August 2021 PMID 34348149

A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength.

Patricia M Horvath, Natali L Chanaday, Baris Alten, Ege T Kavalali, Lisa M Monteggia

Mentions

35
Peak: 8 in Aug 2021
across 4 sources since Aug 2021

Extended reach

147,698
potential audience

Total likes

19

Video views

23

Mentions per month

Aug 2021 – Dec 2021

Where it's discussed

  • News20 articles
  • X / Twitter10 posts
  • Blogs3 articles
  • YouTube2 videos

AI synopsis

What people are saying

The consensus among digital discussions highlights the article’s relevance and scientific interest, with phrases like 'super interesting' and mentions of supporting reproducibility, which reflect active engagement and recognition of its potential influence, especially within academic and research communities.

AgreementModerate agreement

Most discussions show positive reactions, with users expressing appreciation for the research and its potential implications, indicating general agreement on its importance.

InterestHigh interest

The discussions demonstrate high curiosity, with posts describing the article as 'super interesting' and noting its relevance for journal clubs and scientific communities.

EngagementModerate engagement

Many discussions include references to specific sections of the research, like reproducibility support and summarizing the study’s focus, suggesting moderate but meaningful engagement.

ImpactModerate impact

The shared interest in reproducibility and recognition of the study's significance in understanding synaptic mechanisms imply the research could influence further studies or clinical approaches, although not universally claimed as groundbreaking.

Abstract in brief

  • The study explores how spontaneous inhibitory neurotransmitter activity influences the expression of BDNF, a protein important for neuron growth and plasticity, by affecting calcium signaling and gene transcription.
  • Blocking inhibitory signals increases BDNF and Npas4 gene transcription through NMDA receptors and calcium channels, which in turn can lead to changes in synaptic strength.
  • These findings suggest that spontaneous inhibitory activity Helps regulate resting synaptic strength via BDNF and gene transcription, playing a key role in maintaining brain plasticity.]

Top posts

Most liked on X and Bluesky
Dr. Rajesh Khanna of the KhannaLabUF
@KhannaLabUF · X

Super interesting article! Next journal club ⁦@LisaBoinon⁩?? ⁦@AubinMoutal⁩? A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength. https://t.co/PmaDp4g9fH

Aug 13, 2021 · 10 likes · 3 shares · 3,151 followers View post →
Cell Reports
@CellReports · X

A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength https://t.co/fBEacWAj2q

Aug 5, 2021 · 8 likes · 1 share · 141,506 followers View post →
Ariakas Enoreth
@Aenoreth · X

A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength https://t.co/gePnUawHcD

Aug 31, 2021 · 1,005 followers View post →
Dr. Kimberly Raab Graham
@raabgraham_lab · X

A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength - https://t.co/yI7prC9lEP #ScholarAlerts

Aug 10, 2021 · 575 followers View post →
Fitness Therapy: Neuroscience Professional Learner
@LaCourCouture · X

Interesting find of the day #7: A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength #BDNF #gaba #5HTP #FitnessTherapy https://t.co/rOoNDOMwv4

Oct 13, 2021 · 446 followers View post →
Mahdi Dolatyari
@mahdidolatyari1 · X

RT @KhannaLabUA: Super interesting article! Next journal club ⁦@LisaBoinon⁩?? ⁦@AubinMoutal⁩? A subthreshold synaptic mechanism regulating…

Aug 16, 2021 · 3 shares · 376 followers View post →

All mentions

Fitness Therapy: Neuroscience Professional Learner
@LaCourCouture · X

Interesting find of the day #7: A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength #BDNF #gaba #5HTP #FitnessTherapy https://t.co/rOoNDOMwv4

Oct 13, 2021 · 446 followers View post →
RRID Robot
@RobotRrid · X

The authors of "A subthreshold synaptic mechanism regulating BDNF…" (https://t.co/8FGVjDiYIs) included RRIDs in their paper! We appreciate the author's support of reproducibility. #accelerateopenscience #reproducibility

Sep 8, 2021 · 161 followers View post →
Ariakas Enoreth
@Aenoreth · X

A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength https://t.co/gePnUawHcD

Aug 31, 2021 · 1,005 followers View post →
Mahdi Dolatyari
@mahdidolatyari1 · X

RT @KhannaLabUA: Super interesting article! Next journal club ⁦@LisaBoinon⁩?? ⁦@AubinMoutal⁩? A subthreshold synaptic mechanism regulating…

Aug 16, 2021 · 3 shares · 376 followers View post →
Laurent Martin
@LaurentMartin__ · X

RT @KhannaLabUA: Super interesting article! Next journal club ⁦@LisaBoinon⁩?? ⁦@AubinMoutal⁩? A subthreshold synaptic mechanism regulating…

Aug 13, 2021 · 3 shares · 27 followers View post →
VGranados
@VinicioGranados · X

RT @KhannaLabUA: Super interesting article! Next journal club ⁦@LisaBoinon⁩?? ⁦@AubinMoutal⁩? A subthreshold synaptic mechanism regulating…

Aug 13, 2021 · 3 shares · 309 followers View post →
Dr. Rajesh Khanna of the KhannaLabUF
@KhannaLabUF · X

Super interesting article! Next journal club ⁦@LisaBoinon⁩?? ⁦@AubinMoutal⁩? A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength. https://t.co/PmaDp4g9fH

Aug 13, 2021 · 10 likes · 3 shares · 3,151 followers View post →
Dr. Kimberly Raab Graham
@raabgraham_lab · X

A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength - https://t.co/yI7prC9lEP #ScholarAlerts

Aug 10, 2021 · 575 followers View post →
Marlenne Perales
@PeralesMarlenne · X

RT @CellReports: A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength https://t.co/fBEacWAj2q

Aug 5, 2021 · 1 share · 92 followers View post →
Cell Reports
@CellReports · X

A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength https://t.co/fBEacWAj2q

Aug 5, 2021 · 8 likes · 1 share · 141,506 followers View post →