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The discussions around the research highlight the nocebo effect, with phrases such as 'most statin side effects are nocebo' appearing frequently. This terminology conveys a sense of urgency and clarity, as seen in posts referencing specific trials like the SAMSON trial, which reinforces the concept that many symptoms may not stem from the drug itself. Words like 'brilliant trial' and 'game changer' emphasize the perceived importance and transformative potential of these findings, suggesting that the community views this research as crucial for both clinical practice and patient understanding.
Many posts express a positive reception to the findings of the study, indicating a general consensus regarding its importance.
The discussions show a high level of curiosity about the implications of the nocebo effect related to statin use, with several users highlighting the study's relevance.
While some posts delve into methodological aspects, the overall engagement level is moderate, with several users simply sharing the study without deep analysis.
Users generally perceive the findings of the study as having a significant impact on the understanding of statin-related side effects.
Este artículo es realmente sorprendente. No diferencias entre los efectos secundarios que el paciente siente al tomar estatinas o placebo. Pero lo interesante es que lo que yo utilizaba (suspender y ver evolución), no sirve! Pasa lo mismo con el placebo! https://t.co/jOh99FnoFr https://t.co/jLwVBwIjvT
SAMSON Trial. ⚠️ The majority of symptoms caused by statins tablets
News #ACC23 about drug for those w/statin intolerance...but little about statin intolerance is mostly a myth... @ProfDFrancis did the definitive study. So for all the hullabaloo, shouldn't we be talking about that? https://t.co/lR1eHCLrvS @ginakolata @matthewherper @LNeergaard https://t.co/peDi16mbx5
Detener, evaluar y reiniciar la estatina puede confirmar una intolerancia inexistente. Este ensayo muestra que, incluso así, el 50% de los pacientes etiquetados como intolerantes a las estatinas en realidad no lo son. https://t.co/40Pxg0EUeq @sociedadSEEN @LipidoSeen @SEMERGENap https://t.co/jLfVH7v6tG
¿Efecto #Nocebo?
9/ Sidebar: whether the MSK side-effects of statins are “real” or psychosomatic is a fascinating question, but may be a moot point if patients are stopping their statin regardless. Nonetheless, here’s one of my favorite studies of statins vs. placebo. https://t.co/zcI6cenhLa https://t.co/hLzchmUuMG
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The video explores the nocebo phenomenon, revealing how negative expectations may lead to the perception of side effects in medications like statins. Findings suggest participants reported similar symptoms from both…
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This week, John Mandrola MD discusses dual antiplatelet therapy after PCI, the side effects of statins, and considerations in HF care. The analysis emphasizes that many reported statin side effects may be linked to the…
Reporting on potential fraud in medicine, AF stroke, and a new cholesterol-lowering drug, John Mandrola MD discusses key findings from recent studies. Notably, research shows reported statin side effects may stem from…
@stubbstefl @ifixhearts https://t.co/YXdZqimISj Check this out. It’s an interesting study that shows most statin side effects are the result of a nocebo effect
@bogdienache Presumably you've seen this study https://t.co/tgIBIkM5WI which I thought was a neat nocebo demonstration for statins
@krenzx @gregmushen 90% of statin side effects are nocebo https://t.co/JE9WeMVqe9
Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment https://t.co/SfZhvZskuC
【参考文献】#薬ツイ Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment https://t.co/TApI9ZVBCA
@peto682 @MichaelAlbertMD https://t.co/C9gnfpzCpr Which side effects?
