Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFold2 and #RoseTTAFold to model 3D structures of protein-protein interactions, including higher order complexes, in #yeast https://t.co/JSsfvbU1FL https://t.co/7gzPUMLEnY
Computed structures of core eukaryotic protein complexes.
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Nov 2021 – Sep 2025Where it's discussed
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AI synopsis
What people are saying
Overall, the social discussions reflect high enthusiasm and support, citing examples such as models of enzyme assemblies, new insights into key cellular processes, and the use of advanced AI techniques. Words like 'exciting', 'mind-blowing', and 'game changer' demonstrate both the excitement and perceived importance of this research, revealing a community deeply engaged with the scientific breakthrough.
Most discussions support the significance and innovative nature of the publication, emphasizing advances in structure prediction and biological insights.
Posts express high interest, highlighting breakthroughs in protein modeling and potential applications in biology and medicine.
Many discussions reflect deep engagement through mentioning specific methods like AlphaFold and RoseTTAFold and exploring implications for cellular functions.
The discussions suggest the research could have a transformative impact on understanding protein interactions and cellular machinery, with several recognizing its broad relevance.
Abstract in brief
- Protein-protein interactions are essential for biological functions, yet many eukaryotic protein complex structures remain unknown, highlighting the need for better identification methods.
- Using advanced techniques like coevolution analysis and deep-learning models (RoseTTAFold and AlphaFold), researchers screened 8.3 million yeast protein pairs to predict interactions and construct structural models.
- They identified 1505 potential interacting pairs, characterized 106 previously unknown protein assemblies, and provided insights into 806 complexes not structurally documented, emphasizing their importance in key cellular processes.
Top posts
Most liked on X and BlueskyI’m more of a #DNA fan myself, but this is mind blowing work in structure prediction and interaction. @UWproteindesign Computed structures of core eukaryotic protein complexes https://t.co/pf9DGgjDlI
"Using #DeepLearning methods to systematically identify and build structures for the protein complexes that mediate key processes in eukaryotes." #Science #proteins #Biology #cells ⏯️Computed structures of core eukaryotic protein complexes https://t.co/v5jMcof4dJ https://t.co/kFHc1F8tgD
Using #AlphaFold to help predict the structures of large protein complexes enabled researchers at @UWproteindesign, @UTSWnews, and colleagues to gain new insights into their vital biological functions. https://t.co/8vktioTbbn https://t.co/1Rz0BM5QYu
あ、PPI予測やられたな? Computed structures of core eukaryotic protein complexes https://t.co/QqI4H0WyHn
D. Bakerも複合体予測出してきた Computed structures of core eukaryotic protein complexes https://t.co/GZgmfwR7yf
All mentions
Exploring Protein Design with Foldit: Insights from Experts
Join us on March 30 at 9:30 AM PST for the IUBMB Trainee Initiative event featuring Drs. David Baker and Brian Koepnick. Discover how citizen scientists use Foldit for innovative protein design, including applications…
Innovations in Protein Design: Join the IUBMB Event with Experts
Join us on March 30 at 9:30 AM PST for the IUBMB Trainee Initiative's first event. Learn about protein structure prediction and design through the online game Foldit, featuring talks and Q&A sessions with Drs. David…
This effort is the culmination of a series of proteome interaction prediction stories from Ecoli (https://t.co/9Cn55FaGQL), to yeast (https://t.co/DqKtaIrzXw), and human bacterial pathogens (https://t.co/NPKmEJzils)!
RT @oxkawaka: Computed structures of core eukaryotic protein complexes さぁ、RoseTTAFold と AlphaFoldのコンビで示してやるよ複合体たちの予測をなと言うお話。 https://t.co…
RT @emblebi: Using #AlphaFold to help predict the structures of large protein complexes enabled researchers at @UWproteindesign, @UTSWnews,…
RT @emblebi: Using #AlphaFold to help predict the structures of large protein complexes enabled researchers at @UWproteindesign, @UTSWnews,…
RT @emblebi: Using #AlphaFold to help predict the structures of large protein complexes enabled researchers at @UWproteindesign, @UTSWnews,…
Using #AlphaFold to help predict the structures of large protein complexes enabled researchers at @UWproteindesign, @UTSWnews, and colleagues to gain new insights into their vital biological functions. https://t.co/8vktioTbbn https://t.co/1Rz0BM5QYu
RT @CascalesLab: Proteome-wide amino-acid coevolution and structural modeling using RoseTTAFold and AlphaFold2 identified new protein comp…
@sandeepbiochem1 @emblebi @UWproteindesign @ISBSIB Hi Sandeep. You can get more information about how these predicted complexes were generated from the publication: https://t.co/mUTMkiwwIL
An article "Computed structures of core eukaryotic protein complexes."published in #Science by a team from #UTSMC & #UW. They developed a bioinformatics and deep learning pipeline to identify potentially interacting protein pairs and model the 3D structure of protein complexes. https://t.co/JzeLa4syMc
@biogerontology @A_Aspuru_Guzik @MLevitt_NP2013 Congrats! Maybe predicted protein-protein interaction (https://t.co/AMw56anGoL) could further help to validate your pathways from iPANDA/PandaOmics?
