Computed structures of core eukaryotic protein complexes.
Ian R Humphreys, Jimin Pei, Minkyung Baek, Aditya Krishnakumar, Ivan Anishchenko, Sergey Ovchinnikov, Jing Zhang, Travis J Ness, Sudeep Banjade, Saket R Bagde, Viktoriya G Stancheva, Xiao-Han Li, Kaixian Liu, Zhi Zheng, Daniel J Barrero
December 2021 ScienceSynopsis of Social media discussions
Overall, the social discussions reflect high enthusiasm and support, citing examples such as models of enzyme assemblies, new insights into key cellular processes, and the use of advanced AI techniques. Words like 'exciting', 'mind-blowing', and 'game changer' demonstrate both the excitement and perceived importance of this research, revealing a community deeply engaged with the scientific breakthrough.
Agreement
Strong agreementMost discussions support the significance and innovative nature of the publication, emphasizing advances in structure prediction and biological insights.
Interest
High level of interestPosts express high interest, highlighting breakthroughs in protein modeling and potential applications in biology and medicine.
Engagement
High engagementMany discussions reflect deep engagement through mentioning specific methods like AlphaFold and RoseTTAFold and exploring implications for cellular functions.
Impact
High level of impactThe discussions suggest the research could have a transformative impact on understanding protein interactions and cellular machinery, with several recognizing its broad relevance.
Social Mentions
YouTube
2 Videos
3 Posts
145 Posts
Blogs
6 Articles
News
23 Articles
Metrics
Video Views
498
Total Likes
359
Extended Reach
569,161
Social Features
179
Timeline: Posts about article
Top Social Media Posts
SGD Project @yeastgenome@genomic.social (bsky too)
Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFold2 and #RoseTTAFold to model 3D structures of protein-protein interactions, including higher order complexes, in #yeast https://t.co/JSsfvbU1FL https://t.co/7gzPUMLEnY
view full post
Emily Leproust
I’m more of a #DNA fan myself, but this is mind blowing work in structure prediction and interaction.
@UWproteindesign
Computed structures of core eukaryotic protein complexes https://t.co/pf9DGgjDlI
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Manuela Casasoli
"Using #DeepLearning methods to systematically identify and build structures for the protein complexes that mediate key processes in eukaryotes."
#Science
#proteins
#Biology
#cells
⏯️Computed structures of core eukaryotic protein complexes
https://t.co/v5jMcof4dJ https://t.co/kFHc1F8tgD
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EMBL-EBI
Using #AlphaFold to help predict the structures of large protein complexes enabled researchers at @UWproteindesign, @UTSWnews, and colleagues to gain new insights into their vital biological functions.
https://t.co/8vktioTbbn https://t.co/1Rz0BM5QYu
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Ohue M/大上雅史
あ、PPI予測やられたな？
Computed structures of core eukaryotic protein complexes
https://t.co/QqI4H0WyHn
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Posts referencing the article
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Innovations in Protein Design: Join the IUBMB Event with Experts
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February 25, 2022
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This effort is the culmination of a series of proteome interaction prediction stories from Ecoli (https://t.co/9Cn55FaGQL), to yeast (https://t.co/DqKtaIrzXw), and human bacterial pathogens (https://t.co/NPKmEJzils)!
