Nat Rev Neurosci March 2022 PMID 35027710

Forgetting as a form of adaptive engram cell plasticity.

Tomás J Ryan, Paul W Frankland

Mentions

138
Peak: 35 in Jan 2022
across 6 sources since Jan 2022

Extended reach

1,266,209
potential audience

Total likes

275

Video views

2,037

Mentions per month

Jan 2022 – Nov 2024

Where it's discussed

  • X / Twitter58 posts
  • News56 articles
  • Facebook10 posts
  • Blogs9 articles
  • YouTube3 videos
  • Reddit2 posts

AI synopsis

What people are saying

The overall tone suggests a collective appreciation for the innovative view that forgetting may serve a beneficial purpose, with mentions of environmental modulation and neural remodeling, alongside questions about implications for diseases like Alzheimer’s. Words like 'amazing,' 'cool,' and references to research examples reflect a tone of curiosity and scholarly interest, supporting the perception of moderate agreement and engagement with notable potential impact.

AgreementModerate agreement

Most discussions appear to support the idea that forgetting is a purposeful, adaptive process, with several posts highlighting its potential benefits for brain plasticity and learning.

InterestModerate interest

Posts indicate a moderate level of interest, especially with comments like 'good read' and references to the 'coolest topic in neuroscience,' showing curiosity but not extreme fascination.

EngagementModerate engagement

Comments show some depth with individuals referencing specific researchers, studies, and posing questions about how forgetting functions in various conditions like dementia, demonstrating active engagement.

ImpactModerate impact

There is a recognition that this conceptual shift could influence understanding of memory and neurological health, suggesting a notion of meaningful impact within neuroscience discussions.

Abstract in brief

  • Forgetting is viewed as a form of brain plasticity that involves changing the accessibility of engram cells, which are neuron groups that store memories, making them harder or easier to reactivate.
  • The process of forgetting differs based on mechanisms, duration, and reversibility, but it generally involves remodeling neural circuits to switch engram cells from an accessible to an inaccessible state.
  • Environmental factors and disease states can influence forgetting by altering engram cell accessibility, with diseases potentially hijacking natural forgetting mechanisms to cause memory loss.]

Top posts

Most liked on X and Bluesky
Nature Rev Neurosci
@NatRevNeurosci · X

Forgetting as a form of adaptive engram cell plasticity – a new Perspective by Tomás Ryan and Paul Frankland @TJRyan_77 and @Franklandlab https://t.co/Vf1yccQnMA https://t.co/fpz8qXl8ui

Jan 13, 2022 · 114 likes · 17 shares · 78,635 followers View post →
Nature Rev Neurosci
@NatRevNeurosci · X

Forgetting as a form of adaptive engram cell plasticity – a new Perspective by Tomás Ryan and Paul Frankland @TJRyan_77 and @Franklandlab https://t.co/Vf1yccQnMA https://t.co/9tJK44uIiE

Jan 18, 2022 · 38 likes · 8 shares · 78,635 followers View post →
Brian Roemmele
@BrianRoemmele · X

The research is in: you never really “forget” a memory. “Forgetting as a form of adaptive engram cell plasticity”—Nature Reviews Neuroscience https://t.co/6SWDZUhGE4

Feb 8, 2022 · 29 likes · 8 shares · 390,605 followers View post →
Fatema Nakhuda
@fnakhuda28 · X

Had an amazing opportunity to give a talk to super cool undergrads on arguably the coolest topic in neuroscience- “engrams”! Slide is from @Franklandlab’s and @TJRyan_77’s 2022 review on forgetting as a form of adaptive engram cell plasticity. https://t.co/2jM46611ki

Oct 18, 2023 · 13 likes · 2 shares · 100 followers View post →
Neuroscience News
@NeuroscienceNew · X

“Forgetting as a form of adaptive engram cell plasticity” by Tomás Ryan et al. Nature Reviews Neuroscience https://t.co/QmJVtLu8bh

Jan 13, 2022 · 12 likes · 7 shares · 505,374 followers View post →
Alessandro Crimi
@Dr_Alex_Crimi · X

Is 'forgetting' actually a form of #learning? Even in case of #dementia and #alzheimer? "Forgetting as a form of adaptive engram cell plasticity" from @NatureNeuro review #memory #neuroscience #network https://t.co/35MtqooxKI

