Front Mol Neurosci November 2021 PMID 34858140

Does Low Grade Systemic Inflammation Have a Role in Chronic Pain?

Wen Bo Sam Zhou, JingWen Meng, Ji Zhang

Mentions

70
Peak: 38 in Jan 2023
across 3 sources since Nov 2021

Extended reach

851,883
potential audience

Total likes

9,061

Video views

348,437

Mentions per month

Nov 2021 – Sep 2025

Where it's discussed

  • X / Twitter66 posts
  • YouTube2 videos
  • Facebook2 posts

AI synopsis

What people are saying

The discussions prominently feature terms like 'shared risk factor' and 'perpetuate persistent pain', highlighting the interconnectedness of systemic inflammation with conditions such as anxiety and obesity. The tone is largely informative, reflecting a consensus on the publication's relevance by using phrases like 'very interesting article' and 'great review', which emphasize the importance and potential implications of the research.

AgreementModerate agreement

The majority of posts agree that low-grade systemic inflammation is a significant factor in chronic pain discussions, though not unanimously.

InterestHigh interest

There is a high level of interest in the topic, as evidenced by the frequency of posts discussing the article and its implications.

EngagementModerate engagement

While many posts reference the article, the depth of engagement varies, with some users providing brief insights without detailed analysis.

ImpactHigh impact

Many users perceive the publication as having a significant impact on understanding chronic pain and related comorbidities.

Abstract in brief

  • Chronic pain, often resulting from peripheral neuropathy due to trauma or disease, remains poorly understood and inadequately treated, affecting patients' quality of life.
  • Systemic chronic inflammation (SCI) is a state of low-grade, persistent inflammation in the body that could contribute to the onset of chronic pain and related mental health issues.
  • Evidence from clinical studies suggests a link between SCI and various types of chronic pain, highlighting the need for more research to explore these complex interactions further.

Top posts

Most liked on X and Bluesky
The Sp⚽️rts Physio
@AdamMeakins · X

Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetuate persistent pain! https://t.co/ovduKYALos

Jan 2, 2023 · 198 likes · 41 shares · 107,689 followers View post →
Derek Griffin
@DerekGriffin86 · X

Low grade systemic inflammation may be one potential mechanism underlying nociplastic pain phenotype. Systemic, low grade inflammation can sensitive nociceptors in the absence of overt tissue damage. https://t.co/7QV06UabyY

Dec 21, 2022 · 75 likes · 13 shares · 38,366 followers View post →
Christoph Burch
@ChristophBurch · X

Does Low Grade Systemic Inflammation Have a Role in Chronic Pain? Wen Bo Sam Zhou et al. Front Mol Neurosci. https://t.co/4aWAJj6CQi

Dec 10, 2021 · 23 likes · 5 shares · 15,324 followers View post →
Derek Griffin
@DerekGriffin86 · X

Low grade systemic inflammation may be a shared risk factor for pain & other cardiometabolic comorbidities. https://t.co/W9TPyEq3uA

Feb 2, 2025 · 19 likes · 2 shares · 38,366 followers View post →
Agingdoc
@agingdoc1 · X

Does Low Grade Systemic Inflammation Have a Role in Chronic Pain?

Jan 29, 2023 · 7 likes · 3 shares · 41,826 followers View post →
Frontiers - Neuroscience
@FrontNeurosci · X

New Research: Does Low Grade Systemic Inflammation Have a Role in Chronic Pain?: One of the major clinical manifestations of peripheral neuropathy, either resulting from trauma or diseases, is chronic pain. While it significantly… https://t.co/iPvQX3HE6N #Molecular #Neuroscience

Nov 21, 2021 · 4 likes · 80,920 followers View post →

All mentions

Moojin Jeong
@Malehealth2023 · X

RT @DerekGriffin86: Low grade systemic inflammation may be a shared risk factor for pain & other cardiometabolic comorbidities. https://t.c…

Feb 2, 2025 · 2 shares · 30 followers View post →
Ben Cormack
@CorKinetic · X

RT @DerekGriffin86: Low grade systemic inflammation may be a shared risk factor for pain & other cardiometabolic comorbidities. https://t.c…