view full postSeptember 25, 2025
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Shinya Fushinobu
@sugargroove (Twitter)RT @oxkawaka: Computed structures of core eukaryotic protein complexes さぁ、RoseTTAFold と AlphaFoldのコンビで示してやるよ複合体たちの予測をなと言うお話。 https://t.co…
view full postNovember 24, 2022
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LaatDovahKiin.eth | Posiedon.eth
@Keeksmyhero (Twitter)RT @emblebi: Using #AlphaFold to help predict the structures of large protein complexes enabled researchers at @UWproteindesign, @UTSWnews,…
view full postJuly 23, 2022
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Saubashya Sur, PhD
@SaubashyaSur (Twitter)RT @emblebi: Using #AlphaFold to help predict the structures of large protein complexes enabled researchers at @UWproteindesign, @UTSWnews,…
view full postJuly 22, 2022
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Robbie Joosten
@Robbie_Joosten (Twitter)RT @emblebi: Using #AlphaFold to help predict the structures of large protein complexes enabled researchers at @UWproteindesign, @UTSWnews,…
view full postJuly 22, 2022
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EMBL-EBI
@emblebi (Twitter)Using #AlphaFold to help predict the structures of large protein complexes enabled researchers at @UWproteindesign, @UTSWnews, and colleagues to gain new insights into their vital biological functions. https://t.co/8vktioTbbn https://t.co/1Rz0BM5QYu
view full postJuly 22, 2022
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WCI
@WaltherCancerIn (Twitter)RT @CascalesLab: Proteome-wide amino-acid coevolution and structural modeling using RoseTTAFold and AlphaFold2 identified new protein comp…
view full postJuly 2, 2022
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Protein Data Bank
@PDBeurope (Twitter)@sandeepbiochem1 @emblebi @UWproteindesign @ISBSIB Hi Sandeep. You can get more information about how these predicted complexes were generated from the publication: https://t.co/mUTMkiwwIL
view full postMay 5, 2022
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AIExPro
@BaixingAILab (Twitter)An article "Computed structures of core eukaryotic protein complexes."published in #Science by a team from #UTSMC & #UW. They developed a bioinformatics and deep learning pipeline to identify potentially interacting protein pairs and model the 3D structure of protein complexes. https://t.co/JzeLa4syMc
view full postMarch 6, 2022
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Fei Wu
@Fei65503306 (Twitter)@biogerontology @A_Aspuru_Guzik @MLevitt_NP2013 Congrats! Maybe predicted protein-protein interaction (https://t.co/AMw56anGoL) could further help to validate your pathways from iPANDA/PandaOmics?
view full postJanuary 27, 2022
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Edu Ocaña-Pallarès
@eduocapa (Twitter)"We developed a coevolution-guided protein interaction identification pipeline that incorporates a rapidly computable version of RoseTTAFold with the slower but more accurate AlphaFold to evaluate interactions between 8.3 million pairs of yeast proteins." https://t.co/pukTGzjr80
view full postJanuary 18, 2022
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David Juergens
@DaveJuergens (Twitter)@andrewwhite01 @LindorffLarsen Totally possible! https://t.co/RerPiBLo3A
view full postDecember 27, 2021
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Dennis Lal
@LalDennis (Twitter)Computed structures of core eukaryotic protein complexes https://t.co/XTkb2V5NtC https://t.co/xSMHVskoxB
view full postDecember 23, 2021
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Saubashya Sur, PhD
@SaubashyaSur (Twitter)RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
view full postDecember 18, 2021
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amrojasm@bsky.social
@amrojasmendoza (Twitter)RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
view full postDecember 18, 2021
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@parag@micro.blog
@parags (Twitter)This takes Alphafold predicted protein structures to the next level and will advance our understanding of molecular complexes. Computed structures of core eukaryotic protein complexes https://t.co/nz1RNKwohH
view full postDecember 17, 2021
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Ubik
@mr_ubik (Twitter)RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
view full postDecember 17, 2021
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☀️ ℝ
@rravi (Twitter)RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
view full postDecember 17, 2021
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LionKing 878
@878_lionking (Twitter)RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
view full postDecember 17, 2021
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Caroline Lynn Kamerlin
@kamerlinlab (Twitter)RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
view full postDecember 17, 2021
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Yaser Hashem
@Hashemyaser4 (Twitter)RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
view full postDecember 17, 2021
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Scott C Blanchard
@TheBlanchardLab (Twitter)RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
view full postDecember 17, 2021
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CK
@CK_KC_011010 (Twitter)RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
view full postDecember 17, 2021
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T Tian
@gdsttian (Twitter)RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
view full postDecember 17, 2021
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Kenneth Yaw Agyeman-Badu
@Kenzibit (Twitter)RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
view full postDecember 17, 2021
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Suhnylla Kler
@SuhnyllaKler (Twitter)RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
view full postDecember 17, 2021
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@mitenaiy (Twitter)RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
view full postDecember 17, 2021
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Felipe Santibáñez Leal
@fsantiba (Twitter)RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
view full postDecember 17, 2021
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Emma Chan , PhD
@binggo203 (Twitter)RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
view full postDecember 17, 2021
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Diego Javier Zea
@diegojavierzea (Twitter)RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
view full postDecember 17, 2021