Jan 15, 2022 · 11 likes · 2 shares · 7,742 followers View post →

All mentions

Ewa Zarnowska
@ewadorotaz · X

RT @NatRevNeurosci: Forgetting as a form of adaptive engram cell plasticity – a new Perspective by Tomás Ryan and Paul Frankland @TJRyan_…

Nov 6, 2024 · 8 shares · 1,988 followers View post →
Jibran Khokhar
@DrJKhokhar · X

RT @NatRevNeurosci: Forgetting as a form of adaptive engram cell plasticity – a new Perspective by Tomás Ryan and Paul Frankland @TJRyan_…

Nov 6, 2024 · 8 shares · 10,771 followers View post →
Ryan Lab
@RyanLabTCD · X

RT @NatRevNeurosci: Forgetting as a form of adaptive engram cell plasticity – a new Perspective by Tomás Ryan and Paul Frankland @TJRyan_…

Nov 6, 2024 · 8 shares · 780 followers View post →
m e l l a m p h y️
@youtopos · X

RT @BrianRoemmele: The research is in: you never really “forget” a memory. “Forgetting as a form of adaptive engram cell plasticity”—Natur…

Jul 18, 2024 · 8 shares · 1,793 followers View post →
ISNR
@ISNRORG · X

Tomás J. Ryan, Paul W. Frankland. Forgetting as a form of adaptive engram cell plasticity. Nature Reviews Neuroscience, 2022; DOI: 10.1038/s41583-021-00548-3

Feb 23, 2024 · 2 likes · 1,363 followers View post →
AGSBS
@yorkuagsbs · X

RT @fnakhuda28: Had an amazing opportunity to give a talk to super cool undergrads on arguably the coolest topic in neuroscience- “engrams”…

Oct 22, 2023 · 2 shares · 106 followers View post →
Georg R. Zoidl
@RZoidl · X

RT @fnakhuda28: Had an amazing opportunity to give a talk to super cool undergrads on arguably the coolest topic in neuroscience- “engrams”…

Oct 18, 2023 · 2 shares · 409 followers View post →
Fatema Nakhuda
@fnakhuda28 · X

Had an amazing opportunity to give a talk to super cool undergrads on arguably the coolest topic in neuroscience- “engrams”! Slide is from @Franklandlab’s and @TJRyan_77’s 2022 review on forgetting as a form of adaptive engram cell plasticity. https://t.co/2jM46611ki

Oct 18, 2023 · 13 likes · 2 shares · 100 followers View post →
Shaista Jabeen
@shaista1286imb · X

RT @NatRevNeurosci: Forgetting as a form of adaptive engram cell plasticity – a new Perspective by Tomás Ryan and Paul Frankland @TJRyan_…

Sep 29, 2023 · 17 shares · 245 followers View post →
pattishank
@pattishank · X

RT @NatRevNeurosci: Forgetting as a form of adaptive engram cell plasticity – a new Perspective by Tomás Ryan and Paul Frankland @TJRyan_…

Jul 13, 2022 · 8 shares · 9,745 followers View post →
m e l l a m p h y️
@youtopos · X

RT @NeuroscienceNew: “Forgetting as a form of adaptive engram cell plasticity” by Tomás Ryan et al. Nature Reviews Neuroscience https://t.…

Apr 20, 2022 · 7 shares · 1,793 followers View post →
m e l l a m p h y️
@youtopos · X

RT @BrianRoemmele: The research is in: you never really “forget” a memory. “Forgetting as a form of adaptive engram cell plasticity”—Natur…

Apr 20, 2022 · 8 shares · 1,793 followers View post →
Pavel_Prosselkov
@PavelProsselkov · X

"...forgetting rates are modulated by environmental conditions" PP: some freshly published nonsense from the "engram" fairytale https://t.co/adHQ0E37rD

Feb 23, 2022 · 3,806 followers View post →
KRG
@kevrgallant · X

RT @BrianRoemmele: The research is in: you never really “forget” a memory. “Forgetting as a form of adaptive engram cell plasticity”—Natur…

