Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders.

Sara Ramírez, Roberta Haddad-Tóvolli, Marija Radosevic, Miriam Toledo, Adriana Pané, Daniel Alcolea, Vicent Ribas, Maria Milà-Guasch, Macarena Pozo, Arnaud Obri, Elena Eyre, Alicia G Gómez-Valadés, Iñigo Chivite, Tomas Van Eeckhout, Ioannis Zalachoras

February 2022 Cell Metab

Synopsis of Social media discussions

Discussions mostly revolve around the core idea that hypothalamic pregnenolone links metabolic disorders with memory, as seen in posts highlighting its mediating role; the tone is factual and concise, reflecting general agreement and interest but limited in-depth analysis.

A
Agreement
 Moderate agreement

Most discussions acknowledge the significance of hypothalamic pregnenolone in linking metabolism and cognition, indicating general agreement on the findings.

I
Interest
 Moderate level of interest

The posts show moderate interest, with many sharing the main point without deep analysis, but some referencing the connection to metabolic health and memory.

E
Engagement
 Moderate level of engagement

Participants tend to echo the main message and share related terminologies, suggesting a basic level of engagement rather than deep technical discussion.

I
Impact
 Moderate level of impact

The emphasis on potential connections between metabolism and cognitive function suggests awareness of the study's importance but lacks evidence of widespread application or policy implications.

Social Mentions

YouTube

2 Videos

Twitter

12 Posts

News

3 Articles

Metrics

Video Views

182

Total Likes

23

Extended Reach

68,824

Social Features

17

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Hypothalamic Pregnenolone's Role in Recognition Memory and Metabolic Disorders

Hypothalamic Pregnenolone's Role in Recognition Memory and Metabolic Disorders

Obesity and type 2 diabetes impair memory by reducing hypothalamic pregnenolone production. Interfering with pregnenolone synthesis in POMC neurons worsens memory, highlighting their critical role in linking energy regulation and cognition.

ivLab

April 19, 2024

156 views

Hypothalamic Pregnenolone's Role in Memory and Metabolic Disorders

Hypothalamic Pregnenolone's Role in Memory and Metabolic Disorders

Obesity and diabetes impair recognition memory partly due to reduced hypothalamic pregnenolone production, with POMC neurons playing a key role in this process, affecting hippocampal plasticity. The study highlights potential targets for cognitive dysfunction in metabolic disorders.

ivLab

April 26, 2024

26 views

  • CopperKettle
    @Artyom_Yekat (Twitter)

    RT @Cell_Metabolism: Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders https://t.co/jBv4da3wln
    view full post

    November 23, 2022

    6

  • Dipòsit Digital UB
    @DD_UB (Twitter)

    Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders https://t.co/CZsVPE3evj
    view full post

    March 3, 2022

  • Miguel Ángel Sogorb
    @MASogorb (Twitter)

    Hallan una sustancia que conecta el metabolismo con el rendimiento cognitivo https://t.co/YnpJ1eBPqH Más información: Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders https://t.co/zK0emuEMmq
    view full post

    February 12, 2022

  • Chisato Okamoto MD, PhD
    @chiahina (Twitter)

    RT @Cell_Metabolism: Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders https://t.co/jBv4da3wln
    view full post

    February 3, 2022

    6

  • Yi Lu
    @YiLu72150820 (Twitter)

    RT @Cell_Metabolism: Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders https://t.co/jBv4da3wln
    view full post

    February 3, 2022

    6

  • Marc Schneeberger Pane
    @marcschp (Twitter)

    RT @Cell_Metabolism: Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders https://t.co/jBv4da3wln
    view full post

    February 3, 2022

    6

  • Prof. EHM NDOUR
    @ehmndour111 (Twitter)

    RT @Metabbot: Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders. Cell Metab #metabolomics https:/…
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    February 3, 2022

    2

  • Bioinformatics Trends 
    @BinfoTrends (Twitter)

    RT @Metabbot: Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders. Cell Metab #metabolomics https:/…
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    February 3, 2022

    2

  • Metabolomics Papers
    @Metabbot (Twitter)

    Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders. Cell Metab #metabolomics https://t.co/V5psQjpUPa
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    February 3, 2022

    2

    2

  • Ciencia de la 4T
    @Ciencia4T (Twitter)

    RT @Cell_Metabolism: Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders https://t.co/jBv4da3wln
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    February 2, 2022

    6

  • Cell Metabolism
    @Cell_Metabolism (Twitter)

    Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders https://t.co/jBv4da3wln
    view full post

    February 2, 2022

    18

    6

  • Dr.ドクター | 糖尿病専門医Youtuber
    @Dr_doctor_DM (Twitter)

    Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders https://t.co/pBphLlTmnL
    view full post

    February 1, 2022

    1

Abstract Synopsis

  • The study found that obesity and type 2 diabetes can impair memory, partly due to reduced production of pregnancyolone, a neurosteroid, in the hypothalamus, which is a brain region involved in energy regulation and cognition.
  • Specifically, interfering with pregnancyolone synthesis in POMC neurons (but not other neurons like AgRP) worsened recognition memory, suggesting that POMC neurons play a key role in this process through an autocrine (self-acting) mechanism affecting hippocampal plasticity.
  • The findings were also supported by observations in humans with obesity, indicating that hypothalamic pregnancyolone and POMC neurons might be important targets for understanding and treating cognitive problems associated with metabolic disorders.]