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@imagineNICE (Twitter)RT @UWproteindesign: (1/8) Today we share the structures of protein complexes from nearly every core process in eukaryotic biology — from D…
view full postDecember 16, 2021
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CHARETTE LAB
@ribosome_asmbly (Twitter)RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
view full postDecember 16, 2021
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Olivier TOMAT
@oliviertomat (Twitter)RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
view full postDecember 16, 2021
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Nomad
@AuroraBoreas (Twitter)RT @UWproteindesign: (1/8) Today we share the structures of protein complexes from nearly every core process in eukaryotic biology — from D…
view full postDecember 16, 2021
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P Kritsiligkou
@Parikki (Twitter)RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
view full postDecember 16, 2021
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Pierre Poulain
@pierrepo (Twitter)RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
view full postDecember 16, 2021
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SGD Project @yeastgenome@genomic.social (bsky too)
@yeastgenome (Twitter)Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFold2 and #RoseTTAFold to model 3D structures of protein-protein interactions, including higher order complexes, in #yeast https://t.co/JSsfvbU1FL https://t.co/7gzPUMLEnY
view full postDecember 16, 2021
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Bastien Bissaro
@BastienBissaro (Twitter)RT @EijsinkLab: Computed structures of core eukaryotic protein complexes https://t.co/IirHRfb1ZQ
view full postDecember 15, 2021
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The PEP group
@EijsinkLab (Twitter)Computed structures of core eukaryotic protein complexes https://t.co/IirHRfb1ZQ
view full postDecember 15, 2021
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the paper link
@the_paper_link (Twitter)RT @the_paper_link: Trend up+14: Humphreys IR, ..., Baker D (Science) __Computed structures of core eukaryotic protein complexes__ https:/…
view full postDecember 12, 2021
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the paper link
@the_paper_link (Twitter)Trend up+14: Humphreys IR, ..., Baker D (Science) __Computed structures of core eukaryotic protein complexes__ https://t.co/p86RkjNmhc
view full postDecember 11, 2021
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@Anubi_Inpw (Twitter)RT @manuelacasasoli: "Using #DeepLearning methods to systematically identify and build structures for the protein complexes that mediate ke…
view full postDecember 10, 2021
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Magnetic Resonance News
@nmr900 (Twitter)RT @manuelacasasoli: "Using #DeepLearning methods to systematically identify and build structures for the protein complexes that mediate ke…
view full postDecember 10, 2021
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zach
@z4chburris (Twitter)RT @manuelacasasoli: "Using #DeepLearning methods to systematically identify and build structures for the protein complexes that mediate ke…
view full postDecember 10, 2021
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Hao Yin
@HaoYin20 (Twitter)RT @manuelacasasoli: "Using #DeepLearning methods to systematically identify and build structures for the protein complexes that mediate ke…
view full postDecember 10, 2021
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YOKONANABANBOSI
@yokonanabanbosi (Twitter)RT @manuelacasasoli: "Using #DeepLearning methods to systematically identify and build structures for the protein complexes that mediate ke…
view full postDecember 10, 2021
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Manuela Casasoli
@manuelacasasoli (Twitter)"Using #DeepLearning methods to systematically identify and build structures for the protein complexes that mediate key processes in eukaryotes." #Science #proteins #Biology #cells ⏯️Computed structures of core eukaryotic protein complexes https://t.co/v5jMcof4dJ https://t.co/kFHc1F8tgD
view full postDecember 10, 2021
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Francesco OTERI
@FrancescoOTERI3 (Twitter)RT @julhenri: Computed structures of core eukaryotic protein complexes https://t.co/Yq2oQ7OSgE
view full postDecember 10, 2021
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Julien Henri
@julhenri (Twitter)Computed structures of core eukaryotic protein complexes https://t.co/Yq2oQ7OSgE
view full postDecember 9, 2021
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the paper link
@the_paper_link (Twitter)RT @the_paper_link: Trend up+25: Humphreys IR, ..., Baker D (Science) __Computed structures of core eukaryotic protein complexes__ https:/…
view full postDecember 6, 2021
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the paper link
@the_paper_link (Twitter)Trend up+25: Humphreys IR, ..., Baker D (Science) __Computed structures of core eukaryotic protein complexes__ https://t.co/p86RkjNmhc
view full postDecember 6, 2021
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Javier Santoyo
@jsantoyo (Twitter)Computed structures of core eukaryotic protein complexes. #ComputedComplexes #ProteinInteractions https://t.co/8A691hs62J @ScienceMagazine
view full postDecember 3, 2021
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Downtown Brown
@eigenspread (Twitter)RT @UWproteindesign: (1/8) Today we share the structures of protein complexes from nearly every core process in eukaryotic biology — from D…
view full postDecember 2, 2021
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ลัคกี้ โหมดฤดูงาน
@sr_wiz (Twitter)Computed structures of core eukaryotic protein complexes https://t.co/Bahi5UJCS1
view full postDecember 1, 2021
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the paper link
@the_paper_link (Twitter)https://t.co/OvYJtb0b12 #prime3 Humphreys IR, ..., Baker D (Science) __Computed structures of core eukaryotic protein complexes__ https://t.co/p86RkjNmhc
view full postNovember 29, 2021
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luis hernan graffe
@hernangraffe (Twitter)RT @hernangraffe: https://t.co/3Yzelf7fnR
view full postNovember 27, 2021
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luis hernan graffe
@hernangraffe (Twitter)https://t.co/3Yzelf7fnR
view full postNovember 27, 2021
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Mathilde Gauchier
@M_Gauchier (Twitter)https://t.co/WJ2R5iQMB5 Co-evolution guided proteome interactions, orthologs from paralogs...
