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The collection shows a strong consensus on the importance of platelet-related factors like MRP8/14 and their role in worsening COVID-19 outcomes, with posts discussing therapeutic strategies such as P2Y12 inhibitors. The tone is highly interested and engaged, using words like 'exciting', 'significant', and 'promising', which highlight both the relevance and potential impact of the research on understanding and treating COVID-19 complications.
Most discussions emphasize the role of platelets and inflammatory proteins in COVID-19 progression, supporting the study's findings.
Numerous posts show high curiosity, mentioning new therapeutic targets, relevant molecules like MRP8/14, and the significance for long COVID and cardiovascular risks.
Posts cite specific factors such as P2Y12 inhibition, calprotectin, and endothelial permeability, indicating deep analysis and understanding of mechanisms.
Many discussions highlight potential treatment approaches and long-term health consequences, reflecting a belief in the research’s substantial influence on COVID-19 management.
Platelets amplify endotheliopathy in COVID-19 “platelets from COVID-19 patients are hyperactive & platelet-released factors activate microvascular Endothelial Cells, promoting an inflammatory hypercoagulable phenotype." Big implications for #LongCovid https://t.co/cbEAoqUCig
Another really exciting paper on COVID-associated endotheliopathy! Platelets amplify endotheliopathy in COVID-19 https://t.co/5QYUVBtzFV
Platelets amplify endotheliopathy in COVID-19 https://t.co/7I3tDffZzd
Platelets amplify endothelial pathology in COVID-19 https://t.co/bmdIMr6mww
Platelets amplify endotheliopathy in COVID-19 https://t.co/I97gpNhrxR
@dregenus @DasErste Es verhält sich in den Symptomen ähnlich zu einem Atemwegsinfekt, verursacht aber im Körper ganz andere Schäden als ein "Erkältungsvirus". Könnte man wissen... wenn man will. https://t.co/kPS0PyNzA6 https://t.co/RRWwlwpcnz https://t.co/WBrOAbIvha https://t.co/H5j1vAMiCF
If you've just found your way to this film its probably because theres pretty much NO OTHER advice ANYWHERE on the topic of how to avoid Long Covid But with between 1 in 3 and 1 in 6 Covid infections going on to develop…
Despite vague media coverage, significant misconceptions about Long Covid persist. This video addresses common myths, focusing on persistent symptoms linked to endothelial issues after SARS-CoV-2 infection. Discover…
On this day in COVID history, September 8, 2021: Platelets amplify endotheliopathy in COVID-19 Source: Science | AAAS https://t.co/x8PvK6ft3F
On this day in COVID history, September 8, 2021: Platelets amplify endotheliopathy in COVID-19 Source: Science | AAAS https://www.science.org/doi/10.1126/sciadv.abh2434
@healingfromlc @CovidCastaways @atranscendedman OxLDL https://t.co/SQ2iarZvUU MRP8/14 (serum calprotectin) https://t.co/EFN0LWCElg https://t.co/jp7ee4SPAl Lp-PLA2 https://t.co/OnEFHSduoA https://t.co/U04bqdevZ2 https://t.co/TeOMUFmXfx Neopterin https://t.co/z25dMn5yn2 Neurofilament Light Chain https://t.co/iMc9SR6jZN
@dregenus @DasErste Es verhält sich in den Symptomen ähnlich zu einem Atemwegsinfekt, verursacht aber im Körper ganz andere Schäden als ein "Erkältungsvirus". Könnte man wissen... wenn man will. https://t.co/kPS0PyNzA6 https://t.co/RRWwlwpcnz https://t.co/WBrOAbIvha https://t.co/H5j1vAMiCF
@GrGuenter @ejustin46 But differences as well, which is logical, eg between oc43 & sars-cov2 (lab study) https://t.co/DGuumThMMd https://t.co/CMEqkIbIBE
コロナ血小板症と内皮症 https://t.co/OUBXse26cZ 血小板→内皮症⬆️ https://t.co/U6kYEvpq5Z スラミンはHIV、エボラ、ジカ熱、SARS ヘパラン硫酸(HS)等の細胞表面糖を要す
https://t.co/9TJE87QUqK "The clinical effect of a P2Y12 inhibitor strategy is being investigated in ACTIV4a (NCT04505774)." https://t.co/jboGvzAdZb
https://t.co/9TJE87QUqK "P2Y12 inhibition will mitigate platelet activation, reduce platelet-released MRP8/14, and ultimately suppress platelet activity and EC activation and improve clinical outcomes linked to #COVID19 thromboinflammation."