Feb 2, 2025 · 2 shares · 28,398 followers View post →
Derek Griffin
@DerekGriffin86 · X

Low grade systemic inflammation may be a shared risk factor for pain & other cardiometabolic comorbidities. https://t.co/W9TPyEq3uA

Feb 2, 2025 · 19 likes · 2 shares · 38,366 followers View post →
Jonas Bermejo
@jonasbbermejo · X

https://t.co/BKHaYowGOF

Jul 3, 2024 · 5 followers View post →
John Nykiforuk
@john_nykiforuk · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Mar 9, 2023 · 41 shares · 401 followers View post →
Jeffrey Gross, M.D.
@DrJeffreyGross · X

RT @agingdoc1: Does Low Grade Systemic Inflammation Have a Role in Chronic Pain?

Jan 30, 2023 · 3 shares · 47 followers View post →
Anupam Khemariya
@AnupamKhemariya · X

RT @agingdoc1: Does Low Grade Systemic Inflammation Have a Role in Chronic Pain?

Jan 29, 2023 · 3 shares · 104 followers View post →
Dr. Shashank Joshi
@AskDrShashank · X

RT @agingdoc1: Does Low Grade Systemic Inflammation Have a Role in Chronic Pain?

Jan 29, 2023 · 3 shares · 32,519 followers View post →
Agingdoc
@agingdoc1 · X

Does Low Grade Systemic Inflammation Have a Role in Chronic Pain?

Jan 29, 2023 · 7 likes · 3 shares · 41,826 followers View post →
Nilo
@Nilo16135453 · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 6, 2023 · 41 shares · 40 followers View post →
DRBH1000
@DRBH1000 · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 6, 2023 · 41 shares · 1,342 followers View post →
Sergio Victorino Arroyo
@FisioVictorino · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 4, 2023 · 41 shares · 1,344 followers View post →
AlexanderTkachev
@AlexanderTkac11 · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 4, 2023 · 41 shares · 81 followers View post →
FABRIZIO
@FABRIZI43211321 · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 4, 2023 · 41 shares · 19 followers View post →
Kletterphysio.ch
@kletterphysio · X

Very interesting article about low grade inflammation and it' s role in chronic pain! Does Low Grade Systemic Inflammation Have a Role in Chronic Pain? https://t.co/TqPq3LDmCg

Jan 4, 2023 · 43 followers View post →
MSKphile
@riquier_sylvain · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 4, 2023 · 41 shares · 79 followers View post →
Amber
@AmbercormackPt · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 3, 2023 · 41 shares · 88 followers View post →
María Isabel Pombo Carrera
@PomboCarrera · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 3, 2023 · 41 shares · 62 followers View post →
Katrine Petersen
@KatrinePeterse9 · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 3, 2023 · 41 shares · 245 followers View post →
Sarah
@sarahkayayay · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 3, 2023 · 41 shares · 56 followers View post →
Ander Zulet
@AnderZulet · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 3, 2023 · 41 shares · 1,179 followers View post →
Roger Hilfiker
@RogerHilfiker · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 3, 2023 · 41 shares · 1,618 followers View post →
Romeo Fisio
@RomeoMndez · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 3, 2023 · 41 shares · 232 followers View post →
Milos Milosavljevic
@MilosMi41287324 · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 3, 2023 · 41 shares · 21 followers View post →
Dr. Cynthia
@creamgarciaPT · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 3, 2023 · 41 shares · 26 followers View post →
Laura Schembri
@lauraxkembri · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 3, 2023 · 41 shares · 175 followers View post →
KaterynaZaichko
@KaterynaZaichko · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 3, 2023 · 41 shares · 61 followers View post →
Andrei Ilnitski
@AndrIlnitski · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 3, 2023 · 41 shares · 427 followers View post →
jnxs
@jnxs18 · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 3, 2023 · 41 shares View post →
Bouke Hepkema
@BoukeHepkema · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 3, 2023 · 41 shares · 37 followers View post →
Paul Westwood
@TriathlonPhysio · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 3, 2023 · 41 shares · 2,384 followers View post →
Evangeline Mantzioris PhD APD AccSD
@EMantzioris · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 3, 2023 · 41 shares · 1,169 followers View post →
Vincent Girod
@KineMeuh · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 3, 2023 · 41 shares · 3,685 followers View post →
Jochem V Schalkwijk
@joppie1976 · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 3, 2023 · 41 shares · 59 followers View post →
Sven Lausen
@svenlausen · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 3, 2023 · 41 shares · 67 followers View post →
J. David
@juandavidby · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 3, 2023 · 41 shares · 24 followers View post →
Jose
@Jose_8523 · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 2, 2023 · 41 shares · 291 followers View post →
Ace Adamson
@adamson_ace · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 2, 2023 · 41 shares · 191 followers View post →
Mateo33
@MatiMateo33 · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 2, 2023 · 41 shares · 43 followers View post →
Philip Chapman
@PhysioPhil79 · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 2, 2023 · 41 shares · 26 followers View post →
Sustancia P
@PhysionBoy · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 2, 2023 · 41 shares · 96 followers View post →
Philipp Greimel
@philippgreimel · X