Feb 9, 2022 · 8 shares · 257 followers View post →
ChattyKathy
@stonksrus · X

RT @BrianRoemmele: The research is in: you never really “forget” a memory. “Forgetting as a form of adaptive engram cell plasticity”—Natur…

Feb 8, 2022 · 8 shares · 1,227 followers View post →
Darren Davies
@darrendotcom · X

RT @BrianRoemmele: The research is in: you never really “forget” a memory. “Forgetting as a form of adaptive engram cell plasticity”—Natur…

Feb 8, 2022 · 8 shares · 236 followers View post →
Shiva, Head of Political Manipulation
@TraderDXB · X

RT @BrianRoemmele: The research is in: you never really “forget” a memory. “Forgetting as a form of adaptive engram cell plasticity”—Natur…

Feb 8, 2022 · 8 shares · 4,716 followers View post →
俺の観賞
@oregakitaworld · X

RT @BrianRoemmele: The research is in: you never really “forget” a memory. “Forgetting as a form of adaptive engram cell plasticity”—Natur…

Feb 8, 2022 · 8 shares · 450 followers View post →
Mr.
@ImundiRL · X

RT @BrianRoemmele: The research is in: you never really “forget” a memory. “Forgetting as a form of adaptive engram cell plasticity”—Natur…

Feb 8, 2022 · 8 shares · 1,211 followers View post →
Brian Roemmele
@BrianRoemmele · X

The research is in: you never really “forget” a memory. “Forgetting as a form of adaptive engram cell plasticity”—Nature Reviews Neuroscience https://t.co/6SWDZUhGE4

Feb 8, 2022 · 29 likes · 8 shares · 390,605 followers View post →
Wafik S. El-Deiry, MD, PhD, FACP
@weldeiry · X

Forgetting as a form of adaptive engram cell plasticity | Nature Reviews Neuroscience https://t.co/jUOJ0Tw5h4

Feb 6, 2022 · 1 like · 18,133 followers View post →
Jaume
@santacanajaume · X

Forgetting as a form of adaptive engram cell plasticity | Nature Reviews Neurosciencem https://t.co/CUxoE9A46d

Feb 6, 2022 · 124 followers View post →
Paulo F.
@PFinuras · X

Good read "Human forgetfulness is a feature, not a bug" Forgetting as a form of adaptive engram cell plasticity https://t.co/KBpAp7CFWj

Feb 2, 2022 · 866 followers View post →
Paulo F.
@PFinuras · X

Ryan, T.J., Frankland, P.W. Forgetting as a form of adaptive engram cell plasticity. Nat Rev Neurosci (2022). https://t.co/InWDcjCQoO

Jan 22, 2022 · 866 followers View post →
John White
@JohnJohnwhite54 · X

RT @VentureNGSS: Feeling forgetful? A new theory says your brain is adapting to its environment. “Forgetting as a form of adaptive engram c…

Jan 21, 2022 · 1 share · 6 followers View post →
Venture
@VentureNGSS · X

Feeling forgetful? A new theory says your brain is adapting to its environment. “Forgetting as a form of adaptive engram cell plasticity” #ngss #middleschoolscience #scienceteachers #memory #sciencenews #science #plasticity #neuroscience https://t.co/yH6ET1NLRx

Jan 20, 2022 · 1 like · 1 share · 27 followers View post →
Dr. Sanjee Perera
@SanjeePerera1 · X

RT @Dr_Alex_Crimi: Is 'forgetting' actually a form of #learning? Even in case of #dementia and #alzheimer? "Forgetting as a form of adaptiv…

Jan 20, 2022 · 2 shares · 4,384 followers View post →
Feng-Quan Zhou
@FengQuanZhou1 · X

RT @NatRevNeurosci: Forgetting as a form of adaptive engram cell plasticity – a new Perspective by Tomás Ryan and Paul Frankland @TJRyan_…

Jan 18, 2022 · 8 shares · 50 followers View post →
Andy Xor
@andy_xor · X

RT @NatRevNeurosci: Forgetting as a form of adaptive engram cell plasticity – a new Perspective by Tomás Ryan and Paul Frankland @TJRyan_…

Jan 18, 2022 · 8 shares · 1,435 followers View post →
Nature Rev Neurosci
@NatRevNeurosci · X

