J Med Virol April 2022 PMID 34914115

Omicron and Delta variant of SARS-CoV-2: A comparative computational study of spike protein.

Suresh Kumar, Thiviya S Thambiraja, Kalimuthu Karuppanan, Gunasekaran Subramaniam

Mentions

65
Peak: 23 in Dec 2021
across 5 sources since Dec 2021

Extended reach

299,944
potential audience

Total likes

1,199

Video views

39,429

Mentions per month

Dec 2021 – Nov 2025

Where it's discussed

  • X / Twitter46 posts
  • Facebook11 posts
  • News4 articles
  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

Discussions demonstrate a focus on the mutation details and biological implications of Omicron versus Delta, with posts mentioning mutation sharing, ACE2 binding affinity, and membrane fusion. The tone varies from informational to speculative, emphasizing scientific curiosity but not overall urgent impact, indicating a community engaging with the scientific nuances but with limited perception of immediate high impact.

AgreementModerate agreement

Most discussions acknowledge the research, especially the computational findings on higher ACE2 affinity of Omicron and its distinct mutations, indicating general support or recognition of its relevance.

InterestHigh interest

Posts show high curiosity about Omicron's characteristics, its implications for the pandemic, and the mutation details, reflecting strong engagement with the topic.

EngagementModerate engagement

Several posts reference specific findings, such as mutation comparisons and effects on infectivity, suggesting some deep engagement with the article's scientific data.

ImpactModerate impact

While some discussions hint at the future implications, such as the potential for Omicron to signify the 'beginning of the end,' many focus on scientific details rather than immediate policy or health impacts.

Top posts

Most liked on X and Bluesky
Francis Villatoro
@emulenews · X

#bioRxiv Omicron and Delta Variant of SARS-CoV-2: A Comparative Computational Study of Spike protein https://t.co/Z2BNxKJbqz computational studies found that the Omicron variant had a higher affinity for human ACE2 than the Delta variant. https://t.co/HubGlrKgR9

Dec 5, 2021 · 13 likes · 6 shares · 45,127 followers View post →
bioRxiv
@biorxivpreprint · X

Omicron and Delta Variant of SARS-CoV-2: A Comparative Computational Study of Spike protein https://t.co/e3hIrK8W1L #bioRxiv

Dec 3, 2021 · 5 likes · 1 share · 137,985 followers View post →
Patrick Shaw Stewart
@PatrickSSte · X

A recent paper shows that Omicron Spike probably doesn’t fuse cells like eg Delta, which suggests that Spike no longer "flips"⬇️ https://t.co/EQL60fco8h https://t.co/2pHHOgSx3A

Jan 11, 2022 · 4 likes · 1 share · 2,115 followers View post →
suresh
@MsuSuresh · X

Our Publication covered in news media- #delta and #Omicron Of #SARSCoV2 comparison. https://t.co/omVihnH6mR https://t.co/l5hbKVBEvI

Feb 26, 2022 · 3 likes · 1 share · 158 followers View post →
Patrick Shaw Stewart
@PatrickSSte · X

@Daoyu15 @tony_vandongen @breakfast_dogs @dmoulding 1/ Morning everyone I'm confused about Omicron now I think it's clear that Om's a very different strain from previous variants because it doesn’t fuse membranes ⬇️ https://t.co/EQL60fco8h https://t.co/y1iVV00uQz

Jan 14, 2022 · 2 likes · 1 share · 2,115 followers View post →
Patrick Shaw Stewart
@PatrickSSte · X

@K_G_Andersen @macroliter @stuartjdneil Om spike is predicted to bind ACE2 with higher affinity than Delta https://t.co/EQL60fco8h However it doesn't appear to cause ANY cell-cell fusion⬇️ https://t.co/EQL60fco8h It seems possible that it no longer "flips" with all those disruptive mutations https://t.co/jgD0Oo0As9

Jan 11, 2022 · 2 likes · 2,115 followers View post →

All mentions

Scott Fournier
@scott4nier · X

@normanpie @ClareCraigPath What is your rebuttal to the evidence presented in the the Kumar et al. study? "Omicron and Delta variant of SARS-CoV-2: A comparative computational study of spike protein"

