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Nat Commun September 2021 PMID 34471116

Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity.

Bettina Weigelin, Annemieke Th den Boer, Esther Wagena, Kelly Broen, Harry Dolstra, Rob J de Boer, Carl G Figdor, Johannes Textor, Peter Friedl

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Mentions

38
Peak: 32 in Sep 2021
across 4 sources since Sep 2021

Extended reach

114,663
potential audience

Total likes

107

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74

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Sep 2021 – Dec 2023

Where it's discussed

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AI synopsis

What people are saying

The discussions reflect general agreement and interest, with posts supporting the research, such as noting the role of additive cytotoxicity in cancer treatment, and some sharing related publications or expressing support. The tone is positive and focused on the scientific implications, demonstrating recognition of the potential for this mechanism to enhance future therapies.

AgreementStrong agreement

The majority of the discussions endorse the findings, emphasizing the effectiveness of additive cytotoxicity in cancer elimination.

InterestModerate interest

Participants show moderate interest, with many comments simply acknowledging the publication and reiterating key points.

EngagementModerate engagement

Some posts engage by sharing related research or expressing support, but overall, the level of deep discussion is modest.

ImpactModerate impact

Comments suggest that the findings could be significant for advancing immunotherapy, indicating a recognition of potential impact.

Abstract in brief

  • Cytotoxic T cells can kill cancer cells more effectively through a process called additive cytotoxicity, where multiple sublethal damage events accumulate over time to induce tumor cell death.
  • In solid tumors, CTLs often fail to kill target cells during a single interaction, but multiple sequential hits delivered within short intervals (less than 50 minutes) can successfully eliminate cancer cells by summing their damaging effects.
  • This multihit mechanism is especially effective in high-density CTL regions within tumors, and increasing the frequency or severity of damage could enhance immune responses against cancer.]
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Eytan Ruppin, MD, PhD
@EytanRuppin · X

Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity https://t.co/VTDVLwybGL

Sep 6, 2021 · 78 likes · 21 shares · 5,057 followers View post →
Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry · X

Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity | Nature Communications https://t.co/WpAuNDtoRe

Sep 6, 2021 · 13 likes · 3 shares · 18,131 followers View post →
Mauro Corrado
@MauroCorradoBio · X

Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity | Nature Communications https://t.co/LvbFU06rDf

Sep 7, 2021 · 12 likes · 1 share · 2,004 followers View post →
ilyas sahin, MD
@ilyassahinMD · X

RT @weldeiry: Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity | Nature Communications https://t.c…

Sep 6, 2021 · 3 shares · 20,808 followers View post →
Palmarine128
@Palmarine128 · X

RT @NCIEytanRuppin: Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity https://t.co/VTDVLwybGL

Sep 7, 2021 · 21 shares · 15,080 followers View post →
Olivier Elemento
@ElementoLab · X

RT @weldeiry: Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity | Nature Communications https://t.c…

Sep 6, 2021 · 3 shares · 6,249 followers View post →

All mentions

arnoldo morales
@cokivacoa · X

Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity | Nature Communications https://t.co/rcgPiw0XZM

Dec 11, 2023 · 858 followers View post →
RRID Robot
@RobotRrid · X

RRIDs were included in the Nature Communications paper "Cytotoxic T cells are able to efficiently eliminat…" (https://t.co/Q6oJ1XYjNE). We appreciate the author's support of reproducibility. #STMpublishing #ReproducibleResearch

Sep 17, 2021 · 161 followers View post →
WUYTSITIR
@misszzsiri · X

RT @NCIEytanRuppin: Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity https://t.co/VTDVLwybGL

Sep 7, 2021 · 21 shares · 7 followers View post →
Ray DuBois, MD, PhD
@Rndubois · X

#Cytotoxic #T_cells are able to efficiently #eliminate #cancer #cells by additive cytotoxicity; https://t.co/O59f4FXszW

Sep 7, 2021 · 5,576 followers View post →
https://amalianegreponti.substack.com
@aliama · X

RT @NCIEytanRuppin: Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity https://t.co/VTDVLwybGL

Sep 7, 2021 · 21 shares · 1,747 followers View post →
Matosevic Lab
@matoseviclab · X

RT @NCIEytanRuppin: Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity https://t.co/VTDVLwybGL

Sep 7, 2021 · 21 shares · 434 followers View post →
Umar Farooq, PhD
@umarbioc · X

RT @MauroCorradoBio: Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity | Nature Communications http…

Sep 7, 2021 · 1 share · 213 followers View post →
John Kenten
@JohnKenten · X

RT @NCIEytanRuppin: Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity https://t.co/VTDVLwybGL

Sep 7, 2021 · 21 shares · 575 followers View post →
Inspecting Immunology
@InspectingI · X

RT @NCIEytanRuppin: Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity https://t.co/VTDVLwybGL