"We developed a coevolution-guided protein interaction identification pipeline that incorporates a rapidly computable version of RoseTTAFold with the slower but more accurate AlphaFold to evaluate interactions between 8.3 million pairs of yeast proteins." https://t.co/pukTGzjr80
@andrewwhite01 @LindorffLarsen Totally possible! https://t.co/RerPiBLo3A
Computed structures of core eukaryotic protein complexes https://t.co/XTkb2V5NtC https://t.co/xSMHVskoxB
RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
This takes Alphafold predicted protein structures to the next level and will advance our understanding of molecular complexes. Computed structures of core eukaryotic protein complexes https://t.co/nz1RNKwohH
RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
RT @UWproteindesign: (1/8) Today we share the structures of protein complexes from nearly every core process in eukaryotic biology — from D…
RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
RT @UWproteindesign: (1/8) Today we share the structures of protein complexes from nearly every core process in eukaryotic biology — from D…
RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
RT @yeastgenome: Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFol…
Exciting @ScienceMagazine paper from David Baker's lab @UWproteindesign describes using deep-learning algorithms #AlphaFold2 and #RoseTTAFold to model 3D structures of protein-protein interactions, including higher order complexes, in #yeast https://t.co/JSsfvbU1FL https://t.co/7gzPUMLEnY
RT @EijsinkLab: Computed structures of core eukaryotic protein complexes https://t.co/IirHRfb1ZQ
Computed structures of core eukaryotic protein complexes https://t.co/IirHRfb1ZQ
RT @the_paper_link: Trend up+14: Humphreys IR, ..., Baker D (Science) __Computed structures of core eukaryotic protein complexes__ https:/…
Trend up+14: Humphreys IR, ..., Baker D (Science) __Computed structures of core eukaryotic protein complexes__ https://t.co/p86RkjNmhc
RT @manuelacasasoli: "Using #DeepLearning methods to systematically identify and build structures for the protein complexes that mediate ke…
RT @manuelacasasoli: "Using #DeepLearning methods to systematically identify and build structures for the protein complexes that mediate ke…
RT @manuelacasasoli: "Using #DeepLearning methods to systematically identify and build structures for the protein complexes that mediate ke…
RT @manuelacasasoli: "Using #DeepLearning methods to systematically identify and build structures for the protein complexes that mediate ke…
RT @manuelacasasoli: "Using #DeepLearning methods to systematically identify and build structures for the protein complexes that mediate ke…
"Using #DeepLearning methods to systematically identify and build structures for the protein complexes that mediate key processes in eukaryotes." #Science #proteins #Biology #cells ⏯️Computed structures of core eukaryotic protein complexes https://t.co/v5jMcof4dJ https://t.co/kFHc1F8tgD
RT @julhenri: Computed structures of core eukaryotic protein complexes https://t.co/Yq2oQ7OSgE
Computed structures of core eukaryotic protein complexes https://t.co/Yq2oQ7OSgE
RT @the_paper_link: Trend up+25: Humphreys IR, ..., Baker D (Science) __Computed structures of core eukaryotic protein complexes__ https:/…
Trend up+25: Humphreys IR, ..., Baker D (Science) __Computed structures of core eukaryotic protein complexes__ https://t.co/p86RkjNmhc
Computed structures of core eukaryotic protein complexes. #ComputedComplexes #ProteinInteractions https://t.co/8A691hs62J @ScienceMagazine
RT @UWproteindesign: (1/8) Today we share the structures of protein complexes from nearly every core process in eukaryotic biology — from D…
Computed structures of core eukaryotic protein complexes https://t.co/Bahi5UJCS1
https://t.co/OvYJtb0b12 #prime3 Humphreys IR, ..., Baker D (Science) __Computed structures of core eukaryotic protein complexes__ https://t.co/p86RkjNmhc
RT @hernangraffe: https://t.co/3Yzelf7fnR
https://t.co/3Yzelf7fnR
https://t.co/WJ2R5iQMB5 Co-evolution guided proteome interactions, orthologs from paralogs...
