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J Am Geriatr Soc April 2022 PMID 35029305

Effect of antipsychotics on mortality risk in patients with dementia with and without comorbidities.

Ane Nørgaard, Christina Jensen-Dahm, Theresa Wimberley, Jesper Hastrup Svendsen, Kazi Ishtiak-Ahmed, Thomas Munk Laursen, Gunhild Waldemar, Christiane Gasse

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Mentions

51
Peak: 36 in Jan 2022
across 3 sources since Jan 2022

Extended reach

148,222
potential audience

Total likes

85

Video views

12

Mentions per month

Jan 2022 – Mar 2025

Where it's discussed

  • X / Twitter44 posts
  • News4 articles
  • YouTube3 videos

AI synopsis

What people are saying

The evaluations convey strong agreement on the mortality risks of antipsychotics, supported by phrases like '35% increased risk,' and emphasize the relevance of understanding these findings for clinical care, with tone and word choices reflecting concern and seriousness. Words like 'highest mortality' and 'consider' suggest an emphasis on cautious prescription and heightened awareness of the study's significance.

AgreementModerate agreement

Most discussions agree that antipsychotics are associated with increased mortality in dementia patients, emphasizing the stated 35% risk increase.

InterestHigh interest

Posts express high interest, with several referencing specific data, implications for patient care, and highlighting the importance of understanding medication risks.

EngagementModerate engagement

The discussions show moderate engagement, with some participants referencing additional studies, professional guidelines, and emphasizing the need for careful decision-making.

ImpactModerate impact

The consensus indicates that these discussions could influence clinical practice and policy, reflecting moderate perceived impact on patient management decisions.

Abstract in brief

  • The study examined how starting antipsychotic medications affects the risk of death in dementia patients, especially considering whether those with heart disease or diabetes are at greater risk.
  • Using nationwide Danish registry data, researchers matched dementia patients who started antipsychotics with similar patients who did not, and found that those on antipsychotics had a 35% higher risk of death within 180 days.
  • While patients with heart disease or diabetes showed higher mortality rates, the increased risk from antipsychotic use was similar regardless of these comorbidities, indicating no additional interaction between medication and the underlying health conditions.
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Top posts

Most liked on X and Bluesky
JAGS
@AGSJournal · X

Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients with dementia and comorbidites of heart disease and diabetes treated with antipsychotics. #geriatrics https://t.co/AjB6dMP0MO https://t.co/T24tIIPyf8

Jan 27, 2022 · 58 likes · 37 shares · 11,214 followers View post →
森川 暢 /Toru Morikawa Community Hospitalist @ Nara
@aquariusmed · X

#ジャーナル 高齢認知症患者への抗精神病薬の投与は死亡率を悪化。糖尿病や心疾患の有無に関係なく、抗精神病薬は死亡リスクを悪化させる。 https://t.co/t4p0UHwDG0

Jan 16, 2022 · 13 likes · 2 shares · 4,621 followers View post →
Oscar Macho
@osmachope · X

Effect of antipsychotics on mortality risk in patients with dementia with and without comorbidities https://t.co/MREBbvIiT3

Jan 31, 2022 · 7 likes · 4 shares · 3,039 followers View post →
Montefiore Geriatrics
@MontefioreGeri · X

Another reminder to consider goals of care and risks vs benefits prior to initiating #antipsychotics in those with #dementia. "Effect of antipsychotics on mortality risk in patients with dementia with and without comorbidities" https://t.co/gaJxYwEWSn

Jan 20, 2022 · 3 likes · 288 followers View post →
Lauren C.
@Lau_Cob_ · X

@sulmoney @ReadReadj “Exposure to antipsychotics was associated with an overall 35% increased risk of death after adjusting for potentially confounding factors.” https://t.co/GiaRfkrSra.

Apr 14, 2024 · 2 likes · 2,562 followers View post →
Walid Alkeridy وليد الكريدي
@WalidAlkeridy · X

Effect of antipsychotics on mortality risk in patients with dementia with and without comorbidities - Nørgaard - - Journal of the American Geriatrics Society - Wiley Online Library https://t.co/HARjorRO3Y

Jan 21, 2022 · 1 like · 1,294 followers View post →

All mentions

Lauren C.
@Lau_Cob_ · X

@sulmoney @ReadReadj “Exposure to antipsychotics was associated with an overall 35% increased risk of death after adjusting for potentially confounding factors.” https://t.co/GiaRfkrSra.

