Cell Metab February 2022 PMID 35108514

Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders.

Sara Ramírez, Roberta Haddad-Tóvolli, Marija Radosevic, Miriam Toledo, Adriana Pané, Daniel Alcolea, Vicent Ribas, Maria Milà-Guasch, Macarena Pozo, Arnaud Obri, Elena Eyre, Alicia G Gómez-Valadés, Iñigo Chivite, Tomas Van Eeckhout, Ioannis Zalachoras

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Mentions

Peak: 10 in Feb 2022

across 3 sources since Feb 2022

Extended reach

68,824

potential audience

Total likes

Video views

182

Mentions per month

Feb 2022 – Apr 2024

Where it's discussed

X / Twitter12 posts
News3 articles
YouTube2 videos

AI synopsis

What people are saying

Discussions mostly revolve around the core idea that hypothalamic pregnenolone links metabolic disorders with memory, as seen in posts highlighting its mediating role; the tone is factual and concise, reflecting general agreement and interest but limited in-depth analysis.

AgreementModerate agreement

Most discussions acknowledge the significance of hypothalamic pregnenolone in linking metabolism and cognition, indicating general agreement on the findings.

InterestModerate interest

The posts show moderate interest, with many sharing the main point without deep analysis, but some referencing the connection to metabolic health and memory.

EngagementModerate engagement

Participants tend to echo the main message and share related terminologies, suggesting a basic level of engagement rather than deep technical discussion.

ImpactModerate impact

The emphasis on potential connections between metabolism and cognitive function suggests awareness of the study's importance but lacks evidence of widespread application or policy implications.

Abstract in brief

The study found that obesity and type 2 diabetes can impair memory, partly due to reduced production of pregnancyolone, a neurosteroid, in the hypothalamus, which is a brain region involved in energy regulation and cognition.
Specifically, interfering with pregnancyolone synthesis in POMC neurons (but not other neurons like AgRP) worsened recognition memory, suggesting that POMC neurons play a key role in this process through an autocrine (self-acting) mechanism affecting hippocampal plasticity.
The findings were also supported by observations in humans with obesity, indicating that hypothalamic pregnancyolone and POMC neurons might be important targets for understanding and treating cognitive problems associated with metabolic disorders.]

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Hypothalamic Pregnenolone's Role in Recognition Memory and Metabolic Disorders

Obesity and type 2 diabetes impair memory by reducing hypothalamic pregnenolone production. Interfering with pregnenolone synthesis in POMC neurons worsens memory, highlighting their critical role in linking energy…

ivLab · Apr 19, 2024 156 views

Hypothalamic Pregnenolone's Role in Memory and Metabolic Disorders

Obesity and diabetes impair recognition memory partly due to reduced hypothalamic pregnenolone production, with POMC neurons playing a key role in this process, affecting hippocampal plasticity. The study highlights…

ivLab · Apr 26, 2024 26 views

CopperKettle

@Artyom_Yekat · X

RT @Cell_Metabolism: Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders https://t.co/jBv4da3wln

Nov 23, 2022 · 6 shares · 379 followers View post →

Dipòsit Digital UB

@DD_UB · X

Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders https://t.co/CZsVPE3evj

Mar 3, 2022 · 488 followers View post →

Miguel Ángel Sogorb

@MASogorb · X

Hallan una sustancia que conecta el metabolismo con el rendimiento cognitivo https://t.co/YnpJ1eBPqH Más información: Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders https://t.co/zK0emuEMmq

Feb 12, 2022 · 158 followers View post →

Chisato Okamoto MD, PhD

@chiahina · X

RT @Cell_Metabolism: Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders https://t.co/jBv4da3wln

Feb 3, 2022 · 6 shares · 50 followers View post →

Yi Lu

@YiLu72150820 · X

RT @Cell_Metabolism: Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders https://t.co/jBv4da3wln

Feb 3, 2022 · 6 shares · 353 followers View post →

Marc Schneeberger Pane

@marcschp · X

RT @Cell_Metabolism: Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders https://t.co/jBv4da3wln

Feb 3, 2022 · 6 shares · 637 followers View post →

Prof. EHM NDOUR

@ehmndour111 · X

RT @Metabbot: Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders. Cell Metab #metabolomics https:/…

Feb 3, 2022 · 2 shares · 60 followers View post →

Bioinformatics Trends 

@BinfoTrends · X

RT @Metabbot: Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders. Cell Metab #metabolomics https:/…

Feb 3, 2022 · 2 shares · 8,157 followers View post →

Metabolomics Papers

@Metabbot · X

Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders. Cell Metab #metabolomics https://t.co/V5psQjpUPa

Feb 3, 2022 · 2 likes · 2 shares · 1,488 followers View post →

Ciencia de la 4T

@Ciencia4T · X

RT @Cell_Metabolism: Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders https://t.co/jBv4da3wln

Feb 2, 2022 · 6 shares · 284 followers View post →

Cell Metabolism

@Cell_Metabolism · X

Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders https://t.co/jBv4da3wln

Feb 2, 2022 · 18 likes · 6 shares · 53,678 followers View post →

Dr.ドクター | 糖尿病専門医Youtuber

@Dr_doctor_DM · X

Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders https://t.co/pBphLlTmnL

Feb 1, 2022 · 1 like · 2,827 followers View post →

Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders.

Mentions per month

Where it's discussed

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Abstract in brief

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Hypothalamic Pregnenolone's Role in Recognition Memory and Metabolic Disorders

Hypothalamic Pregnenolone's Role in Memory and Metabolic Disorders