RT @AdamMeakins: Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetu…

Jan 2, 2023 · 41 shares · 29 followers View post →
The Sp⚽️rts Physio
@AdamMeakins · X

Chronic low grade systemic inflammation caused by lack of physical activity, obesity, anxiety etc could create and perpetuate persistent pain! https://t.co/ovduKYALos

Jan 2, 2023 · 198 likes · 41 shares · 107,689 followers View post →
Spineguy
@Spineguys · X

Frontiers | Does Low Grade Systemic Inflammation Have a Role in Chronic Pain? Great review of factors in chronic pain https://t.co/hwfx2khixt

Dec 22, 2022 · 128 followers View post →
Koushik
@koushikphysio · X

RT @DerekGriffin86: Low grade systemic inflammation may be one potential mechanism underlying nociplastic pain phenotype. Systemic, low gra…

Dec 22, 2022 · 13 shares · 518 followers View post →
Craig Liebenson
@CraigLiebenson · X

RT @DerekGriffin86: Low grade systemic inflammation may be one potential mechanism underlying nociplastic pain phenotype. Systemic, low gra…

Dec 22, 2022 · 13 shares · 8,217 followers View post →
Judi
@Judi_Hunter · X

RT @DerekGriffin86: Low grade systemic inflammation may be one potential mechanism underlying nociplastic pain phenotype. Systemic, low gra…

Dec 22, 2022 · 13 shares · 378 followers View post →
Dominic Ledinger
@DomLedinger · X

RT @DerekGriffin86: Low grade systemic inflammation may be one potential mechanism underlying nociplastic pain phenotype. Systemic, low gra…

Dec 22, 2022 · 13 shares · 89 followers View post →
Dennis Kuhnert
@DennisKuhner1 · X

RT @DerekGriffin86: Low grade systemic inflammation may be one potential mechanism underlying nociplastic pain phenotype. Systemic, low gra…

Dec 22, 2022 · 13 shares · 22 followers View post →
Alessandro Giannini
@AleGiannini82 · X

RT @DerekGriffin86: Low grade systemic inflammation may be one potential mechanism underlying nociplastic pain phenotype. Systemic, low gra…

Dec 22, 2022 · 13 shares · 578 followers View post →
Tout pour ma santé
@ToutpourmaSante · X

RT @DerekGriffin86: Low grade systemic inflammation may be one potential mechanism underlying nociplastic pain phenotype. Systemic, low gra…

Dec 22, 2022 · 13 shares · 503 followers View post →
M
@MartinJuarez_Ft · X

RT @DerekGriffin86: Low grade systemic inflammation may be one potential mechanism underlying nociplastic pain phenotype. Systemic, low gra…

Dec 21, 2022 · 13 shares · 129 followers View post →
Daniel
@danielhemi4 · X

RT @DerekGriffin86: Low grade systemic inflammation may be one potential mechanism underlying nociplastic pain phenotype. Systemic, low gra…