Apr 14, 2024 · 2 likes · 2,562 followers View post →
Rosiel Elwyn
@fairysatellite · X

#Antipsychotics = high mortality risk in #dementia patients with & w/out comorbidities “35% inc risk of death compared with no use. Rel risk did not differ with & w/out heart disease, cerebrovascular disease, diabetes… no positive additive interaction” https://t.co/ieLR96m3tb

Feb 9, 2022 · 1 like · 1,225 followers View post →
Gabriela Barrios MD
@gabybarriosmd · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Feb 3, 2022 · 37 shares · 56 followers View post →
Surriya Colleen Ahmad, MD
@emergencyimprov · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Feb 3, 2022 · 37 shares · 224 followers View post →
Teguh Kristian
@teguhkristian · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Feb 3, 2022 · 37 shares · 181 followers View post →
Miquel Mas
@DrMqAgMas · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Feb 3, 2022 · 37 shares · 2,464 followers View post →
American Geriatrics Society
@AmerGeriatrics · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Feb 3, 2022 · 37 shares · 26,325 followers View post →
Carmelo
@carmelprzrz · X

RT @osmachope: Effect of antipsychotics on mortality risk in patients with dementia with and without comorbidities https://t.co/MREBbvIiT3

Feb 1, 2022 · 4 shares · 451 followers View post →
Laure Rouch
@RouchLaure · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Jan 31, 2022 · 37 shares · 717 followers View post →
Paco Tarazona
@Sabater71 · X

RT @osmachope: Effect of antipsychotics on mortality risk in patients with dementia with and without comorbidities https://t.co/MREBbvIiT3

Jan 31, 2022 · 4 shares · 1,219 followers View post →
A.R. García
@air_garcia · X

RT @osmachope: Effect of antipsychotics on mortality risk in patients with dementia with and without comorbidities https://t.co/MREBbvIiT3

Jan 31, 2022 · 4 shares · 802 followers View post →
Pame
@YuridiaPame1 · X

RT @osmachope: Effect of antipsychotics on mortality risk in patients with dementia with and without comorbidities https://t.co/MREBbvIiT3

Jan 31, 2022 · 4 shares · 197 followers View post →
Oscar Macho
@osmachope · X

Effect of antipsychotics on mortality risk in patients with dementia with and without comorbidities https://t.co/MREBbvIiT3

Jan 31, 2022 · 7 likes · 4 shares · 3,039 followers View post →
Rita López Bru
@RitaLopBru · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Jan 29, 2022 · 37 shares · 65 followers View post →
Alvaro Casas Herrero
@alvaro_casasher · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Jan 29, 2022 · 37 shares · 2,602 followers View post →
Giuseppe Maltese
@docmaltese · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Jan 28, 2022 · 37 shares · 1,780 followers View post →
Johns Hopkins Geriatric Medicine & Gerontology
@JHGeriatrics · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Jan 28, 2022 · 37 shares · 3,272 followers View post →
Mohamed ELOKL دكتور محمد العكل
@ELOKL1 · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Jan 28, 2022 · 37 shares · 173 followers View post →
Mary-Lynn Peters
@MLPeters84 · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Jan 28, 2022 · 37 shares · 164 followers View post →
Flávio Xavier
@FMFX · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Jan 28, 2022 · 37 shares · 578 followers View post →
José Carlos Velho
@JoseCarlosVelho · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Jan 27, 2022 · 37 shares · 488 followers View post →
Ariela Orkaby MD MPH
@DrAROrkaby · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Jan 27, 2022 · 37 shares · 869 followers View post →
Samir Sinha
@DrSamirSinha · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Jan 27, 2022 · 37 shares · 12,176 followers View post →
Paula Span
@paula_span · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Jan 27, 2022 · 37 shares · 9,048 followers View post →
koureiigaku
@koureiigaku · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Jan 27, 2022 · 37 shares · 848 followers View post →
Debby Keller, MD
@debby_keller · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Jan 27, 2022 · 37 shares · 7,133 followers View post →
โต๊ะอุ่น
@kotatsudream · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Jan 27, 2022 · 37 shares · 72 followers View post →
Irene Blackberry
@IreneBlackberry · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Jan 27, 2022 · 37 shares · 369 followers View post →
Medicina
@envelhecercom · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Jan 27, 2022 · 37 shares · 50 followers View post →
lucero
@lucymatsu · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Jan 27, 2022 · 37 shares · 153 followers View post →
Mliston240
@mliston240 · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Jan 27, 2022 · 37 shares · 22 followers View post →
CAIN
@CAIN_Lab · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Jan 27, 2022 · 37 shares · 2,530 followers View post →
Anna Pendrey
@AnnaPendrey · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Jan 27, 2022 · 37 shares · 62 followers View post →
Daniel Sevilla
@danisevisan · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Jan 27, 2022 · 37 shares · 846 followers View post →
Marcela Jirón
@dr_mjiron · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Jan 27, 2022 · 37 shares · 140 followers View post →
zach on stacks
@Macchzac · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Jan 27, 2022 · 37 shares · 169 followers View post →
Xtian_ sci hub
@Xtian_tuck · X