RT @NMPajewski: @asouth_neph I’ve always liked this crossover trial on statin side effects https://t.co/Okcn8aTQnX
@asouth_neph I’ve always liked this crossover trial on statin side effects https://t.co/Okcn8aTQnX
@holmanm It’s crazy the lengths that big pharma
Journal article full access #FOAMed #JACC : https://t.co/oKdQtxITjc
@Toaster_Pastry https://t.co/2vA2Ip2w4x Brilliant trial led by @DrJHoward and senior author @ProfDFrancis. I think we’ve got enough to say it’s almost always nocebo…
@Tellit007 @JuddWhitta32246 @Drlipid Here are a couple that investigate those claims. https://t.co/UBOIOYPRRt https://t.co/YnqpleTr4F
Link zum Volltext: https://t.co/rBVpaIYy4V
@AngryCardio @_01_17__ SAMSON trial was one that was widely shared. It appears to have been double published - once as a letter in NEJM and now again as a full paper in JACC. https://t.co/QqvjMKD3yx https://t.co/hnc2Uyc6OB
RT @CFAndersenMD: 9/ Sidebar: whether the MSK side-effects of statins are “real” or psychosomatic is a fascinating question, but may be a m…
9/ Sidebar: whether the MSK side-effects of statins are “real” or psychosomatic is a fascinating question, but may be a moot point if patients are stopping their statin regardless. Nonetheless, here’s one of my favorite studies of statins vs. placebo. https://t.co/zcI6cenhLa https://t.co/hLzchmUuMG
RT @primastcar:
RT @primastcar:
RT @primastcar:
This study is a great demonstration of the NOCEBO effect
RT @hmkyale: News #ACC23 about drug for those w/statin intolerance...but little about statin intolerance is mostly a myth... @ProfDFrancis…
RT @hmkyale: News #ACC23 about drug for those w/statin intolerance...but little about statin intolerance is mostly a myth... @ProfDFrancis…
RT @hmkyale: News #ACC23 about drug for those w/statin intolerance...but little about statin intolerance is mostly a myth... @ProfDFrancis…
RT @hmkyale: News #ACC23 about drug for those w/statin intolerance...but little about statin intolerance is mostly a myth... @ProfDFrancis…
RT @hmkyale: News #ACC23 about drug for those w/statin intolerance...but little about statin intolerance is mostly a myth... @ProfDFrancis…
RT @hmkyale: News #ACC23 about drug for those w/statin intolerance...but little about statin intolerance is mostly a myth... @ProfDFrancis…
RT @hmkyale: News #ACC23 about drug for those w/statin intolerance...but little about statin intolerance is mostly a myth... @ProfDFrancis…
RT @hmkyale: News #ACC23 about drug for those w/statin intolerance...but little about statin intolerance is mostly a myth... @ProfDFrancis…
@ProfDFrancis @ginakolata @matthewherper @LNeergaard From his paper: 'Most symptoms caused by statins were nocebo. Clinicians should not interpret symptom intensity or timing of symptom onset or offset as indicating pharmacological causation, because the pattern is identical for placebo.' https://t.co/lR1eHCLrvS
News #ACC23 about drug for those w/statin intolerance...but little about statin intolerance is mostly a myth... @ProfDFrancis did the definitive study. So for all the hullabaloo, shouldn't we be talking about that? https://t.co/lR1eHCLrvS @ginakolata @matthewherper @LNeergaard https://t.co/peDi16mbx5
@EmilTalani @TaymazMD https://t.co/FdL2Lq2ThD
Paper นี้อ่านโคตรบันเทิง -> เปรียบเทียบ Side effect pattern ของ Statin VS Placebo VS No Treatment ในคนไข้ที่เคยหยุดใช้ statin เพราะมี Side effect ผลสรุป Side effect ของ Statin เป็น Nocebo effect
@IngaKsd @JuhaniKnuuti @lasleh @laaksotero Sanoit, että - vain 1/100 hyötyisi (katteeton väite) - saisivat paljon haittoja (katteeton väite) Ks. https://t.co/Fh29p4YGqh https://t.co/YUD5Yy9tdm https://t.co/USTF1ntbTo https://t.co/OM5xVx5ly0
RT @FatimaVillaf: ¿Efecto #Nocebo?
RT @FatimaVillaf: ¿Efecto #Nocebo?
RT @FatimaVillaf: ¿Efecto #Nocebo?
RT @FatimaVillaf: ¿Efecto #Nocebo?
RT @FatimaVillaf: ¿Efecto #Nocebo?
RT @FatimaVillaf: ¿Efecto #Nocebo?
