PubHawk
September 2021 PMID 34346557

Youthful and age-related matreotypes predict drugs promoting longevity.

Cyril Statzer, Elisabeth Jongsma, Sean X Liu, Alexander Dakhovnik, Franziska Wandrey, Pavlo Mozharovskyi, Fred Zülli, Collin Y Ewald

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Mentions

73
Peak: 37 in Aug 2021
across 6 sources since Jan 2021

Extended reach

717,890
potential audience

Total likes

224

Video views

1,545

Mentions per month

Jan 2021 – Aug 2025

Where it's discussed

  • X / Twitter61 posts
  • News3 articles
  • Blogs3 articles
  • YouTube2 videos
  • Facebook2 posts
  • Reddit2 posts

AI synopsis

What people are saying

The discussions exhibit enthusiasm for the research findings, with multiple users referencing the impact of specific compounds like 'tretinoin' and 'chondroitin sulfate' on collagen levels and lifespan, hinting at transformative possibilities. Phrases like 'interesting paper' and 'new way of screening' manifest a positive tone and curiosity, illustrating the community's eagerness to explore new methods in longevity research.

AgreementStrong agreement

Most discussions express strong support for the publication's findings, highlighting their significance in drug discovery for longevity.

InterestHigh interest

Participants demonstrate high curiosity regarding the implications of youthful and age-related matreotypes.

EngagementModerate engagement

While many discussions reference the research, some remain more superficial in their analysis.

ImpactHigh impact

Contributors perceive that the publication will have a substantial influence on future research and drug development in the field of aging.

Abstract in brief

  • Researchers have identified a pattern of gene expression (agerelated matreotype) linked to aging, which helps in identifying drugs that can promote longevity.
  • By utilizing youthful and age-stratified human transcriptomes, they screened for potential geroprotective drug candidates.
  • Their findings included validating existing compounds and discovering new ones that improve collagen levels and could extend lifespan, showcasing a novel method for drug screening focused on extracellular matrix homeostasis.
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Top posts

Most liked on X and Bluesky
Collin Ewald
@CollinEwald · X

Happy to see our paper out in @AgingCell. #Youthful and age-related #matreotypes predict #drugs promoting #longevity. Congrats to @cyril_statzer, @JongsmaE, @ADakhovnik #Ewaldlab @ETH @mibelle_biochem https://t.co/8cRUgRcmSG

Aug 4, 2021 · 82 likes · 17 shares · 4,532 followers View post →
Aging Science News
@AgingBiology · X

Youthful and age-related matreotypes predict drugs promoting longevity @CollinEwald https://t.co/D1VIrKuXb6

Aug 4, 2021 · 19 likes · 5 shares · 30,785 followers View post →
Aging Science News
@AgingBiology · X

Youthful and age-related matreotypes predict drugs promoting longevity @CollinEwald https://t.co/CnZiY5UOpi

Jan 28, 2021 · 17 likes · 6 shares · 30,785 followers View post →
Agingdoc
@agingdoc1 · X

Youthful and age‐related matreotypes predict drugs promoting longevity https://t.co/UvqF7zY1cv @AgingCell https://t.co/VUoLj2dlmg

Aug 4, 2021 · 14 likes · 1 share · 41,872 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Youthful and age-related matreotypes predict drugs promoting longevity "most of the established pro-longevity compounds shown to extend lifespan in model organisms also alter extracellular matrix gene expression (i.e., matrisome) in human cell lines." https://t.co/r93o6lp1uK

Oct 1, 2023 · 11 likes · 1 share · 292,420 followers View post →
Collin Ewald
@CollinEwald · X

I was on @LWThompson5 #Lowell's #podcast and was happy that he let me experiment with pulling up figures from our papers to explain concepts in a visual way. #Extracellular #Matrix, #Machine #Learning, & #Longevity #Research https://t.co/r69bNVHCNQ https://t.co/E30LLJsaLO