Forgetting as a form of adaptive engram cell plasticity – a new Perspective by Tomás Ryan and Paul Frankland @TJRyan_77 and @Franklandlab https://t.co/Vf1yccQnMA https://t.co/9tJK44uIiE

Jan 18, 2022 · 38 likes · 8 shares · 78,635 followers View post →
Researching the Brain
@Brain_Database · X

Forgetting as a form of adaptive engram cell plasticity https://t.co/6lQqISv57M

Jan 16, 2022 · 1,037 followers View post →
STIGMABASE
@stigmabase · X

TW : Forgetting as a form of adaptive engram cell plasticity: ...presymptomatic autosomal dominant Alzheimer’s disease: a cross-sectional study. Lancet Neurol. 17, 123–132 (2018).PubMed... https://t.co/V49fnM2ZEy https://t.co/VvnRth17tk

Jan 15, 2022 · 1,120 followers View post →
Alessandro Crimi
@Dr_Alex_Crimi · X

Is 'forgetting' actually a form of #learning? Even in case of #dementia and #alzheimer? "Forgetting as a form of adaptive engram cell plasticity" from @NatureNeuro review #memory #neuroscience #network https://t.co/35MtqooxKI

Jan 15, 2022 · 11 likes · 2 shares · 7,742 followers View post →
Jagan Mohan R., MD
@qctr · X

Why do we forget? New #theory proposes ‘#forgetting’ is actually a form of #learning https://t.co/Lg5z6ufsxq From: Forgetting as a form of adaptive engram cell plasticity https://t.co/4VLekN9EyE

Jan 15, 2022 · 1 like · 147 followers View post →
Garima
@Garima15744161 · X

RT @NatRevNeurosci: Forgetting as a form of adaptive engram cell plasticity – a new Perspective by Tomás Ryan and Paul Frankland @TJRyan_…

Jan 14, 2022 · 17 shares · 6 followers View post →
H2020MESCoBraD
@MESCoBraD · X

RT @NatRevNeurosci: Forgetting as a form of adaptive engram cell plasticity – a new Perspective by Tomás Ryan and Paul Frankland @TJRyan_…

Jan 14, 2022 · 17 shares · 122 followers View post →
luca Leli.
@adamoprogresso · X

RT @adamoprogresso: Forgetting as a form of adaptive engram cell plasticity | Nature Reviews Neuroscience https://t.co/4bWlJB5o1B

Jan 14, 2022 · 1 share · 3,245 followers View post →
Ismaeel Bin-Jaliah إسماعيل بن جالية
@isbinjaliah · X

RT @NeuroscienceNew: “Forgetting as a form of adaptive engram cell plasticity” by Tomás Ryan et al. Nature Reviews Neuroscience https://t.…

Jan 13, 2022 · 7 shares · 715 followers View post →
SID
@sickafsid · X

RT @NatRevNeurosci: Forgetting as a form of adaptive engram cell plasticity – a new Perspective by Tomás Ryan and Paul Frankland @TJRyan_…

Jan 13, 2022 · 17 shares · 766 followers View post →
NaO
@spikeoutOXY · X

RT @NeuroscienceNew: “Forgetting as a form of adaptive engram cell plasticity” by Tomás Ryan et al. Nature Reviews Neuroscience https://t.…

Jan 13, 2022 · 7 shares · 153 followers View post →
notoriousknj
@notoriousknj · X

RT @NeuroscienceNew: “Forgetting as a form of adaptive engram cell plasticity” by Tomás Ryan et al. Nature Reviews Neuroscience https://t.…

Jan 13, 2022 · 7 shares · 565 followers View post →
Brian Dean
@bdean_ · X

RT @NatRevNeurosci: Forgetting as a form of adaptive engram cell plasticity – a new Perspective by Tomás Ryan and Paul Frankland @TJRyan_…

Jan 13, 2022 · 17 shares · 563 followers View post →
Yoana
@YoanaEstradaR · X

RT @NeuroscienceNew: “Forgetting as a form of adaptive engram cell plasticity” by Tomás Ryan et al. Nature Reviews Neuroscience https://t.…

Jan 13, 2022 · 7 shares · 78 followers View post →
Ariakas Enoreth
@Aenoreth · X

RT @NatRevNeurosci: Forgetting as a form of adaptive engram cell plasticity – a new Perspective by Tomás Ryan and Paul Frankland @TJRyan_…