RT @FatimaVillaf: ¿Efecto #Nocebo?
RT @FatimaVillaf: ¿Efecto #Nocebo?
RT @FatimaVillaf: ¿Efecto #Nocebo?
¿Efecto #Nocebo?
Atorva vs placebo The majority of symptoms caused by statin tablets were nocebo. https://t.co/kGLiy5xEcI
@DrNadolsky Based on his message seems reasonably understanding of recs. I always like to bring up the SAMSON trial to ease concerns and what not. https://t.co/MUenhYDkfj @JACCJournals
@loscharlos @dbkell @resiapretorius @doctorasadkhan @ShaneyWright @WesElyMD @farid__jalali @fearnley_k @lisa_iannattone @LongCovidSOS @long_covid @drschweig @jencurtinmd @MVGutierrezMD @LekshmiMD @elisaperego78 @j_b_kennedy @D_Bone @brucep13 @zalaly @benking01 @microbeminded2 Also ppl who have 'had trouble tolerating statins' should be aware of the Sampson Trial https://t.co/hiroHrtwmn https://t.co/mjGsa8bOra
RT @EdoajoEric: Pssst. Muscle aches after starting a statin, especially a low intensity regimen like pravastatin 10 or 20mg daily, are almo…
Pssst. Muscle aches after starting a statin, especially a low intensity regimen like pravastatin 10 or 20mg daily, are almost certainly the nocebo effect and not genuine myopathy. https://t.co/hiroHru4bV https://t.co/5mK4i9biSp
RT @Tom_Babington1: @FructoseNo @MaryanneDemasi It would have been really useful to bring in the Samson trial at this point "However, man…
@FructoseNo @MaryanneDemasi It would have been really useful to bring in the Samson trial at this point "However, many patients who discontinue their statins notice that their symptoms resolve, and only return once they resume their medication" https://t.co/DyhiJ0I5dX https://t.co/vtomdI1Ozt
https://t.co/Y32uYZW9t6 - SAMSON: estudió pacientes que habían presentado EA severos q les obligaba a discontinuar estatinas. ➡️Ensayo clínico doble ciego, de crossover múltiple con 3 brazos: estatina (atorvastatina 20mg), placebo (manufacturado idéntico a la estatina) y sin tto
@emedfocus @DrNadolsky There is no doubt a small number get side effects, but this is largely a nocebo effect than something pathological. Check out this study- @jaccjournals https://t.co/F0FmryddkE
RT @cardiomet_CE: 13) The #SAMSON trial suggests as much as 90% of reported #statin associated side effects are due to the #nocebo effect
RT @cardiomet_CE: 13) The #SAMSON trial suggests as much as 90% of reported #statin associated side effects are due to the #nocebo effect
13) The #SAMSON trial suggests as much as 90% of reported #statin associated side effects are due to the #nocebo effect
@CosmicCraig @justinbailey32 @kevinnbass This study shows insights into why. In short, its likely the nocebo effect. If you expect to have side effects from taking something, it increases your chance of having side effects. https://t.co/B6SUkKsQMP
RT @agingdoc1: Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment (2021) https://t.co/FmNSmav0kL
Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment (2021) https://t.co/FmNSmav0kL
@stoneatti Does it occur? Yes. Is it as prevalent as people suggest? No. The SAMSON trial described a significant percentage of intolerance is due to NOCEBO. https://t.co/K0SvilgHAO
@The_Nutrivore Also interested in her explaining the "debilitating side effects" https://t.co/DyhiJ0I5dX https://t.co/PaPTbguE9c https://t.co/JTKETcth3F
RT @pash22: Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment https://t.co/EsdzBVYf4t via @AlexNowbar et al ht…
RT @pash22: Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment https://t.co/EsdzBVYf4t via @AlexNowbar et al ht…
Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment https://t.co/EsdzBVYf4t via @AlexNowbar et al https://t.co/2c3MZpBCNx
RT @MichaelAlbertMD: Maybe one of the most ingenious studies of all time (SAMSON trial): https://t.co/K0SvilgHAO