May 17, 2023 · 10 likes · 1 share · 4,534 followers View post →

All mentions

luis hernan graffe
@hernangraffe · X

https://t.co/OopM0RiVNY

Aug 10, 2025 · 3,148 followers View post →
luis hernan graffe
@hernangraffe · X

https://t.co/OopM0RiVNY

Aug 10, 2025 · 3,148 followers View post →
Julio Mohnsam
@JulioMohnsam · X

Ácido Hialurônico ORAL: O Segredo da Longevidade (e Pele Jovem!) que Voc... https://t.co/KZU65PX2gU via @YouTube

May 13, 2025 · 1 like · 17 followers View post →
J. C. Mohnsam
@CesarMohnsam · X

https://t.co/D1uIcULlyP

May 13, 2025 · 151 followers View post →
J. C. Mohnsam
@CesarMohnsam · X

Ácido Hialurônico ORAL: O Segredo da Longevidade (e Pele Jovem!) que Voc... https://t.co/y9Icmv0VSK via @YouTube

May 13, 2025 · 151 followers View post →
Mike Lustgarten, PhD
@mike_lustgarten · X

RT @Mangan150: Youthful and age-related matreotypes predict drugs promoting longevity "most of the established pro-longevity compounds sho…

Oct 1, 2023 · 1 share · 9,727 followers View post →
P.D. Mangan Health & Freedom Maximalist
@Mangan150 · X

Youthful and age-related matreotypes predict drugs promoting longevity "most of the established pro-longevity compounds shown to extend lifespan in model organisms also alter extracellular matrix gene expression (i.e., matrisome) in human cell lines." https://t.co/r93o6lp1uK

Oct 1, 2023 · 11 likes · 1 share · 292,420 followers View post →
Aging TV
@AgingTV · X

Extracellular Matrix, Machine Learning, & Longevity Research- Collin Ewald-Learning with Lowell 185 #Aging #Longevity #longevity #lifespan #ExtracellularMatrix @CollinEwald https://t.co/S95EP8uzrB https://t.co/h2Vju7LNrb

May 19, 2023 · 1 like · 46 followers View post →
Cecilia
@jycp42 · X

RT @CollinEwald: I was on @LWThompson5 #Lowell's #podcast and was happy that he let me experiment with pulling up figures from our papers t…

May 17, 2023 · 1 share · 32 followers View post →
Collin Ewald
@CollinEwald · X

I was on @LWThompson5 #Lowell's #podcast and was happy that he let me experiment with pulling up figures from our papers to explain concepts in a visual way. #Extracellular #Matrix, #Machine #Learning, & #Longevity #Research https://t.co/r69bNVHCNQ https://t.co/E30LLJsaLO

May 17, 2023 · 10 likes · 1 share · 4,534 followers View post →
Collin Ewald
@CollinEwald · X

RT @LWThompson5: New interview with @CollinEwald on Extracellular Matrix, Machine Learning, & Longevity Research https://t.co/zQ3FSu1hMJ

May 17, 2023 · 1 share · 4,534 followers View post →
Lowell
@LWThompson5 · X

New interview with @CollinEwald on Extracellular Matrix, Machine Learning, & Longevity Research https://t.co/zQ3FSu1hMJ

May 16, 2023 · 5 likes · 1 share · 586 followers View post →
Collin Ewald
@CollinEwald · X

RT @MartinBJensen: They defined a youthful 'matreotype' in worms (see https://t.co/BM4jCY87Pi), and used this as a phenotypic readout for #…

Sep 1, 2021 · 1 share · 4,532 followers View post →
Martin Borch Jensen
@MartinBJensen · X

They defined a youthful 'matreotype' in worms (see https://t.co/BM4jCY87Pi), and used this as a phenotypic readout for #DrugDiscovery. Chondroitin sulphate and other hits. (Note idk how evolutionarily conserved ECM is). 3/3 @CarolynBertozzi bat-signal, #glycotime for aging?