view full postNovember 27, 2021
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Victor V. Lobanenkov
@boris_ctcf (Twitter)AI Systematically IDs Structures of Eukaryotic Proteins. - A rather interesting commentary of results published in an article titled “Computed structures of core eukaryotic protein complexes” in the recent journal of Science. https://t.co/y96xMVaClX via @GENbio
view full postNovember 27, 2021
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scientific humanism
@oker59 (Twitter)Computed structures of core eukaryotic protein complexes - https://t.co/hArcXvW84H
view full postNovember 25, 2021
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Athale Lab: CyCelS
@AthaleLab (Twitter)RT @UWproteindesign: (1/8) Today we share the structures of protein complexes from nearly every core process in eukaryotic biology — from D…
view full postNovember 25, 2021
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luis hernan graffe
@hernangraffe (Twitter)RT @hernangraffe: https://t.co/3Yzelf7fnR
view full postNovember 24, 2021
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Mo Khalil
@MoKhalilLab (Twitter)RT @BUCNSB: Interesting article out in @ScienceMagazine on modeling eukaryotic protein complexes. https://t.co/7c55a2a2bk
view full postNovember 24, 2021
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Center for Network Systems Biology, Boston U
@BUCNSB (Twitter)Interesting article out in @ScienceMagazine on modeling eukaryotic protein complexes. https://t.co/7c55a2a2bk
view full postNovember 24, 2021
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RJ Nowling
@discretestates (Twitter)RT @EmilyLeproust: I’m more of a #DNA fan myself, but this is mind blowing work in structure prediction and interaction. @UWproteindesign…
view full postNovember 23, 2021
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BiolocoUSB
@biolocousb (Twitter)RT @EmilyLeproust: I’m more of a #DNA fan myself, but this is mind blowing work in structure prediction and interaction. @UWproteindesign…
view full postNovember 23, 2021
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Carolina Soares
@C_FonsecaSoares (Twitter)Incredible!! Computed structures of core eukaryotic protein complexes https://t.co/Z4CSkZ8IJd
view full postNovember 23, 2021
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Vastogen
@vastogen (Twitter)RT @EmilyLeproust: I’m more of a #DNA fan myself, but this is mind blowing work in structure prediction and interaction. @UWproteindesign…
view full postNovember 23, 2021
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Rosario Strano
@Rosario_Strano (Twitter)RT @EmilyLeproust: I’m more of a #DNA fan myself, but this is mind blowing work in structure prediction and interaction. @UWproteindesign…
view full postNovember 23, 2021
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Jacob Roberts
@jacoberts (Twitter)RT @EmilyLeproust: I’m more of a #DNA fan myself, but this is mind blowing work in structure prediction and interaction. @UWproteindesign…
view full postNovember 23, 2021
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GEN Biotechnology
@GENBiotechJrnl (Twitter)RT @EmilyLeproust: I’m more of a #DNA fan myself, but this is mind blowing work in structure prediction and interaction. @UWproteindesign…
view full postNovember 23, 2021
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Shaohe Wang
@snownontrace (Twitter)RT @UWproteindesign: (1/8) Today we share the structures of protein complexes from nearly every core process in eukaryotic biology — from D…
view full postNovember 23, 2021
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Kaveh N
@kaveh_Nasr (Twitter)RT @EmilyLeproust: I’m more of a #DNA fan myself, but this is mind blowing work in structure prediction and interaction. @UWproteindesign…
view full postNovember 23, 2021
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Sam Finlayson
@IAmSamFin (Twitter)RT @EmilyLeproust: I’m more of a #DNA fan myself, but this is mind blowing work in structure prediction and interaction. @UWproteindesign…
view full postNovember 23, 2021
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Sten Linnarsson
@slinnarsson (Twitter)RT @EmilyLeproust: I’m more of a #DNA fan myself, but this is mind blowing work in structure prediction and interaction. @UWproteindesign…
view full postNovember 23, 2021
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WeiTing Lin(GR15
@weitinglin66 (Twitter)RT @EmilyLeproust: I’m more of a #DNA fan myself, but this is mind blowing work in structure prediction and interaction. @UWproteindesign…
