N Engl J Med November 2021 PMID 34758252

Angiotensin Receptor-Neprilysin Inhibition in Acute Myocardial Infarction.

Marc A Pfeffer, Brian Claggett, Eldrin F Lewis, Christopher B Granger, Lars Køber, Aldo P Maggioni, Douglas L Mann, John J V McMurray, Jean-Lucien Rouleau, Scott D Solomon, Philippe G Steg, Otavio Berwanger, Maja Cikes, Carmine G De Pasquale, Cara East

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Mentions

201

Peak: 128 in Nov 2021

across 5 sources since Nov 2021

Extended reach

704,331

potential audience

Total likes

341

Video views

518

Mentions per month

Nov 2021 – Apr 2025

Where it's discussed

X / Twitter177 posts
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Facebook5 posts
Blogs5 articles
YouTube2 videos

AI synopsis

What people are saying

Discussions prominently highlight the failure of sacubitril-valsartan to demonstrate benefits over ramipril for patients with acute myocardial infarction and reduced ejection fraction, with phrases like 'no significant benefit' and references to the trial's negative outcomes. This choice of language conveys a critical tone towards the effectiveness of ARNI therapy in this particular context, suggesting a consensus on the need to reconsider treatment strategies.

AgreementLow agreement

Many discussions reflect skepticism regarding the benefits of ARNI therapy versus ramipril, indicating a level of disagreement with the findings.

InterestHigh interest

There is a high level of curiosity about the implications of the trial results, with many participants engaging actively in discussions about its relevance.

EngagementModerate engagement

While the depth of engagement varies, several posts reference specific data and findings from the study, indicating a moderate level of analysis.

ImpactHigh impact

Overall, users perceive a significant impact from the study on clinical practices, especially concerning post-myocardial infarction treatments.

Abstract in brief

Sacubitril-valsartan shows promise in heart failure by reducing cardiovascular death and hospitalization compared to the traditional ramipril treatment.
In a study involving 5,661 patients with myocardial infarction and reduced heart function, outcomes favored sacubitril-valsartan in terms of hospitalizations related to heart failure.
Although both drugs had similar rates of treatment discontinuation due to side effects, sacubitril-valsartan did not significantly lead to lower overall adverse outcomes compared to ramipril.

Read the full abstract

All mentions

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Advancements in Heart Failure Treatment: Sacubitril-Valsartan Insights

The safety of very low LDLC, sacubitril-valsartan's promise in heart failure, and the impact of SGLT2 inhibitors are discussed in this podcast. It analyzes recent findings on treatment outcomes, including…

Medscape · Mar 27, 2024 11 views

Hany Ragy

@Hragy · X

@FadyMFouad https://t.co/f6xvtEL3YH

Apr 7, 2025 · 80,419 followers View post →

Gonzalo Perez

@gonzaeperez · X

@CardioBornan @siacprevent @jpcostabel @clara_clarais @rigotordoc @DrPontecarlosi @MediCasos @MedicinaSAM @ceciliabahit @SABOURETCardio @drmiguelmarcos El PARADISE MI no demostró beneficio en pacientes post IAM con insuficiencia cardíaca o FEY ⬇️ A diferencia de ensayos con IECA/ARA2, en este estudio, >90% de los pacientes fueron revascularizados https://t.co/6AUXKnoqF3

Nov 8, 2024 · 1 like · 17,208 followers View post →

Rhys Williams

@RhysWMPharm · X

@PharmacistHF https://t.co/ckQ78UohJF https://t.co/GOeIxpDuhG https://t.co/cXcMFJOrca

Jun 19, 2024 · 1 like · 1,196 followers View post →

Takuya Kishi @ねこ好き循環器内科医

@tkishi_cardiol · X

RT @nebetake: @KagiyamaNobu あと最近の心不全治療薬のMI + LVEF低下へのエビデンスだとARNIのPARADISE-MIも大事ですね。一緒に合わせて確認すると理解が深まるかもしれません。 ARNIはACEI(ラミプリル)と比較しprimary e…

Apr 8, 2024 · 1 share · 14,686 followers View post →

Takeru Nabeta

@nebetake · X

@KagiyamaNobu あと最近の心不全治療薬のMI + LVEF低下へのエビデンスだとARNIのPARADISE-MIも大事ですね。一緒に合わせて確認すると理解が深まるかもしれません。 ARNIはACEI(ラミプリル)と比較しprimary eventを改善しない。傾向はありますが... https://t.co/bDh2n7I7Os

Apr 7, 2024 · 10 likes · 1 share · 2,181 followers View post →

循環器病薬剤師ネットワーク(#循薬ネット)

@Cardio_Pharm_JP · X

そして、心不全既往の無い心筋梗塞発症例（LVEF<40% もしくは肺うっ血を伴う等の諸条件あり）に対しては、ACEIとイベント発生率に差は無い。 PARADISE-MI https://t.co/zJm1xRsV2E

Feb 24, 2024 · 8 likes · 1 share · 4,405 followers View post →

文献メモ

@bunken_kensaku · X

このあと読む：Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction https://t.co/i06LRMkmlL

Feb 24, 2024 · 6 likes · 273 followers View post →

@MARTINSVEL

@MARTINSVEL · X

RT @javier20ch: ✍️Artículos originales:

May 6, 2023 · 12 shares · 413 followers View post →

Faby G.