May 4, 2025 · 519 followers View post →
suresh
@MsuSuresh · X

First to report- Omicron variant is less harmful to the lower respiratory tract (2/2) Publication link: https://t.co/NDiiXiKnaO @MSUmalaysia @MSUmalaysiaFHLS @researchMSU

Dec 1, 2023 · 158 followers View post →
suresh
@MsuSuresh · X

Achievements of our group (2022-2023) (1/1) 1. First to report: Omicron Variant will have higher transmission: Received Highest citation, Highly Read and Highly Downloaded article certificate. Publication: https://t.co/NDiiXiKnaO @MSUmalaysia @MSUmalaysiaFHLS @researchMSU https://t.co/QwK7vwPI40

Dec 1, 2023 · 158 followers View post →
suresh
@MsuSuresh · X

I am glad that our work published in 2021 in Journal of Medical Virology received certificate of appreciation from Journal for top cited, top downloaded and most read in 2022. #SARSCoV2 #COVID19 #Bioinformatics #omicron https://t.co/Hs50pW5l71

May 9, 2023 · 158 followers View post →
Armand du Plessis
@Armandd59974822 · X

@djkom1978 En ce qui concerne le variant omicron, il se distingue en particulier par des mutations de la protéine spike, par rapport à d'autres variants notables tels que le delta: https://t.co/LYD2Pkh5fM

Oct 13, 2022 · 1 like · 31 followers View post →
riddick
@riddickghost13 · X

@alexandrosM https://t.co/KevI6yegQm

Aug 30, 2022 · 547 followers View post →
M
@0xcd16 · X

@hjelle_brian NB Omicron shared 3 out of Delta's 10 Spike mutations (colored red by me). Are we ever going to see another variant without D614G? At what point do we update the boosters from Wuhan-Hu-1 - and to what? (I have no idea!) https://t.co/fR96QX7a36 https://t.co/71FrGmXBHy

Apr 1, 2022 · 1 like · 517 followers View post →
Andromaque@1984
@Andromaque19841 · X

Ce serait pas à cause de ça ??? https://t.co/qUZYBp9qot

Mar 30, 2022 · 2,275 followers View post →
Daniel Kerlinsky MD
@DrDan20000 · X

Omicron and Delta variant of SARS‐CoV‐2: A comparative computational study of spike protein - Kumar - 2022 - Journal of Medical Virology - Wiley Online Library https://t.co/5dHyZlmTP6

Mar 22, 2022 · 7,301 followers View post →
suresh
@MsuSuresh · X

Our Publication covered in news media- #delta and #Omicron Of #SARSCoV2 comparison. https://t.co/omVihnH6mR https://t.co/l5hbKVBEvI

Feb 26, 2022 · 3 likes · 1 share · 158 followers View post →
n_ataie
@n_ataie · X

RT @n_ataie: There are a large number of mutational differences between Delta/original Covid and Omicron. This needed an explanation. The v…

Feb 6, 2022 · 1 share · 90 followers View post →
Mariola Zwolak
@ZwolakMariola · X

https://t.co/oDTFbKAYeD

Jan 30, 2022 · 1 followers View post →
n_ataie
@n_ataie · X

There are a large number of mutational differences between Delta/original Covid and Omicron. This needed an explanation. The virus was evolving at a certain rate, then suddenly we see an acceleration, what can account for this? https://t.co/O0GF3iFqR7 https://t.co/0LkVkcB3Q9

Jan 30, 2022 · 1 share · 90 followers View post →
Ananda
@Ananda10149510 · X

RT @PatrickSSte: @Daoyu15 @tony_vandongen @breakfast_dogs @dmoulding 1/ Morning everyone I'm confused about Omicron now I think it's clea…

Jan 14, 2022 · 1 share · 476 followers View post →
Patrick Shaw Stewart
@PatrickSSte · X

@Daoyu15 @tony_vandongen @breakfast_dogs @dmoulding 1/ Morning everyone I'm confused about Omicron now I think it's clear that Om's a very different strain from previous variants because it doesn’t fuse membranes ⬇️ https://t.co/EQL60fco8h https://t.co/y1iVV00uQz

Jan 14, 2022 · 2 likes · 1 share · 2,115 followers View post →
四谷言ノ助
@g_yotuya · X