RT @MichaelAlbertMD: Maybe one of the most ingenious studies of all time (SAMSON trial): https://t.co/K0SvilgHAO
RT @MichaelAlbertMD: Maybe one of the most ingenious studies of all time (SAMSON trial): https://t.co/K0SvilgHAO
Open Access UCL Research: Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment - UCL Discovery https://t.co/vn7HFBp3U0
Elicit on the side effects of statins
RT @theproof: @dr_cois Seems you are onto something https://t.co/HXHZoVWyZ3
@TuckerGoodrich Yes. We also have genetic studies showing various mutations that increase HDL-C levels do not seem to lower risk https://t.co/HXHZoVWyZ3
@dr_cois Seems you are onto something https://t.co/HXHZoVWyZ3
Il peut être spécifiquement évalué dans les essais cliniques, mais cela nécessite une méthodologie adaptée : exemple des douleurs musculaires sous statines ➡️Essai SAMSON https://t.co/pb7paXyOon
@ProfDConnelly @BHFScotland @fi_strachan @DrKate_Miller How about statins cause muscle pains? @ProfDFrancis https://t.co/SfQl047nz7 https://t.co/T2QUlafloa
RT @unainternista: Uno de los must (y de mis favoritos) de #2021 presentado por el presidente de la @sea_es Dr José María Mostaza: Efecto…
El efecto nocebo( efecto adverso de la medicina es igual al placebo) de las estatinas, es aplicable a las vacunas. Nadie lo estudia por qué la Ciencia lo comprende. @SIAC_cardio https://t.co/YM8bZohPaQ
Uno de los must (y de mis favoritos) de #2021 presentado por el presidente de la @sea_es Dr José María Mostaza: Efecto nocebo de las estatinas https://t.co/zHHRBSLKru #efectonocebo #whatsnext2022 https://t.co/fRaJdr96wI
@bmoneyfourfive1 @n1k0laj1 @perrycockdock @The_Nutrivore This is the publication I was referencing https://t.co/DyhiJ0I5dX Anyway, it looks like only 2/15 authors disclosed fees or grants from pharmaceutical companies. I don't see why this is concerning. Even if all of them disclosed COI's, I wouldn't necessarily be concerned.
@bmoneyfourfive1 @n1k0laj1 @perrycockdock @Tom_Babington1 If the evidence quality for benefits is shit, wouldn't the evidence quality for side effects be shit as well? Regardless, most of the side effects are the nocebo effect. 9/10 times the side effects are all in their head. https://t.co/bYCeAnisBo
@smurthys Also, the vast majority of statin side effects can be explained for the nocebo effect. https://t.co/Zl3iUGNDom
@_Chris_Duggan @ScepticalDoctor @MichaelMindrum Data on statin adherence is one of the prime examples. People stop them for all sorts of reasons not supported by evidence. https://t.co/bnq6wpGBAO https://t.co/n1PFd0JMFt https://t.co/K0SvilgHAO
RT @Links_Medicus: Side effect patterns in a crossover trial of statin, placebo, and no treatment – This N-of-1 trial, now published in ful…
Maybe one of the most ingenious studies of all time (SAMSON trial): https://t.co/K0SvilgHAO
RT @ALEX_MISCHIE: Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment https://t.co/9NMwXV848k The majority of s…
RT @mbotana: Detener, evaluar y reiniciar la estatina puede confirmar una intolerancia inexistente. Este ensayo muestra que, incluso así, e…
RT @mbotana: Detener, evaluar y reiniciar la estatina puede confirmar una intolerancia inexistente. Este ensayo muestra que, incluso así, e…
RT @mbotana: Detener, evaluar y reiniciar la estatina puede confirmar una intolerancia inexistente. Este ensayo muestra que, incluso así, e…
RT @mbotana: Detener, evaluar y reiniciar la estatina puede confirmar una intolerancia inexistente. Este ensayo muestra que, incluso así, e…
RT @mbotana: Detener, evaluar y reiniciar la estatina puede confirmar una intolerancia inexistente. Este ensayo muestra que, incluso así, e…
RT @mbotana: Detener, evaluar y reiniciar la estatina puede confirmar una intolerancia inexistente. Este ensayo muestra que, incluso así, e…