AI Systematically IDs Structures of Eukaryotic Proteins. - A rather interesting commentary of results published in an article titled “Computed structures of core eukaryotic protein complexes” in the recent journal of Science. https://t.co/y96xMVaClX via @GENbio
Computed structures of core eukaryotic protein complexes - https://t.co/hArcXvW84H
RT @UWproteindesign: (1/8) Today we share the structures of protein complexes from nearly every core process in eukaryotic biology — from D…
RT @hernangraffe: https://t.co/3Yzelf7fnR
RT @BUCNSB: Interesting article out in @ScienceMagazine on modeling eukaryotic protein complexes. https://t.co/7c55a2a2bk
Interesting article out in @ScienceMagazine on modeling eukaryotic protein complexes. https://t.co/7c55a2a2bk
RT @EmilyLeproust: I’m more of a #DNA fan myself, but this is mind blowing work in structure prediction and interaction. @UWproteindesign…
RT @EmilyLeproust: I’m more of a #DNA fan myself, but this is mind blowing work in structure prediction and interaction. @UWproteindesign…
Incredible!! Computed structures of core eukaryotic protein complexes https://t.co/Z4CSkZ8IJd
RT @EmilyLeproust: I’m more of a #DNA fan myself, but this is mind blowing work in structure prediction and interaction. @UWproteindesign…
RT @EmilyLeproust: I’m more of a #DNA fan myself, but this is mind blowing work in structure prediction and interaction. @UWproteindesign…
RT @EmilyLeproust: I’m more of a #DNA fan myself, but this is mind blowing work in structure prediction and interaction. @UWproteindesign…
RT @EmilyLeproust: I’m more of a #DNA fan myself, but this is mind blowing work in structure prediction and interaction. @UWproteindesign…
RT @UWproteindesign: (1/8) Today we share the structures of protein complexes from nearly every core process in eukaryotic biology — from D…
RT @EmilyLeproust: I’m more of a #DNA fan myself, but this is mind blowing work in structure prediction and interaction. @UWproteindesign…
RT @EmilyLeproust: I’m more of a #DNA fan myself, but this is mind blowing work in structure prediction and interaction. @UWproteindesign…
RT @EmilyLeproust: I’m more of a #DNA fan myself, but this is mind blowing work in structure prediction and interaction. @UWproteindesign…
RT @EmilyLeproust: I’m more of a #DNA fan myself, but this is mind blowing work in structure prediction and interaction. @UWproteindesign…
RT @EmilyLeproust: I’m more of a #DNA fan myself, but this is mind blowing work in structure prediction and interaction. @UWproteindesign…
https://t.co/3Yzelf7fnR
I’m more of a #DNA fan myself, but this is mind blowing work in structure prediction and interaction. @UWproteindesign Computed structures of core eukaryotic protein complexes https://t.co/pf9DGgjDlI
RT @NatureBiotech: Deep learning predicts the structure of protein complexes based on paired multiple sequence alignments and amino acid co…
RT @Bio_stations: タンパク質"複合体"の構造を予測 近年進歩しているAIによるタンパク質の構造予測を複合体にも拡張。アミノ酸共振化解析と深層学習で真核生物のタンパク質複合体の構造を予測。機能未知の因子とかも見ている 時代の進歩すごい、!もう複合体も見れるの…
RT @UWproteindesign: (1/8) Today we share the structures of protein complexes from nearly every core process in eukaryotic biology — from D…
RT @UWproteindesign: (1/8) Today we share the structures of protein complexes from nearly every core process in eukaryotic biology — from D…
RT @IanRHum: We use recent advances in proteome-wide coevolution analysis and breakthroughs in artificial-intelligence-based structure mode…
RT @sekmi: The artificial intelligence #AI revolution in #structuralbiology continues and begins a new era in which computation plays a fun…
Trend up+7: Humphreys IR, ..., Baker D (Science) __Computed structures of core eukaryotic protein complexes__ https://t.co/p86RkjNmhc
RT @RebeccaRambar: L'intelligence artificielle prédit avec succès les interactions entre des complexes protéiques eucaryotes selon une étud…