Dec 21, 2022 · 13 shares · 7 followers View post →
jim verners
@jverners · X

RT @DerekGriffin86: Low grade systemic inflammation may be one potential mechanism underlying nociplastic pain phenotype. Systemic, low gra…

Dec 21, 2022 · 13 shares · 31 followers View post →
ɹǝʇlnoԀ pıʌɐᗡ
@Retlouping · X

RT @DerekGriffin86: Low grade systemic inflammation may be one potential mechanism underlying nociplastic pain phenotype. Systemic, low gra…

Dec 21, 2022 · 13 shares · 26,277 followers View post →
Peter O'Sullivan
@PeteOSullivanPT · X

RT @DerekGriffin86: Low grade systemic inflammation may be one potential mechanism underlying nociplastic pain phenotype. Systemic, low gra…

Dec 21, 2022 · 13 shares · 57,423 followers View post →
Derek Griffin
@DerekGriffin86 · X

Low grade systemic inflammation may be one potential mechanism underlying nociplastic pain phenotype. Systemic, low grade inflammation can sensitive nociceptors in the absence of overt tissue damage. https://t.co/7QV06UabyY

Dec 21, 2022 · 75 likes · 13 shares · 38,366 followers View post →
painPRO Education
@PainproE · X

RT @ChristophBurch: Does Low Grade Systemic Inflammation Have a Role in Chronic Pain? Wen Bo Sam Zhou et al. Front Mol Neurosci. https://t…

Dec 11, 2021 · 5 shares · 100 followers View post →
REMAP Therapeutics
@REMAPTherapy · X

RT @ChristophBurch: Does Low Grade Systemic Inflammation Have a Role in Chronic Pain? Wen Bo Sam Zhou et al. Front Mol Neurosci. https://t…

Dec 10, 2021 · 5 shares · 1,289 followers View post →
JoaquimLamora
@JoaquimLamora · X

RT @ChristophBurch: Does Low Grade Systemic Inflammation Have a Role in Chronic Pain? Wen Bo Sam Zhou et al. Front Mol Neurosci. https://t…

Dec 10, 2021 · 5 shares · 1,134 followers View post →
Kineblasto
@Kineblasto · X

RT @ChristophBurch: Does Low Grade Systemic Inflammation Have a Role in Chronic Pain? Wen Bo Sam Zhou et al. Front Mol Neurosci. https://t…

Dec 10, 2021 · 5 shares · 111 followers View post →
ACPSEMdance
@ACPSEMdance · X

RT @ChristophBurch: Does Low Grade Systemic Inflammation Have a Role in Chronic Pain? Wen Bo Sam Zhou et al. Front Mol Neurosci. https://t…

Dec 10, 2021 · 5 shares · 2,971 followers View post →
Christoph Burch
@ChristophBurch · X

Does Low Grade Systemic Inflammation Have a Role in Chronic Pain? Wen Bo Sam Zhou et al. Front Mol Neurosci. https://t.co/4aWAJj6CQi

Dec 10, 2021 · 23 likes · 5 shares · 15,324 followers View post →
Alan Edwards Centre for Research on Pain
@aecrpain · X

From our labs, Does Low Grade Systemic Inflammation Have a Role in Chronic Pain? https://t.co/AFZYoNJxbp #AECRPresearch @McGillDentistry @McGillMed

Dec 9, 2021 · 3 likes · 1,068 followers View post →
Chemokine P01
@ChemokineP01 · X

Does Low Grade Systemic Inflammation Have a Role in Chronic Pain? https://t.co/aVyT6nfB1w

Dec 3, 2021 · 18 followers View post →
Frontiers - Neuroscience
@FrontNeurosci · X

New Research: Does Low Grade Systemic Inflammation Have a Role in Chronic Pain?: One of the major clinical manifestations of peripheral neuropathy, either resulting from trauma or diseases, is chronic pain. While it significantly… https://t.co/iPvQX3HE6N #Molecular #Neuroscience

Nov 21, 2021 · 4 likes · 80,920 followers View post →