧水
@bub7wells · X

目には目を、歯には歯を、そしてコロナウイルスにはコロナウイルスを。 https://t.co/ss85ren7IS

Aug 26, 2021 · 1 share · 147 followers View post →
HiPolit
@HiPo1it · X

„PeerJ”: naukowcy chcą zwalczać SARS-CoV2 z pomocą SARS-CoV2 | Polska Agencja Prasowa SA https://t.co/p4wmFXQOij "A synthetic defective interfering SARS-CoV-2" https://t.co/f4WIJTQitZ

Jul 11, 2021 · 628 followers View post →
MarkQuarter
@MarkQuarter · X

RT @ArisKatzourakis: Virus can catch viruses too, and they can really put a damper on replication. Interesting proof of principle of a synt…

Jul 10, 2021 · 28 shares · 1,611 followers View post →
HN Bot
@TechTweetBot · X

'A synthetic defective interfering SARS-CoV-2' by pndy Read more about this story here --> https://t.co/fvjYLNywHR

Jul 9, 2021 · 259 followers View post →
Center of Excellence in Industrial Biotechnology
@CoEIB_PSU · X

RT @joselab_psu: Our SARS-CoV-2 work with Archetti Lab. @ciddpsu @anoop74_a @SMajowicz @BMB_PSU https://t.co/I8dEUg3Igf

Jul 6, 2021 · 4 shares · 396 followers View post →
Monika Cechova Mich
@biomonika · X

RT @ArisKatzourakis: Virus can catch viruses too, and they can really put a damper on replication. Interesting proof of principle of a synt…

Jul 2, 2021 · 28 shares · 1,354 followers View post →
No, this
@pcdillard · X

RT @ArisKatzourakis: Virus can catch viruses too, and they can really put a damper on replication. Interesting proof of principle of a synt…

Jul 2, 2021 · 28 shares · 1,207 followers View post →
Defender of
@e2dot7182818284 · X

RT @ArisKatzourakis: Virus can catch viruses too, and they can really put a damper on replication. Interesting proof of principle of a synt…

Jul 2, 2021 · 28 shares · 4,321 followers View post →
Marcelli
@Marcelli1314 · X

RT @ArisKatzourakis: Virus can catch viruses too, and they can really put a damper on replication. Interesting proof of principle of a synt…

Jul 2, 2021 · 28 shares · 518 followers View post →
Nikhil Karani
@nikhilkarani1 · X

RT @ArisKatzourakis: Virus can catch viruses too, and they can really put a damper on replication. Interesting proof of principle of a synt…

Jul 2, 2021 · 28 shares · 475 followers View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @ArisKatzourakis: Virus can catch viruses too, and they can really put a damper on replication. Interesting proof of principle of a synt…

Jul 2, 2021 · 28 shares · 32,506 followers View post →
Ifff @Iff0815@mstdn.social
@Iff85678573 · X

RT @ArisKatzourakis: Virus can catch viruses too, and they can really put a damper on replication. Interesting proof of principle of a synt…

Jul 2, 2021 · 28 shares · 332 followers View post →
Felipe Coiro
@CoiroFelipe · X

RT @ArisKatzourakis: Virus can catch viruses too, and they can really put a damper on replication. Interesting proof of principle of a synt…

Jul 2, 2021 · 28 shares · 511 followers View post →
Martha H. Galicia Ve
@mhgalicia · X

RT @ArisKatzourakis: Virus can catch viruses too, and they can really put a damper on replication. Interesting proof of principle of a synt…

Jul 2, 2021 · 28 shares · 114 followers View post →
Roselyn Martin
@roslmartin · X

RT @ArisKatzourakis: Virus can catch viruses too, and they can really put a damper on replication. Interesting proof of principle of a synt…

Jul 2, 2021 · 28 shares · 46,946 followers View post →
The Ferrari Lab: @TheFerrariLab.bsky.social
@TheFerrariLab · X

RT @joselab_psu: Our SARS-CoV-2 work with Archetti Lab. @ciddpsu @anoop74_a @SMajowicz @BMB_PSU https://t.co/I8dEUg3Igf

Jul 1, 2021 · 4 shares · 5,259 followers View post →
Ricard Lopez
@RicardLopez123 · X

RT @ArisKatzourakis: Virus can catch viruses too, and they can really put a damper on replication. Interesting proof of principle of a synt…