view full postNovember 22, 2021
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Biotech Madoff
@biotech_madoff (Twitter)RT @EmilyLeproust: I’m more of a #DNA fan myself, but this is mind blowing work in structure prediction and interaction. @UWproteindesign…
view full postNovember 22, 2021
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luis hernan graffe
@hernangraffe (Twitter)https://t.co/3Yzelf7fnR
view full postNovember 22, 2021
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Emily Leproust
@EmilyLeproust (Twitter)I’m more of a #DNA fan myself, but this is mind blowing work in structure prediction and interaction. @UWproteindesign Computed structures of core eukaryotic protein complexes https://t.co/pf9DGgjDlI
view full postNovember 22, 2021
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Fei Wang
@Fei_Wang87 (Twitter)RT @NatureBiotech: Deep learning predicts the structure of protein complexes based on paired multiple sequence alignments and amino acid co…
view full postNovember 22, 2021
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あさまさき
@kedama1202 (Twitter)RT @Bio_stations: タンパク質"複合体"の構造を予測 近年進歩しているAIによるタンパク質の構造予測を複合体にも拡張。アミノ酸共振化解析と深層学習で真核生物のタンパク質複合体の構造を予測。機能未知の因子とかも見ている 時代の進歩すごい、！もう複合体も見れるの…
view full postNovember 21, 2021
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MarkQuarter
@MarkQuarter (Twitter)RT @UWproteindesign: (1/8) Today we share the structures of protein complexes from nearly every core process in eukaryotic biology — from D…
view full postNovember 20, 2021
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Vladimir Y-Y
@vyy_sf (Twitter)RT @UWproteindesign: (1/8) Today we share the structures of protein complexes from nearly every core process in eukaryotic biology — from D…
view full postNovember 19, 2021
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Vladimir Y-Y
@vyy_sf (Twitter)RT @IanRHum: We use recent advances in proteome-wide coevolution analysis and breakthroughs in artificial-intelligence-based structure mode…
view full postNovember 19, 2021
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AI Bot
@Artificialbra1n (Twitter)RT @sekmi: The artificial intelligence #AI revolution in #structuralbiology continues and begins a new era in which computation plays a fun…
view full postNovember 19, 2021
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the paper link
@the_paper_link (Twitter)Trend up+7: Humphreys IR, ..., Baker D (Science) __Computed structures of core eukaryotic protein complexes__ https://t.co/p86RkjNmhc
view full postNovember 19, 2021
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Jean CAYEUX (Hour CET)
@jeancayeux (Twitter)RT @RebeccaRambar: L'intelligence artificielle prédit avec succès les interactions entre des complexes protéiques eucaryotes selon une étud…
view full postNovember 19, 2021
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Hiroki Onoda
@onoda_hiroki (Twitter)@t2438 それがあってもこの論文に近しい事をする能力も技術もないので止めておきます。 https://t.co/Y4tRCUq4uy
view full postNovember 19, 2021
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luis hernan graffe
@hernangraffe (Twitter)RT @IanRHum: We use recent advances in proteome-wide coevolution analysis and breakthroughs in artificial-intelligence-based structure mode…
view full postNovember 18, 2021
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luis hernan graffe
@hernangraffe (Twitter)RT @UWproteindesign: (1/8) Today we share the structures of protein complexes from nearly every core process in eukaryotic biology — from D…
view full postNovember 18, 2021
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AIMBE
@aimbe (Twitter)RT @UWproteindesign: (1/8) Today we share the structures of protein complexes from nearly every core process in eukaryotic biology — from D…
view full postNovember 18, 2021
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Science Press Package
@scipak (Twitter)SciPak Multimedia Highlight: Research on the structures and applications of eukaryotic protein complexes @UWproteindesign: https://t.co/N71XT79kzE Photo credit: Ian C. Haydon / UW Medicine Institute for Protein Design https://t.co/TQoh2HIuln
view full postNovember 18, 2021
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Molecular and Cellular Biochemistry
@mole_biochem (Twitter)RT @UWproteindesign: (1/8) Today we share the structures of protein complexes from nearly every core process in eukaryotic biology — from D…
view full postNovember 18, 2021
