IUBMB Life January 2022 PMID 34423888

FOXO transcription factors in antioxidant defense.

Niklas Krafczyk, Lars-Oliver Klotz

Mentions

57
Peak: 6 in Nov 2022
across 5 sources since May 2022

Extended reach

283,364
potential audience

Total likes

7,344

Video views

266,186

Mentions per month

May 2022 – Oct 2025

Where it's discussed

  • News26 articles
  • X / Twitter16 posts
  • Facebook9 posts
  • YouTube4 videos
  • Blogs2 articles

AI synopsis

What people are saying

The discussions highlight FOXO3 as a key factor in lifespan extension and health, with several posts referring to its role in aging and resilience, e.g., claims that FOXO3 'hurts a lot' despite being 'the #1 lifespan improver,' indicating recognition of its powerful impact. The tone varies from scientific to promotional, reflecting a general interest in strategies like cold exposure and supplements, which align with the article’s focus on cellular stress responses and antioxidant defense.

AgreementModerate agreement

Most discussions acknowledge the importance of FOXO3 in aging and health, with some expressing agreement with its role as a lifespan enhancer.

InterestModerate interest

Posts show moderate interest, often connecting FOXO3 to topics like longevity, energy, and aging, but without deep scientific detail.

EngagementNeutral engagement

Engagement is mixed; some posts mention supplementary treatments and behavioral strategies, yet few delve into detailed mechanisms or data.

ImpactModerate impact

The conversations suggest an awareness of FOXO3's potential influence on health and aging, but impact remains moderate due to superficial engagement.

Abstract in brief

  • FOXO transcription factors are important proteins that help cells respond to oxidative stress by regulating genes involved in antioxidant defense, metabolism, and cell survival.
  • They support cellular strategies such as preventing the formation of reactive oxygen species, repairing damaged molecules, and activating protective signaling pathways, and their activity is regulated by redox processes including gene expression and modifications of their proteins.
  • Specifically, FOXO activity is influenced by changes in thiol groups (sulfur-containing parts of proteins), which affect their function, highlighting the importance of maintaining thiol balance for proper FOXO activity and cellular antioxidant responses.

Top posts

Most liked on X and Bluesky
Edward
@Tour30A · X

What carbs do to our longevity and resilience. Thomas knows! https://t.co/6ERDM47hU2

Jan 29, 2025 · 2 likes · 7,421 followers View post →
Won Dong
@fkiller · X

아직 모든 정보를 소화하지 못한 상태인데 FOXO3가 꽤 오랫동안 연구되고 있었구나. 지금까지 느낀 바로는 의학적 검증으로 가는 동안 관련 물질(exosome, FOXO3)들이 TA-65처럼 supplement로 엄청 팔리지 싶다. https://t.co/3qxGzuJuRo https://t.co/8eVUtuEfag

Sep 17, 2025 · 2 likes · 1,819 followers View post →
B. Holiday (Diabetic lives matter).
@bholiday · X

FOXO3 is the #1 LIFESPAN IMPROVER - But it Hurts a Lot https://t.co/kKvlKfEtRQ via @YouTube

Jun 17, 2022 · 2,251 followers View post →
dominique renucci
@yogayantra · X

Is Andrew Huberman RIGHT About Cold Exposure? AUTOPHAGY and FOXO3 https://t.co/gh2mzKJ5GW via @YouTube

May 15, 2022 · 1,020 followers View post →
⚔
@LuisCipherMstar · X

Surprising Newfound Cause of Accelerated Aging Discovered (how to mitiga... https://t.co/0jztPv4W6z via @YouTube

Jan 28, 2025 · 853 followers View post →
Cheo (Chāy Ō)
@CheoWalker · X

Thomas DeLauer The #1 Thing Improving Lifespan is ALSO HURTING YOU https://t.co/nynBCUIZxk #keto

Jun 16, 2022 · 362 followers View post →

All mentions

Won Dong
@fkiller · X

아직 모든 정보를 소화하지 못한 상태인데 FOXO3가 꽤 오랫동안 연구되고 있었구나. 지금까지 느낀 바로는 의학적 검증으로 가는 동안 관련 물질(exosome, FOXO3)들이 TA-65처럼 supplement로 엄청 팔리지 싶다. https://t.co/3qxGzuJuRo https://t.co/8eVUtuEfag