@Fabiolaghh · X

RT @javier20ch: ✍️Artículos originales:

May 6, 2023 · 12 shares · 410 followers View post →

JorgeEdoChava75

@QicenoJorge · X

RT @FarmaMadridAP: (NEJM)

Mar 29, 2023 · 25 shares · 996 followers View post →

Colin C

@doc_ccc · X

@JJCuthbert @cardiacshah @Chillslincoln79 @psquireslincoln @ChelsyCliff @ElifEzgiUstun @TinLwin9 @OllyBrown @clhyland_hewitt Just because something works in chronic HFrEF doesn't mean it will be beneficial for post-MI LVSD. https://t.co/xTDkXfnGyS

Mar 3, 2023 · 4 likes · 1,739 followers View post →

Jesal

@Jesal191 · X

RT @javier20ch: ✍️Artículos originales:

Feb 24, 2023 · 12 shares · 27 followers View post →

Jamesoto

@Jamesoto14 · X

RT @javier20ch: ✍️Artículos originales:

Feb 23, 2023 · 12 shares · 218 followers View post →

Diego Esteban Revelo

@DRdiegorevelo · X

RT @javier20ch: ✍️Artículos originales:

Feb 19, 2023 · 12 shares · 41 followers View post →

Edward Scissorhands

@Druidaeduardo · X

RT @javier20ch: ✍️Artículos originales:

Feb 17, 2023 · 12 shares · 1,122 followers View post →

Santiago Oquendo MD

@rksanti · X

RT @javier20ch: ✍️Artículos originales:

Feb 15, 2023 · 12 shares · 4,107 followers View post →

David rojas

@Davidgaleno23 · X

RT @javier20ch: ✍️Artículos originales:

Feb 14, 2023 · 12 shares · 30 followers View post →

lucero

@lucymatsu · X

RT @javier20ch: ✍️Artículos originales:

Feb 14, 2023 · 12 shares · 153 followers View post →

MercheRC

@rc_merche · X

RT @javier20ch: ✍️Artículos originales:

Feb 14, 2023 · 12 shares · 311 followers View post →

Juan Carlos Obaya

@jcobaya69 · X

RT @javier20ch: ✍️Artículos originales:

Feb 14, 2023 · 12 shares · 856 followers View post →

Dr. FEVI

@javier20ch · X

✍️Artículos originales:

Feb 14, 2023 · 18 likes · 12 shares · 13,432 followers View post →

Dr. Crabiologue, MD

@cardioparis · X

@Dr_Agibus Attention pour 2/ l’essai princeps est négatif ! https://t.co/uBoC2ABSJP

Dec 13, 2022 · 357 followers View post →

Joel M. Topf, MD FACP

@kidney_boy · X

@kamran_hayaan @usamaisawake @willyhfrick Unless they had an mi as the cause of their heart failure. https://t.co/wv7ekiTbSQ

Dec 5, 2022 · 63,282 followers View post →

加藤隆寛

@tak_pharmacist · X

MIでEF低下or 肺うっ血にARNIは予後を改善しない結果だったけど、虚血解除後EF戻った例がどれほどあったかや、リスク低下は予想より少なかったのでパワー不足だった可能性など疑問はある。Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction | NEJM https://t.co/5PNltbO9XV

Nov 11, 2022 · 1 like · 401 followers View post →

にいやん

@niiyan51 · X

Angiotensin Receptor-Neprilysin Inhibition in Acute Myocardial Infarction https://t.co/pF1R3psDlm

Oct 2, 2022 · 1,074 followers View post →

Dr. Pedro A. Carrillo Moreno

@cardiodocpedro · X

Jun 18, 2022 · 2 likes · 4,252 followers View post →

María Moral

@twittmariamoral · X

RT @Farmacia_HUGU:

Mar 3, 2022 · 3 shares · 851 followers View post →

Tamara

@tamaracc20 · X

RT @Farmacia_HUGU:

Mar 3, 2022 · 3 shares · 117 followers View post →

Antonio Rüdiger

@antonibri · X

RT @Farmacia_HUGU:

Mar 3, 2022 · 3 shares · 222 followers View post →

Farmacia Hospital Guadalajara

@Farmacia_HUGU · X

Mar 2, 2022 · 10 likes · 3 shares · 973 followers View post →

鯵ゼミ_Journal Club

@AJSR_since2005 · X

#080 Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction N Engl J Med 2021;385:1845-55. PARADISE-MI試験サクビトリル-バルサルタンは、ラミプリルと比較して、急性心筋梗塞後の心血管死などの複合エンドポイントを改善させることはなかった

Feb 5, 2022 · 6 followers View post →

Tenich

@Marktenich · X

RT @accpcardprn: PARADISE-MI failed to show significant benefit of ARNI therapy as compared to ramipril in patients acutely post-MI with EF…

Jan 20, 2022 · 11 shares · 345 followers View post →

Neeraj

@Phrmacologist · X

RT @accpcardprn: PARADISE-MI failed to show significant benefit of ARNI therapy as compared to ramipril in patients acutely post-MI with EF…

Jan 20, 2022 · 11 shares · 279 followers View post →

Sabrina Dunham, PharmD, BCPS, BCCP

@sabrina_dunham · X

RT @accpcardprn: PARADISE-MI failed to show significant benefit of ARNI therapy as compared to ramipril in patients acutely post-MI with EF…

Jan 20, 2022 · 11 shares · 249 followers View post →

Ali Y. Alghubayshi | علي الغبيشي

@alialghobishi · X

RT @accpcardprn: PARADISE-MI failed to show significant benefit of ARNI therapy as compared to ramipril in patients acutely post-MI with EF…

