PubHawk
Signal Transduct Target Ther November 2021 PMID 34824210

The JAK/STAT signaling pathway: from bench to clinic.

Xiaoyi Hu, Jing Li, Maorong Fu, Xia Zhao, Wei Wang

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Mentions

19
Peak: 1 in Nov 2021
across 5 sources since Nov 2021

Extended reach

1,385
potential audience

Total likes

3

Video views

228

Mentions per month

Nov 2021 – Jul 2025

Where it's discussed

  • News12 articles
  • X / Twitter2 posts
  • Facebook2 posts
  • Blogs2 articles
  • YouTube1 videos

AI synopsis

What people are saying

The discussions express strong interest and moderate engagement, with users referencing the pathway’s role in diseases and potential therapies, exemplified by phrases like 'game changer' and mentions of targeted treatments, emphasizing the clinical relevance and transformative potential of the research.

AgreementModerate agreement

Most discussions acknowledge the importance of the JAK/STAT pathway and its potential for clinical applications, indicating general agreement with the publication's significance.

InterestHigh interest

Posts show high interest, with frequent mentions of its relevance to cancer, autoimmune diseases, and therapeutic targeting, reflecting enthusiasm about the research.

EngagementModerate engagement

Discussions include references to specific research details, such as the role of inhibitors and disease links, suggesting moderate engagement with some in-depth analysis.

ImpactModerate impact

Comments highlight the pathway's potential to influence future treatments and research directions, implying a recognition of its meaningful impact.

Abstract in brief

  • The JAK-STAT signaling pathway, discovered over 25 years ago, is a crucial cellular communication system that helps regulate processes like cancer and inflammation by transmitting signals from the cell membrane to the nucleus.
  • Dysregulation of this pathway is linked to the development of various cancers and autoimmune diseases, making it an important target for medical research and treatment.
  • The review covers how the JAK-STAT pathway is composed, activated, and regulated, as well as the potential of inhibitors of this pathway for treating different diseases.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Abdul M. Ssekandi, MBChB, MSc., M.A.P.S
@JC_by_AMS · X

The JAK/STAT signaling pathway: from bench to clinic Xiaoyi Hu et al. https://t.co/6mEb1bBIQ7 https://t.co/Syr5bAOg3E

Jul 27, 2025 · 3 likes · 1,137 followers View post →
OWLMSPA
@OWLMSPA · X

The JAK/STAT signaling pathway: from bench to clinic | Signal Transduction and Targeted Therapy #WP1066 https://t.co/y6buygSL9K

Nov 26, 2021 · 20 followers View post →

All mentions

Abdul M. Ssekandi, MBChB, MSc., M.A.P.S
@JC_by_AMS · X

The JAK/STAT signaling pathway: from bench to clinic Xiaoyi Hu et al. https://t.co/6mEb1bBIQ7 https://t.co/Syr5bAOg3E

Jul 27, 2025 · 3 likes · 1,137 followers View post →
OWLMSPA
@OWLMSPA · X

The JAK/STAT signaling pathway: from bench to clinic | Signal Transduction and Targeted Therapy #WP1066 https://t.co/y6buygSL9K

Nov 26, 2021 · 20 followers View post →