@nukomarun 翻訳して読んでいただければ。 かなり違います。 https://t.co/ZcuCeWIiAT

Jan 13, 2022 · 4,170 followers View post →
j christian
@jchrist57239072 · X

RT @PatrickSSte: A recent paper shows that Omicron Spike probably doesn’t fuse cells like eg Delta, which suggests that Spike no longer "fl…

Jan 12, 2022 · 1 share · 1,022 followers View post →
Patrick Shaw Stewart
@PatrickSSte · X

A recent paper shows that Omicron Spike probably doesn’t fuse cells like eg Delta, which suggests that Spike no longer "flips"⬇️ https://t.co/EQL60fco8h https://t.co/2pHHOgSx3A

Jan 11, 2022 · 4 likes · 1 share · 2,115 followers View post →
Patrick Shaw Stewart
@PatrickSSte · X

@K_G_Andersen @macroliter @stuartjdneil Om spike is predicted to bind ACE2 with higher affinity than Delta https://t.co/EQL60fco8h However it doesn't appear to cause ANY cell-cell fusion⬇️ https://t.co/EQL60fco8h It seems possible that it no longer "flips" with all those disruptive mutations https://t.co/jgD0Oo0As9

Jan 11, 2022 · 2 likes · 2,115 followers View post →
四谷言ノ助
@g_yotuya · X

@disco_v8 ああ、あった https://t.co/ZcuCeWIiAT

Jan 10, 2022 · 1 like · 4,170 followers View post →
News Diversifier
@NewsDiversifier · X

Hey @MikeParrot87: url | source | doi 1) https://t.co/uhLVN2rUCr | Medline | 10.1038/s41467-021-27369-3 2) https://t.co/j3u7jyd0GN | Medline | 10.1002/jmv.27526

Jan 8, 2022 · 4 followers View post →
En la Puerta de Urgencias
@p_de_urgencias · X

¿Es ómicron el principio del fin de la pandemia? #OmicronVarient #pandemia #coronavirus https://t.co/v3CcckNSP5

Jan 7, 2022 · 348 followers View post →
OmicronVariant
@OmicronDaily · X

Omicron and Delta Variant of SARS‐CoV‐2: A Comparative Computational Study of Spike Protein https://t.co/1Ta0CmhmEy #Omicron #OmicronVariant #b11529

Dec 17, 2021 · 13 followers View post →
Phage Papers
@Phage_Papers · X

Omicron and Delta Variant of SARS-CoV-2: A Comparative Computational Study of Spike Protein https://t.co/rUs8NjFm4L

Dec 16, 2021 · 644 followers View post →
Apolinar Picado Jr.
@ilsvezio · X

Omicron and Delta Variant of SARS-CoV-2: A Comparative Computational Study of Spike protein https://t.co/ccT4xuyWpX

Dec 6, 2021 · 68 followers View post →
Dr Elizabeth Annabel O'Donnell PhD CPsychol
@AnnabelDonnell · X

Omicron and Delta Variant of SARS-CoV-2: A Comparative Computational Study of Spike protein https://t.co/4TuB9oeYLZ

Dec 6, 2021 · 329 followers View post →
Isatou Sarr
@IsatouSarr4 · X

Omicron and Delta Variant of SARS-CoV-2: A Comparative Computational Study of Spike protein https://t.co/KApt4xNZQj

Dec 6, 2021 · 1 like · 45 followers View post →
MASALUD Laboratorio Clínico
@masalud1 · X

RT @emulenews: #bioRxiv Omicron and Delta Variant of SARS-CoV-2: A Comparative Computational Study of Spike protein https://t.co/Z2BNxKJbqz…

Dec 5, 2021 · 6 shares · 363 followers View post →
Enrique Viguera
@EnriqueViguera · X

RT @emulenews: #bioRxiv Omicron and Delta Variant of SARS-CoV-2: A Comparative Computational Study of Spike protein https://t.co/Z2BNxKJbqz…

Dec 5, 2021 · 6 shares · 3,280 followers View post →
Angel Galan Galan
@AngelGalanGalan · X

RT @emulenews: #bioRxiv Omicron and Delta Variant of SARS-CoV-2: A Comparative Computational Study of Spike protein https://t.co/Z2BNxKJbqz…