Sep 17, 2025 · 2 likes · 1,819 followers View post →
Edward
@Tour30A · X

What carbs do to our longevity and resilience. Thomas knows! https://t.co/6ERDM47hU2

Jan 29, 2025 · 2 likes · 7,421 followers View post →
⚔
@LuisCipherMstar · X

Surprising Newfound Cause of Accelerated Aging Discovered (how to mitiga... https://t.co/0jztPv4W6z via @YouTube

Jan 28, 2025 · 853 followers View post →
Analytical Sentient |
@EFIListGOAT · X

https://t.co/TLQJYEfc45 https://t.co/RnnTvfenMy https://t.co/2AcA0sesjN https://t.co/Wucc8vkKyj https://t.co/5UoLBY2fmN https://t.co/P4uKpeVMxo https://t.co/XEUeFjoHrt https://t.co/18P0uUcZa7 https://t.co/KkYtcX52kE

Jul 15, 2023 · 171 followers View post →
Cheo (Chāy Ō)
@CheoWalker · X

Thomas DeLauer This is Why You're TIRED After Age 40 - The Best Ways to Improve Energy https://t.co/oYE5fEpUVO #keto

Nov 7, 2022 · 362 followers View post →
Cheo (Chāy Ō)
@CheoWalker · X

Thomas DeLauer This is Why You're TIRED After Age 40 - The Best Ways to Improve Energy https://t.co/oYE5fEHvNm #keto

Nov 7, 2022 · 362 followers View post →
Cheo (Chāy Ō)
@CheoWalker · X

Thomas DeLauer This is Why You're TIRED After Age 40 - The Best Ways to Improve Energy https://t.co/oYE5fEpUVO #keto

Nov 6, 2022 · 362 followers View post →
Cheo (Chāy Ō)
@CheoWalker · X

Thomas DeLauer This is Why You're TIRED After Age 40 - The Best Ways to Improve Energy https://t.co/oYE5fEpUVO #keto

Nov 5, 2022 · 362 followers View post →
Cheo (Chāy Ō)
@CheoWalker · X

Thomas DeLauer This is Why You're TIRED After Age 40 - The Best Ways to Improve Energy https://t.co/oYE5fEpUVO #keto

Nov 5, 2022 · 362 followers View post →
Cheo (Chāy Ō)
@CheoWalker · X

Thomas DeLauer This is Why You're TIRED After Age 40 - The Best Ways to Improve Energy https://t.co/oYE5fEpUVO #keto

Nov 4, 2022 · 362 followers View post →
Jihad Baker
@credit_rush · X

This is Why You're TIRED After Age 40 - The Best Ways to Improve Energy https://t.co/cLQm7q8cni via @YouTube

Oct 21, 2022 · 16 followers View post →
Cheo (Chāy Ō)
@CheoWalker · X

Thomas DeLauer STOP Fatigue & Increase Resilience to Disease with These Steps https://t.co/oYE5fEqsLm #keto

Oct 21, 2022 · 362 followers View post →
B. Holiday (Diabetic lives matter).
@bholiday · X

FOXO3 is the #1 LIFESPAN IMPROVER - But it Hurts a Lot https://t.co/kKvlKfEtRQ via @YouTube

Jun 17, 2022 · 2,251 followers View post →
Cheo (Chāy Ō)
@CheoWalker · X

Thomas DeLauer The #1 Thing Improving Lifespan is ALSO HURTING YOU https://t.co/nynBCUIZxk #keto

Jun 16, 2022 · 362 followers View post →
dominique renucci
@yogayantra · X

Is Andrew Huberman RIGHT About Cold Exposure? AUTOPHAGY and FOXO3 https://t.co/gh2mzKJ5GW via @YouTube

May 15, 2022 · 1,020 followers View post →
Cheo (Chāy Ō)
@CheoWalker · X

Thomas DeLauer Response to Huberman on Cold Exposure | There’s EVEN MORE https://t.co/gkwxlYuwu9 #keto

May 14, 2022 · 362 followers View post →
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