Genome Biol January 2022 PMID 35067223

Nanopore adaptive sampling: a tool for enrichment of low abundance species in metagenomic samples.

Samuel Martin, Darren Heavens, Yuxuan Lan, Samuel Horsfield, Matthew D Clark, Richard M Leggett

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Mentions

153

Peak: 61 in Jan 2022

across 4 sources since May 2021

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468,170

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242

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May 2021 – Mar 2025

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What people are saying

Several discussions highlight specific aspects of the research, mentioning the use of a 'predictive calculator' and the challenges of handling time related to adaptive sampling. Phrases like 'plenty of headroom to make it even better' and 'fantastic achievement' in the discussions reflect a positive outlook and hint at potential future advancements, showcasing the sentiment of optimism and engagement surrounding the publication.

AgreementModerate agreement

Many posts express a generally positive outlook towards the publication's methodology and findings, suggesting a level of consensus.

InterestHigh interest

There is high enthusiasm expressed in various comments, indicating strong curiosity and importance of the topic to the relevant audience.

EngagementModerate engagement

While several discussions dive into technical matters, they often remain surface-level, focusing more on the publication's existence rather than deep analysis.

ImpactHigh impact

Users articulate a belief that the paper's findings and methodology will significantly influence future research in metagenomics.

Abstract in brief

Adaptive sampling improves the detection of rare species in nanopore sequencing by using software-controlled enrichment techniques.
In experiments with synthetic mock communities, the method achieved up to 13.87-fold enrichment of the least abundant species for longer read lengths.
A mathematical model was developed to predict enrichment outcomes based on molecule length and abundance, which aligned well with results from both mock and real microbial communities.

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All mentions

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KONE BOÏ

@boi_kone · X

RT @matholomoo: @OmicsOmicsBlog We have published (https://t.co/2W24eDblJd) an adaptive sequencing mathematical model (available as a web…

Nov 8, 2023 · 4 shares · 300 followers View post →

Keith Robison

@OmicsOmicsBlog · X

RT @matholomoo: @OmicsOmicsBlog We have published (https://t.co/2W24eDblJd) an adaptive sequencing mathematical model (available as a web…

Nov 1, 2023 · 4 shares · 9,982 followers View post →

Simón Villanueva Corrales

@Sivico26 · X

RT @matholomoo: @OmicsOmicsBlog We have published (https://t.co/2W24eDblJd) an adaptive sequencing mathematical model (available as a web…

Nov 1, 2023 · 4 shares · 229 followers View post →

Krishna Yerramsetty

@yerrkimo · X

RT @matholomoo: @OmicsOmicsBlog We have published (https://t.co/2W24eDblJd) an adaptive sequencing mathematical model (available as a web…

Nov 1, 2023 · 4 shares · 222 followers View post →

Matthew Clark

@matholomoo · X

Nov 1, 2023 · 10 likes · 4 shares · 639 followers View post →

Kodama Yuichi

@curatorjp · X

Nanopore adaptive sampling: a tool for enrichment of low abundance species in metagenomic samples | Genome Biology | Full Text https://t.co/KO4K1MYFCe

May 16, 2023 · 75 followers View post →

Benjamin Vernot

@melanoidin · X

@PartridgeCG I'm not sure about cost, but maybe something like nanopore adaptive sampling, to select for reads that are close-ish to the genome of interest? https://t.co/SCNWgDQSzk

Mar 7, 2023 · 1,676 followers View post →

Alexander Wittenberg

@AW_NGS · X

RT @matholomoo: @AW_NGS @philippecubry @AlbertVilella @biodiversityge1 @nanopore @KeyGeneInfo We modelled many of the factors affecting nan…

Nov 29, 2022 · 1 share · 5,010 followers View post →

Matthew Clark

@matholomoo · X

@AW_NGS @philippecubry @AlbertVilella @biodiversityge1 @nanopore @KeyGeneInfo We modelled many of the factors affecting nanopore adaptive sequencing, and have a predictive calculator you can use to design better experiments. See paper at https://t.co/bvTuPGc849

Nov 29, 2022 · 5 likes · 1 share · 639 followers View post →

SeqComplete

@SeqComplete · X

#nanopores Nanopore adaptive sampling: a tool for enrichment of low abundance species in metagenomic samples | Genome Biology | Full Text https://t.co/aTlpR3FStd, see more https://t.co/aSBVBTKTPt

Mar 30, 2022 · 4,408 followers View post →

NanoGeoBio

@NanoGeoBio · X