RT @mbotana: Detener, evaluar y reiniciar la estatina puede confirmar una intolerancia inexistente. Este ensayo muestra que, incluso así, e…
RT @mbotana: Detener, evaluar y reiniciar la estatina puede confirmar una intolerancia inexistente. Este ensayo muestra que, incluso así, e…
RT @mbotana: Detener, evaluar y reiniciar la estatina puede confirmar una intolerancia inexistente. Este ensayo muestra que, incluso así, e…
RT @mbotana: Detener, evaluar y reiniciar la estatina puede confirmar una intolerancia inexistente. Este ensayo muestra que, incluso así, e…
RT @mbotana: Detener, evaluar y reiniciar la estatina puede confirmar una intolerancia inexistente. Este ensayo muestra que, incluso así, e…
Detener, evaluar y reiniciar la estatina puede confirmar una intolerancia inexistente. Este ensayo muestra que, incluso así, el 50% de los pacientes etiquetados como intolerantes a las estatinas en realidad no lo son. https://t.co/40Pxg0EUeq @sociedadSEEN @LipidoSeen @SEMERGENap https://t.co/jLfVH7v6tG
Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment https://t.co/blC8e29M2i
RT @jvillacastin: Este artículo es realmente sorprendente. No diferencias entre los efectos secundarios que el paciente siente al tomar est…
@machadolac @josegallucci Trial released this week demonstrating the power of the nocebo effect. https://t.co/MmfS86k6TM
RT @jvillacastin: Este artículo es realmente sorprendente. No diferencias entre los efectos secundarios que el paciente siente al tomar est…
【交差試験】1ヶ月分のアトルバスタチンが入ったボトルを4本、プラセボが入ったボトルを4本、空のボトルを4本、計12ヶ月服用してもらい、毎日の症状強度を測定してもらったところ、スタチン服用中の症状強度は未服用時より高かったが、プラセボ服用中も同様に高かった。 #ペ読 https://t.co/Ip1UfiWOj4
RT @jvillacastin: Este artículo es realmente sorprendente. No diferencias entre los efectos secundarios que el paciente siente al tomar est…
RT @alavallecobo: SAMSON Trial. ⚠️ The majority of symptoms caused by statins tablets
RT @jvillacastin: Este artículo es realmente sorprendente. No diferencias entre los efectos secundarios que el paciente siente al tomar est…
RT @Lguevaramath: Side-Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment | comment: Paul D. Thompson MD https://t.c…
RT @jvillacastin: Este artículo es realmente sorprendente. No diferencias entre los efectos secundarios que el paciente siente al tomar est…
RT @jvillacastin: Este artículo es realmente sorprendente. No diferencias entre los efectos secundarios que el paciente siente al tomar est…
RT @jvillacastin: Este artículo es realmente sorprendente. No diferencias entre los efectos secundarios que el paciente siente al tomar est…
RT @Lguevaramath: Side-Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment | comment: Paul D. Thompson MD https://t.c…
Side-Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment | comment: Paul D. Thompson MD https://t.co/tIwUXukjdA via @practiceupdate. @mencardio @torresviera @torresviera @ernestocardio @DrPontecarlosi @jjamaro
RT @jvillacastin: Este artículo es realmente sorprendente. No diferencias entre los efectos secundarios que el paciente siente al tomar est…
RT @jvillacastin: Este artículo es realmente sorprendente. No diferencias entre los efectos secundarios que el paciente siente al tomar est…
RT @jvillacastin: Este artículo es realmente sorprendente. No diferencias entre los efectos secundarios que el paciente siente al tomar est…
RT @jvillacastin: Este artículo es realmente sorprendente. No diferencias entre los efectos secundarios que el paciente siente al tomar est…
RT @jvillacastin: Este artículo es realmente sorprendente. No diferencias entre los efectos secundarios que el paciente siente al tomar est…
RT @jvillacastin: Este artículo es realmente sorprendente. No diferencias entre los efectos secundarios que el paciente siente al tomar est…