Sep 1, 2021 · 4 likes · 1 share · 6,568 followers View post →
Debbie @ Genetic Lifehacks
@GeneticLifehack · X

"Here, we found that most of the established pro-longevity compounds shown to extend lifespan in model organisms also alter extracellular matrix gene expression (i.e., matrisome) in human cell lines. " https://t.co/q87Kcc5MUn

Aug 31, 2021 · 1 like · 1,530 followers View post →
Agingdoc
@agingdoc1 · X

Ultimately published in @AgingCell: https://t.co/j5BLUV17lZ

Aug 31, 2021 · 2 likes · 41,872 followers View post →
Science Socks
@SocksScience · X

RT @AgeingUK: Youthful and age‐related matreotypes predict drugs promoting longevity https://t.co/QIUZsT1eDB https://t.co/3E31sYeHvV

Aug 13, 2021 · 2 shares · 453 followers View post →
Science
@Long_life_sci · X

RT @AgeingUK: Youthful and age‐related matreotypes predict drugs promoting longevity https://t.co/QIUZsT1eDB https://t.co/3E31sYeHvV

Aug 9, 2021 · 2 shares · 32 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

This study suggests that tretinoin, chondroitin sulfate, and hyaluronic acid may restore the age-related decline of collagen homeostasis and increase lifespan. https://t.co/xH1ymTZbTC To gain further mechanistic insights into ageing and longevity: https://t.co/ev3fKAQQ7D

Aug 6, 2021 · 885 followers View post →
M. Carmen Gomez-Cabrera
@MCarmenGomezCab · X

https://t.co/rGn3NG4xiU

Aug 5, 2021 · 1 like · 304 followers View post →
AgeingUK
@AgeingUK · X

Youthful and age‐related matreotypes predict drugs promoting longevity https://t.co/QIUZsT1eDB https://t.co/3E31sYeHvV

Aug 5, 2021 · 2 likes · 2 shares · 3,021 followers View post →
Arnab Mukhopadhyay
@smartelegans · X

Interesting paper from @CollinEwald lab. A new way of screening for pro-longevity drugs. Youthful and age-related matreotypes predict drugs promoting longevity https://t.co/FNpmXq8wEr

Aug 5, 2021 · 2 likes · 2,904 followers View post →
ValerioIzzi
@ValerioIzzi · X

RT @CollinEwald: Happy to see our paper out in @AgingCell. #Youthful and age-related #matreotypes predict #drugs promoting #longevity. Cong…

Aug 5, 2021 · 17 shares · 881 followers View post →
Nutriop Longevity
@nutriop · X

Youthful and age-related matreotypes predict drugs promoting longevity https://t.co/7srxU3blgi https://t.co/PMkzGGSR6F

Aug 5, 2021 · 80 followers View post →
AgeingUK
@AgeingUK · X

RT @AgingBiology: Youthful and age-related matreotypes predict drugs promoting longevity @CollinEwald https://t.co/D1VIrKuXb6

Aug 5, 2021 · 5 shares · 3,021 followers View post →
Società Italiana di Gerontologia e Geriatria
@GeriSocITA · X

Youthful and age-related matreotypes predict drugs promoting longevity.: https://t.co/hHbHVR7FHL

Aug 5, 2021 · 725 followers View post →
eMatrix_GENYO
@eMatrixGENYO · X

RT @CollinEwald: Happy to see our paper out in @AgingCell. #Youthful and age-related #matreotypes predict #drugs promoting #longevity. Cong…

Aug 5, 2021 · 17 shares · 165 followers View post →
Fay
@fay90028966 · X

RT @agingdoc1: Youthful and age‐related matreotypes predict drugs promoting longevity https://t.co/UvqF7zY1cv @AgingCell https://t.co/VU…

Aug 4, 2021 · 1 share · 142 followers View post →
Superoxide Dismutase
@SDismutase · X

RT @AgingBiology: Youthful and age-related matreotypes predict drugs promoting longevity @CollinEwald https://t.co/D1VIrKuXb6

Aug 4, 2021 · 5 shares · 23 followers View post →
Fruit Worms
@fruitWormPapers · X

Youthful and age-related matreotypes predict drugs promoting longevity https://t.co/bwyZRiuHPv

Aug 4, 2021 · 1,248 followers View post →
Dr. Aviseka
@aviseka · X

RT @CollinEwald: Happy to see our paper out in @AgingCell. #Youthful and age-related #matreotypes predict #drugs promoting #longevity. Cong…