Jan 20, 2022 · 11 shares · 1,863 followers View post →

Fatimah Alshehri

@Banitoto · X

RT @accpcardprn: PARADISE-MI failed to show significant benefit of ARNI therapy as compared to ramipril in patients acutely post-MI with EF…

Jan 19, 2022 · 11 shares · 33,118 followers View post →

Greg Perry

@ID_GregPerry · X

RT @accpcardprn: PARADISE-MI failed to show significant benefit of ARNI therapy as compared to ramipril in patients acutely post-MI with EF…

Jan 19, 2022 · 11 shares · 257 followers View post →

Maya Chilbert (Holsen)

@MayaHolsen · X

RT @accpcardprn: PARADISE-MI failed to show significant benefit of ARNI therapy as compared to ramipril in patients acutely post-MI with EF…

Jan 19, 2022 · 11 shares · 422 followers View post →

Born to Hunt

@BorntoHunt0823 · X

RT @accpcardprn: PARADISE-MI failed to show significant benefit of ARNI therapy as compared to ramipril in patients acutely post-MI with EF…

Jan 19, 2022 · 11 shares · 26 followers View post →

ACCP Cardiology PRN

@accpcardprn · X

Jan 19, 2022 · 64 likes · 11 shares · 9,298 followers View post →

cardio-met

@cardiomet_CE · X

16) PARADISE-MI demonstrated no significant benefit of #ARNI over #ACEi in patients with acute #MI with reduced LVEF and/or pulmonary congestion (https://t.co/XtZJ5pBREd). Thus, evidence to date does not support using ARNI over ACEi to reduce CV death or incident HF in acute MI. https://t.co/dw6hzm8X52

Jan 11, 2022 · 11 likes · 4,157 followers View post →

東北大学循環器内科

@cardio_tu · X

ピックアップ論文 -臨床-　（担当：西宮健介病院助教） Angiotensin Receptor-Neprilysin Inhibition in Acute Myocardial Infarction. NEJM 2021;385:1845-55. doi: 10.1056/NEJMoa2104508

Dec 20, 2021 · 1 like · 1,321 followers View post →

にいやん

@niiyan51 · X

Angiotensin Receptor-Neprilysin Inhibition in Acute Myocardial Infarction https://t.co/pF1R3pbAjm

Dec 11, 2021 · 1,074 followers View post →

Antonio Manteca

@amango30 · X

RT @RevistaMFSamfyc: Inhibición de neprilisina-receptor de angiotensina en el infarto agudo de miocardio https://t.co/WbGLKgcIWM PMID 34758…

Dec 7, 2021 · 1 share · 138 followers View post →

猫になりたい薬剤師

@Vannyamoto · X

Angiotensin Receptor-Neprilysin Inhibition in Acute Myocardial Infarction https://t.co/ZeTVWN53FB

Dec 4, 2021 · 1,042 followers View post →

Madiha Syed

@madihasyed85 · X

RT @SOCCA_CritCare: ARNI, use beyond symptomatic heart failure? https://t.co/dvaXQfIsiL https://t.co/Fq4HUkUMlQ

Dec 1, 2021 · 1 share · 226 followers View post →

Guinot PG

@GuinotPg · X

Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction | NEJM https://t.co/H2Ffcd5zal

Dec 1, 2021 · 1 like · 273 followers View post →

Society of Critical Care Anesthesiologists

@SOCCA_CritCare · X

ARNI, use beyond symptomatic heart failure? https://t.co/dvaXQfIsiL https://t.co/Fq4HUkUMlQ

Dec 1, 2021 · 2 likes · 1 share · 3,990 followers View post →

Revista MFAndalucia

@RevistaMFSamfyc · X

Inhibición de neprilisina-receptor de angiotensina en el infarto agudo de miocardio https://t.co/WbGLKgcIWM PMID 34758252

Dec 1, 2021 · 2 likes · 1 share · 722 followers View post →

Quini

@DrQuini · X

Tiempo de estudio 22 meses. https://t.co/MEwTPMFR4o

Nov 29, 2021 · 1,218 followers View post →

John H. Randall

@JohnHRandall1 · X

RT @JohnHRandall1: Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction | NEJM https://t.co/aH3g67fmOo

Nov 23, 2021 · 1 share · 44 followers View post →

John H. Randall

@JohnHRandall1 · X

Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction | NEJM https://t.co/aH3g67fmOo

Nov 23, 2021 · 1 share · 44 followers View post →

パン焦がし薬剤師(やっちゃん)@牡丹山薬局

@yo_ishii_2021 · X

『急性心筋梗塞におけるアンジオテンシン受容体-ネプリライシン阻害作用について』https://t.co/JtPsp2blcN https://t.co/6s3zMHvxGT

Nov 22, 2021 · 1 like · 2,319 followers View post →

宇津貴史 /Utsu, Takashi

@Office_j · X

「CV死亡・HF”入院”」も0.91 [0.78-1.07]。 https://t.co/QsmS2LIUh7　Nov.11

Nov 21, 2021 · 1 like · 4,904 followers View post →

Michael Buratovich

@MichaelBuratovi · X

So - Entresto works great for Heart Failure, but for heart attacks it's no better than ACEIs. Angiotensin Receptor-Neprilysin Inhibition in Acute Myocardial Infarction | comment: Douglas L Mann MD https://t.co/wDliCuqDg3 via @practiceupdate

