PubHawk
December 2021 PMID 34619076

"Sweet death": Fructose as a metabolic toxin that targets the gut-liver axis.

Mark A Febbraio, Michael Karin

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Mentions

31
Peak: 4 in Feb 2025
across 5 sources since Oct 2021

Extended reach

34,217
potential audience

Total likes

290

Video views

12,884

Mentions per month

Oct 2021 – Apr 2025

Where it's discussed

  • X / Twitter17 posts
  • YouTube6 videos
  • Facebook4 posts
  • News2 articles
  • Blogs2 articles

AI synopsis

What people are saying

Discussions show a general agreement on the harmful effects of HFCS, with users emphasizing its role in metabolic diseases, as seen in comments referencing intestinal barrier damage and fatty liver disease. The tone combines informational tone with concern, reflecting both curiosity and acknowledgment of the article’s significance in public health debates.

AgreementModerate agreement

Most discussions acknowledge the harmful effects of high-fructose corn syrup (HFCS) and support the idea that fructose can damage the gut and liver, aligning with the article's conclusions.

InterestModerate interest

The social discussions demonstrate curiosity about the subject, with some users referencing scientific studies and expressing concern over dietary choices.

EngagementModerate engagement

Participants actively share information, questions, and opinions about fructose's health impacts, showing a moderate level of in-depth engagement.

ImpactModerate impact

The discussions highlight awareness about the potential health risks associated with HFCS and fructose, indicating a recognition of its broader public health relevance.

Abstract in brief

  • Fructose, once mainly found in fruit, became more common in diets through high-fructose corn syrup (HFCS), and its increased intake is linked to higher rates of obesity and type 2 diabetes, though the exact mechanisms are still unclear.
  • Recent research shows that fructose is metabolized not only in the liver but also in the small intestine, where it can damage the intestinal barrier, contributing to metabolic diseases via the gut-liver axis.
  • Understanding how fructose impacts both the gut and liver offers new opportunities for preventing and treating diseases related to high fructose consumption.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Isabela
@isa_ramul · X

Ref: doi:10.1016/j.regpep.2008.06.008, https://t.co/eZ0iJst49T, doi:10.1016/j.cmet.2021.09.004, https://t.co/vBpNseAvAd

Nov 8, 2022 · 2 likes · 1,841 followers View post →
Metabolic Health
@MetabolicMed2 · X

"Sweat death" #Fructose damages the gut and the liver https://t.co/GEwFBdqnGY #sugar #fat #keto #health #weightlossjourney #weightgain #weightloss

Dec 7, 2021 · 2 likes · 6 followers View post →
DrRPalmquist
@DrPalmquist · X

Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis https://t.co/N6QI8PgxUe

Mar 30, 2024 · 1 like · 3,162 followers View post →
James Smith
@SergeantJSmith · X

@ChrisXtopher73 @arva61138 Not the same. HFCS is banned in several countries. Sugar is not. But keep lying to yourself. https://t.co/WMz8ktzOhG

Feb 16, 2025 · 1 like · 2,207 followers View post →
Frank J. Herrmann
@4141245879freun · X

@Sam_Apple1 Corn syrup

Aug 17, 2022 · 1 like · 914 followers View post →
Frank J. Herrmann
@4141245879freun · X

@RogerSeheult The problem is not fructose in e.g. fresh fruits, totally fine. However, so many foods nowadays are sweetened with this garbage: High-fructose corn syrup (HFCS) leads to intestinal epithelial barrier deterioration. Happy diabetes etc.! https://t.co/nZbTqFKb9L

Sep 13, 2023 · 1 like · 914 followers View post →

All mentions

James Smith
@SergeantJSmith · X

@tingxiao7 @arva61138 lol Corn can be made into ethanol for fuel. We shouldn’t consume HFCS https://t.co/WMz8ktzOhG

Feb 16, 2025 · 2,207 followers View post →
James Smith
@SergeantJSmith · X

@benzman82 @arva61138 https://t.co/WMz8ktzOhG

Feb 16, 2025 · 2,207 followers View post →
James Smith
@SergeantJSmith · X

@ChrisXtopher73 @arva61138 Not the same. HFCS is banned in several countries. Sugar is not. But keep lying to yourself. https://t.co/WMz8ktzOhG