Aug 4, 2021 · 17 shares · 2,453 followers View post →
Manuella Godoi
@womanum · X

RT @CollinEwald: Happy to see our paper out in @AgingCell. #Youthful and age-related #matreotypes predict #drugs promoting #longevity. Cong…

Aug 4, 2021 · 17 shares · 235 followers View post →
GenomeArc
@genomearc · X

RT @CollinEwald: Happy to see our paper out in @AgingCell. #Youthful and age-related #matreotypes predict #drugs promoting #longevity. Cong…

Aug 4, 2021 · 17 shares · 1,108 followers View post →
Swiss Society for Aging Research
@swiss_aging · X

RT @CollinEwald: Happy to see our paper out in @AgingCell. #Youthful and age-related #matreotypes predict #drugs promoting #longevity. Cong…

Aug 4, 2021 · 17 shares · 269 followers View post →
SwissMatrixBio
@SwissMatrixBio · X

RT @CollinEwald: Happy to see our paper out in @AgingCell. #Youthful and age-related #matreotypes predict #drugs promoting #longevity. Cong…

Aug 4, 2021 · 17 shares · 454 followers View post →
The Phoenix Lab
@The_Phoenix_Lab · X

RT @AgingBiology: Youthful and age-related matreotypes predict drugs promoting longevity @CollinEwald https://t.co/D1VIrKuXb6

Aug 4, 2021 · 5 shares · 210 followers View post →
Alexander Dakhovnik
@ADakhovnik · X

RT @CollinEwald: Happy to see our paper out in @AgingCell. #Youthful and age-related #matreotypes predict #drugs promoting #longevity. Cong…

Aug 4, 2021 · 17 shares · 77 followers View post →
Joan Chang
@tranejoan · X

RT @CollinEwald: Happy to see our paper out in @AgingCell. #Youthful and age-related #matreotypes predict #drugs promoting #longevity. Cong…

Aug 4, 2021 · 17 shares · 958 followers View post →
Fay
@fay90028966 · X

RT @AgingBiology: Youthful and age-related matreotypes predict drugs promoting longevity @CollinEwald https://t.co/D1VIrKuXb6

Aug 4, 2021 · 5 shares · 142 followers View post →
Fay
@fay90028966 · X

RT @CollinEwald: Happy to see our paper out in @AgingCell. #Youthful and age-related #matreotypes predict #drugs promoting #longevity. Cong…

Aug 4, 2021 · 17 shares · 142 followers View post →
mcmullanlab_papers
@mcmullan_papers · X

Youthful and age-related matreotypes predict drugs promoting longevity https://t.co/v28AyBfF30

Aug 4, 2021 · 24 followers View post →
Agingdoc
@agingdoc1 · X

Youthful and age‐related matreotypes predict drugs promoting longevity https://t.co/UvqF7zY1cv @AgingCell https://t.co/VUoLj2dlmg

Aug 4, 2021 · 14 likes · 1 share · 41,872 followers View post →
João Pedro de Magalhães
@jpsenescence · X

RT @AgingBiology: Youthful and age-related matreotypes predict drugs promoting longevity @CollinEwald https://t.co/D1VIrKuXb6

Aug 4, 2021 · 5 shares · 18,281 followers View post →
Mibelle Biochemistry
@mibelle_biochem · X

RT @CollinEwald: Happy to see our paper out in @AgingCell. #Youthful and age-related #matreotypes predict #drugs promoting #longevity. Cong…

Aug 4, 2021 · 17 shares · 903 followers View post →
Aging Science News
@AgingBiology · X

Youthful and age-related matreotypes predict drugs promoting longevity @CollinEwald https://t.co/D1VIrKuXb6

Aug 4, 2021 · 19 likes · 5 shares · 30,785 followers View post →
aHmEd WaQaS
@RavianAhmed · X

RT @CollinEwald: Happy to see our paper out in @AgingCell. #Youthful and age-related #matreotypes predict #drugs promoting #longevity. Cong…

