A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength.

Patricia M Horvath, Natali L Chanaday, Baris Alten, Ege T Kavalali, Lisa M Monteggia

August 2021

Synopsis of Social media discussions

The consensus among digital discussions highlights the article’s relevance and scientific interest, with phrases like 'super interesting' and mentions of supporting reproducibility, which reflect active engagement and recognition of its potential influence, especially within academic and research communities.

A
Agreement
 Moderate agreement

Most discussions show positive reactions, with users expressing appreciation for the research and its potential implications, indicating general agreement on its importance.

I
Interest
 High level of interest

The discussions demonstrate high curiosity, with posts describing the article as 'super interesting' and noting its relevance for journal clubs and scientific communities.

E
Engagement
 Moderate level of engagement

Many discussions include references to specific sections of the research, like reproducibility support and summarizing the study’s focus, suggesting moderate but meaningful engagement.

I
Impact
 Moderate level of impact

The shared interest in reproducibility and recognition of the study's significance in understanding synaptic mechanisms imply the research could influence further studies or clinical approaches, although not universally claimed as groundbreaking.

Social Mentions

YouTube

2 Videos

Twitter

10 Posts

Blogs

3 Articles

News

20 Articles

Metrics

Video Views

23

Total Likes

19

Extended Reach

147,698

Social Features

35

Timeline: Posts about article

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  • Fitness Therapy: Neuroscience Professional Learner
    @LaCourCouture (Twitter)

    Interesting find of the day #7: A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength #BDNF #gaba #5HTP #FitnessTherapy https://t.co/rOoNDOMwv4
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    October 13, 2021

  • RRID Robot
    @RobotRrid (Twitter)

    The authors of "A subthreshold synaptic mechanism regulating BDNF…" (https://t.co/8FGVjDiYIs) included RRIDs in their paper! We appreciate the author's support of reproducibility. #accelerateopenscience #reproducibility
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    September 8, 2021

  • Ariakas Enoreth
    @Aenoreth (Twitter)

    A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength https://t.co/gePnUawHcD
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    August 31, 2021

  • Mahdi Dolatyari
    @mahdidolatyari1 (Twitter)

    RT @KhannaLabUA: Super interesting article! Next journal club ⁦@LisaBoinon⁩?? ⁦@AubinMoutal⁩? A subthreshold synaptic mechanism regulating…
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    August 16, 2021

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  • Laurent Martin
    @LaurentMartin__ (Twitter)

    RT @KhannaLabUA: Super interesting article! Next journal club ⁦@LisaBoinon⁩?? ⁦@AubinMoutal⁩? A subthreshold synaptic mechanism regulating…
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    August 13, 2021

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  • VGranados
    @VinicioGranados (Twitter)

    RT @KhannaLabUA: Super interesting article! Next journal club ⁦@LisaBoinon⁩?? ⁦@AubinMoutal⁩? A subthreshold synaptic mechanism regulating…
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    August 13, 2021

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  • Dr. Rajesh Khanna of the KhannaLabUF
    @KhannaLabUF (Twitter)

    Super interesting article! Next journal club ⁦@LisaBoinon⁩?? ⁦@AubinMoutal⁩? A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength. https://t.co/PmaDp4g9fH
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    August 13, 2021

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  • Dr. Kimberly Raab Graham
    @raabgraham_lab (Twitter)

    A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength - https://t.co/yI7prC9lEP #ScholarAlerts
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    August 10, 2021

  • Marlenne Perales
    @PeralesMarlenne (Twitter)

    RT @CellReports: A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength https://t.co/fBEacWAj2q
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    August 5, 2021

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  • Cell Reports
    @CellReports (Twitter)

    A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength https://t.co/fBEacWAj2q
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    August 5, 2021

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Abstract Synopsis

  • The study explores how spontaneous inhibitory neurotransmitter activity influences the expression of BDNF, a protein important for neuron growth and plasticity, by affecting calcium signaling and gene transcription.
  • Blocking inhibitory signals increases BDNF and Npas4 gene transcription through NMDA receptors and calcium channels, which in turn can lead to changes in synaptic strength.
  • These findings suggest that spontaneous inhibitory activity Helps regulate resting synaptic strength via BDNF and gene transcription, playing a key role in maintaining brain plasticity.]