Este artículo es realmente sorprendente. No diferencias entre los efectos secundarios que el paciente siente al tomar estatinas o placebo. Pero lo interesante es que lo que yo utilizaba (suspender y ver evolución), no sirve! Pasa lo mismo con el placebo! https://t.co/jOh99FnoFr https://t.co/jLwVBwIjvT
"The majority of symptoms caused by statin tablets were nocebo, with no difference between placebo and statin." Side-Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment https://t.co/heessM0R5Z via @practiceupdate
RT @DrJHoward: Excited to say the SAMSON Trial's full data has now been published in @JACCJournals. There is lots of interesting data, such…
RT @alavallecobo: SAMSON Trial. ⚠️ The majority of symptoms caused by statins tablets
Side-Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment https://t.co/V8HLQU6RNU #cardiology
Randomized, double-blind, crossover trial of statins shows myalgias increased the same amount for active and placebo arms, do difference between groups @ProfDFrancis @JACCJournals https://t.co/mebYIpi1zL
Side effect patterns in a crossover trial of statin, placebo, and no treatment – This N-of-1 trial, now published in full, suggests the nocebo effect causes most of statins muscle adverse effects. – via @JACCJournals https://t.co/IE18uJg4VW
RT @alavallecobo: SAMSON Trial. ⚠️ The majority of symptoms caused by statins tablets
Side Effect Patterns in a Crossover Trial of #Statin, Placebo, and No Treatment - ScienceDirect Results are as I suspected… how about you #Twitterx ? https://t.co/iJbjUB544T
RT @alavallecobo: SAMSON Trial. ⚠️ The majority of symptoms caused by statins tablets
RT @alavallecobo: SAMSON Trial. ⚠️ The majority of symptoms caused by statins tablets
RT @alavallecobo: SAMSON Trial. ⚠️ The majority of symptoms caused by statins tablets
RT @alavallecobo: SAMSON Trial. ⚠️ The majority of symptoms caused by statins tablets
RT @alavallecobo: SAMSON Trial. ⚠️ The majority of symptoms caused by statins tablets
RT @alavallecobo: SAMSON Trial. ⚠️ The majority of symptoms caused by statins tablets
RT @cpgale3: Looking forward to speaking with @DrJHoward next week about his randomised clinical trial: Side Effect Patterns in a Crossove…
RT @alavallecobo: SAMSON Trial. ⚠️ The majority of symptoms caused by statins tablets
RT @alavallecobo: SAMSON Trial. ⚠️ The majority of symptoms caused by statins tablets
RT @cpgale3: Looking forward to speaking with @DrJHoward next week about his randomised clinical trial: Side Effect Patterns in a Crossove…
RT @alavallecobo: SAMSON Trial. ⚠️ The majority of symptoms caused by statins tablets
Looking forward to speaking with @DrJHoward next week about his randomised clinical trial: Side Effect Patterns in a Crossover Trial of Statin, Placebo, & No Treatment @jaccjournals https://t.co/AnSvZOvChW
RT @alavallecobo: SAMSON Trial. ⚠️ The majority of symptoms caused by statins tablets
RT @alavallecobo: SAMSON Trial. ⚠️ The majority of symptoms caused by statins tablets
RT @alavallecobo: SAMSON Trial. ⚠️ The majority of symptoms caused by statins tablets
SAMSON Trial. ⚠️ The majority of symptoms caused by statins tablets
Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment https://t.co/9NMwXV848k The majority of symptoms caused by statin tablets were nocebo. https://t.co/OOPHHOaKTp
Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No T... https://t.co/IldbMOrb1K https://t.co/a0Y8C1Ppbm
Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment | Journal of the American College of Cardiology https://t.co/UdZs109hmi
Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment | Journal of the American College of Cardiology 面白い研究デザイン https://t.co/pu8iXANZ6E