Jan 13, 2022 · 17 shares · 1,008 followers View post →
Neuroscience News
@NeuroscienceNew · X

“Forgetting as a form of adaptive engram cell plasticity” by Tomás Ryan et al. Nature Reviews Neuroscience https://t.co/QmJVtLu8bh

Jan 13, 2022 · 12 likes · 7 shares · 505,374 followers View post →
Pete Skomoroch
@peteskomoroch · X

RT @NatRevNeurosci: Forgetting as a form of adaptive engram cell plasticity – a new Perspective by Tomás Ryan and Paul Frankland @TJRyan_…

Jan 13, 2022 · 17 shares · 51,291 followers View post →
Jamie Hanson (@jamielarsh.bsky.social)
@JamieLarsH · X

RT @NatRevNeurosci: Forgetting as a form of adaptive engram cell plasticity – a new Perspective by Tomás Ryan and Paul Frankland @TJRyan_…

Jan 13, 2022 · 17 shares · 9,661 followers View post →
luca Leli.
@adamoprogresso · X

Forgetting as a form of adaptive engram cell plasticity | Nature Reviews Neuroscience https://t.co/4bWlJB5o1B

Jan 13, 2022 · 1 like · 1 share · 3,245 followers View post →
Billy Peshev
@BilPeshev · X

Forgetting as a form of adaptive engram cell plasticity | Nature Reviews Neuroscience https://t.co/yeRS55mAwL

Jan 13, 2022 · 1 like · 109 followers View post →
Burgalossi Lab
@ABurgalossi · X

RT @NatRevNeurosci: Forgetting as a form of adaptive engram cell plasticity – a new Perspective by Tomás Ryan and Paul Frankland @TJRyan_…

Jan 13, 2022 · 17 shares · 1,153 followers View post →
Tomás Ryan
@TJRyan_77 · X

RT @NatRevNeurosci: Forgetting as a form of adaptive engram cell plasticity – a new Perspective by Tomás Ryan and Paul Frankland @TJRyan_…

Jan 13, 2022 · 17 shares · 13,452 followers View post →
Magis
@tilltheendmagis · X

RT @NatRevNeurosci: Forgetting as a form of adaptive engram cell plasticity – a new Perspective by Tomás Ryan and Paul Frankland @TJRyan_…

Jan 13, 2022 · 17 shares · 8 followers View post →
.
@LITFmag · X

RT @NatRevNeurosci: Forgetting as a form of adaptive engram cell plasticity – a new Perspective by Tomás Ryan and Paul Frankland @TJRyan_…

Jan 13, 2022 · 17 shares · 1,255 followers View post →
Laura Andreae
@L_andreae · X

RT @NatRevNeurosci: Forgetting as a form of adaptive engram cell plasticity – a new Perspective by Tomás Ryan and Paul Frankland @TJRyan_…

Jan 13, 2022 · 17 shares · 1,866 followers View post →
Tanmay Rastogi 
@TanmayRastogi07 · X

RT @NatRevNeurosci: Forgetting as a form of adaptive engram cell plasticity – a new Perspective by Tomás Ryan and Paul Frankland @TJRyan_…

Jan 13, 2022 · 17 shares · 148 followers View post →
Kevin Mitchell
@WiringTheBrain · X

RT @NatRevNeurosci: Forgetting as a form of adaptive engram cell plasticity – a new Perspective by Tomás Ryan and Paul Frankland @TJRyan_…

Jan 13, 2022 · 17 shares · 40,168 followers View post →
Nature Rev Neurosci
@NatRevNeurosci · X

Forgetting as a form of adaptive engram cell plasticity – a new Perspective by Tomás Ryan and Paul Frankland @TJRyan_77 and @Franklandlab https://t.co/Vf1yccQnMA https://t.co/fpz8qXl8ui

Jan 13, 2022 · 114 likes · 17 shares · 78,635 followers View post →
Bertoglio lab (FMC/UFSC)
@bertogliolab · X

Forgetting as a form of adaptive engram cell plasticity https://t.co/remvPPtZTN

Jan 13, 2022 · 7 likes · 2 shares · 1,705 followers View post →