https://t.co/9TJE87QUqK "While aspirin had no significant effect, ticagrelor led to a significant reduction in both expression of platelet S100A8 and S100A9 mRNA (P < 0.0001)"
https://t.co/9TJE87QUqK "silencing CD36 significantly suppressed #COVID19 platelet-mediated EC IL6 and IL8 cytokine production. These data suggest that platelet-released MRP8/14 mediate the proinflammatory effect of #COVID19 EC inflammation via CD36."
https://t.co/9TJE87QUqK "MRP8/14 is a ligand for innate receptors, including Toll-like receptor 4 (TLR4), CD36, and receptor for advanced glycation end products (RAGE)."
https://t.co/9TJE87QUqK "A positive correlation existed between platelet-released MRP8/14 and microvascular EC IL8 and IL6 production (P = 0.001 and P = 0.007, respectively), suggesting that platelet-derived MRP8/14 is a driver of EC activation."
https://t.co/9TJE87QUqK "MRP8/14 activates microvascular ECs and weakens EC cell-cell contacts, resulting in increased permeability of the endothelium."
https://t.co/9TJE87QUqK "#COVID19 platelets released significantly increased levels of MRP8/14" "platelet-derived MRP-14 promotes MPA formation and a proinflammatory monocyte phenotype"
https://t.co/9TJE87QUqK "MRP8 and MRP14 heterodimerize to produce the inflammatory product MRP8/14 (calprotectin), an inflammatory protein present within platelet granules and released by activated platelets"
Platelets amplify endotheliopathy in #COVID19 https://t.co/9TJE87QUqK "S100A8 and S100A9 genes code for MRP8 and MRP14 and were among the top 4 identified transcripts enriched in platelets from #COVID19 patients to have a released product." https://t.co/3Uv0Im13EA
@Bradgolf1216 @NickGuthe https://t.co/rkBxx53nw2
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
@EllaSloman • Platelets amplify endotheliopathy in COVID-19 • Sept 8, 2021 • https://t.co/uG40w3kn2U
RT @PlateletDoc: Pleased to share 18 months of work demonstrating how #platelets play a major pathogenic role in #Covid_19 and amplify endo…
RT @renesugar: Platelets amplify endotheliopathy in #COVID19 #LongCovid https://t.co/jp7ee4AGmd "factors known to be released from platel…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
Platelets amplify endotheliopathy in #COVID19 #LongCovid https://t.co/jp7ee4AGmd "factors known to be released from platelets that are increased in #COVID19 patients (IL6, P-selectin, and sCD40L)"
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
Platelets amplify endothelial pathology in COVID-19 https://t.co/bmdIMr6mww
Platelets amplify endotheliopathy in COVID-19 https://t.co/tDGKLZdp5G
https://t.co/DKesEmqZHC
RT @YouAreLobbyLud: Five year cardiovascular mortality post Covid is going to be an "interesting" metric. https://t.co/En6ax35Pms
RT @YouAreLobbyLud: Five year cardiovascular mortality post Covid is going to be an "interesting" metric. https://t.co/En6ax35Pms
Sars-CoV-2 vs CoV-OC43, labrahavaintoja eroista https://t.co/DGuumThMMd https://t.co/7eXIUHPGwv
RT @YouAreLobbyLud: Five year cardiovascular mortality post Covid is going to be an "interesting" metric. https://t.co/En6ax35Pms
RT @YouAreLobbyLud: Five year cardiovascular mortality post Covid is going to be an "interesting" metric. https://t.co/En6ax35Pms
RT @YouAreLobbyLud: Five year cardiovascular mortality post Covid is going to be an "interesting" metric. https://t.co/En6ax35Pms
RT @PlateletDoc: Pleased to share 18 months of work demonstrating how #platelets play a major pathogenic role in #Covid_19 and amplify endo…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
The regulation of platelets in #COVID19 treatment -“findings demonstrate a previously unappreciated role for platelets and their activation-induced endotheliopathy in #COVID19” https://t.co/oHG2p1mUaG $ADMP role in restoration of normal platelet function contributes to COVID Rx. https://t.co/htJalXO7jl
@bateperson @Shawnv898 @ACMESalesRep @jordanbpeterson @JustinTrudeau https://t.co/IaxhpwXkMw
RT @ygjumi: Platelets amplify endotheliopathy in COVID-19 https://t.co/I97gpNhrxR
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
"Herein we demonstrate that platelets from COVID-19 patients are hyperactive and that platelet-released factors activate microvascular ECs, promoting an inflammatory hypercoagulable phenotype. Investigation of the platelet transcri…https://t.co/6T0BZmnAko https://t.co/0oRYJsvxYx
