Nat Metab September 2021 PMID 34552272

Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation.

Ana Andres-Hernando, Christina Cicerchi, Masanari Kuwabara, David J Orlicky, Laura Gabriela Sanchez-Lozada, Takahiko Nakagawa, Richard J Johnson, Miguel A Lanaspa

Mentions

30
Peak: 22 in Sep 2021
across 2 sources since Sep 2021

Extended reach

103,313
potential audience

Total likes

141

Video views

2,942

Mentions per month

Sep 2021 – Jul 2025

Where it's discussed

  • X / Twitter28 posts
  • YouTube2 videos

AI synopsis

What people are saying

Discussions emphasize the novelty and significance of the research, with commentators highlighting the mechanistic link between umami compounds and obesity, referencing specific biochemical pathways like nucleotide breakdown and uric acid production. The tone is analytical and optimistic, with phrases like 'highly relevant' and 'important for understanding' that reveal strong interest and recognition of the study’s potential impact.

AgreementStrong agreement

Most discussions acknowledge the significance of the findings, emphasizing the scientific novelty and potential implications for understanding obesity and metabolic syndrome.

InterestHigh interest

Posts show high curiosity, with many discussing the mechanistic aspects like nucleotide degradation and uric acid production, and expressing eagerness to explore the details.

EngagementModerate engagement

Several posts reflect deep engagement by referencing the research methods, such as noting the role of enzymes like AMP deaminase 2, and contemplating the broader implications of umami's effects.

ImpactHigh impact

Users perceive this publication as highly impactful, highlighting its importance for future research, dietary considerations, and clinical applications, framing it as a significant breakthrough.

Abstract in brief

  • Umami foods, which contain MSG and other nucleotides, can promote obesity and metabolic syndrome by triggering a pathway that involves nucleotide breakdown and uric acid production.
  • The study shows that MSG causes obesity, brain inflammation, and leptin resistance in male mice by activating an enzyme called AMP deaminase 2, which leads to purine degradation; mice without this enzyme are protected from these effects.
  • The findings suggest that umami, like sugar and salt, enhances food intake and energy storage through similar mechanisms involving purine metabolism, but excessive consumption of these tastes can contribute to obesity and diabetes.]

Top posts

Most liked on X and Bluesky
FrezzaLab
@FrezzaLab · X

Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation | Nature Metabolism https://t.co/YbTQBnw7y1

Sep 23, 2021 · 17 likes · 7 shares · 26,985 followers View post →
Sherezade MR
@sherezade_mr · X

@angelmartin_nc Mapa cerebro noticia: https://t.co/Ba8fJrkNCp Cerebro papers: https://t.co/h2COTXGJIo Percebes surferos: https://t.co/mluaTZx4aW Paper percebes: https://t.co/p2SC2CVS7k Paper umami: https://t.co/Y6SOBUwLB1 Paper “colorea mejor”: https://t.co/I963nLRMKM

Oct 14, 2021 · 8 likes · 3 shares · 11,894 followers View post →
Steve Alexander
@mqzspa · X

"Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation" https://t.co/afhqYBCqzl

Sep 22, 2021 · 5 likes · 3 shares · 944 followers View post →
Sai P Pydi
@saip_pydi · X

Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation | Nature Metabolism https://t.co/CmaiFW2RWq

Sep 22, 2021 · 3 likes · 2 shares · 647 followers View post →
Kevin Tharp
@Derpology · X

"Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation | Nature Metabolism" https://t.co/MbwLsa6UK2

Sep 23, 2021 · 2 likes · 1,224 followers View post →
Nick Krontiris
@nick_krontiris · X

Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation https://t.co/lvNsIgkLL4 #Obesity #MetabolicSyndrome

Sep 24, 2021 · 1 like · 19,023 followers View post →

All mentions

RRID Robot
@RobotRrid · X

The authors of "Umami-induced obesity and metabolic syndrome is me…" (https://t.co/WVyTm83M7r) included RRIDs in their paper! RRIDs like this improve reproducibility in scientific research. #reproducibility #OpenScience

Jun 18, 2022 · 161 followers View post →
あつこ@彷徨える大衆 (Atsuko)
@plutoatsuko · X

専門分野ではないので理解不十分ですが、どうやら旨味とフラクトースと塩が肥満等の代謝疾患を起こす説は有力のようです。 Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation | Nature Metabolism https://t.co/DxPKBNaFMg

Oct 17, 2021 · 105 followers View post →
Alex MR
@alexmartinros · X

RT @sherezade_mr: @angelmartin_nc Mapa cerebro noticia: https://t.co/Ba8fJrkNCp Cerebro papers: https://t.co/h2COTXGJIo Percebes surferos…

Oct 14, 2021 · 3 shares · 807 followers View post →
Walter Maes
@waltermaes · X

RT @sherezade_mr: @angelmartin_nc Mapa cerebro noticia: https://t.co/Ba8fJrkNCp Cerebro papers: https://t.co/h2COTXGJIo Percebes surferos…