@t2438 それがあってもこの論文に近しい事をする能力も技術もないので止めておきます。 https://t.co/Y4tRCUq4uy
RT @IanRHum: We use recent advances in proteome-wide coevolution analysis and breakthroughs in artificial-intelligence-based structure mode…
RT @UWproteindesign: (1/8) Today we share the structures of protein complexes from nearly every core process in eukaryotic biology — from D…
RT @UWproteindesign: (1/8) Today we share the structures of protein complexes from nearly every core process in eukaryotic biology — from D…
SciPak Multimedia Highlight: Research on the structures and applications of eukaryotic protein complexes @UWproteindesign: https://t.co/N71XT79kzE Photo credit: Ian C. Haydon / UW Medicine Institute for Protein Design https://t.co/TQoh2HIuln
RT @UWproteindesign: (1/8) Today we share the structures of protein complexes from nearly every core process in eukaryotic biology — from D…
Computed structures of core eukaryotic protein complexes https://t.co/brURC0Bspy #generalscience #feedly
RT @Bio_stations: タンパク質"複合体"の構造を予測 近年進歩しているAIによるタンパク質の構造予測を複合体にも拡張。アミノ酸共振化解析と深層学習で真核生物のタンパク質複合体の構造を予測。機能未知の因子とかも見ている 時代の進歩すごい、!もう複合体も見れるの…
RT @UWproteindesign: (1/8) Today we share the structures of protein complexes from nearly every core process in eukaryotic biology — from D…
Researchers used #AI & evolutionary analysis to make 3D models of eukaryotic #protein interactions. The #study found 100+ probable protein complexes for the first time and provided structural models for 700+ more. https://t.co/JUrarUWoXz #innovation https://t.co/QVYSsPvi3z
RT @ScienceMagazine: Using a combination of #RoseTTAFold and #AlphaFold to screen millions of pairs of yeast proteins, researchers in Scien…
RT @IanRHum: We use recent advances in proteome-wide coevolution analysis and breakthroughs in artificial-intelligence-based structure mode…
RT @ScienceMagazine: Using a combination of #RoseTTAFold and #AlphaFold to screen millions of pairs of yeast proteins, researchers in Scien…
RT @ScienceMagazine: Using a combination of #RoseTTAFold and #AlphaFold to screen millions of pairs of yeast proteins, researchers in Scien…
RT @RebeccaRambar: L'intelligence artificielle prédit avec succès les interactions entre des complexes protéiques eucaryotes selon une étud…
RT @ScienceMagazine: Using a combination of #RoseTTAFold and #AlphaFold to screen millions of pairs of yeast proteins, researchers in Scien…
RT @ScienceMagazine: Using a combination of #RoseTTAFold and #AlphaFold to screen millions of pairs of yeast proteins, researchers in Scien…
RT @ScienceMagazine: Using a combination of #RoseTTAFold and #AlphaFold to screen millions of pairs of yeast proteins, researchers in Scien…
RT @ScienceMagazine: Using a combination of #RoseTTAFold and #AlphaFold to screen millions of pairs of yeast proteins, researchers in Scien…
Computed structures of core eukaryotic protein complexes https://t.co/ScacbdT7rC
Proteome-wide amino-acid coevolution and structural modeling using RoseTTAFold and AlphaFold2 identified new protein complexes and computed their structures. Computed structures of core eukaryotic protein complexes https://t.co/ETeOdAcCzf
...and protein complexes! Computed structures of core eukaryotic protein complexes - https://t.co/M5tsy2BAK2 https://t.co/cE6luxVXX0
This is so cool! @UWProteinDesign makes protein structures freely available for almost all key processes in eukaryotic cells. #Alphafold, #RoseTTAFold Computed structures of core eukaryotic protein complexes https://t.co/5zfopf6McY
Computed structures of core eukaryotic protein complexes https://t.co/pW3UTTlT7F
Open-sourcing of protein-structure software is already paying off | Ars Technica https://t.co/uLXPabAbBg https://t.co/Gi854RElES
