The overall tone reveals strong agreement and interest, as seen in phrases like 'superior to enoxaparin,' 'low bleeding risk,' and 'may change practice,' which demonstrate excitement and support. Posts often reference detailed data, mechanisms, and future implications, reflecting deep engagement and recognition of the article's possible profound impact on thrombosis prevention.
AgreementStrong agreement
Most discussions express strong support and excitement for the promising results of abelacimab, highlighting its superiority over traditional treatments like enoxaparin.
InterestHigh interest
There is high curiosity and enthusiasm among posters about the new anticoagulant mechanism, with many eager to see future clinical applications.
EngagementHigh engagement
Multiple posts reference specific data, mechanisms, and implications, indicating deep involvement with the research details.
ImpactHigh impact
The discussions suggest a significant potential to change current standards in VTE prevention, with many considering it a potential game-changer in thrombosis management.
Abstract in brief
Abelacimab, a monoclonal antibody targeting factor XI, was tested in a clinical trial to prevent venous thromboembolism (VTE) after knee surgery, showing promising results in reducing blood clots compared to standard treatment.
The study found that doses of 75 mg and 150 mg of abelacimab were more effective than enoxaparin in preventing VTE, with fewer clot events and a low risk of bleeding, indicating that factor XI plays a significant role in clot formation post-surgery.
Overall, the trial suggests that a single intravenous dose of abelacimab can effectively prevent VTE with minimal bleeding risk, highlighting its potential as a new option for thromboprophylaxis after surgeries.]
Visual Abstract - Abelacimab for Prevention of Venous Thromboembolism https://t.co/yJnGqln166 https://t.co/wxZ19VGrzb
Aug 18, 2021 · 86 likes · 41 shares · 934,285 followersView post →
S
sloba
@slobadoktor · X
Abelacimab for Prevention of Venous Thromboembolism | NEJM novi, bezbedniji i efikasniji put u prevenciji venskog tromboembolizma. Blokada XI faktora koagulacije. Manje tromboza i manje krvarenja nakon zamene kolena. https://t.co/MmFNLyzTWG
Aug 3, 2021 · 20 likes · 1 share · 18,186 followersView post →
BT
Bijoy Telivala
@BijoyTelivala · X
@Bloodman https://t.co/vxBpZjhBd1
When do you think we shall see them in the clinic ?
Abelacimab (Factor XI mAb) IV x 1 post-op knee arthroplasty at 75mg (5%) or 150mg (4%) led to fewer VTE 30d-events vs enoxaparin 40mg sc daily (22%) w ~similar bleeding rates in open-label parallel-group N=412 study https://t.co/B2tbXK4BfX @NEJM @Anthos_Tx @blackstone @Novartis
@sciencescanner @BiotechObserver no evidence that it reduces thrombosis?
and what is that?
Abelacimab for Prevention of Venous Thromboembolism | NEJM https://t.co/hLjQ1ifH1B https://t.co/S9rF0YVwgq
Nov 20, 2023 · 2 likes · 18,932 followersView post →
AM
Ahmed Mohsen
@drahmedmohsen85 · X
RT @cardiomet_CE: 13) A little more about #abelacimab (following up on slide 9c): It is a highly selective, fully humanized monoclonal anti…
Nov 12, 2023 · 1 share · 24,240 followersView post →
CM
cardio-met
@cardiomet_CE · X
13) A little more about #abelacimab (following up on slide 9c): It is a highly selective, fully humanized monoclonal antibody #Mab with no evidence of off-
Nov 12, 2023 · 3 likes · 1 share · 4,218 followersView post →
D
Das
@ssdas29 · X
Abelacimab for Prevention of Venous Thromboembolism
https://t.co/jHFEDMEy7Q
Abelacimab use in percutaneous intervention in ESRD patients?? #antiThrombotic https://t.co/y9YMRzBmY8
Pretty big news. Better AC with less bleeding. Of note, abelacimab was previously shown to reduce VTE after TKA up to 80% compared to LVX (although these were asymptomatic and VTE rates were way higher than we typically see). https://t.co/5XpcfsdOfp #orthotwitter https://t.co/qTePzs1UY5
Have you ever wanted to give someone postop DVT prophylaxis without worrying about bleeding risk? Well, that future may not be that far
https://t.co/CtGDtmPbzQ
Jun 30, 2022 · 3 likes · 1 share · 235 followersView post →
Sا
Sulaiman Alamro سليمان العمرو
@SmAlamro · X
A single intravenous dose of abelacimab ( Novel Factor XI Inhibitor ) for Post-operative VTE prophylaxis was found to be superior to Levonox at a dose of 75 mg and 150 mg.
https://t.co/56kdB7KBPz
The Future may be here, would u give your AFib patient a single monthly SQ injection ?