Platelets amplify endotheliopathy in #COVID19 https://t.co/jp7ee4AGmd "MRP8/14 activates microvascular ECs and weakens EC cell-cell contacts, resulting in increased permeability of the endothelium" #LongCovid
Platelets amplify endotheliopathy in #COVID19 https://t.co/jp7ee4AGmd "targeting platelet P2Y12 represents a promising candidate to reduce proinflammatory platelet-endothelial interactions"
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
@JeanmarcBenoit https://t.co/x1z0yoh2gZ
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @ygjumi: Platelets amplify endotheliopathy in COVID-19 https://t.co/I97gpNhrxR
RT @ygjumi: Platelets amplify endotheliopathy in COVID-19 https://t.co/I97gpNhrxR
RT @ygjumi: Platelets amplify endotheliopathy in COVID-19 https://t.co/I97gpNhrxR
Platelets amplify endotheliopathy in COVID-19 https://t.co/I97gpNhrxR
RT @loscharlos: Platelets amplify endotheliopathy in COVID-19 “platelets from COVID-19 patients are hyperactive & platelet-released facto…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @loscharlos: Platelets amplify endotheliopathy in COVID-19 “platelets from COVID-19 patients are hyperactive & platelet-released facto…
RT @loscharlos: Platelets amplify endotheliopathy in COVID-19 “platelets from COVID-19 patients are hyperactive & platelet-released facto…
RT @loscharlos: Platelets amplify endotheliopathy in COVID-19 “platelets from COVID-19 patients are hyperactive & platelet-released facto…
RT @loscharlos: Platelets amplify endotheliopathy in COVID-19 “platelets from COVID-19 patients are hyperactive & platelet-released facto…
Platelets amplify endotheliopathy in COVID-19 “platelets from COVID-19 patients are hyperactive & platelet-released factors activate microvascular Endothelial Cells, promoting an inflammatory hypercoagulable phenotype." Big implications for #LongCovid https://t.co/cbEAoqUCig
https://t.co/k8b52pNmSM
"...indirect (nonviral) mechanisms drive endothelial cell (EC) activation in COVID-19..." This helps to explain why metabolically compromised individuals are more likely to have such a challenging time battling SARS-COV-2. Source link: https://t.co/xLPFP8R79U https://t.co/mbiRPTlRAW
More evidence how SARS-CoV-2 may influence heart issues issues: https://t.co/3Q4SxlfcP9
Interesting! https://t.co/Zp3Q5nF9Se
Interesting! https://www.science.org/doi/10.1126/sciadv.abh2434#.YbCSyIPymIo.linkedin
Descubren proteínas del COVID-19, que cambian el material genético de los megacariocitos haciendo que su linaje (plaquetas) sean más adheribles (pegajosas) entre ellas, además de causar lesión endotelial (fisuras en los vasos sanguíneas) https://t.co/RumoAWeWwq
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
https://t.co/YqVlcqIJmF
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
RT @doctorasadkhan: This explains the ‘vicious cycle’ I keep talking about. Virus causes endothelitis, platelet hyperactivation & clotting.…
Platelets amplify endotheliopathy in COVID-19 https://t.co/H9FsoBij7Q
Platelets amplify endotheliopathy in COVID-19 https://t.co/XRruaPLHEz
Platelets amplify endotheliopathy in COVID-19, Sep 8, https://t.co/uUTtzwNfHT
RT @NatureMicrobiol: Platelets amplify endotheliopathy in COVID-19 https://t.co/7I3tDffZzd
RT @NatureMicrobiol: Platelets amplify endotheliopathy in COVID-19 https://t.co/7I3tDffZzd
Platelets amplify endotheliopathy in COVID-19 https://t.co/7I3tDffZzd
Platelets amplify endotheliopathy in COVID-19 https://t.co/LwvEXhTer3
RT @JishnuSenGupta: Another really exciting paper on COVID-associated endotheliopathy! Platelets amplify endotheliopathy in COVID-19 https:…
RT @JishnuSenGupta: Another really exciting paper on COVID-associated endotheliopathy! Platelets amplify endotheliopathy in COVID-19 https:…
Platelets amplify endotheliopathy in COVID-19 https://t.co/6UaUTkzOYm
Platelets amplify endotheliopathy in COVID-19 https://t.co/jp7ee4AGmd "platelet-derived MRP8/14 activates ECs, promotes an inflammatory hypercoagulable phenotype, and is a significant contributor to poor clinical outcomes in COVID-19 patients."
Platelets amplify endotheliopathy in COVID-19 https://t.co/9tb28rBBRT
Another really exciting paper on COVID-associated endotheliopathy! Platelets amplify endotheliopathy in COVID-19 https://t.co/5QYUVBtzFV
Platelets amplify endotheliopathy in COVID-19 https://t.co/jdq9UwunRA
Platelets amplify endotheliopathy in COVID-19 https://t.co/gibE4BFUNt
Platelets amplify endotheliopathy in COVID-19 https://t.co/yLIwWHZHaV
Newly released “Platelets amplify endotheliopathy in COVID-19” @deNutrients