Nov 20, 2021 · 1,169 followers View post →

IANCARDIOLOGY

@CardioIAN · X

@CardioIAN #CardioTwitter https://t.co/JHky9DrJrG

Nov 18, 2021 · 8,263 followers View post →

Cardiology

@PracUpCardio · X

Angiotensin Receptor-Neprilysin Inhibition in Acute Myocardial Infarction https://t.co/TVJmuI77zm #cardiology

Nov 18, 2021 · 2 likes · 883 followers View post →

Elliott Guerrero

@DoctorElliottBG · X

Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction https://t.co/C8CX36HADw

Nov 17, 2021 · 43 followers View post →

joaquin ignacio serrano lopez de las hazas

@joaquinserlo · X

RT @rincondesisifo: (NEJM) Sacubitrilo-valsartán NO superior a ramipril en pac post IAM y FE reducida https://t.co/RV0sVQHY96 ECA #PARADISE…

Nov 17, 2021 · 45 shares · 562 followers View post →

Bea Calderon

@BCalderonH · X

RT @rincondesisifo: (NEJM) Sacubitrilo-valsartán NO superior a ramipril en pac post IAM y FE reducida https://t.co/RV0sVQHY96 ECA #PARADISE…

Nov 17, 2021 · 45 shares · 176 followers View post →

emiliamontagud

@emiliamontagud · X

RT @FarmaMadridAP: (NEJM)

Nov 17, 2021 · 25 shares · 89 followers View post →

Bhavya Tyagi

@bhav_dr · X

RT @medichulston: Entresto is not effective when given in the days following an MI in patients with LV impairment. Let the heart heal, then…

Nov 17, 2021 · 1 share · 230 followers View post →

M@ Isabel Navarro

@misabelnaga · X

RT @rincondesisifo: (NEJM) Sacubitrilo-valsartán NO superior a ramipril en pac post IAM y FE reducida https://t.co/RV0sVQHY96 ECA #PARADISE…

Nov 17, 2021 · 45 shares · 668 followers View post →

rocotero

@rocotero · X

RT @rincondesisifo: (NEJM) Sacubitrilo-valsartán NO superior a ramipril en pac post IAM y FE reducida https://t.co/RV0sVQHY96 ECA #PARADISE…

Nov 17, 2021 · 45 shares · 840 followers View post →

Raquel Gayarre

@RaquelGayarre · X

RT @FarmaMadridAP: (NEJM)

Nov 17, 2021 · 25 shares · 754 followers View post →

Jose Felix Sastre

@josefelixsast · X

RT @rincondesisifo: (NEJM) Sacubitrilo-valsartán NO superior a ramipril en pac post IAM y FE reducida https://t.co/RV0sVQHY96 ECA #PARADISE…

Nov 17, 2021 · 45 shares · 320 followers View post →

Javier López Moreno

@javlopmor88 · X

RT @rincondesisifo: (NEJM) Sacubitrilo-valsartán NO superior a ramipril en pac post IAM y FE reducida https://t.co/RV0sVQHY96 ECA #PARADISE…

Nov 16, 2021 · 45 shares · 429 followers View post →

Jhosep Fernandez

@Jhosepfedz · X

Estimado @Felipediezhoyo me gustaría saber tu valiosa opinión de esto... https://t.co/o9rG6zmwKH

Nov 16, 2021 · 1 like · 164 followers View post →

Alicia futicool +S

@futicool · X

RT @FarmaMadridAP: (NEJM)

Nov 16, 2021 · 25 shares · 1,002 followers View post →

Laura Pérez

@tatana2007 · X

RT @rincondesisifo: (NEJM) Sacubitrilo-valsartán NO superior a ramipril en pac post IAM y FE reducida https://t.co/RV0sVQHY96 ECA #PARADISE…

Nov 16, 2021 · 45 shares · 238 followers View post →

Héctor Alonso

@hec_310 · X

RT @FarmaMadridAP: (NEJM)

Nov 16, 2021 · 25 shares · 2,014 followers View post →

Jose Maria Ruiz

@josemariaruizsb · X

RT @FarmaMadridAP: (NEJM)

Nov 16, 2021 · 25 shares · 266 followers View post →

Jose Maria Ruiz

@josemariaruizsb · X

RT @rincondesisifo: (NEJM) Sacubitrilo-valsartán NO superior a ramipril en pac post IAM y FE reducida https://t.co/RV0sVQHY96 ECA #PARADISE…

Nov 16, 2021 · 45 shares · 266 followers View post →

Mneee3

@crafty8798 · X

RT @NEJM: This randomized, double-blind, active-controlled trial compared sacubitril–valsartan with ramipril in patients who had acute myoc…

Nov 16, 2021 · 19 shares · 291 followers View post →

Anna Ferrer

@afertra · X

RT @FarmaMadridAP: (NEJM)

Nov 16, 2021 · 25 shares · 446 followers View post →

Dr. Miguel Molina - Ecografia Clínica - POCUS

@dmiguelmolina · X

RT @FarmaMadridAP: (NEJM)

Nov 16, 2021 · 25 shares · 2,578 followers View post →

George Hulston

@medichulston · X

Entresto is not effective when given in the days following an MI in patients with LV impairment. Let the heart heal, then re-assess the LV. https://t.co/GTSI1OqQJw