Jul 1, 2021 · 28 shares · 3,695 followers View post →
polechimp
@adskankster · X

RT @ArisKatzourakis: Virus can catch viruses too, and they can really put a damper on replication. Interesting proof of principle of a synt…

Jul 1, 2021 · 28 shares · 213 followers View post →
Opal Tulip
@opaltulip · X

RT @ArisKatzourakis: Virus can catch viruses too, and they can really put a damper on replication. Interesting proof of principle of a synt…

Jul 1, 2021 · 28 shares · 171 followers View post →
Jacob Yount
@YountLabOSU · X

RT @ArisKatzourakis: Virus can catch viruses too, and they can really put a damper on replication. Interesting proof of principle of a synt…

Jul 1, 2021 · 28 shares · 3,533 followers View post →
Martin von Kosice
@MartinPanigaj · X

RT @ArisKatzourakis: Virus can catch viruses too, and they can really put a damper on replication. Interesting proof of principle of a synt…

Jul 1, 2021 · 28 shares · 120 followers View post →
Petr Svoboda
@SvobodaLab · X

RT @ArisKatzourakis: Virus can catch viruses too, and they can really put a damper on replication. Interesting proof of principle of a synt…

Jul 1, 2021 · 28 shares · 4,545 followers View post →
Harrison
@HarrisonTF · X

RT @ArisKatzourakis: Virus can catch viruses too, and they can really put a damper on replication. Interesting proof of principle of a synt…

Jul 1, 2021 · 28 shares · 1,849 followers View post →
Gard Jenset
@gjenset · X

RT @ArisKatzourakis: Virus can catch viruses too, and they can really put a damper on replication. Interesting proof of principle of a synt…

Jul 1, 2021 · 28 shares · 595 followers View post →
Romain Martin
@RomainMartinIO · X

RT @ArisKatzourakis: Virus can catch viruses too, and they can really put a damper on replication. Interesting proof of principle of a synt…

Jul 1, 2021 · 28 shares · 2,305 followers View post →
Navierstokes
@Navierstokes69 · X

RT @ArisKatzourakis: Virus can catch viruses too, and they can really put a damper on replication. Interesting proof of principle of a synt…

Jul 1, 2021 · 28 shares · 73 followers View post →
Constant Variable
@TwoTooMany3 · X

RT @ArisKatzourakis: Virus can catch viruses too, and they can really put a damper on replication. Interesting proof of principle of a synt…

Jul 1, 2021 · 28 shares · 243 followers View post →
Skatiq
@Skatiq3 · X

RT @ArisKatzourakis: Virus can catch viruses too, and they can really put a damper on replication. Interesting proof of principle of a synt…

Jul 1, 2021 · 28 shares · 274 followers View post →
Aris Katzourakis
@ArisKatzourakis · X

Virus can catch viruses too, and they can really put a damper on replication. Interesting proof of principle of a synthetic defective interfering SARS-CoV-2. https://t.co/JFR2vVshfT

Jul 1, 2021 · 97 likes · 28 shares · 33,316 followers View post →
Bob Majowicz
@majowir · X

RT @joselab_psu: Our SARS-CoV-2 work with Archetti Lab. @ciddpsu @anoop74_a @SMajowicz @BMB_PSU https://t.co/I8dEUg3Igf

Jul 1, 2021 · 4 shares · 57 followers View post →
PeerJ - the Journal of Life & Environment
@PeerJLife · X

Highlighted in Coronaviruses and Viral Respiratory Infections - A synthetic defective interfering SARS-CoV-2 Research from Yao et al. @penn_state Read the full @PeerJLife article https://t.co/6IWuMFPZFs #Covid19 https://t.co/BtF74lVbnD

Jul 1, 2021 · 3,675 followers View post →
Sydney Aspen Majowicz, Ph.D.
@SMajowicz · X

RT @joselab_psu: Our SARS-CoV-2 work with Archetti Lab. @ciddpsu @anoop74_a @SMajowicz @BMB_PSU https://t.co/I8dEUg3Igf

Jul 1, 2021 · 4 shares · 76 followers View post →
Jose Lab
@joselab_psu · X

Our SARS-CoV-2 work with Archetti Lab. @ciddpsu @anoop74_a @SMajowicz @BMB_PSU https://t.co/I8dEUg3Igf

Jul 1, 2021 · 10 likes · 4 shares · 1,215 followers View post →