RT @jsantoyo: Computed structures of core eukaryotic protein complexes. #ProteinComplexes #ComputedStructures https://t.co/8A691hs62J @Scie…
Computed structures of core eukaryotic protein complexes. #ProteinComplexes #ComputedStructures https://t.co/8A691hs62J @ScienceMagazine
RT @_VerenaKohler: Computed structures of core eukaryotic protein complexes https://t.co/CV6FRiKrno
Computed structures of core eukaryotic protein complexes https://t.co/CV6FRiKrno
Computed structures of core eukaryotic protein complexes. https://t.co/YoABTY4ILX
Computed structures of core eukaryotic protein complexes https://t.co/2pMO95SEag
Computed structures of core eukaryotic protein complexes https://t.co/ONTZb1ZAaZ
Computed structures of core eukaryotic protein complexes https://t.co/TAIFvhpVo1
RT @KampranisLab: So many enzyme assemblies, not seen before, but could be very important for regulating growth and other key functions
Computed structures of core eukaryotic protein complexes | https://t.co/3jHZQMcIcK #proteomics https://t.co/Z3kxuxNG05
RT @waynestatechem: #WSUchemistry's Tamara Hendrickson (@Prof_Tamara) and Travis Ness contributed to this important research article in @Sc…
#WSUchemistry's Tamara Hendrickson (@Prof_Tamara) and Travis Ness contributed to this important research article in @ScienceMagazine: "Computed structures of core #eukaryotic protein complexes." https://t.co/L06CcEudrx
So many enzyme assemblies, not seen before, but could be very important for regulating growth and other key functions
Amazing work using RoseTTAFold and AlphaFold predicts many yeast protein complexes, including a very reasonalbe model for GPI transamidase complex formed by 5 subunits!!! Computed structures of core eukaryotic protein complexes https://t.co/rhwYFvoVWx
Molecular Machines Are The Engines Of Biological Processes The Recently Parsed Computed Structures of Core Eukaryotic Protein Complexes: https://t.co/i1Z8R2H0LM… Hat Tip: Drew Berry, Replisome Animation https://t.co/xBXRnwVkSA
RT @tonets: あ、PPI予測やられたな? Computed structures of core eukaryotic protein complexes https://t.co/QqI4H0WyHn
RT @tonets: あ、PPI予測やられたな? Computed structures of core eukaryotic protein complexes https://t.co/QqI4H0WyHn
RT @nob_mai: D. Bakerも複合体予測出してきた Computed structures of core eukaryotic protein complexes https://t.co/GZgmfwR7yf
RT @tonets: あ、PPI予測やられたな? Computed structures of core eukaryotic protein complexes https://t.co/QqI4H0WyHn
あ、PPI予測やられたな? Computed structures of core eukaryotic protein complexes https://t.co/QqI4H0WyHn
Computed structures of core eukaryotic protein complexes https://t.co/d0EOIpzuZp
Computed structures of core eukaryotic protein complexes https://t.co/O8VOcmQEqC
NEW #LMBpublications Computed structures of core eukaryotic protein complexes https://t.co/cBVhcjuwXe
RT @nob_mai: D. Bakerも複合体予測出してきた Computed structures of core eukaryotic protein complexes https://t.co/GZgmfwR7yf
RT @westr: Computed structures of core eukaryotic protein complexes https://t.co/YekdQfna0R ... within the #yeast #proteome.
Computed structures of core eukaryotic protein complexes さぁ、RoseTTAFold と AlphaFoldのコンビで示してやるよ複合体たちの予測をなと言うお話。 https://t.co/yq2HpOSwzD
Computed structures of core eukaryotic protein complexes https://t.co/XrIM8F03WK
D. Bakerも複合体予測出してきた Computed structures of core eukaryotic protein complexes https://t.co/GZgmfwR7yf
RT @westr: Computed structures of core eukaryotic protein complexes https://t.co/YekdQfna0R ... within the #yeast #proteome.
Computed structures of core eukaryotic protein complexes https://t.co/YekdQfna0R ... within the #yeast #proteome.
Computed structures of core eukaryotic protein complexes https://t.co/DjZOiVBc1C
Computed structures of core eukaryotic protein complexes https://t.co/6Gntm3eaKx
Computed structures of core eukaryotic protein complexes https://t.co/Scls6r6pZn
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