Nov 16, 2021 · 1 like · 1 share · 4,308 followers View post →

Raúl Moya Malo

@raulmoyamalo · X

RT @FarmaMadridAP: (NEJM)

Nov 16, 2021 · 25 shares · 614 followers View post →

Rafael Alvarez

@RafaelAM1976 · X

RT @FarmaMadridAP: (NEJM)

Nov 16, 2021 · 25 shares · 310 followers View post →

George Kolostoumpis

@gkolost · X

RT @NEJM: This randomized, double-blind, active-controlled trial compared sacubitril–valsartan with ramipril in patients who had acute myoc…

Nov 16, 2021 · 19 shares · 2,089 followers View post →

Javier Ruiz

@_javierrm · X

RT @FarmaMadridAP: (NEJM)

Nov 16, 2021 · 25 shares · 175 followers View post →

Juan Carlos Obaya

@jcobaya69 · X

RT @NEJM: This randomized, double-blind, active-controlled trial compared sacubitril–valsartan with ramipril in patients who had acute myoc…

Nov 16, 2021 · 19 shares · 856 followers View post →

Pau Frias Ruiz

@Paufris · X

RT @rincondesisifo: (NEJM) Sacubitrilo-valsartán NO superior a ramipril en pac post IAM y FE reducida https://t.co/RV0sVQHY96 ECA #PARADISE…

Nov 16, 2021 · 45 shares · 978 followers View post →

CIMES

@cimesalvador · X

RT @rincondesisifo: (NEJM) Sacubitrilo-valsartán NO superior a ramipril en pac post IAM y FE reducida https://t.co/RV0sVQHY96 ECA #PARADISE…

Nov 16, 2021 · 45 shares · 1,492 followers View post →

SFarmacia Hospital Riotinto

@SfarmaciaR · X

RT @rincondesisifo: (NEJM) Sacubitrilo-valsartán NO superior a ramipril en pac post IAM y FE reducida https://t.co/RV0sVQHY96 ECA #PARADISE…

Nov 16, 2021 · 45 shares · 467 followers View post →

Factam Farmacia

@FactamFarmacia · X

RT @FarmaMadridAP: (NEJM)

Nov 16, 2021 · 25 shares · 1,662 followers View post →

John H. Randall

@JohnHRandall1 · X

RT @NEJM: This randomized, double-blind, active-controlled trial compared sacubitril–valsartan with ramipril in patients who had acute myoc…

Nov 16, 2021 · 19 shares · 44 followers View post →

Chus Hernandez

@mjharroyo · X

RT @FarmaMadridAP: (NEJM)

Nov 16, 2021 · 25 shares · 206 followers View post →

Carlos Garcia

@carlosfargc · X

RT @rincondesisifo: (NEJM) Sacubitrilo-valsartán NO superior a ramipril en pac post IAM y FE reducida https://t.co/RV0sVQHY96 ECA #PARADISE…

Nov 16, 2021 · 45 shares · 1,156 followers View post →

Carlos Garcia

@carlosfargc · X

Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction | NEJM https://t.co/IcxMUx9jaV

Nov 16, 2021 · 1 like · 1,156 followers View post →

marianmad

@mariandmad · X

RT @rincondesisifo: (NEJM) Sacubitrilo-valsartán NO superior a ramipril en pac post IAM y FE reducida https://t.co/RV0sVQHY96 ECA #PARADISE…

Nov 16, 2021 · 45 shares · 44 followers View post →

Rubén Martín

@RubenMatins · X

RT @rincondesisifo: (NEJM) Sacubitrilo-valsartán NO superior a ramipril en pac post IAM y FE reducida https://t.co/RV0sVQHY96 ECA #PARADISE…

Nov 16, 2021 · 45 shares · 459 followers View post →

PharmaDecisions LLC

@PharmaDecisions · X

RT @NEJM: This randomized, double-blind, active-controlled trial compared sacubitril–valsartan with ramipril in patients who had acute myoc…

Nov 16, 2021 · 19 shares · 452 followers View post →

Anna Kate Barton

@AnnaKateBarton · X

RT @RyanWereski:

Nov 16, 2021 · 1 share · 2,856 followers View post →

Ryan Wereski

@RyanWereski · X

Nov 16, 2021 · 4 likes · 1 share · 200 followers View post →

Miquel Casanova |-/

@ni1twit · X

RT @rincondesisifo: (NEJM) Sacubitrilo-valsartán NO superior a ramipril en pac post IAM y FE reducida https://t.co/RV0sVQHY96 ECA #PARADISE…

Nov 16, 2021 · 45 shares · 107 followers View post →

RamonGitana

@RamnPons2 · X

RT @FarmaMadridAP: (NEJM)

Nov 16, 2021 · 25 shares · 171 followers View post →

santiago teso

@santiagoteso1 · X

RT @FarmaMadridAP: (NEJM)

Nov 16, 2021 · 25 shares · 220 followers View post →

MN José Rafael Saavedra

@joserasaavedra · X

RT @NEJM: This randomized, double-blind, active-controlled trial compared sacubitril–valsartan with ramipril in patients who had acute myoc…

Nov 16, 2021 · 19 shares · 130 followers View post →

Otavio Berwanger

@OtavioBerwanger · X

RT @NEJM: This randomized, double-blind, active-controlled trial compared sacubitril–valsartan with ramipril in patients who had acute myoc…

Nov 16, 2021 · 19 shares · 1,178 followers View post →

Mónica García

@g_asensiomonica · X

RT @FarmaMadridAP: (NEJM)