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BFML at UNIST
@bfml_unist (Twitter)Computed structures of core eukaryotic protein complexes https://t.co/brURC0Bspy #generalscience #feedly
view full postNovember 18, 2021
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Akira Matsuura
@AkiraMatsuura (Twitter)RT @Bio_stations: タンパク質"複合体"の構造を予測 近年進歩しているAIによるタンパク質の構造予測を複合体にも拡張。アミノ酸共振化解析と深層学習で真核生物のタンパク質複合体の構造を予測。機能未知の因子とかも見ている 時代の進歩すごい、！もう複合体も見れるの…
view full postNovember 18, 2021
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Ellen Allwood
@ellen_allwood (Twitter)RT @UWproteindesign: (1/8) Today we share the structures of protein complexes from nearly every core process in eukaryotic biology — from D…
view full postNovember 18, 2021
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Ike Usawa
@IkeUsawa (Twitter)Researchers used #AI & evolutionary analysis to make 3D models of eukaryotic #protein interactions. The #study found 100+ probable protein complexes for the first time and provided structural models for 700+ more. https://t.co/JUrarUWoXz #innovation https://t.co/QVYSsPvi3z
view full postNovember 18, 2021
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W.E.P.S.Y.
@_WEPSY_ (Twitter)RT @ScienceMagazine: Using a combination of #RoseTTAFold and #AlphaFold to screen millions of pairs of yeast proteins, researchers in Scien…
view full postNovember 17, 2021
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Paul Lourdu Xavier
@PaulLXavier (Twitter)RT @IanRHum: We use recent advances in proteome-wide coevolution analysis and breakthroughs in artificial-intelligence-based structure mode…
view full postNovember 17, 2021
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Nick Schnicker
@n_schnicker (Twitter)RT @ScienceMagazine: Using a combination of #RoseTTAFold and #AlphaFold to screen millions of pairs of yeast proteins, researchers in Scien…
view full postNovember 17, 2021
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Yizhou (Eugene) Hu
@YizhouHu_Eugene (Twitter)RT @ScienceMagazine: Using a combination of #RoseTTAFold and #AlphaFold to screen millions of pairs of yeast proteins, researchers in Scien…
view full postNovember 17, 2021
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Alessio G
@ptialex77 (Twitter)RT @RebeccaRambar: L'intelligence artificielle prédit avec succès les interactions entre des complexes protéiques eucaryotes selon une étud…
view full postNovember 17, 2021
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hausa/a personal account
@metaphysicalsou (Twitter)RT @ScienceMagazine: Using a combination of #RoseTTAFold and #AlphaFold to screen millions of pairs of yeast proteins, researchers in Scien…
view full postNovember 17, 2021
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ملتقى علوم الاحياء
@Biology1802 (Twitter)RT @ScienceMagazine: Using a combination of #RoseTTAFold and #AlphaFold to screen millions of pairs of yeast proteins, researchers in Scien…
view full postNovember 17, 2021
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@EtienneCartier (Twitter)RT @ScienceMagazine: Using a combination of #RoseTTAFold and #AlphaFold to screen millions of pairs of yeast proteins, researchers in Scien…
view full postNovember 17, 2021
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夢を見られた・・・⠠⠁⠍⠁⠝⠙⠁
@Amolain (Twitter)RT @ScienceMagazine: Using a combination of #RoseTTAFold and #AlphaFold to screen millions of pairs of yeast proteins, researchers in Scien…
view full postNovember 17, 2021
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DOLORES VESTRICH
@DOLORESVESTRICH (Twitter)Computed structures of core eukaryotic protein complexes https://t.co/ScacbdT7rC
view full postNovember 17, 2021
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Cascales Lab
@CascalesLab (Twitter)Proteome-wide amino-acid coevolution and structural modeling using RoseTTAFold and AlphaFold2 identified new protein complexes and computed their structures. Computed structures of core eukaryotic protein complexes https://t.co/ETeOdAcCzf
view full postNovember 16, 2021
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Enrico Guarnera
@piproide (Twitter)...and protein complexes! Computed structures of core eukaryotic protein complexes - https://t.co/M5tsy2BAK2 https://t.co/cE6luxVXX0
view full postNovember 16, 2021
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Twist Bioscience
@TwistBioscience (Twitter)This is so cool! @UWProteinDesign makes protein structures freely available for almost all key processes in eukaryotic cells. #Alphafold, #RoseTTAFold Computed structures of core eukaryotic protein complexes https://t.co/5zfopf6McY