Sep 7, 2021 · 21 shares · 1,537 followers View post →
Roychoudhuri Lab
@RoychoudhuriLab · X

RT @NCIEytanRuppin: Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity https://t.co/VTDVLwybGL

Sep 7, 2021 · 21 shares · 2,281 followers View post →
Leng Han
@lenghan_bioinfo · X

RT @NCIEytanRuppin: Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity https://t.co/VTDVLwybGL

Sep 7, 2021 · 21 shares · 1,116 followers View post →
Palmarine128
@Palmarine128 · X

RT @NCIEytanRuppin: Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity https://t.co/VTDVLwybGL

Sep 7, 2021 · 21 shares · 15,080 followers View post →
Wanding Zhou
@zhouwanding · X

RT @NCIEytanRuppin: Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity https://t.co/VTDVLwybGL

Sep 7, 2021 · 21 shares · 690 followers View post →
Jette is Mataray
@white_bite · X

RT @NCIEytanRuppin: Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity https://t.co/VTDVLwybGL

Sep 7, 2021 · 21 shares · 4,715 followers View post →
Louisa Frances Alim
@louisaalim · X

RT @NCIEytanRuppin: Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity https://t.co/VTDVLwybGL

Sep 7, 2021 · 21 shares · 165 followers View post →
Sanna Madan
@SannaMadan · X

RT @NCIEytanRuppin: Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity https://t.co/VTDVLwybGL

Sep 7, 2021 · 21 shares · 1,131 followers View post →
NK Leb #UpdateTheVaccines
@NickytaLeb · X

RT @NCIEytanRuppin: Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity https://t.co/VTDVLwybGL

Sep 7, 2021 · 21 shares · 2,949 followers View post →
Mauro Corrado
@MauroCorradoBio · X

Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity | Nature Communications https://t.co/LvbFU06rDf

Sep 7, 2021 · 12 likes · 1 share · 2,004 followers View post →
InCytometry - Graham Bottley
@InCytometry · X

RT @NCIEytanRuppin: Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity https://t.co/VTDVLwybGL

Sep 7, 2021 · 21 shares · 3,077 followers View post →
Lugli Lab
@luglilab · X

RT @NCIEytanRuppin: Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity https://t.co/VTDVLwybGL

Sep 7, 2021 · 21 shares · 2,308 followers View post →
Rajesh Nair
@RajeshNair2610 · X

RT @NCIEytanRuppin: Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity https://t.co/VTDVLwybGL

Sep 7, 2021 · 21 shares · 63 followers View post →
Eytan Ruppin, MD, PhD
@EytanRuppin · X

RT @NCIEytanRuppin: Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity https://t.co/VTDVLwybGL

Sep 6, 2021 · 21 shares · 5,057 followers View post →
ilyas sahin, MD
@ilyassahinMD · X

RT @weldeiry: Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity | Nature Communications https://t.c…

Sep 6, 2021 · 3 shares · 20,808 followers View post →
David Russler-Germain, MD/PhD
@dgermain21 · X

RT @NCIEytanRuppin: Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity https://t.co/VTDVLwybGL

Sep 6, 2021 · 21 shares · 3,665 followers View post →
Elad Sharon
@EladSharonMD · X

RT @NCIEytanRuppin: Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity https://t.co/VTDVLwybGL

Sep 6, 2021 · 21 shares · 3,830 followers View post →
Joo Sang Lee
@joo_sang_lee · X

RT @NCIEytanRuppin: Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity https://t.co/VTDVLwybGL

Sep 6, 2021 · 21 shares · 314 followers View post →
Yanguang (Carter) Cao
@Cartercao2 · X

RT @weldeiry: Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity | Nature Communications https://t.c…

Sep 6, 2021 · 3 shares · 336 followers View post →
Eytan Ruppin, MD, PhD
@EytanRuppin · X

Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity https://t.co/VTDVLwybGL

Sep 6, 2021 · 78 likes · 21 shares · 5,057 followers View post →
Olivier Elemento
@ElementoLab · X

RT @weldeiry: Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity | Nature Communications https://t.c…

Sep 6, 2021 · 3 shares · 6,249 followers View post →
Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry · X

Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity | Nature Communications https://t.co/WpAuNDtoRe

Sep 6, 2021 · 13 likes · 3 shares · 18,131 followers View post →
Ingentium Melanoma
@ingentium_mel · X

Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity. https://t.co/KZWSJQ0GZK https://t.co/pKg6iLbD9N

Sep 3, 2021 · 205 followers View post →
Lymphoma Papers
@Lymphoma_Papers · X

Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity #lymphoma #lymsm https://t.co/aNKin5JEi8

Sep 3, 2021 · 2,449 followers View post →
Paperbirds_Oncology
@PaperbirdsO · X

New article: Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity https://t.co/wkQYE1jZwQ #melanoma #oncology https://t.co/yyOMc5IozJ

Sep 2, 2021 · 892 followers View post →