RT @AGSJournal: Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients w…

Jan 27, 2022 · 37 shares · 30,467 followers View post →
JAGS
@AGSJournal · X

Antipsychotics increase mortality risk by 35% in patients with dementia. Highest mortality rates are found among patients with dementia and comorbidites of heart disease and diabetes treated with antipsychotics. #geriatrics https://t.co/AjB6dMP0MO https://t.co/T24tIIPyf8

Jan 27, 2022 · 58 likes · 37 shares · 11,214 followers View post →
pinacol
@pinacol · X

【コホート研究】認知症と診断された65-95歳の患者において、抗精神病薬への曝露は、非曝露と比較して、死亡リスクの増加と関連した。粗死亡率は、抗精神病薬開始時点で併存疾患がない患者より心疾患と糖尿病のある患者で高かった。 #ペ読 https://t.co/8bzdIaocsd

Jan 22, 2022 · 1,616 followers View post →
Walid Alkeridy وليد الكريدي
@WalidAlkeridy · X

Effect of antipsychotics on mortality risk in patients with dementia with and without comorbidities - Nørgaard - - Journal of the American Geriatrics Society - Wiley Online Library https://t.co/HARjorRO3Y

Jan 21, 2022 · 1 like · 1,294 followers View post →
Montefiore Geriatrics
@MontefioreGeri · X

Another reminder to consider goals of care and risks vs benefits prior to initiating #antipsychotics in those with #dementia. "Effect of antipsychotics on mortality risk in patients with dementia with and without comorbidities" https://t.co/gaJxYwEWSn

Jan 20, 2022 · 3 likes · 288 followers View post →
うと
@utouto0117 · X

RT @aquariusmed: #ジャーナル 高齢認知症患者への抗精神病薬の投与は死亡率を悪化。糖尿病や心疾患の有無に関係なく、抗精神病薬は死亡リスクを悪化させる。 https://t.co/t4p0UHwDG0

Jan 17, 2022 · 2 shares · 670 followers View post →
スナックしおじゅん
@siosiojunjun · X

RT @aquariusmed: #ジャーナル 高齢認知症患者への抗精神病薬の投与は死亡率を悪化。糖尿病や心疾患の有無に関係なく、抗精神病薬は死亡リスクを悪化させる。 https://t.co/t4p0UHwDG0

Jan 16, 2022 · 2 shares · 12,624 followers View post →
森川 暢 /Toru Morikawa Community Hospitalist @ Nara
@aquariusmed · X

#ジャーナル 高齢認知症患者への抗精神病薬の投与は死亡率を悪化。糖尿病や心疾患の有無に関係なく、抗精神病薬は死亡リスクを悪化させる。 https://t.co/t4p0UHwDG0

Jan 16, 2022 · 13 likes · 2 shares · 4,621 followers View post →