Cancers (Basel) July 2021 PMID 34298717

The PATHFINDER Study: Assessment of the Implementation of an Investigational Multi-Cancer Early Detection Test into Clinical Practice.

Lincoln D Nadauld, Charles H McDonnell, Tomasz M Beer, Minetta C Liu, Eric A Klein, Andrew Hudnut, Richard A Whittington, Bruce Taylor, Geoffrey R Oxnard, Jafi Lipson, Margarita Lopatin, Rita Shaknovich, Karen C Chung, Eric T Fung, Deborah Schrag

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Mentions

15
Peak: 2 in Apr 2024
across 3 sources since Jul 2021

Extended reach

13,105
potential audience

Total likes

6

Video views

17

Mentions per month

Jul 2021 – Apr 2024

Where it's discussed

  • News8 articles
  • X / Twitter5 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions reflect a keen interest in the study's potential, highlighted by phrases like 'aimed at how MCED integrates in standards of care' and references to detailed data such as 'PPV 44.6%' and participant risks. The tone shows cautious optimism, balancing enthusiasm with acknowledgment of the ongoing nature of research, which explains the moderate scores across engagement and impact.

AgreementModerate agreement

Most discussions acknowledge the significance of the PATHFINDER study and its potential for early cancer detection, though some remain cautiously optimistic rather than fully endorsing it.

InterestHigh interest

The social discussions demonstrate high interest, referencing detailed aspects of the study like signal percentages, prevalence, and integration into clinical practice.

EngagementModerate engagement

Participants reference specific details such as the study's methodology, participant risk factors, and ongoing related research, indicating moderate depth of engagement.

ImpactModerate impact

Discussions suggest recognition of potential transformative effects on screening and diagnosis but also highlight that results are preliminary and part of ongoing research, implying moderate perceived impact.

Abstract in brief

  • The PATHFINDER study is a large, ongoing clinical trial that evaluates a new blood test (based on detecting methylated cell-free DNA) for early detection of multiple cancers in people aged 50 and above, with some additional risk factors.
  • The main goal is to determine how many follow-up diagnostic tests are needed after a positive cancer signal is detected and how accurately the test identifies cancer, with the expectation of diagnosing about 52 cancers among the participants.
  • This study aims to see how well this blood test can be integrated into current medical practice and improve early cancer detection by analyzing test performance, diagnostic pathways, and predictive value.]

Top posts

Most liked on X and Bluesky
Raymond McCauley
@raymondmccauley · X

@sbarnettARK The PATHFINDER study, of the GRAIL cfDNA + methylation, will roll-up the results of STRIVE (BrCa screen) & SUMMIT (high risk lung), both ongoing. So not yet demo'd. But aimed at how MCED integrates in standards of care. https://t.co/4JWAVistL4

Aug 18, 2021 · 2 likes · 4,806 followers View post →
Dale Yuzuki
@DaleYuzuki · X

Wood #AACR23 Grail's Pathfinder study. 6200 participants, 15 institutions. Age >50, history of cancer or smoking, another group average risk. 2021 ref https://t.co/ljSzGdpM6o Overall signal 1.4%; high risk 1.5%. PPV 44.6%, 57.1% in high risk. Most with Dx resolution 57/63

Apr 18, 2023 · 1 like · 5,657 followers View post →
Dr Sam Merriel
@SamMerriel · X

@Dr_PJEdwards @CanTest_PC @CRUKresearch @CaPRINetwork @BoomboomchiefsT @richarddneal @fmw22 @GLyratzopoulos @BrianDNicholson @drtomround @FunstonGarth Hi @Dr_PJEdwards Some papers https://t.co/gb72oClQGT https://t.co/WVY7zEvHJC Try these sites https://t.co/xhmSdcaZBD https://t.co/vl6CPWVc41

Sep 13, 2021 · 1 like · 1,598 followers View post →
Paperbirds_Oncology
@PaperbirdsO · X

New article: The PATHFINDER Study: Assessment of the Implementation of an Investigational Multi-Cancer Early Detection Test into Clinical Practice https://t.co/pASGYQmj0W #kidneycancer #oncology https://t.co/JnRJGEFmrz

Jul 24, 2021 · 891 followers View post →

All mentions

the paper link
@the_paper_link · X

https://t.co/4thOXpm25p #prime2 Nadauld LD, ..., Marinac CR (Cancers (Basel)) __The PATHFINDER Study: Assessment of the Implementation of an Investigational Multi-Cancer Early Detection Test into Clinical Practice__ https://t.co/8lzquB0LNq

May 1, 2023 · 137 followers View post →
Dale Yuzuki
@DaleYuzuki · X

Wood #AACR23 Grail's Pathfinder study. 6200 participants, 15 institutions. Age >50, history of cancer or smoking, another group average risk. 2021 ref https://t.co/ljSzGdpM6o Overall signal 1.4%; high risk 1.5%. PPV 44.6%, 57.1% in high risk. Most with Dx resolution 57/63

Apr 18, 2023 · 1 like · 5,657 followers View post →
Dr Sam Merriel
@SamMerriel · X

@Dr_PJEdwards @CanTest_PC @CRUKresearch @CaPRINetwork @BoomboomchiefsT @richarddneal @fmw22 @GLyratzopoulos @BrianDNicholson @drtomround @FunstonGarth Hi @Dr_PJEdwards Some papers https://t.co/gb72oClQGT https://t.co/WVY7zEvHJC Try these sites https://t.co/xhmSdcaZBD https://t.co/vl6CPWVc41

Sep 13, 2021 · 1 like · 1,598 followers View post →
Raymond McCauley
@raymondmccauley · X

@sbarnettARK The PATHFINDER study, of the GRAIL cfDNA + methylation, will roll-up the results of STRIVE (BrCa screen) & SUMMIT (high risk lung), both ongoing. So not yet demo'd. But aimed at how MCED integrates in standards of care. https://t.co/4JWAVistL4

Aug 18, 2021 · 2 likes · 4,806 followers View post →
Paperbirds_Oncology
@PaperbirdsO · X

New article: The PATHFINDER Study: Assessment of the Implementation of an Investigational Multi-Cancer Early Detection Test into Clinical Practice https://t.co/pASGYQmj0W #kidneycancer #oncology https://t.co/JnRJGEFmrz

Jul 24, 2021 · 891 followers View post →