Abelacimab for Prevention of Venous Thromboembolism | NEJM https://t.co/uBqT71v9ZA
Apr 1, 2022 · 1 like · 80,688 followersView post →
RP
Ross Urry, PharmD
@Ross_Urry · X
My favorite APPE journal club so far? https://t.co/8KT5dBuaMX https://t.co/sihSSY7JTG
Podcast- Abelacimab for Prevention of Venous Thromboembolism, Dr. Jeffrey Weitz, M.D. -@Cardio_KULeuven #VenousThromboembolism #Cardiology #Research
Link to Audio-
https://t.co/V2ko6imkIy https://t.co/rho2nxR5N3
Abelacimab for Prevention of Venous Thromboembolism: A great article on postop DVT prophylaxis with a Factor XI inhibitor
https://t.co/tNVasIGtwa https://t.co/eSdtZMkKnl
Abelacimab for Prevention of Venous Thromboembolism. A fascinating article on postop DVT prophylaxis with a Factor XI inhibitor. Interesting reading for all of us benign hematologists
https://t.co/tNVasIGtwa https://t.co/CIqnZFCjBM
Aug 31, 2021 · 1 like · 2,321 followersView post →
PM
Philip McCarthy
@PLMcCarthyMD · X
Abelacimab for Prevention of Venous Thromboembolism
https://t.co/zmKYhx2OXu
Aug 28, 2021 · 1 like · 4,427 followersView post →
MP
Miguel Angel Pozas
@mapozas · X
RT @NEJM: Visual Abstract - Abelacimab for Prevention of Venous Thromboembolism https://t.co/yJnGqln166 https://t.co/wxZ19VGrzb
Aug 25, 2021 · 41 shares · 18 followersView post →
CN
CanVECTOR Network
@canvector · X
#ClotPLUS: "Abelacimab for Prevention of Venous Thromboembolism."
https://t.co/PvOwtez5aC
#VTE #Thrombosis #Research #Clots https://t.co/D9zDOTKqoC
Aug 23, 2021 · 2 likes · 1,838 followersView post →
ZJ
Zemedu legesse Jima
@ZemeduJ · X
Abelacimab for Prevention of Venous Thromboembolism | NEJM https://t.co/56f1nBwM1A
Neat concept, an anti-factor XI mAb that could be a hemostasis-sparing anti-thrombotic
The 22% VTE rate in the LMWH control seems high, but is presumably an artifact of dx by mandatory venography
Curious about real-world NNT/NNH, other applications, $
https://t.co/BOTA1VLySS https://t.co/s0bQCwRZCV
VTE予防にもマブが。
#DVT #VTE
Abelacimab for Prevention of Venous Thromboembolism | NEJM https://t.co/nekqmywO6h
Aug 12, 2021 · 3 likes · 3,314 followersView post →
KP
K Pavithran
@drkpavithran · X
A single IV dose of abelacimab (a mAb that inhibits factor XI) prevents VTE after total knee arthroplasty with a low risk of bleeding
https://t.co/tBH01Rax87 https://t.co/q2iUbycQF0
Aug 11, 2021 · 3 likes · 1,329 followersView post →
AG
Antibiotic Steward Bassam Ghanem
@ABsteward · X
Aug 11, 2021 · 5 likes · 1 share · 60,166 followersView post →
猫
猫になりたい薬剤師
@Vannyamoto · X
Abelacimab for Prevention of Venous Thromboembolism - PubMed
ファクターXI阻害薬
アベラシマブ https://t.co/7N1w8s4kwO
Interesting data on abelacimab, mAb against FXI, for dvt prophy after arthroplasty. Low dose (30 mg) non inferior to enoxaparin, higher doses (75 mg,150 mg) superior. Low bleeding and clotting risk. But what to do with breakthrough VTE? https://t.co/99nxMF7RRR
y se ha estudiado su relación con la trombosis venosa profunda, el cual ha arrojado increíbles resultados
en la prevención de trombosis venosa.
19 de julio de 2021
DOI: 10.1056 / NEJMoa2105872 https://t.co/jraSgdVazZ
Reading this and focusing on the control group like wow “22 % of knee replacement pt who received 40 mg of enoxaparin after knee replacement got a DVT”. Abelacimab for Prevention of Venous Thromboembolism | NEJM https://t.co/GpBkO80Q1e
Abelacimab for Prevention of Venous Thromboembolism | NEJM novi, bezbedniji i efikasniji put u prevenciji venskog tromboembolizma. Blokada XI faktora koagulacije. Manje tromboza i manje krvarenja nakon zamene kolena. https://t.co/MmFNLyzTWG
Aug 3, 2021 · 20 likes · 1 share · 18,186 followersView post →
TT
Tá de Clinicagem - TdC
@tadeclinicagem · X
Abelacimab EV (anticorpo monoclonal que impede ativação do FXI) foi comparado em diferentes doses (30, 75 e 150mg) com enoxaparina 40mg SC em um estudo fase 2, randomizado e aberto, em pacientes submetidos a artroplastia de joelho
https://t.co/eOpZCjLHuC
"Factor XI inhibition with a single intravenous dose of abelacimab after total knee arthroplasty was effective for the prevention of venous thromboembolism and was associated with a low risk of bleeding." https://t.co/Mj0ovxyeNU
Factor XI inhibition with a single intravenous dose of abelacimab after total knee arthroplasty was effective for the prevention of venous thromboembolism and was associated with a low risk of bleeding. @NEJM @VerhammePeter https://t.co/bLkGcpUC5n
Abelacimab vs. enoxaparin trial: Factor XI inhibition with a single IV dose of abelacimab after total knee arthroplasty was effective for the prevention of #VTE and was associated with a low risk of bleeding.