Nov 16, 2021 · 25 shares · 3,944 followers View post →

Ali Omar

@aliomer93 · X

RT @NEJM: This randomized, double-blind, active-controlled trial compared sacubitril–valsartan with ramipril in patients who had acute myoc…

Nov 16, 2021 · 19 shares · 264 followers View post →

Ismail Polat Canbolat

@CanbolatIP · X

ARNI is not better than ramipril when started after acute MI https://t.co/BU5bLT2j7q

Nov 16, 2021 · 6 likes · 1,474 followers View post →

Catherine

@CatherineZhang · X

RT @NEJM: This randomized, double-blind, active-controlled trial compared sacubitril–valsartan with ramipril in patients who had acute myoc…

Nov 16, 2021 · 19 shares · 423 followers View post →

ECO-ElSalvador

@EcoElsalvador · X

RT @NEJM: This randomized, double-blind, active-controlled trial compared sacubitril–valsartan with ramipril in patients who had acute myoc…

Nov 16, 2021 · 19 shares · 96 followers View post →

Pablo

@pferrvic · X

RT @FarmaMadridAP: (NEJM)

Nov 16, 2021 · 25 shares · 2,822 followers View post →

Tom

@youareinformed · X

Angiotensin Receptor-Neprilysin Inhibition in Acute Myocardial Infarction https://t.co/o57Warnhpb

Nov 16, 2021 · 3,278 followers View post →

Jose Daniel Mosquera Lozano

@jdmosqueral · X

Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction | NEJM https://t.co/1ofirCpqYY

Nov 16, 2021 · 1 like · 232 followers View post →

青島周一@【書籍】「生成AIと学ぶ医学論文の読み方・考え方」発売中！

@syuichiao89 · X

RT @nitrotake: 急性心筋梗塞に対してサクビトリルバルサルタンはラミプリルと比較して、複合アウトカムの差はなかった。 11.9%vs13.2% HR:0.90(0.78-1.04)P=0.17 https://t.co/8nwhnZrf1R

Nov 15, 2021 · 1 share · 8,608 followers View post →

たけちゃん

@nitrotake · X

急性心筋梗塞に対してサクビトリルバルサルタンはラミプリルと比較して、複合アウトカムの差はなかった。 11.9%vs13.2% HR:0.90(0.78-1.04)P=0.17 https://t.co/8nwhnZrf1R

Nov 15, 2021 · 1 share · 1,444 followers View post →

David Sulman

@DSulman · X

Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction | NEJM https://t.co/7iEaxuIZFp

Nov 15, 2021 · 304 followers View post →

pinacol

@pinacol · X

【RCT】LVEF低下、肺鬱血またはその両方を合併する心筋梗塞患者へのサクビトリル-バルサルタンの投与は、ラミプリルの投与と比較して、心血管死亡や心不全の発生を減少させなかった。 #ペ読 https://t.co/1PwpA6lNsE

Nov 13, 2021 · 1,615 followers View post →

Lorenzo Bertomeu

@BertomeuLorenzo · X

RT @SeguraCardio:

Nov 13, 2021 · 26 shares · 1,409 followers View post →

Marlyn Peñalver

@marlyn1207 · X

RT @vic_pallares: Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction | NEJM https://t.co/d29jt5gVlF PARADISE-MI ➡️S…

Nov 13, 2021 · 17 shares · 132 followers View post →

Guayacan Chiquito

@guayacanchiquit · X

RT @vic_pallares: Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction | NEJM https://t.co/d29jt5gVlF PARADISE-MI ➡️S…

Nov 12, 2021 · 17 shares · 344 followers View post →

Eduardo Zatarain

@EduZatarain · X

RT @SeguraCardio:

Nov 12, 2021 · 26 shares · 903 followers View post →

Ivan Mendoza

@mencardio · X

RT @vic_pallares: Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction | NEJM https://t.co/d29jt5gVlF PARADISE-MI ➡️S…

Nov 12, 2021 · 17 shares · 7,255 followers View post →

Dr. L

@Dr__ELE · X

RT @SeguraCardio:

Nov 12, 2021 · 26 shares · 234 followers View post →

Semergen Extremadura

@SemergenEx · X

RT @vic_pallares: Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction | NEJM https://t.co/d29jt5gVlF PARADISE-MI ➡️S…

Nov 12, 2021 · 17 shares · 1,067 followers View post →

Nabil Naser

@NabilNaser11 · X

Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction: PARADISE - MI Trial. https://t.co/IkOIrqjqRS

Nov 12, 2021 · 1 like · 476 followers View post →

gustavo rojas lara

@gmdc1958 · X

RT @SeguraCardio:

Nov 12, 2021 · 26 shares · 999 followers View post →

Yoshinobu Murasato

@YMurasato · X

RT @SeguraCardio:

Nov 12, 2021 · 26 shares · 885 followers View post →

ali uyar

@aliuyar1963 · X

RT @ALEX_MISCHIE: Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction https://t.co/BOgmpeUjOA https://t.co/0Q5xSDd8ES

Nov 12, 2021 · 1 share · 214 followers View post →

Abhijeet Yelale

@AbhijeetCardio · X

RT @SeguraCardio:

Nov 12, 2021 · 26 shares · 90 followers View post →

the paper link

@the_paper_link · X

Trend up+15: Pfeffer MA, ..., Paradise-mi Investigators and Committees (N Engl J Med) __Angiotensin Receptor-Neprilysin Inhibition in Acute Myocardial Infarction__ https://t.co/H9AULhEg7e

