October 2021 PMID 34498208

Neuronal Swelling: A Non-osmotic Consequence of Spreading Depolarization.

Julia A Hellas, R David Andrew

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Peak: 12 in Feb 2022

across 3 sources since Sep 2021

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700,951

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Sep 2021 – Jul 2025

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What people are saying

The overall tone reflects a positive reception, with many posts expressing excitement about the publication, as seen in the sharing of their own research experiences and enthusiasm for the topic. The use of words like 'excited' and phrases such as 'contribution to the field' indicate a high level of interest and recognition of the research's importance, though the engagement remains primarily at an enthusiastic and supportive level rather than deeply technical.

AgreementModerate agreement

Most discussions express support or interest in the publication, indicating general agreement with its significance.

InterestHigh interest

Posts show high enthusiasm and curiosity about the research findings, with several sharing excitement about their own involvement or publication.

EngagementModerate engagement

Posts reflect moderate engagement, often referencing specific studies, authors, or personal contributions, indicating a genuine interest without deep technical analysis.

ImpactModerate impact

Discussions recognize the potential implications of understanding non-osmotic swelling mechanisms, though mostly in a supportive and appreciative tone.

Abstract in brief

Neuronal swelling during brain ischemia and spreading depolarization is primarily driven by nonosmotic mechanisms involving ion-water cotransporters and amino acid water pumps, rather than simple osmotic water influx through aquaporins.
While astrocytes swell in response to osmotic changes due to their expression of aquaporins, neurons resist volume changes under osmotic stress but swell dramatically during ischemia because of disrupted ion regulation.
Understanding the molecular mechanisms behind neuronal swelling, including water pumps and cotransporters, is crucial for developing treatments to promote recovery from cytotoxic edema caused by spreading depolarizations and brain ischemia.]

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Neuronal Swelling During Brain Ischemia and Spreading Depolarization

Neuronal swelling during brain ischemia and spreading depolarization is driven mainly by nonosmotic mechanisms involving ion-water cotransporters and amino acid water pumps, not simple osmotic water influx through…

賴宇凡Sara · May 28, 2025 651,141 views

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@ishowshan72805 · X

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Jul 21, 2025 · 1 followers View post →

Roxana Flores A. MD,PhD

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