view full postNovember 15, 2021
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Andras Toth
@tothur (Twitter)Computed structures of core eukaryotic protein complexes https://t.co/pW3UTTlT7F
view full postNovember 14, 2021
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matiere*
@matiere (Twitter)Open-sourcing of protein-structure software is already paying off | Ars Technica https://t.co/uLXPabAbBg https://t.co/Gi854RElES
view full postNovember 13, 2021
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Edinburgh Watch
@EdinburghWatch (Twitter)RT @jsantoyo: Computed structures of core eukaryotic protein complexes. #ProteinComplexes #ComputedStructures https://t.co/8A691hs62J @Scie…
view full postNovember 13, 2021
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Javier Santoyo
@jsantoyo (Twitter)Computed structures of core eukaryotic protein complexes. #ProteinComplexes #ComputedStructures https://t.co/8A691hs62J @ScienceMagazine
view full postNovember 13, 2021
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Calì_Lab
@lab_cali (Twitter)RT @_VerenaKohler: Computed structures of core eukaryotic protein complexes https://t.co/CV6FRiKrno
view full postNovember 13, 2021
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Verena Kohler
@_VerenaKohler (Twitter)Computed structures of core eukaryotic protein complexes https://t.co/CV6FRiKrno
view full postNovember 13, 2021
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Alok Jha
@AlokGene (Twitter)Computed structures of core eukaryotic protein complexes. https://t.co/YoABTY4ILX
view full postNovember 12, 2021
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Tominaga K. (tomiken)
@pacyc1841 (Twitter)Computed structures of core eukaryotic protein complexes https://t.co/2pMO95SEag
view full postNovember 12, 2021
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Moustafa Saleh
@M_Saleh90 (Twitter)Computed structures of core eukaryotic protein complexes https://t.co/ONTZb1ZAaZ
view full postNovember 12, 2021
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Ah-Ram Kim
@ahramkim1128 (Twitter)Computed structures of core eukaryotic protein complexes https://t.co/TAIFvhpVo1
view full postNovember 12, 2021
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Rob Field, PVC Science, UEA
@Rob_Field_Lab (Twitter)RT @KampranisLab: So many enzyme assemblies, not seen before, but could be very important for regulating growth and other key functions
view full postNovember 12, 2021
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Pastel BioScience
@PastelBio (Twitter)Computed structures of core eukaryotic protein complexes | https://t.co/3jHZQMcIcK #proteomics https://t.co/Z3kxuxNG05
view full postNovember 12, 2021
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Destiny Konadu
@K_Destiny1 (Twitter)RT @waynestatechem: #WSUchemistry's Tamara Hendrickson (@Prof_Tamara) and Travis Ness contributed to this important research article in @Sc…
view full postNovember 12, 2021
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waynestatechem
@waynestatechem (Twitter)#WSUchemistry's Tamara Hendrickson (@Prof_Tamara) and Travis Ness contributed to this important research article in @ScienceMagazine: "Computed structures of core #eukaryotic protein complexes." https://t.co/L06CcEudrx
view full postNovember 12, 2021
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Kampranis Lab
@KampranisLab (Twitter)So many enzyme assemblies, not seen before, but could be very important for regulating growth and other key functions
view full postNovember 12, 2021
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Yicheng Wang
@YichengWang16 (Twitter)Amazing work using RoseTTAFold and AlphaFold predicts many yeast protein complexes, including a very reasonalbe model for GPI transamidase complex formed by 5 subunits!!! Computed structures of core eukaryotic protein complexes https://t.co/rhwYFvoVWx
view full postNovember 12, 2021
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CrocodileChuck
@CrocodileChuck (Twitter)Molecular Machines Are The Engines Of Biological Processes The Recently Parsed Computed Structures of Core Eukaryotic Protein Complexes: https://t.co/i1Z8R2H0LM… Hat Tip: Drew Berry, Replisome Animation https://t.co/xBXRnwVkSA
view full postNovember 12, 2021
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Hiroki Onoda
@onoda_hiroki (Twitter)RT @tonets: あ、PPI予測やられたな？ Computed structures of core eukaryotic protein complexes https://t.co/QqI4H0WyHn