Nov 11, 2021 · 137 followers View post →

Lorenzo Bertomeu

@BertomeuLorenzo · X

RT @vic_pallares: Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction | NEJM https://t.co/d29jt5gVlF PARADISE-MI ➡️S…

Nov 11, 2021 · 17 shares · 1,409 followers View post →

Roberto E Lopez Mata

@relm_11969 · X

RT @SeguraCardio:

Nov 11, 2021 · 26 shares · 1,143 followers View post →

| Daniel Sierra LM |

@DanielSierraLM · X

RT @SeguraCardio:

Nov 11, 2021 · 26 shares · 2,497 followers View post →

Roberto Lugo

@RobertoLG86MI · X

RT @SeguraCardio:

Nov 11, 2021 · 26 shares · 54 followers View post →

Justin Chiong

@justinchiong_ · X

RT @SeguraCardio:

Nov 11, 2021 · 26 shares · 314 followers View post →

Carola

@LaCabroline · X

RT @SeguraCardio:

Nov 11, 2021 · 26 shares · 391 followers View post →

Issam Ahmad Altnji

@ialtnji · X

RT @ValleAlfonso: #PARADISE-MI in @NEJM

Nov 11, 2021 · 8 shares · 295 followers View post →

LeonardH

@OSheaLaos · X

RT @adamcifu: A. Can't say these negative results are a surprise. B. Can someone remind my why the control group in these studies is never…

Nov 11, 2021 · 4 shares · 429 followers View post →

Manuel Gaxiola

@cardiogax · X

RT @SeguraCardio:

Nov 11, 2021 · 26 shares · 7,991 followers View post →

Dr. Angelo Martinez Urb.

@DrAmartinezur93 · X

RT @SeguraCardio:

Nov 11, 2021 · 26 shares · 516 followers View post →

Andrés F Buitrago S

@AFBSM · X

RT @ValleAlfonso: #PARADISE-MI in @NEJM

Nov 11, 2021 · 8 shares · 143 followers View post →

Armando Nochebuena. MD

@j4rmando · X

RT @SeguraCardio:

Nov 11, 2021 · 26 shares · 1,420 followers View post →

Juan Antonio Castillo

@JACastilloMo · X

RT @SeguraCardio:

Nov 11, 2021 · 26 shares · 829 followers View post →

John P Erwin III MD MBA MACC (#BigPoppy )

@HeartOTXHeartMD · X

RT @adamcifu: A. Can't say these negative results are a surprise. B. Can someone remind my why the control group in these studies is never…

Nov 11, 2021 · 4 shares · 39,659 followers View post →

McMaster Heart Function Education

@MacHeartFailure · X

RT @SeguraCardio:

Nov 11, 2021 · 26 shares · 509 followers View post →

Eduardo Enriquez

@EnriquezEdwardo · X

RT @vic_pallares: Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction | NEJM https://t.co/d29jt5gVlF PARADISE-MI ➡️S…

Nov 11, 2021 · 17 shares · 760 followers View post →

Alejandro Cuesta

@Doc_AleCuesta · X

Sin beneficio adicional en comparación con Ramipril. Si tuviste un infarto, que no te falte el IECA. Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction | NEJM https://t.co/INnHuKQbvF

Nov 11, 2021 · 1 like · 2,118 followers View post →

Elirub Rojas

@Elicardiove · X

RT @vic_pallares: Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction | NEJM https://t.co/d29jt5gVlF PARADISE-MI ➡️S…

Nov 11, 2021 · 17 shares · 586 followers View post →

Felix Valencia

@FelixValencia10 · X

RT @acorderofort: Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction @NEJM https://t.co/Je312mJpMf

Nov 11, 2021 · 1 share · 1,706 followers View post →

ALEXANDRU MISCHIE

@ALEX_MISCHIE · X

Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction https://t.co/BOgmpeUjOA https://t.co/0Q5xSDd8ES

Nov 11, 2021 · 4 likes · 1 share · 10,319 followers View post →

Francis Alenghat

@alenghat · X

RT @adamcifu: A. Can't say these negative results are a surprise. B. Can someone remind my why the control group in these studies is never…

Nov 11, 2021 · 4 shares · 1,006 followers View post →

د . احمد سمان

@Ahmed43101178 · X

RT @papathanasiou_: Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction | NEJM https://t.co/0T57fpiRDO

Nov 11, 2021 · 2 shares · 6,360 followers View post →

Linda

@wordfinga · X

RT @SeguraCardio:

Nov 11, 2021 · 26 shares · 4,593 followers View post →

Juan Emiro Herrera

@JuanEmiro · X

RT @ValleAlfonso: #PARADISE-MI in @NEJM

Nov 11, 2021 · 8 shares · 992 followers View post →

循環器内科と心臓リハビリの高針クリニック - takabari cardiology -

@TakabariClinic · X

Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction | NEJM https://t.co/KYUOk5sX7O

Nov 11, 2021 · 56 followers View post →

Karsten Schenke

@kaschenke · X

RT @papathanasiou_: Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction | NEJM https://t.co/0T57fpiRDO

Nov 11, 2021 · 2 shares · 4,483 followers View post →

Harriette Van Spall, MD MPH

@hvanspall · X

RT @SeguraCardio:

Nov 11, 2021 · 26 shares · 17,822 followers View post →

Dr. L

@Dr__ELE · X

RT @vic_pallares: Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction | NEJM https://t.co/d29jt5gVlF PARADISE-MI ➡️S…

Nov 11, 2021 · 17 shares · 234 followers View post →

Maria Papathanasiou

@papathanasiou_ · X

Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction | NEJM https://t.co/0T57fpiRDO

Nov 11, 2021 · 10 likes · 2 shares · 2,167 followers View post →

Natsir Ramadhan

@natsiradhan · X

RT @SeguraCardio:

Nov 11, 2021 · 26 shares · 559 followers View post →

Juan Bonastre

@jbon54 · X

En pacientes con IAM y FE reducida o congestión pulmonar sacubitril-valsartan no fue superior al ramipril Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction | NEJM https://t.co/VKAdSbZrJE

Nov 11, 2021 · 194 followers View post →

CardioEd Bot

@CardioBot · X

RT @SeguraCardio:

Nov 11, 2021 · 26 shares · 1,205 followers View post →

Francisca Martínez

@famartinez2001 · X

RT @vic_pallares: Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction | NEJM https://t.co/d29jt5gVlF PARADISE-MI ➡️S…

Nov 11, 2021 · 17 shares · 10,009 followers View post →

Carolina Ortiz

@Carol_O_C · X

RT @SeguraCardio:

Nov 11, 2021 · 26 shares · 2,759 followers View post →

Diego Segura-Rodríguez

@SeguraCardio · X

Nov 11, 2021 · 66 likes · 26 shares · 25,763 followers View post →

Felice Gragnano

@FeliceGragnano · X

RT @MarcoDelBuono3: PARADISE-MI trial:Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction https://t.co/IUTXIbFkAK

Nov 11, 2021 · 1 share · 5,284 followers View post →

SEMERGEN | Médicos de AP #SEMERGEN25

@SEMERGENap · X

RT @vic_pallares: Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction | NEJM https://t.co/d29jt5gVlF PARADISE-MI ➡️S…

Nov 11, 2021 · 17 shares · 33,040 followers View post →

Hiroyuki Okura, MD(大倉宏之)

@HiroyukiOkura · X

Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction | NEJM https://t.co/1MK0Hf5j51

Nov 11, 2021 · 1 like · 1,126 followers View post →

renalRCTs

@renalRCTs · X

Angiotensin Receptor-Neprilysin Inhibition in Acute Myocardial Infarction https://t.co/1hfkzH5rvr https://t.co/WGt4sptsuC

Nov 11, 2021 · 39 followers View post →

GÜRKAN

@GRKAN48189372 · X

RT @ValleAlfonso: #PARADISE-MI in @NEJM

Nov 11, 2021 · 8 shares · 79 followers View post →

rafavidalperez

@rafavidalperez · X

RT @ValleAlfonso: #PARADISE-MI in @NEJM

Nov 11, 2021 · 8 shares · 13,836 followers View post →

Dr. Martha Gulati ♥️

@DrMarthaGulati · X

RT @ValleAlfonso: #PARADISE-MI in @NEJM

Nov 11, 2021 · 8 shares · 64,763 followers View post →

Dr. Jose Gabian Fortes

@gabianfortes · X

RT @ValleAlfonso: #PARADISE-MI in @NEJM

Nov 11, 2021 · 8 shares · 251 followers View post →

Juan Carlos Elizalde:.

@JuanElizalde777 · X

RT @vic_pallares: Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction | NEJM https://t.co/d29jt5gVlF PARADISE-MI ➡️S…

Nov 11, 2021 · 17 shares · 2,362 followers View post →

Alfonso Valle

@ValleAlfonso · X

#PARADISE-MI in @NEJM

Nov 11, 2021 · 37 likes · 8 shares · 21,711 followers View post →

Raffaele Rasoini

@RasoiniR · X

RT @adamcifu: A. Can't say these negative results are a surprise. B. Can someone remind my why the control group in these studies is never…

Nov 11, 2021 · 4 shares · 426 followers View post →

Jose De La Flor

@josedelaflor4 · X

RT @vic_pallares: Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction | NEJM https://t.co/d29jt5gVlF PARADISE-MI ➡️S…

Nov 11, 2021 · 17 shares · 456 followers View post →

K.Nakazono@critical_care_pharmacist with AST

@ClinpharmZono · X

Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction | NEJM https://t.co/lDkrka469r AMI後短期アウトカム（観察期間中央値22か月）では、ACEiを凌駕することはなかった。 HFrEFの試験結果を考えると、長期間投与によるメリットは期待できると思うが、コストが問題になる

Nov 11, 2021 · 4 likes · 1,887 followers View post →

Vicente Pallares

@vic_pallares · X

Nov 11, 2021 · 26 likes · 17 shares · 5,424 followers View post →

Marco Del Buono

@MarcoDelBuono3 · X

PARADISE-MI trial:Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction https://t.co/IUTXIbFkAK https://t.co/fXrk9eGE8B

Nov 10, 2021 · 1 like · 1 share · 1,280 followers View post →

Alberto Cordero

@acorderofort · X

Angiotensin Receptor–Neprilysin Inhibition in Acute Myocardial Infarction @NEJM https://t.co/Je312mJpMf

Nov 10, 2021 · 1 share · 4,891 followers View post →

Adam Cifu

@adamcifu · X

Nov 10, 2021 · 15 likes · 4 shares · 26,014 followers View post →

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