Aug 4, 2021 · 17 shares · 253 followers View post →
Ocampo Lab
@OcampoLab · X

RT @CollinEwald: Happy to see our paper out in @AgingCell. #Youthful and age-related #matreotypes predict #drugs promoting #longevity. Cong…

Aug 4, 2021 · 17 shares · 2,878 followers View post →
Jorge I. Castillo-Quan, MD, PhD
@CastilloQuan_JI · X

RT @CollinEwald: Happy to see our paper out in @AgingCell. #Youthful and age-related #matreotypes predict #drugs promoting #longevity. Cong…

Aug 4, 2021 · 17 shares · 2,053 followers View post →
Eline Jongsma
@JongsmaE · X

RT @CollinEwald: Happy to see our paper out in @AgingCell. #Youthful and age-related #matreotypes predict #drugs promoting #longevity. Cong…

Aug 4, 2021 · 17 shares · 20 followers View post →
Jaime Osuna Luque
@OsunaLuqueJ · X

RT @CollinEwald: Happy to see our paper out in @AgingCell. #Youthful and age-related #matreotypes predict #drugs promoting #longevity. Cong…

Aug 4, 2021 · 17 shares · 625 followers View post →
Collin Ewald
@CollinEwald · X

Happy to see our paper out in @AgingCell. #Youthful and age-related #matreotypes predict #drugs promoting #longevity. Congrats to @cyril_statzer, @JongsmaE, @ADakhovnik #Ewaldlab @ETH @mibelle_biochem https://t.co/8cRUgRcmSG

Aug 4, 2021 · 82 likes · 17 shares · 4,532 followers View post →
cryoboy
@anku505 · X

RT @AgingBiology: Youthful and age-related matreotypes predict drugs promoting longevity @CollinEwald https://t.co/CnZiY5UOpi

Jan 28, 2021 · 6 shares · 845 followers View post →
Vasilis Armenis
@vasilisx91 · X

RT @AgingBiology: Youthful and age-related matreotypes predict drugs promoting longevity @CollinEwald https://t.co/CnZiY5UOpi

Jan 28, 2021 · 6 shares · 674 followers View post →
Alex Freeman
@alex__freeman · X

RT @AgingBiology: Youthful and age-related matreotypes predict drugs promoting longevity @CollinEwald https://t.co/CnZiY5UOpi

Jan 28, 2021 · 6 shares · 39 followers View post →
Ocampo Lab
@OcampoLab · X

RT @AgingBiology: Youthful and age-related matreotypes predict drugs promoting longevity @CollinEwald https://t.co/CnZiY5UOpi

Jan 28, 2021 · 6 shares · 2,878 followers View post →
AgingResearch
@TheAgingField · X

RT @AgingBiology: Youthful and age-related matreotypes predict drugs promoting longevity @CollinEwald https://t.co/CnZiY5UOpi

Jan 28, 2021 · 6 shares · 5,261 followers View post →
Aging Science News
@AgingBiology · X

Youthful and age-related matreotypes predict drugs promoting longevity @CollinEwald https://t.co/CnZiY5UOpi

Jan 28, 2021 · 17 likes · 6 shares · 30,785 followers View post →
Nutriop Longevity
@nutriop · X

Youthful and age-related matreotypes predict drugs promoting longevity https://t.co/YYatNCdwag https://t.co/fI8IpHxO52

Jan 28, 2021 · 80 followers View post →
Dityatev Lab
@DityatevL · X

ECM and aging: Youthful and age-related matreotypes predict drugs promoting longevity https://t.co/KWZSXLfjW6

Jan 28, 2021 · 1 like · 562 followers View post →
Agingdoc
@agingdoc1 · X

Youthful and age-related matreotypes predict drugs promoting longevity “...most of the established pro-longevity compounds shown to extend lifespan in model organisms also alter extracellular matrix gene expression (i.e., matrisome) in human cell lines.” https://t.co/tuATTKWKDs

Jan 27, 2021 · 2 likes · 41,872 followers View post →
bioRxiv
@biorxivpreprint · X

Youthful and age-related matreotypes predict drugs promoting longevity https://t.co/jWKpj490pv #bioRxiv

Jan 27, 2021 · 137,454 followers View post →