@VerhammePeter @NEJM
https://t.co/zTibNtByxQ https://t.co/sFrR4CGJin
"Factor XI inhibition with a single intravenous dose of abelacimab after total knee arthroplasty was effective for the prevention of venous thromboembolism and was associated with a low risk of bleeding"
https://t.co/3j2duskcu8 https://t.co/uv1job4Yrj
Jul 22, 2021 · 1 like · 12,345 followersView post →
DS
Dr.Rajiv Sankaranarayanan
@DrRajivsankar · X
RT @SABOURETCardio: #Abelacimab: new entry to prevent #DVT #cardiotwitter https://t.co/dvnbHBfsBy
Jul 21, 2021 · 1 like · 3,017 followersView post →
MH
Med Peds Hospitalist
@medpedshosp · X
Abelacimab for Prevention of Venous Thromboembolism | NEJM https://t.co/OCkFA84lsE
Jul 21, 2021 · 1 like · 14,317 followersView post →
EP
Edmonton Stroke Program
@EdmontonStroke · X
Very-interesting results, Factor XI antibody better compared to enoxaparin to prevent DVT. Abelacimab for Prevention of Venous Thromboembolism | NEJM https://t.co/wp4CwryZJ5
Monoclonal Ab that binds to factor XI superior to enoxaparin in VTE prevention in TKA.
Still bothers me to see something reportedly better blood thinner (less VTE) AND less bleeding events.
Abelacimab (a monoclonal antibody that binds to factor XI and locks it in the inactive precursor conformation) for Prevention of Venous Thromboembolism | NEJM https://t.co/6Z6OHjm60Y
*Abelacimab antagonista del factor XI en dosis de 75 y 150 mg demostró ser superior a enoxaparina 40 mg SC cada 12 horas, en prevención de TE post operatorio de remplazo de rodilla.
https://t.co/PwVaQVGOUH https://t.co/qJnHVVnUwr
Las tasas de tromboembolismo venoso después de la artroplastia total de rodilla electiva favorecieron al monoclonal abelacimab sobre anticoagulante estándar enoxaparina (Lovenox) en ensayo de fase II.
Abelacimab for Prevention of Venous Thromboembolism.
https://t.co/Mw6IYLbjnc
Jul 21, 2021 · 1 like · 1 share · 3,231 followersView post →
AP
Ankit Patel
@ankitbpatel7 · X
Glad to see the hematologist got their alphabet soup correct. Am I right, @DGlaucomflecken?
Interested to see what larger and longer studies will show. https://t.co/Z9Kaz1IQnU
Abelacimab (Factor XI mAb) IV x 1 post-op knee arthroplasty at 75mg (5%) or 150mg (4%) led to fewer VTE 30d-events vs enoxaparin 40mg sc daily (22%) w ~similar bleeding rates in open-label parallel-group N=412 study https://t.co/B2tbXK4BfX @NEJM @Anthos_Tx @blackstone @Novartis
Anticuerpo monoclonal para la prevención de TVP post IQ protesis rodilla. Tasa de eventos del 22% en el comparador enoxaparina...diría que eso no refleja la realidad!
https://t.co/9zIdLNiiCx
Jul 20, 2021 · 1 like · 1 share · 848 followersView post →
PV
Peter Verhamme
@VerhammePeter · X
RT @cardiomet_CE: Kudos to @VerhammePeter and team . . . more support for anti-FXI/XIa as the next frontier in anticoagulant management!
ht…
Kudos to @VerhammePeter and team . . . more support for anti-FXI/XIa as the next frontier in anticoagulant management!
https://t.co/lFsCif6YWC
@MAK_PhD
Abelacimab for Prevention of Venous Thromboembolism: factor XI is at least as important as tissue factor in the pathogenesis of post- operative venous thromboembolism | NEJM https://t.co/QFceZJWSdb
This study compared the efficacy and safety of the investigational drug Abelacimab, a monoclonal antibody targeting factor XI, to Enoxaparin for prevention ...
doi:10.1056/nejmoa2105872 patients with kidney failure undergoing hemodialysis: a randomized ... doi:10.1056/nejmoa1405760 venous thromboembolism with ...
Updates in Pathogenesis and TX of Cancer and VTE | PDF | Science ...
News
doi: 10.1056/NEJMp030086 ment of venous thromboembolism in people ... Drug-drug interactions: implications for anticoagulation, with 10.1056/NEJMoa2105872