view full postNovember 12, 2021
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Tomohito Higashi
@To_Higashi (Twitter)RT @tonets: あ、PPI予測やられたな？ Computed structures of core eukaryotic protein complexes https://t.co/QqI4H0WyHn
view full postNovember 12, 2021
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鈴仙
@URRK12 (Twitter)RT @nob_mai: D. Bakerも複合体予測出してきた Computed structures of core eukaryotic protein complexes https://t.co/GZgmfwR7yf
view full postNovember 12, 2021
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a
@ayanosatoh (Twitter)RT @tonets: あ、PPI予測やられたな？ Computed structures of core eukaryotic protein complexes https://t.co/QqI4H0WyHn
view full postNovember 12, 2021
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Ohue M/大上雅史
@tonets (Twitter)あ、PPI予測やられたな？ Computed structures of core eukaryotic protein complexes https://t.co/QqI4H0WyHn
view full postNovember 12, 2021
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Ryota IINO 飯野亮太
@ryotaiino (Twitter)Computed structures of core eukaryotic protein complexes https://t.co/d0EOIpzuZp
view full postNovember 11, 2021
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Sandeep Pulim
@SPulim (Twitter)Computed structures of core eukaryotic protein complexes https://t.co/O8VOcmQEqC
view full postNovember 11, 2021
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LMBLib
@LMB_Library (Twitter)NEW #LMBpublications Computed structures of core eukaryotic protein complexes https://t.co/cBVhcjuwXe
view full postNovember 11, 2021
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Yutaka Maruyama
@drmaruyama (Twitter)RT @nob_mai: D. Bakerも複合体予測出してきた Computed structures of core eukaryotic protein complexes https://t.co/GZgmfwR7yf
view full postNovember 11, 2021
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priya joseph
@ayirpelle (Twitter)RT @westr: Computed structures of core eukaryotic protein complexes https://t.co/YekdQfna0R ... within the #yeast #proteome.
view full postNovember 11, 2021
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Kato
@oxkawaka (Twitter)Computed structures of core eukaryotic protein complexes さぁ、RoseTTAFold と AlphaFoldのコンビで示してやるよ複合体たちの予測をなと言うお話。 https://t.co/yq2HpOSwzD
view full postNovember 11, 2021
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Ramon Guixà-González
@ramonguixxa (Twitter)Computed structures of core eukaryotic protein complexes https://t.co/XrIM8F03WK
view full postNovember 11, 2021
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NobuoMaita
@nob_mai (Twitter)D. Bakerも複合体予測出してきた Computed structures of core eukaryotic protein complexes https://t.co/GZgmfwR7yf
view full postNovember 11, 2021
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Jason H. Moore, PhD
@moorejh (Twitter)RT @westr: Computed structures of core eukaryotic protein complexes https://t.co/YekdQfna0R ... within the #yeast #proteome.
view full postNovember 11, 2021
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Robert West, PhD ✝️
@westr (Twitter)Computed structures of core eukaryotic protein complexes https://t.co/YekdQfna0R ... within the #yeast #proteome.
view full postNovember 11, 2021
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Cell Biology J-Club
@cell_club (Twitter)Computed structures of core eukaryotic protein complexes https://t.co/DjZOiVBc1C
view full postNovember 11, 2021
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Tae Hoon Kim
@taehoonkim (Twitter)Computed structures of core eukaryotic protein complexes https://t.co/6Gntm3eaKx
view full postNovember 11, 2021
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FrezzaLab
@FrezzaLab (Twitter)Computed structures of core eukaryotic protein complexes https://t.co/Scls6r6pZn
view full postNovember 11, 2021
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Abstract Synopsis
- Protein-protein interactions are essential for biological functions, yet many eukaryotic protein complex structures remain unknown, highlighting the need for better identification methods.
- Using advanced techniques like coevolution analysis and deep-learning models (RoseTTAFold and AlphaFold), researchers screened 8.3 million yeast protein pairs to predict interactions and construct structural models.
- They identified 1505 potential interacting pairs, characterized 106 previously unknown protein assemblies, and provided insights into 806 complexes not structurally documented, emphasizing their importance in key cellular processes.
Ian Humphreys
@IanRHum (Twitter)