Feb 16, 2025 · 1 like · 2,207 followers View post →
Coe
@ThatsNotMyKidd · X

@realTrumpNewsX https://t.co/4i6Fv5oqx8 https://t.co/rKfm74sxel https://t.co/vOJodt0mot https://t.co/TXrhfD7mvU Idk why but it keeps putting my last of the 4 papers as a picture but yeah I could keep dropping these all day. Relatively easy to find if you have any sense of how to research

Dec 1, 2024 · 906 followers View post →
DrRPalmquist
@DrPalmquist · X

Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis https://t.co/N6QI8PgxUe

Mar 30, 2024 · 1 like · 3,162 followers View post →
Lapo Litico
@BruceFake · X

Sempre dalla stessa fonte poi leggi questo vero @Bluefidel47 ? https://t.co/YnIiyS6osB https://t.co/kbYTKDxUG4

Jan 10, 2024 · 357 followers View post →
Frank J. Herrmann
@4141245879freun · X

@RogerSeheult The problem is not fructose in e.g. fresh fruits, totally fine. However, so many foods nowadays are sweetened with this garbage: High-fructose corn syrup (HFCS) leads to intestinal epithelial barrier deterioration. Happy diabetes etc.! https://t.co/nZbTqFKb9L

Sep 13, 2023 · 1 like · 914 followers View post →
fifilapoo
@fifilapoo1 · X

@seidlined @Renee76mcbride @LaughingLynx1 https://t.co/kLyUljrY5b

Jun 26, 2023 · 1 like · 105 followers View post →
Always on-call
@inallcreashun · X

@JimmySm58405905 @DuosEquis @JoshRainerGold https://t.co/Pkr6fBw7Nv

Apr 25, 2023 · 383 followers View post →
Sagittarius
@guani_vic · X

Fructose as metabolic target in gut liver axis https://t.co/UE5YXNhx1x

Feb 10, 2023 · 675 followers View post →
DrRPalmquist
@DrPalmquist · X

“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis: Cell Metabolism https://t.co/N6QI8PxAWe

Dec 18, 2022 · 3,162 followers View post →
Isabela
@isa_ramul · X

Ref: doi:10.1016/j.regpep.2008.06.008, https://t.co/eZ0iJst49T, doi:10.1016/j.cmet.2021.09.004, https://t.co/vBpNseAvAd

Nov 8, 2022 · 2 likes · 1,841 followers View post →
Frank J. Herrmann
@4141245879freun · X

@Sam_Apple1 Corn syrup

Aug 17, 2022 · 1 like · 914 followers View post →
Frank J. Herrmann
@4141245879freun · X

@JetsenSunday @kgopinion It's pretty clear: High-fructose corn syrup (HFCS) leads to intestinal epithelial barrier deterioration. https://t.co/nZbTqFKb9L

Jul 12, 2022 · 1 like · 914 followers View post →
Bernie Selloff - Dead Bankers Société Σ
@EBookberg · X

@GeoffCutmore @davidbelle_ insufficient to mention that #HFCS HIGH FRUCTOSE CORN SYRUP is a toxin that targets ur liver and causes FATTY LIVER DISEASE even in fit people. and the govt won't do dick about removing it from our foods because the @US_FDA is feckless and on the take. https://t.co/VxAo14WJrc

May 18, 2022 · 484 followers View post →
Metabolic Health
@MetabolicMed2 · X

"Sweat death" #Fructose damages the gut and the liver https://t.co/GEwFBdqnGY #sugar #fat #keto #health #weightlossjourney #weightgain #weightloss

Dec 7, 2021 · 2 likes · 6 followers View post →
Paperbirds_Oncology
@PaperbirdsO · X

New article: "Sweet death": Fructose as a metabolic toxin that targets the gut-liver axis https://t.co/vAzrQ9rFMF #livercancer #oncology https://t.co/0aUJuqJsbE

Oct 8, 2021 · 892 followers View post →