Dec 5, 2021 · 6 shares · 452 followers View post →
Nisus Medical
@nisusmedical · X

RT @emulenews: #bioRxiv Omicron and Delta Variant of SARS-CoV-2: A Comparative Computational Study of Spike protein https://t.co/Z2BNxKJbqz…

Dec 5, 2021 · 6 shares · 1,203 followers View post →
Jaime Díez
@astrofotografia · X

RT @emulenews: #bioRxiv Omicron and Delta Variant of SARS-CoV-2: A Comparative Computational Study of Spike protein https://t.co/Z2BNxKJbqz…

Dec 5, 2021 · 6 shares · 12,810 followers View post →
Francis Villatoro
@emulenews · X

#bioRxiv Omicron and Delta Variant of SARS-CoV-2: A Comparative Computational Study of Spike protein https://t.co/Z2BNxKJbqz computational studies found that the Omicron variant had a higher affinity for human ACE2 than the Delta variant. https://t.co/HubGlrKgR9

Dec 5, 2021 · 13 likes · 6 shares · 45,127 followers View post →
PromisingPreprints
@PromPreprint · X

Omicron and Delta Variant of SARS-CoV-2: A Comparative Computational Study of Spike protein https://t.co/oSJBXVBMvL

Dec 5, 2021 · 3,302 followers View post →
K.S. Chew
@cksheng74 · X

Omicron and Delta Variant of SARS-CoV-2: A Comparative Computational Study of Spike protein https://t.co/VYlanljD6y

Dec 5, 2021 · 346 followers View post →
troy
@_tjganz_ · X

RT @biorxivpreprint: Omicron and Delta Variant of SARS-CoV-2: A Comparative Computational Study of Spike protein https://t.co/e3hIrK8W1L #…

Dec 4, 2021 · 1 share · 26 followers View post →
HelmaHase
@HaseHelma · X

Omicron and Delta Variant of SARS-CoV-2: A Comparative Computational Study of Spike protein https://t.co/ORwvxCsiAm

Dec 4, 2021 View post →
Sushil Pokhrel
@sushilpokhrel · X

Omicron and Delta Variant of SARS-CoV-2: A Comparative Computational Study of Spike protein https://t.co/Fq5z3XvQzT

Dec 4, 2021 · 1 like · 2,682 followers View post →
Zohra Bulgari
@BulgariZohra · X

Omicron and Delta Variant of SARS-CoV-2: A Comparative Computational Study of Spike protein https://t.co/KSjANEbv5z Рецептор-связывающий домен Omicron с его 15 мутациями по сравнению с 2-мя мутациями Delta, и, согласно прогнозам, это приводит к более высокому связыванию/

Dec 4, 2021 · 150 followers View post →
Gris
@degogrim · X

Omicron and Delta Variant of SARS-CoV-2: A Comparative Computational Study of Spike protein | bioRxiv https://t.co/LBeIHs8XLX

Dec 4, 2021 · 59 followers View post →
Enrico K.
@vt27kolt11 · X

Omicron and Delta Variant of SARS-CoV-2: A Comparative Computational Study of Spike protein https://t.co/ICWWFR5i2c

Dec 4, 2021 · 1,597 followers View post →
Helio Rocha
@_elioRocha · X

#bioRxiv Omicron and Delta Variant of SARS-CoV-2: A Comparative Computational Study of Spike protein #bioinfo https://t.co/cMRJcMUNNr

Dec 4, 2021 · 608 followers View post →
giovanni dall'olio
@giovannidalloli · X

Omicron and Delta Variant of SARS-CoV-2: A Comparative Computational Study of Spike protein https://t.co/I6lytgQbdC"

Dec 3, 2021 · 2,315 followers View post →
bioRxiv Bioinfo
@biorxiv_bioinfo · X

Omicron and Delta Variant of SARS-CoV-2: A Comparative Computational Study of Spike protein https://t.co/gLt3xP051z #biorxiv_bioinfo

Dec 3, 2021 · 1 like · 18,314 followers View post →
bioRxiv
@biorxivpreprint · X

Omicron and Delta Variant of SARS-CoV-2: A Comparative Computational Study of Spike protein https://t.co/e3hIrK8W1L #bioRxiv

Dec 3, 2021 · 5 likes · 1 share · 137,985 followers View post →
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