Oct 14, 2021 · 3 shares · 1,767 followers View post →
Sue Cuevas
@SueCuevasD · X

RT @sherezade_mr: @angelmartin_nc Mapa cerebro noticia: https://t.co/Ba8fJrkNCp Cerebro papers: https://t.co/h2COTXGJIo Percebes surferos…

Oct 14, 2021 · 3 shares · 115 followers View post →
Sherezade MR
@sherezade_mr · X

@angelmartin_nc Mapa cerebro noticia: https://t.co/Ba8fJrkNCp Cerebro papers: https://t.co/h2COTXGJIo Percebes surferos: https://t.co/mluaTZx4aW Paper percebes: https://t.co/p2SC2CVS7k Paper umami: https://t.co/Y6SOBUwLB1 Paper “colorea mejor”: https://t.co/I963nLRMKM

Oct 14, 2021 · 8 likes · 3 shares · 11,894 followers View post →
Moir2_IR
@Moir2Ir · X

RT @NatMetabolism: Online now! Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation…

Sep 24, 2021 · 5 shares · 80 followers View post →
Nick Krontiris
@nick_krontiris · X

Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation https://t.co/lvNsIgkLL4 #Obesity #MetabolicSyndrome

Sep 24, 2021 · 1 like · 19,023 followers View post →
Heer Lab
@Heer_Lab · X

RT @FrezzaLab: Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation | Nature Metabol…

Sep 23, 2021 · 7 shares · 1,615 followers View post →
Cholsoon Jang
@cholsoon_jang · X

RT @FrezzaLab: Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation | Nature Metabol…

Sep 23, 2021 · 7 shares · 1,035 followers View post →
Kevin Tharp
@Derpology · X

"Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation | Nature Metabolism" https://t.co/MbwLsa6UK2

Sep 23, 2021 · 2 likes · 1,224 followers View post →
Dominika Borek
@dmborek · X

RT @FrezzaLab: Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation | Nature Metabol…

Sep 23, 2021 · 7 shares · 650 followers View post →
Federico Bernuzzi, PhD
@FedericoBernuzz · X

RT @FrezzaLab: Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation | Nature Metabol…

Sep 23, 2021 · 7 shares · 623 followers View post →
Pierre-Henri Ducluzeau
@PHDucluzeau · X

RT @saip_pydi: Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation | Nature Metabol…

Sep 23, 2021 · 2 shares · 124 followers View post →
Massato Hirai
@MassatoHirai · X

RT @FrezzaLab: Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation | Nature Metabol…

Sep 23, 2021 · 7 shares · 108 followers View post →
Ernesto de Bernardis, MD
@debe · X

RT @FrezzaLab: Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation | Nature Metabol…

Sep 23, 2021 · 7 shares · 887 followers View post →
Joanna Poole
@Jopo_dr · X

RT @FrezzaLab: Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation | Nature Metabol…

Sep 23, 2021 · 7 shares · 23,266 followers View post →
Women in Autophagy
@WAutophagy · X

RT @NatMetabolism: Online now! Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation…

Sep 23, 2021 · 5 shares · 2,640 followers View post →
FrezzaLab
@FrezzaLab · X

Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation | Nature Metabolism https://t.co/YbTQBnw7y1

Sep 23, 2021 · 17 likes · 7 shares · 26,985 followers View post →
Marina García Macia
@Juanaloca2002 · X

RT @NatMetabolism: Online now! Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation…

Sep 23, 2021 · 5 shares · 2,811 followers View post →
GenomeArc
@genomearc · X

RT @NatMetabolism: Online now! Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation…

Sep 23, 2021 · 5 shares · 1,106 followers View post →
Akiyuki Taruno
@AkiyukiTaruno · X

RT @mqzspa: "Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation" https://t.co/afhq…

Sep 22, 2021 · 3 shares · 174 followers View post →
M. Kawatani (Hiro or Jr.)
@M_kawatni · X

RT @mqzspa: "Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation" https://t.co/afhq…

Sep 22, 2021 · 3 shares · 192 followers View post →
Sai P Pydi
@saip_pydi · X

Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation | Nature Metabolism https://t.co/CmaiFW2RWq

Sep 22, 2021 · 3 likes · 2 shares · 647 followers View post →
@Katonalab
@katonalab · X

RT @mqzspa: "Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation" https://t.co/afhq…

Sep 22, 2021 · 3 shares · 292 followers View post →
Nahuel
@Nahuel35609591 · X

RT @NatMetabolism: Online now! Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation…

Sep 22, 2021 · 5 shares · 59 followers View post →
Steve Alexander
@mqzspa · X

"Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation" https://t.co/afhqYBCqzl

Sep 22, 2021 · 5 likes · 3 shares · 944 followers View post →
Adam J Rose
@DrAJRose · X

RT @NatMetabolism: Online now! Umami-induced obesity and metabolic syndrome is mediated by nucleotide degradation and uric acid generation…

Sep 22, 2021 · 5 shares · 810 followers View post →